ROCK1 Products

Description

Rho-associated kinase I (ROCK1, ROK beta, p160ROCK) is a serine-threonine protein kinase and an effector of the small GTPase Rho. With N-terminus protein kinase domain and C-terminus Rho-binding domain/pleckstrin homology domain, ROCK1 can be activated by either RhoA or RhoB. In Rho specific ROCK1 activation, a Rho protein binds to the Rho-binding domain and induces a conformational change which opens the kinase domain for the phosphorylation of downstream effectors (1). Activated ROCK1 phosphorylates various signaling proteins, such as myosin light chain phosphatase, LIM kinases, and ezrin-radixin-moesin proteins. Caspase-3 also activates ROCK1; Caspase-3 cleaves ROCK1 at DETD1113/G sequence and removes its inhibitory c-terminal domain. This activation, independent of Rho activity, leads to apoptotic membrane blebbing (2). ROCK1 is involved in regulating actin cytoskeleton assembly, cell migration, centromere positing, smooth muscle contraction, and neurite outgrowth. Its involvement in tumor invasion, hypertension, and bronchial asthma makes ROCK1 an ideal target for drug development (3).

Bioinformatics

Entrez	19877 Mouse 6093 Human 81762 Rat
Uniprot	NM_005406 Human NP_005397 Human NP_005397 Human Q13464 Human Q13464 Human
Product By Gene ID	6093
Alternate Names	EC 2.7.11 EC 2.7.11.1 MGC131603 MGC43611 p160 ROCK-1 P160ROCK p160ROCK p160-ROCK PRO0435 Renal carcinoma antigen NY-REN-35 Rho kinase rho-associated protein kinase 1 Rho-associated, coiled-coil containing protein kinase 1 Rho-associated, coiled-coil-containing protein kinase 1

Research Areas for ROCK1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Breast Cancer
Cancer
Signal Transduction
Wnt Signaling Pathway

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