Recombinant Mouse Tie-1 (1-749) Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Tyrosine -protein kinase with immunoglobulin (Ig) like and epidermal growth factor (EGF) like domains 1 (Tie1), along with the closely related Tie2, is a transmembrane, vascular-specific receptor tyrosine kinase (RTKs) involved in angiogenesis, vascular development, and hematopoiesis (1,2). The Tie molecules are characterized by three Ig-like domains, three EGF-like domains, and three fibronectin type III-like repeats in the extracellular domain (ECD) and a split tyrosine kinase domain in the cytoplasmic region (3,4). The ECD of mouse Tie1 shares 89% amino acid sequence identity with human Tie1. Tie1 is expressed in endothelial and some hematopoietic progenitor cells and helps modulate angiopoietin signaling (5). While Tie1 is unable to directly bind any of the angiopoietins, it can modulate Tie2/angiopoietin signaling through Tie1/Tie2 heterodimer formation (6). Upregulation of Tie1 has been found in some leukemia and tumor related endothelial cells and inhibition of Tie1 has been shown to prevent metastasis and is being studied as a target for anti-angiogenesis treatments (7-9).

Array 11220-TI

• Tie-1 Antibodies
• Tie-1 Antibody Pair
• Tie-1 ELISA Kits
• Tie-1 Lysate
• Tie-1 ELISA
• Tie-1 Proteins and Enzymes