Name: Rictor Antibody
Brand: Novus Biologicals
SKU: NB100-611
Price: 449 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	HuSpecies Glossary
Applications	WB, IP
Clonality	Polyclonal
Host	Rabbit
Conjugate	Unconjugated
Concentration	1.0 mg/ml

Catalog# & Conjugate	Size	Price
Alexa Fluor 350 NB100-611AF350

Alexa Fluor 405 NB100-611AF405

Alexa Fluor 488 NB100-611AF488

Alexa Fluor 532 NB100-611AF532

Alexa Fluor 594 NB100-611AF594

Alexa Fluor 647 NB100-611AF647

Alexa Fluor 700 NB100-611AF700

Alexa Fluor 750 NB100-611AF750

Allophycocyanin NB100-611APC

Biotin NB100-611B

DyLight 350 NB100-611UV

DyLight 405 NB100-611V

DyLight 488 NB100-611G

DyLight 550 NB100-611R

DyLight 594 NB100-611DL594

DyLight 650 NB100-611C

DyLight 680 NB100-611FR

DyLight 755 NB100-611IR

HRP NB100-611H

PE NB100-611PE

PerCP NB100-611PCP

Conjugate	Catalog #	Availability	Size	Price
Alexa Fluor 350	NB100-611AF350
Alexa Fluor 405	NB100-611AF405
Alexa Fluor 488	NB100-611AF488
Alexa Fluor 532	NB100-611AF532
Alexa Fluor 594	NB100-611AF594
Alexa Fluor 647	NB100-611AF647
Alexa Fluor 700	NB100-611AF700
Alexa Fluor 750	NB100-611AF750
Allophycocyanin	NB100-611APC
Biotin	NB100-611B
DyLight 350	NB100-611UV
DyLight 405	NB100-611V
DyLight 488	NB100-611G
DyLight 550	NB100-611R
DyLight 594	NB100-611DL594
DyLight 650	NB100-611C
DyLight 680	NB100-611FR
DyLight 755	NB100-611IR
HRP	NB100-611H
PE	NB100-611PE
PerCP	NB100-611PCP

Immunogen	The immunogen recognized by this antibody maps to a region between residues 1 and 50 of human Rapamycin-Insensitive Companion of mTOR using the numbering given in TrEMBL entry Q6R327 (GeneID 253260).
Specificity	NB100-611 is specific for human Rictor protein.
Isotype	IgG
Clonality	Polyclonal
Host	Rabbit
Gene	RICTOR
Purity	Immunogen affinity purified
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Rictor Antibody

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Publications for Rictor Antibody (NB100-611)(33)

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Storage	Store at 4C. Do not freeze.
Buffer	Tris-Citrate/Phosphate (pH 7.0 - 8.0)
Preservative	0.09% Sodium Azide
Concentration	1.0 mg/ml
Purity	Immunogen affinity purified

