Recombinant Rat IFN-gamma Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interferon-gamma (IFN-gamma ), also known as type II or immune interferon, exerts a wide range of immunoregulatory activities and is considered to be the prototype proinflammatory cytokine (1, 2). Mature rat IFN-gamma exists as a noncovalently linked homodimer of 20 - 25 kDa variably glycosylated subunits (3). It shares 86% amino acid sequence identity with mouse IFN-gamma and 37%‑45% with bovine, canine, cotton rat, equine, feline, human, porcine, and rhesus IFN-gamma . IFN-gamma dimers bind to IFN-gamma RI (alpha subunits) which then interact with IFN-gamma RII (beta subunits) to form the functional receptor complex of two alpha and two beta subunits. Inclusion of IFN-gamma RII increases the binding affinity for ligand and the efficiency of signal transduction (4, 5). IFN‑ gamma is produced by a variety of immune cells under inflammatory conditions, notably by T cells and NK cells (6). It plays a key role in host defense by promoting the development and activation of Th1 cells, chemoattraction and activation of monocytes and macrophages, upregulation of antigen presentation molecules, and immunoglobulin class switching in B cells. It also exhibits antiviral, antiproliferative, and apoptotic effects (6, 7). In addition, IFN-gamma functions as an anti-inflammatory mediator by promoting the development of regulatory T cells and inhibiting Th17 cell differentiation (8, 9). The pleiotropic effects of IFN-gamma contribute to the development of multiple aspects of atherosclerosis (7).

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 5 applications: Bioassay, ELISA (Standard), ELISA Developmet, In Vivo, Stimulation.

Showing Publications 1 - 10 of 42. Show All 42 Publications. Collapse Publications.

Publications using 585-IF	Applications	Species
Asano, S;Okada-Ogawa, A;Kobayashi, M;Yonemoto, M;Hojo, Y;Shibuta, I;Noma, N;Iwata, K;Shinoda, M; Involvement of Interferon Gamma Signaling in Spinal Trigeminal Caudal Subnucleus Astrocyte in Orofacial Neuropathic Pain in Rats with Infraorbital Nerve Injury Molecular pain 2023-12-10 [PMID: 38073236] (In Vivo, Rat)	In Vivo	Rat
Richert, I;Berchard, P;Abbes, L;Novikov, A;Chettab, K;Vandermoeten, A;Dumontet, C;Karanian, M;Kerzerho, J;Caroff, M;Blay, JY;Dutour, A; A TLR4 Agonist Induces Osteosarcoma Regression by Inducing an Antitumor Immune Response and Reprogramming M2 Macrophages to M1 Macrophages Cancers 2023-09-19 [PMID: 37760603] (Bioassay, Rat)	Bioassay	Rat
Urizar, AI;Prause, M;Ingerslev, LR;Wortham, M;Sui, Y;Sander, M;Williams, K;Barrès, R;Larsen, MR;Christensen, GL;Billestrup, N; Beta cell dysfunction induced by bone morphogenetic protein (BMP)-2 is associated with histone modifications and decreased NeuroD1 chromatin binding Cell death & disease 2023-07-05 [PMID: 37407581] (Bioassay, Mouse)	Bioassay	Mouse
AA Perez-Sern, RS Dos Santos, C Ripoll, A Nadal, DL Eizirik, L Marroqui BCL-XL Overexpression Protects Pancreatic beta-Cells against Cytokine- and Palmitate-Induced Apoptosis International Journal of Molecular Sciences, 2023-03-16;24(6):. 2023-03-16 [PMID: 36982731] (Bioassay, Rat)	Bioassay	Rat
A Badia-Sote, J de Vries, W Dykstra, LM Broersen, JM Verkuyl, AB Smit, MHG Verheijen High-Throughput Analysis of Astrocyte Cultures Shows Prevention of Reactive Astrogliosis by the Multi-Nutrient Combination Fortasyn Connect Cells, 2022-04-22;11(9):. 2022-04-22 [PMID: 35563732] (Bioassay, Mouse)	Bioassay	Mouse
S Kim, Y Son Astrocytes Stimulate Microglial Proliferation and M2 Polarization In Vitro through Crosstalk between Astrocytes and Microglia International Journal of Molecular Sciences, 2021-08-16;22(16):. 2021-08-16 [PMID: 34445510] (Bioassay, Rat)	Bioassay	Rat
