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Recombinant Mouse Noggin Protein

Name: Recombinant Mouse Noggin Protein
Brand: Novus Biologicals
SKU: 1967-NG
Price: 420 USD

(87 Publications)

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Recombinant mouse Noggin (1967-NG) inhibits recombinant human BMP-4-induced alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line. The ED50 for this effect is 0.06-0.3 µg/mL in the presence of 50 ...read more

Product Details

Summary

Reactivity	MuSpecies Glossary
Applications	Bioactivity

Order Details

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Catalog# & Formulation	Size	Price
Carrier Free 1967-NG-025/CF

Carrier Free 1967-NG-100/CF

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Recombinant Mouse Noggin Protein Summary

Details of Functionality

Measured by its ability to inhibit BMP-4-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED₅₀ for this effect is 0.06-0.3 µg/mL in the presence of 50 ng/mL of Recombinant Human BMP-4 (Catalog # 314-BP).

Source

Mouse myeloma cell line, NS0-derived mouse Noggin protein

Mouse Noggin (Leu20-Cys232) Accession # P97466	IEGRGGGSGGGSGGGS	10-His tag
N-terminus		C-terminus

Accession #

P97466

N-terminal Sequence

Leu20

Structure / Form

Disulfide-linked homodimer

Protein/Peptide Type

Recombinant Proteins

Gene

Nog

Purity

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.

Endotoxin Note

<0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Dilutions

Bioactivity

Theoretical MW

26 kDa (monomer).
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

SDS-PAGE

30-35 kDa, reducing conditions

Publications

Read Publications using
1967-NG in the following applications:

Bioassay
67 publications
Cell Culture
6 publications
Differentiation
2 publications
In Vivo
9 publications
Tissue Culture
2 publications

Packaging, Storage & Formulations

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Purity	>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution Instructions	Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse Noggin Protein

NOG
Noggin
SYM1
symphalangism 1 (proximal)
synostoses (multiple) syndrome 1
SYNS1
SYNS1A

Background

Noggin was originally cloned based on its dorsalizing activity in Xenopus embryos. Mammalian Noggins were subsequently identified and cloned from human, mouse and rat cDNA libraries. Mouse Noggin cDNA encodes a 232 amino acid (aa) residue precursor protein with 19 aa residue putative signal peptide that is cleaved to generate the 213 aa residue mature protein which is secreted as a homodimeric glycoprotein. Noggin is a highly conserved molecule. Mature mouse Noggin shares 99% and 83% aa sequence identity with human and Xenopus Noggin, respectively. Noggin has a complex pattern of expression during embryogenesis. In the adult, Noggin is expressed in the central nervous system and in several adult peripheral tissues such as lung, skeletal muscle and skin. Noggin has been shown to be a high-affinity BMP (bone morphogenetic protein) binding protein that antagonizes BMP bioactivities.

Smith, W.C. and R.M. Harland (1992) Cell 70:829.
Valenzuela, D.M. et al. (1995) J. Neurosci. 15:6077.
Brunet, L.J. et al. (1998) Science 280:1455.

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Recombinant Mouse
Noggin Protein

1967-NG

Species: Mu

Applications: Bioactivity

Publications for Noggin (1967-NG)(87)

We have publications tested in 6 confirmed species: Human, Mouse, Rat, Chicken, Transgenic Mouse, Xenopus.

We have publications tested in 5 applications: Bioassay, Cell Culture, Differentiation, In Vivo, Tissue Culture.

Showing Publications 1 - 10 of 87. Show All 87 Publications.

