Plexin B2 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Plexin B2 is a 240 kDa member of the B subfamily, Plexin family of semaphorin receptors. It is expressed by cerebellar granule cells, neuroepithelium and chondrocytes and serves as a receptor for Sema4C. Mature human Plexin B2 is 1819 amino acid (aa) in length. It is a type I transmembrane (TM) glycoprotein that contains an 1178 aa extracellular domain (ECD) plus a 620 aa cytoplasmic region. The ECD contains one semaphorin domain (aa 20‑466) and three IPT repeats (aa 803‑1092). The ECD may be cleaved into two subunits, a 170 kDa alpha ‑chain (aa 20‑1164) and an 80 kDa TM beta -chain that remain noncovalently-linked. Multiple splice variants may exist. One shows an alternate start site at Met1369, while a second shows a deletion of aa 67‑638. Over aa 20‑1160, human Plexin B2 is 82% aa identical to mouse Plexin B2.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: ICC, IHC, Western Blot.

Showing Publications 1 - 7 of 7.

Publications using AF5329	Applications	Species
Alves, CJ;Hannah, T;Sadia, S;Kolsteeg, C;Dixon, A;Wiener, RJ;Nguyen, H;Tipping, MJ;Ladeira, JS;Franklin, PFDC;Dutra de Nigro, NP;Dias, RA;Zabala Capriles, PV;Rodrigues Furtado de Mendonça, JP;Slesinger, P;Costa, K;Zou, H;Friedel, RH; Invasion of glioma cells through confined space requires membrane tension regulation and mechano-electrical coupling via Plexin-B2 bioRxiv : the preprint server for biology 2024-01-02 [PMID: 38313256] (Western Blot, ICC, Human)	Western Blot, ICC	Human
Anju Karki, Reshma Purohit, Sofia Tosoni, Narendra Bharathy, Joel E Michalek, Sonja Chen et al. Plexin-B2 and Semaphorins Do Not Drive Rhabdomyosarcoma Proliferation or Migration Sarcoma 5/6/2022 [PMID: 35570846]
C Junqueira, R Dariolli, J Haydak, S Kang, T Hannah, RJ Wiener, S DeFronzo, R Tejero, GL Gusella, A Ramakrishn, R Alves Dias, A Wojcinski, S Kesari, L Shen, EA Sobie, JP Rodrigues, EU Azeloglu, H Zou, RH Friedel Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion Nature Communications, 2021-10-14;12(1):6019. 2021-10-14 [PMID: 34650052] (ICC, Western Blot, Human)	ICC, Western Blot	Human
Chen Jiang, Ahsan Javed, Laura Kaiser, Michele M. Nava, Rui Xu, Dominique T. Brandt et al. Mechanochemical control of epidermal stem cell divisions by B-plexins Nature Communications 2/26/2021 [PMID: 33637728]
Yong Huang, Rut Tejero, Vivian K. Lee, Concetta Brusco, Theodore Hannah, Taylor B. Bertucci et al. Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics Communications Biology 1/29/2021 [PMID: 33514835]
Iratxe Zuazo-Gaztelu, Marta Pàez-Ribes, Patricia Carrasco, Laura Martín, Adriana Soler, Mar Martínez-Lozano et al. Anti-tumor effects of anti-Semaphorin 4D antibody unravel a novel pro-invasive mechanism of vascular targeting agents Cancer Research 10/15/2019 [PMID: 31239269]
Rnd3-induced cell rounding requires interaction with Plexin-B2 J Cell Sci, 2016-09-21;0(0):. 2016-09-21 [PMID: 27656111] (IHC, Human)	IHC	Human

Array AF5329

• Plexin B2 Antibodies
• Plexin B2 Protein
• Plexin B2 Proteins and Enzymes
• Plexin B2 ELISA