N Javeed, TK Her, MR Brown, P Vanderboom, K Rakshit, AM Egan, A Vella, I Lanza, AV Matveyenko Pro-inflammatory beta cell small extracellular vesicles induce beta cell failure through activation of the CXCL10/CXCR3 axis in diabetes Cell Reports, 2021-08-24;36(8):109613. 2021-08-24 [PMID: 34433033] (Stimulation, Mouse)	Stimulation	Mouse
KM Pusic, RP Kraig, AD Pusic IFNgamma-stimulated dendritic cell extracellular vesicles can be nasally administered to the brain and enter oligodendrocytes PLoS ONE, 2021-08-13;16(8):e0255778. 2021-08-13 [PMID: 34388189] (Bioassay, Rat)	Bioassay	Rat
Y Wang, LO Sangaré, TC Paredes-Sa, MA Hassan, S Krishnamur, AM Furuta, BM Markus, S Lourido, JPJ Saeij Genome-wide screens identify Toxoplasma gondii determinants of parasite fitness in IFN&gamma-activated murine macrophages Nat Commun, 2020-10-16;11(1):5258. 2020-10-16 [PMID: 33067458] (Bioassay, Rat)	Bioassay	Rat
S Vig, M Buitinga, D Rondas, I Crèvecoeur, M van Zandvo, E Waelkens, DL Eizirik, C Gysemans, P Baatsen, C Mathieu, L Overbergh Cytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cells Cell Death Dis, 2019-04-05;10(4):309. 2019-04-05 [PMID: 30952835] (Bioassay, Rat)	Bioassay	Rat
S Lively, LC Schlichter Microglia Responses to Pro-inflammatory Stimuli (LPS, IFN?+TNF?) and Reprogramming by Resolving Cytokines (IL-4, IL-10) Front Cell Neurosci, 2018-07-24;12(0):215. 2018-07-24 [PMID: 30087595] (Bioassay, Rat)	Bioassay	Rat
TR Nardelli, EC Vanzela, KC Benedicto, F Brozzi, A Fujita, AK Cardozo, D Eizirik, AC Boschero, F Ortis Prolactin protects against cytokine-induced beta cell death by NFkB and JNK inhibition J. Mol. Endocrinol., 2018-04-09;0(0):. 2018-04-09 [PMID: 29632026] (Bioassay, Rat)	Bioassay	Rat
T Erkens, N Goeminne, A Kegels, M Byloos, P Vinken Analytical performance of a commercial multiplex Luminex-based cytokine panel in the rat J Pharmacol Toxicol Methods, 2018-01-31;91(0):43-49. 2018-01-31 [PMID: 29371052] (ELISA (Standard), Rat)	ELISA (Standard)	Rat
M Lambelet, LF Terra, M Fukaya, K Meyerovich, L Labriola, AK Cardozo, F Allagnat Dysfunctional autophagy following exposure to pro-inflammatory cytokines contributes to pancreatic ?-cell apoptosis Cell Death Dis, 2018-01-24;9(2):96. 2018-01-24 [PMID: 29367588] (Bioassay, Rat)	Bioassay	Rat
JE Lim, E Chung, Y Son A neuropeptide, Substance-P, directly induces tissue-repairing M2 like macrophages by activating the PI3K/Akt/mTOR pathway even in the presence of IFN? Sci Rep, 2017-08-25;7(1):9417. 2017-08-25 [PMID: 28842601] (Bioassay, Rat)	Bioassay	Rat
AL Clark, K Kanekura, Z Lavagnino, LD Spears, D Abreu, J Mahadevan, T Yagi, CF Semenkovic, DW Piston, F Urano Targeting Cellular Calcium Homeostasis to Prevent Cytokine-Mediated Beta Cell Death Sci Rep, 2017-07-17;7(1):5611. 2017-07-17 [PMID: 28717166] (Bioassay, Rat)	Bioassay	Rat
DA Cunha, M Cito, FA Grieco, C Cosentino, T Danilova, L Ladriere, M Lindahl, A Domanskyi, M Bugliani, P Marchetti, DL Eizirik, M Cnop Pancreatic ?-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF) J. Biol. Chem., 2017-07-11;0(0):. 2017-07-11 [PMID: 28698383] (Bioassay, Rat)	Bioassay	Rat
O Stojadinov, TC Wikramanay, AC Villasante, NC Yin, L Liang, E Hinde, J Escandon, M Tomic-Cani, DM Ansell, R Paus, JJ Jimenez Wound healing protects against chemotherapy-induced alopecia in young rats via up-regulating interleukin-1?-mediated signaling Heliyon, 2017-05-30;3(5):e00309. 2017-05-30 [PMID: 28607955] (In Vivo, Rat)	In Vivo	Rat