Publications using 1967-NG	Applications	Species
Xie, S;Zhang, S;de Medeiros, G;Liberali, P;Skotheim, JM; The G1/S transition in mammalian stem cells in vivo is autonomously regulated by cell size bioRxiv : the preprint server for biology 2024-04-11 [PMID: 38645246] (Bioassay, Transgenic Mouse)	Bioassay	Transgenic Mouse
Valdes, P;Henry, KW;Fitzgerald, MQ;Muralidharan, K;Caldwell, AB;Ramachandran, S;Goldstein, LSB;Mobley, WC;Galasko, DR;Subramaniam, S; Limitations of the human iPSC-derived neuron model for early-onset Alzheimer's disease Molecular brain 2023-11-03 [PMID: 37924159] (Bioassay, Human)	Bioassay	Human
Wang, T;Zhu, Y;Chen, L;Zhang, W;Qi, H;Shi, X;Zhong, M;Chen, H;Li, Q; ESRRG-PKM2 axis reprograms metabolism to suppress esophageal squamous carcinoma progression and enhance anti-PD-1 therapy efficacy Journal of translational medicine 2023-09-07 [PMID: 37679788] (Bioassay, Human)	Bioassay	Human
A Yamada, K Yoshizaki, K Saito, M Ishikawa, Y Chiba, S Hoshikawa, M Chiba, R Hino, Y Maruya, H Sato, K Masuda, H Yamaza, T Nakamura, T Iwamoto, S Fukumoto GSK3beta inhibitor-induced dental mesenchymal stem cells regulate ameloblast differentiation Journal of oral biosciences, 2022-10-18;0(0):. 2022-10-18 [PMID: 36270608] (Bioassay, Rat)	Bioassay	Rat
ALM Caldwell, L Sancho, J Deng, A Bosworth, A Miglietta, JK Diedrich, MN Shokhirev, NJ Allen Aberrant astrocyte protein secretion contributes to altered neuronal development in multiple models of neurodevelopmental disorders Nature Neuroscience, 2022-08-30;25(9):1163-1178. 2022-08-30 [PMID: 36042312] (Bioassay, Mouse)	Bioassay	Mouse
S Watanabe, S Kobayashi, N Ogasawara, R Okamoto, T Nakamura, M Watanabe, KB Jensen, S Yui Transplantation of intestinal organoids into a mouse model of colitis Nature Protocols, 2022-02-02;0(0):. 2022-02-02 [PMID: 35110738] (Bioassay, Mouse)	Bioassay	Mouse
TY Kim, S Kim, Y Kim, YS Lee, S Lee, SH Lee, MN Kweon A High-Fat Diet Activates the BAs-FXR Axis and Triggers Cancer-Associated Fibroblast Properties in the Colon Cellular and Molecular Gastroenterology and Hepatology, 2021-12-29;0(0):. 2021-12-29 [PMID: 34971821] (Bioassay, Mouse)	Bioassay	Mouse
KM Mackinlay, BA Weatherbee, V Souza Rosa, CE Handford, G Hudson, T Coorens, LV Pereira, S Behjati, L Vallier, MN Shahbazi, M Zernicka-G An in vitro stem cell model of human epiblast and yolk sac interaction Elife, 2021-08-17;10(0):. 2021-08-17 [PMID: 34403333] (Bioassay, Human)	Bioassay	Human
ACP Correia, D Straub, S Calpe, KK Krishnadat Novel In Vivo Mouse Cryoablation Model to Explore Unique Therapeutic Approaches for Premalignant Columnar Lesions Methods and protocols, 2021-01-05;4(1):. 2021-01-05 [PMID: 33526760] (Bioassay, Mouse)	Bioassay	Mouse
R Morikawa, Y Nemoto, Y Yonemoto, S Tanaka, Y Takei, S Oshima, T Nagaishi, K Tsuchiya, K Nozaki, T Mizutani, T Nakamura, M Watanabe, R Okamoto Intraepithelial lymphocytes suppress the intestinal tumor growth by cell-to-cell contact via CD103/E-cadherin signal Cellular and Molecular Gastroenterology and Hepatology, 2021-01-28;0(0):. 2021-01-28 [PMID: 33515805] (Bioassay, Mouse)	Bioassay	Mouse
AJ Bilotta, C Ma, W Yang, Y Yu, Y Yu, X Zhao, Z Zhou, S Yao, SM Dann, Y Cong Propionate Enhances Cell Speed and Persistence to Promote Intestinal Epithelial Turnover and Repair Cell Mol Gastroenterol Hepatol, 2020-11-22;0(0):. 2020-11-22 [PMID: 33238220] (Cell Culture, Mouse)	Cell Culture	Mouse
SY Chien, CH Tsai, SC Liu, CC Huang, TH Lin, YZ Yang, CH Tang Noggin Inhibits IL-1&beta and BMP-2 Expression, and Attenuates Cartilage Degeneration and Subchondral Bone Destruction in Experimental Osteoarthritis Cells, 2020-04-10;9(4):. 2020-04-10 [PMID: 32290085] (In Vivo, Mouse)	In Vivo	Mouse
M Binder, LC Biggs, MS Kronenberg, P Schneider, I Thesleff, A Balic Novel strategies for expansion of tooth epithelial stem cells and ameloblast generation Sci Rep, 2020-03-18;10(1):4963. 2020-03-18 [PMID: 32188889] (Cell Culture, Mouse)	Cell Culture	Mouse
S Kang, K Long, S Wang, A Sada, T Tumbar Histone H3 K4/9/27 Trimethylation Levels Affect Wound Healing and Stem Cell Dynamics in Adult Skin Stem Cell Reports, 2019-12-19;0(0):. 2019-12-19 [PMID: 31866458] (In Vivo, Mouse)	In Vivo	Mouse
