ROCK1 Antibody (2E2)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 2 of 2.

Publications using H00006093-M01	Applications	Species
Nishimura Y, Bereczky B, Yoshioka K et al. A novel role of Rho-kinase in the regulation of ligand-induced phosphorylated EGFR endocytosis via the early/late endocytic pathway in human fibrosarcoma cells. J Mol Histol. 2011-08-17 [PMID: 21847509]
Gong LL, Fang LH, Peng JH et al. Integration of virtual screening with high-throughput screening for the identification of novel Rho-kinase I inhibitors. J Biotechnol. 2009-12-04 [PMID: 19963024]

Array H00006093-M01

• ROCK1 Antibodies
• ROCK1 ELISA Kits
• ROCK1 Proteins
• ROCK1 Proteins and Enzyme