L Cambier, G de Couto, A Ibrahim, AK Echavez, J Valle, W Liu, M Kreke, RR Smith, L Marbán, E Marbán Y RNA fragment in extracellular vesicles confers cardioprotection via modulation of IL-10 expression and secretion EMBO Mol Med, 2017-03-01;9(3):337-352. 2017-03-01 [PMID: 28167565] (Bioassay, Rat)	Bioassay	Rat
F Brozzi, S Gerlo, FA Grieco, M Juusola, A Balhuizen, S Lievens, C Gysemans, M Bugliani, C Mathieu, P Marchetti, J Tavernier, DL Eizirik Ubiquitin D regulates IRE1?/JNK-dependent apoptosis in pancreatic beta cells J Biol Chem, 2016-04-04;0(0):. 2016-04-04 [PMID: 27044747] (Bioassay, Rat)	Bioassay	Rat
Marroquin Belaunzaran O, Kleber S, Schauer S, Hausmann M, Nicholls F, van den Broek M, Payeli S, Ciurea A, Milling S, Stenner F, Shaw J, Kollnberger S, Bowness P, Petrausch U, Renner C HLA-B27-Homodimer-Specific Antibody Modulates the Expansion of Pro-Inflammatory T-Cells in HLA-B27 Transgenic Rats. PLoS ONE, 2015-06-30;10(6):e0130811. 2015-06-30 [PMID: 26125554] (Bioassay, Rat)	Bioassay	Rat
Miljkovic D, Blazevski J, Petkovic F, Djedovic N, Momcilovic M, Stanisavljevic S, Jevtic B, Mostarica Stojkovic M, Spasojevic I A comparative analysis of multiple sclerosis-relevant anti-inflammatory properties of ethyl pyruvate and dimethyl fumarate. J Immunol, 2015-02-13;194(6):2493-503. 2015-02-13 [PMID: 25681336] (Bioassay, Rat)	Bioassay	Rat
Backe M, Novotny G, Christensen D, Grunnet L, Mandrup-Poulsen T Altering beta-cell number through stable alteration of miR-21 and miR-34a expression. Islets, 2014-01-01;6(1):e27754. 2014-01-01 [PMID: 25483877] (Bioassay, Rat)	Bioassay	Rat
Lazzaro M, Bettegazzi B, Barbariga M, Codazzi F, Zacchetti D, Alessio M Ceruloplasmin potentiates nitric oxide synthase activity and cytokine secretion in activated microglia. J Neuroinflammation, 2014-09-16;11(0):164. 2014-09-16 [PMID: 25224679] (Bioassay, Rat)	Bioassay	Rat
Salzano S, Checconi P, Hanschmann E, Lillig C, Bowler L, Chan P, Vaudry D, Mengozzi M, Coppo L, Sacre S, Atkuri K, Sahaf B, Herzenberg L, Herzenberg L, Mullen L, Ghezzi P Linkage of inflammation and oxidative stress via release of glutathionylated peroxiredoxin-2, which acts as a danger signal. Proc Natl Acad Sci U S A, 2014-08-05;111(33):12157-62. 2014-08-05 [PMID: 25097261] (Bioassay, Mouse)	Bioassay	Mouse
Dahllof M, Christensen D, Harving M, Wagner B, Mandrup-Poulsen T, Lundh M HDAC inhibitor-mediated beta-cell protection against cytokine-induced toxicity is STAT1 Tyr701 phosphorylation independent. J Interferon Cytokine Res, 2014-07-25;35(1):63-70. 2014-07-25 [PMID: 25062500] (Bioassay, Rat)	Bioassay	Rat
Brozzi F, Gerlo S, Grieco F, Nardelli T, Lievens S, Gysemans C, Marselli L, Marchetti P, Mathieu C, Tavernier J, Eizirik D A combined "omics" approach identifies N-Myc interactor as a novel cytokine-induced regulator of IRE1 protein and c-Jun N-terminal kinase in pancreatic beta cells. J Biol Chem, 2014-07-25;289(30):20677-93. 2014-07-25 [PMID: 24936061] (Bioassay, Rat)	Bioassay	Rat
Marroqui L, Santin I, Dos Santos R, Marselli L, Marchetti P, Eizirik D BACH2, a candidate risk gene for type 1 diabetes, regulates apoptosis in pancreatic beta-cells via JNK1 modulation and crosstalk with the candidate gene PTPN2. Diabetes, 2014-03-07;63(7):2516-27. 2014-03-07 [PMID: 24608439] (Bioassay, Rat)	Bioassay	Rat
Steelman A, Smith R, Welsh C, Li J Galectin-9 protein is up-regulated in astrocytes by tumor necrosis factor and promotes encephalitogenic T-cell apoptosis. J Biol Chem, 2013-07-08;288(33):23776-87. 2013-07-08 [PMID: 23836896] (Bioassay, Rat)	Bioassay	Rat
Weaver J, Taylor-Fishwick D Regulation of NOX-1 expression in beta cells: a positive feedback loop involving the Src-kinase signaling pathway. Mol Cell Endocrinol, 2013-02-11;369(1):35-41. 2013-02-11 [PMID: 23410839] (Bioassay, Rat)	Bioassay	Rat
