Recombinant Mouse sFRP-5 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Secreted Frizzled Related Protein‑5 (sFRP‑5), also known as SARP‑3, belongs to a family of Wnt‑binding proteins with homology to the ligand‑binding domain of the Frizzled receptors. sFRPs are approximately 30‑35 kDa in size and contain an N‑terminal Frizzled‑like domain with 10 conserved cysteines and a Netrin‑like C‑terminal domain (1‑3). Mature mouse sFRP‑5 shares 96% and 99% aa sequence identity with human and rat sFRP‑2, respectively (4). During embryonic development, sFRP‑5 is expressed in the anterior visceral endoderm, neural tube, foregut epithelium, and proliferating and prehypertrophic chondrocytes (5‑8). sFRP‑5 activity is required for the development of foregut, liver, ventral pancreas, and somites (6, 7). In the adult, sFRP‑5 is expressed in the retinal pigment epithelium and pancreas (4, 9). sFRP‑5 binds and antagonizes the function of mammalian Wnt‑5a and Wnt‑11 as well as Xenopus Xwnt‑8, resulting in an inhibition of both canonical and non‑canonical Wnt signaling (4, 7, 10). sFRP‑5 down‑regulation is common in breast and gastric cancer cells and is correlated with poor prognosis (11‑13). It functions as a tumor suppressor by inhibiting epithelial‑mesenchymal transition, invasiveness, and tumorigenicity of ovarian cancer cells (14). sFRP‑5 plays an important role in maintaining glucose handling and insulin sensitivity (10). It is secreted by adipocytes and is down‑regulated in mouse models of obesity and type 2 diabetes (10).

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 1 application: Bioassay.

Showing Publications 1 - 3 of 3.

Publications using 7195-SF	Applications	Species
W Liang, P Han, EH Kim, J Mak, R Zhang, AG Torrente, JI Goldhaber, E Marbán, HC Cho Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells Stem Cells, 2019-12-30;0(0):. 2019-12-30 [PMID: 31648393] (Bioassay, Mouse)	Bioassay	Mouse
M Carstensen, K Röhrig, C Niersmann, DM Ouwens, BF Belgardt, M Roden, C Herder Sfrp5 increases glucose-stimulated insulin secretion in the rat pancreatic beta cell line INS-1E PLoS ONE, 2019-03-28;14(3):e0213650. 2019-03-28 [PMID: 30921355] (Bioassay, Rat)	Bioassay	Rat
Yu C, Nguyen T, Irvine K, Sweet M, Frazer I, Blumenthal A Recombinant Wnt3a and Wnt5a elicit macrophage cytokine production and tolerization to microbial stimulation via Toll-like receptor 4. Eur J Immunol, 2014-03-07;44(5):1480-90. 2014-03-07 [PMID: 24643512] (Bioassay, Mouse)	Bioassay	Mouse

Array 7195-SF

• sFRP-5 Antibodies
• sFRP-5 Lysate
• sFRP-5 Proteins and Enzymes
• sFRP-5 ELISA