Recombinant Mouse sFRP-1 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Secreted Frizzled Related Protein-1 (sFRP-1), also known as SARP-2, FRP, and FrzA, belongs to a family of Wnt-binding proteins with homology to the ligand-binding domain of the Frizzled transmembrane Wnt receptors. The sFRP proteins are approximately 30-35 kDa in size and contain an N-terminal Frizzled-like domain with 10 conserved cysteines and a Netrin-like C-terminal domain (1-3). Mature mouse sFRP-1 shares 97% amino acid sequence identity with human and rat sFRP-1. It binds to Wnt-1, -2, -3a, and -4 and prevents their activation of canonical beta-catenin signaling (4-7). sFRP-1 is up-regulated in the ischemic heart where it limits inflammation and the severity of tissue damage following myocardial infarction (8-10). During angiogenesis it induces endothelial cell migration, tube formation, and vessel formation (11). sFRP-1 is expressed by bone marrow stromal cells and osteoclasts (12). It binds to TRANCE/RANK Ligand, inhibits osteoclast and osteoblast formation and survival, and inhibits the formation of trabecular bone (13, 14). sFRP-1 additionally restricts kidney tubule formation (7), the inflammatory activation of leukocytes (10), early B lymphoid progression (12), and vitreous fluid outflow in the eye (15).

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: Bioassay, In Vivo.

Showing Publications 1 - 10 of 10.

Publications using 9019-SF/CF	Applications	Species
A Huyghe, G Furlan, J Schroeder, E Cascales, A Trajkova, M Ruel, F Stüder, M Larcombe, YB Yang Sun, F Mugnier, L De Matteo, A Baygin, J Wang, Y Yu, N Rama, B Gibert, J Kielbassa, L Tonon, P Wajda, N Gadot, M Brevet, M Siouda, P Mulligan, R Dante, P Liu, H Gronemeyer, M Mendoza-Pa, JM Polo, F Lavial Comparative roadmaps of reprogramming and oncogenic transformation identify Bcl11b and Atoh8 as broad regulators of cellular plasticity Nature Cell Biology, 2022-09-08;24(9):1350-1363. 2022-09-08 [PMID: 36075976] (Bioassay, Mouse)	Bioassay	Mouse
ME Fane, Y Chhabra, GM Alicea, DA Maranto, SM Douglass, MR Webster, VW Rebecca, GE Marino, F Almeida, BL Ecker, DJ Zabransky, L Hüser, T Beer, HY Tang, A Kossenkov, M Herlyn, DW Speicher, W Xu, X Xu, EM Jaffee, JA Aguirre-Gh, AT Weeraratna Stromal changes in the aged lung induce an emergence from melanoma dormancy Nature, 2022-06-01;606(7913):396-405. 2022-06-01 [PMID: 35650435] (Bioassay, Mouse)	Bioassay	Mouse
Y Endo, D Asanuma, S Namiki, K Sugihara, K Hirose, A Uemura, Y Kubota, T Miura Quantitative modeling of regular retinal microglia distribution Scientific Reports, 2021-11-22;11(1):22671. 2021-11-22 [PMID: 34811401] (Bioassay, Mouse)	Bioassay	Mouse
P Limraksasi, Y Kosaka, M Zhang, N Horie, T Kondo, H Okawa, M Yamada, H Egusa Shaking culture enhances chondrogenic differentiation of mouse induced pluripotent stem cell constructs Sci Rep, 2020-09-14;10(1):14996. 2020-09-14 [PMID: 32929163] (Bioassay, Mouse)	Bioassay	Mouse
W Liang, P Han, EH Kim, J Mak, R Zhang, AG Torrente, JI Goldhaber, E Marbán, HC Cho Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells Stem Cells, 2019-12-30;0(0):. 2019-12-30 [PMID: 31648393] (Bioassay, Mouse)	Bioassay	Mouse
L Wang, Y Wang, Y Meng, C Zhang, L Di GSK3-activated STAT5 regulates expression of SFRPs to modulate adipogenesis FASEB J., 2018-03-26;0(0):fj201701314R. 2018-03-26 [PMID: 29579399] (Bioassay, Mouse)	Bioassay	Mouse
K Saito-Diaz, H Benchabane, A Tiwari, A Tian, B Li, JJ Thompson, AS Hyde, LM Sawyer, JN Jodoin, E Santos, LA Lee, RJ Coffey, RD Beauchamp, CS Williams, AK Kenworthy, DJ Robbins, Y Ahmed, E Lee APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway Dev. Cell, 2018-03-12;44(5):566-581.e8. 2018-03-12 [PMID: 29533772] (Bioassay, Human)	Bioassay	Human
R Ichijo, H Kobayashi, S Yoneda, Y Iizuka, H Kubo, S Matsumura, S Kitano, H Miyachi, T Honda, F Toyoshima Tbx3-dependent amplifying stem cell progeny drives interfollicular epidermal expansion during pregnancy and regeneration Nat Commun, 2017-09-11;8(1):508. 2017-09-11 [PMID: 28894084] (In Vivo, Mouse)	In Vivo	Mouse
Yu C, Nguyen T, Irvine K, Sweet M, Frazer I, Blumenthal A Recombinant Wnt3a and Wnt5a elicit macrophage cytokine production and tolerization to microbial stimulation via Toll-like receptor 4. Eur J Immunol, 2014-03-07;44(5):1480-90. 2014-03-07 [PMID: 24643512] (Bioassay, Mouse)	Bioassay	Mouse
Li S, Meyer N, Quarto N, Longaker M Integration of multiple signaling regulates through apoptosis the differential osteogenic potential of neural crest-derived and mesoderm-derived Osteoblasts. PLoS ONE, 2013-03-25;8(3):e58610. 2013-03-25 [PMID: 23536803] (Bioassay, Mouse)	Bioassay	Mouse

Array 9019-SF/CF

• sFRP-1 Antibodies
• sFRP-1 Lysate
• sFRP-1 Proteins and Enzymes