Quan Y, Jiang J, Dingledine R EP2 receptor signaling pathways regulate classical activation of microglia. J Biol Chem, 2013-02-12;288(13):9293-302. 2013-02-12 [PMID: 23404506] (Bioassay, Rat)	Bioassay	Rat
Santin I, Moore F, Grieco F, Marchetti P, Brancolini C, Eizirik D USP18 is a key regulator of the interferon-driven gene network modulating pancreatic beta cell inflammation and apoptosis. Cell Death Dis, 2012-11-15;3(0):e419. 2012-11-15 [PMID: 23152055] (Bioassay, Rat)	Bioassay	Rat
Moore F, Naamane N, Colli ML, Bouckenooghe T, Ortis F, Gurzov EN, Igoillo-Esteve M, Mathieu C, Bontempi G, Thykjaer T, Orntoft TF, Eizirik DL STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation. J. Biol. Chem., 2010-10-27;286(2):929-41. 2010-10-27 [PMID: 20980260] (Bioassay, Rat)	Bioassay	Rat
Schwarznau A, Hanson MS, Sperger JM, Schram BR, Danobeitia JS, Greenwood KK, Vijayan A, Fernandez LA IL-1beta receptor blockade protects islets against pro-inflammatory cytokine induced necrosis and apoptosis. J. Cell. Physiol., 2009-08-01;220(2):341-7. 2009-08-01 [PMID: 19334038] (Bioassay, Rat)	Bioassay	Rat
Husberg C, Nygard S, Finsen AV, Damas JK, Frigessi A, Oie E, Waehre A, Gullestad L, Aukrust P, Yndestad A, Christensen G Cytokine expression profiling of the myocardium reveals a role for CX3CL1 (fractalkine) in heart failure. J. Mol. Cell. Cardiol., 2008-05-28;45(2):261-9. 2008-05-28 [PMID: 18585734] (Bioassay, Rat)	Bioassay	Rat
Paintlia AS, Paintlia MK, Singh AK, Singh I Inhibition of rho family functions by lovastatin promotes myelin repair in ameliorating experimental autoimmune encephalomyelitis. Mol. Pharmacol., 2008-01-31;73(5):1381-93. 2008-01-31 [PMID: 18239032] (Bioassay, Rat)	Bioassay	Rat
Oh JY, Kim MK, Shin MS, Lee HJ, Ko JH, Wee WR, Lee JH The anti-inflammatory and anti-angiogenic role of mesenchymal stem cells in corneal wound healing following chemical injury. Stem Cells, 2008;26(4):1047-55. 2008 [PMID: 18192235] (ELISA Developmet, Rat)	ELISA Developmet	Rat
Schell JB, Crane CA, Smith MF, Roberts MR Differential ex vivo nitric oxide production by acutely isolated neonatal and adult microglia. J. Neuroimmunol., 2007-08-15;189(1):75-87. 2007-08-15 [PMID: 17698208] (Bioassay, Rat)	Bioassay	Rat
Roche M, Diamond M, Finn DP In vivo modulation of LPS-induced alterations in brain and peripheral cytokines and HPA axis activity by cannabinoids. J. Neuroimmunol., 2006-09-29;181(1):57-67. 2006-09-29 [PMID: 17011047] (ELISA (Standard), Rat)	ELISA (Standard)	Rat
Rhodes KE, Raivich G, Fawcett JW The injury response of oligodendrocyte precursor cells is induced by platelets, macrophages and inflammation-associated cytokines. Neuroscience, 2006-04-21;140(1):87-100. 2006-04-21 [PMID: 16631314] (In Vivo, Rat)	In Vivo	Rat
Butovsky O, Landa G, Kunis G, Ziv Y, Avidan H, Greenberg N, Schwartz A, Smirnov I, Pollack A, Jung S, Schwartz M Induction and blockage of oligodendrogenesis by differently activated microglia in an animal model of multiple sclerosis. J. Clin. Invest., 2006-03-23;116(4):905-15. 2006-03-23 [PMID: 16557302] (Bioassay, Rat)	Bioassay	Rat
Frewert S, Stockhammer F, Warschewske G, Zenclussen AC, Rupprecht S, Volk HD, Woiciechowsky C Intratumoral infusion of interleukin-1beta and interferon-gamma induces tumor invasion with macrophages and lymphocytes in a rat glioma model. Neurosci. Lett., 2004-07-08;364(3):145-8. 2004-07-08 [PMID: 15196664] (In Vivo, Rat)	In Vivo	Rat
Show All 42 Publications. Collapse Publications.

Array 585-IF

• IFN-gamma Antibodies
• IFN-gamma Antibody Pairs
• IFN-gamma ELISA Kits
• IFN-gamma Kits
• IFN-gamma Lysate
• IFN-gamma Proteins
• IFN-gamma ELISAs
• IFN-gamma Proteins and Enzymes