Publications using NB100-611	Applications	Species
James MF, Stivison E, Beauchamp R et al. Regulation of mTOR complex 2 signaling in neurofibromatosis 2-deficient target cell types. Mol Cancer Res 2012-05-01 [PMID: 22426462]
Ansell SM, Tang H, Kurtin PJ et al. Temsirolimus and rituximab in patients with relapsed or refractory mantle cell lymphoma: a phase 2 study Lancet Oncol 2011-03-24 [PMID: 21440503]
Murata H, Sakaguchi M, Jin Y et al. A new cytosolic pathway from a Parkinson disease-associated kinase, BRPK/PINK1: activation of AKT via mTORC2. J Biol Chem 2011-03-01 [PMID: 21177249]
Liu L, Luo Y, Chen L et al. Rapamycin inhibits cytoskeleton reorganization and cell motility by suppressing RhoA expression and activity. J Biol Chem 2010-12-01 [PMID: 20937815]
Fu L, Kim YA, Wang X et al. Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy. Cancer Res 2009-12-01 [PMID: 19920197]
Dibble CC, Asara JM, Manning BD et al. Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1. Mol Cell Biol 2009-11-01 [PMID: 19720745]
Yu K, Toral-Barza L, Shi C et al. Biochemical, Cellular, In vivo Activity of Novel ATP-Competitive Selective Inhibitors of the Mammalian Target of Rapamycin. Cancer Res 2009-01-01 [PMID: 19584280]
Shu L, Houghton PJ. The mTORC2 complex regulates terminal differentiation of C2C12 myoblasts. Mol Cell Biol 2009-09-01 [PMID: 19564418]
Breuleux M, Klopfenstein M, Stephan C, et al. Increased AKT S473 phosphorylation after mTORC1 inhibition is rictor dependent does not predict tumor cell response to PI3K/mTOR inhibition. Mol Cancer Ther 2009-01-01 [PMID: 19372546]
Sato T, Nakashima A, Guo L et al. Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein. J Biol Chem 2009-05-01 [PMID: 19299511]
Copp J, Manning G, Hunter T et al. TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2. Cancer Res 2009-03-01 [PMID: 19244117]
Beevers CS, Chen L, Liu L et al. Curcumin disrupts the Mammalian target of rapamycin-raptor complex. Cancer Res 2009-02-01 [PMID: 19176385]
Thoreen CC, Kang SA, Chang JW et al. An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J Biol Chem 2009-03-01 [PMID: 19150980]
Lee HK, Kumar P, Fu Q et al. The insulin/Akt signaling pathway is targeted by intracellular beta-amyloid. Mol Biol Cell 2009-03-01 [PMID: 19144826]
Dormond O, Contreras AG, Meijer E et al. CD40-induced signaling in human endothelial cells results in mTORC2- and Akt-dependent expression of vascular endothelial growth factor in vitro and in vivo. J Immunol 2008-12-01 [PMID: 19018001]
Ohne Y, Takahara T, Hatakeyama R et al. Isolation of hyperactive mutants of mammalian target of rapamycin. J Biol Chem 2008-11-01 [PMID: 18812319]
Wang X, Yue P, Kim YA et al. Enhancing mammalian target of rapamycin (mTOR)-targeted cancer therapy by preventing mTOR/raptor inhibition-initiated, mTOR/rictor-independent Akt activation. Cancer Res 2008-09-01 [PMID: 18794129]
Schieke SM, Ma M, Cao L et al. Mitochondrial metabolism modulates differentiation and teratoma formation capacity in mouse embryonic stem cells. J Biol Chem 2008-10-01 [PMID: 18713735]
Rosner M, Hengstschlager M. Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1. Hum Mol Genet 2008-10-01 [PMID: 18614546]
Dan HC, Cooper MJ, Cogswell PC et al. Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK. Genes Dev 2008-06-01 [PMID: 18519641]
Huang J, Dibble CC, Matsuzaki M et al. The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. Mol Cell Biol 2008-06-01 [PMID: 18411301]
Yu Y, Alwine JC. Interaction between simian virus 40 large T antigen and insulin receptor substrate 1 is disrupted by the K1 mutation, resulting in the loss of large T antigen-mediated phosphorylation of Akt. J Virol 2008-05-01 [PMID: 18305032]
Masri J, Bernath A, Martin J et al. mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor. Cancer Res 2007-12-01 [PMID: 18089801]
Dan HC, Adli M, Baldwin AS et al. Regulation of mammalian target of rapamycin activity in PTEN-inactive prostate cancer cells by I kappa B kinase alpha. Cancer Res 2007-07-01 [PMID: 17616684]
Dormond O, Madsen JC, Briscoe DM et al. The effects of mTOR-Akt interactions on anti-apoptotic signaling in vascular endothelial cells. J Biol Chem 2007-08-01 [PMID: 17553806]
Urano J, Sato T, Matsuo T et al. Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells. Proc Natl Acad Sci U S A 2007-02-01 [PMID: 17360675]
Han EK, Leverson JD, McGonigal T et al. Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition. Oncogene 2007-08-01 [PMID: 17334390]
Naimi M, Gautier N, Chaussade C et al. Nuclear forkhead box O1 controls and integrates key signaling pathways in hepatocytes. Endocrinology 2007-05-01 [PMID: 17303659]
Shiota C, Woo JT, Lindner J et al. Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Dev Cell 2006-10-01 [PMID: 16962829]
Jacinto E, Facchinetti V, Liu D et al. SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 2006-10-01 [PMID: 16962653]
Schieke SM, Phillips D, McCoy JP Jr et al. The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity. J Biol Chem 2006-09-01 [PMID: 16847060]
He L, Simmen FA, Mehendale HM et al. Chronic ethanol intake impairs insulin signaling in rats by disrupting Akt association with the cell membrane. Role of TRB3 in inhibition of Akt/protein kinase B activation. J Biol Chem 2006-04-01 [PMID: 16452480]
Hresko RC, Mueckler M. mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes. J Biol Chem 2005-12-01 [PMID: 16221682]
Show All 33 Publications. Collapse Publications.

Gene Symbol	RICTOR
Entrez	253260(Human) 78757(Mouse)
Uniprot	Q6R327()