Recombinant Mouse Plexin B3 His-tag Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Plexin B3 is a type I transmembrane glycoprotein that belongs to the Plexin family of semaphorin receptors which are critical in axon guidance, (1, 2). There are nine mammalian plexins divided into 4 classes all sharing a common architecture: An extracellular domain (ECD) that binds the semaphorin ligand, a single transmembrane domain and a conserved ~600 amino acid (aa) cytoplasmic region (1, 2). The ECD of mouse Plexin B3 consists of a Sema domain, three plexin-semaphorin-integrin (PSI) domains and four Ig-like, plexins, transcription factors (IPT) domains and shares 81% and 95% aa identity with human and rat Plexin B3, respectively. Alternative splicing of Plexin B3 results in at least three different isoforms (3). Plexin B3 is predominantly expressed in the brain and is a highly potent stimulator of neurite outgrowth (3). Plexin B3 and its identified ligand, the transmembrane semaphorin Sema5A, are both expressed during differentiation and migration of central nervous system oligodendrocytes (4 - 6). Plexin B3 is also expressed in peripheral cells such as fibroblasts, epithelial and primary endothelial cells. Plexin B3 activation by sema 5A mediates functional responses in these cells (4). Expression of Sema 5A and plexin B3 in gastric carcinoma contributes to invasion and metastasis of gastric carcinoma (7).

Array 10220-PC

• Plexin B3 Antibodies
• Plexin B3 Protein
• Plexin B3 Proteins and Enzymes