M Ali, F Kabir, JJ Thomson, Y Ma, C Qiu, M Delannoy, SY Khan, SA Riazuddin Comparative transcriptome analysis of hESC- and iPSC-derived lentoid bodies Sci Rep, 2019-12-06;9(1):18552. 2019-12-06 [PMID: 31811247] (Bioassay, Human)	Bioassay	Human
PG Boone, LK Rochelle, JD Ginzel, V Lubkov, WL Roberts, PJ Nicholls, C Bock, ML Flowers, RJ von Furste, BR Stripp, P Agarwal, AD Borowsky, RD Cardiff, LS Barak, MG Caron, HK Lyerly, JC Snyder A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion Nat Commun, 2019-12-02;10(1):5490. 2019-12-02 [PMID: 31792216] (Cell Culture, Mouse)	Cell Culture	Mouse
LG Jones, A Vaida, LM Thompson, FI Ikuomola, JH Caamaño, MD Burkitt, F Miyajima, JM Williams, BJ Campbell, DM Pritchard, CA Duckworth NF-kappaB2 signalling in enteroids modulates enterocyte responses to secreted factors from bone marrow-derived dendritic cells Cell Death Dis, 2019-11-26;10(12):896. 2019-11-26 [PMID: 31772152] (Tissue Culture, Mouse)	Tissue Culture	Mouse
M Bakhti, K Scheibner, S Tritschler, A Bastidas-P, M Tarquis-Me, FJ Theis, H Lickert Establishment of a high-resolution 3D modeling system for studying pancreatic epithelial cell biology inï¿½vitro Mol Metab, 2019-09-24;30(0):16-29. 2019-09-24 [PMID: 31767167] (Bioassay, Mouse)	Bioassay	Mouse
C Chen, Y Yang, Y Yao HBO Promotes the Differentiation of Neural Stem Cells via Interactions Between the Wnt3/beta-Catenin and BMP2 Signaling Pathways Cell Transplant, 2019-11-06;0(0):9636897198835. 2019-11-06 [PMID: 31694396] (Cell Culture, Rat)	Cell Culture	Rat
F Inoue, A Kreimer, T Ashuach, N Ahituv, N Yosef Identification and Massively Parallel Characterization of Regulatory Elements Driving Neural Induction Cell Stem Cell, 2019-10-17;0(0):. 2019-10-17 [PMID: 31631012] (Bioassay, Human)	Bioassay	Human
Y Kim, YS Lee, SW Kang, S Kim, TY Kim, SH Lee, SW Hwang, J Kim, EN Kim, JS Ju, YY Park, MN Kweon Loss of PKM2 in Lgr5+ intestinal stem cells promotes colitis-associated colorectal cancer Sci Rep, 2019-04-17;9(1):6212. 2019-04-17 [PMID: 30996297] (Bioassay, Mouse)	Bioassay	Mouse
Z Meng, T Gwag, Y Sui, SH Park, X Zhou, C Zhou The atypical antipsychotic quetiapine induces hyperlipidemia by activating intestinal PXR signaling JCI Insight, 2019-02-07;4(3):. 2019-02-07 [PMID: 30728326] (Bioassay, Mouse)	Bioassay	Mouse
L Yu, LA Dawson, M Yan, K Zimmel, YL Lin, CP Dolan, M Han, K Muneoka BMP9 stimulates joint regeneration at digit amputation wounds in mice Nat Commun, 2019-02-05;10(1):424. 2019-02-05 [PMID: 30723209] (Bioassay, Mouse)	Bioassay	Mouse
AM Lager, OG Corradin, JM Cregg, MS Elitt, HE Shick, BLL Clayton, KC Allan, HE Olsen, M Madhavan, PJ Tesar Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells Nat Commun, 2018-09-13;9(1):3708. 2018-09-13 [PMID: 30213958] (Cell Culture, Mouse)	Cell Culture	Mouse
F Chen, W Yang, X Huang, AT Cao, AJ Bilotta, Y Xiao, M Sun, L Chen, C Ma, X Liu, CG Liu, S Yao, SM Dann, Z Liu, Y Cong Neutrophils Promote Amphiregulin Production in Intestinal Epithelial Cells through TGF-? and Contribute to Intestinal Homeostasis J. Immunol., 2018-08-31;0(0):. 2018-08-31 [PMID: 30171165] (Bioassay, Mouse)	Bioassay	Mouse
A Spangler, EY Su, AM Craft, P Cahan A single cell transcriptional portrait of embryoid body differentiation and comparison to progenitors of the developing embryo Stem Cell Res, 2018-07-29;31(0):201-215. 2018-07-29 [PMID: 30118958] (Bioassay, Mouse)	Bioassay	Mouse
YA Choksi, VK Reddy, K Singh, CW Barrett, SP Short, B Parang, CE Keating, JJ Thompson, TG Verriere, RE Brown, MB Piazuelo, DM Bader, MK Washington, MK Mittal, T Brand, AP Gobert, LA Coburn, KT Wilson, CS Williams BVES is required for maintenance of colonic epithelial integrity in experimental colitis by modifying intestinal permeability Mucosal Immunol, 2018-06-15;0(0):. 2018-06-15 [PMID: 29907869] (Bioassay, Mouse)	Bioassay	Mouse
M Boyd, M Thodberg, M Vitezic, J Bornholdt, K Vitting-Se, Y Chen, M Coskun, Y Li, BZS Lo, P Klausen, P Jan Schwei, AG Pedersen, N Rapin, K Skovgaard, K Dahlgaard, R Andersson, TB Terkelsen, B Lilje, JT Troelsen, AM Petersen, KB Jensen, I Gögenur, P Thielsen, JB Seidelin, OH Nielsen, JT Bjerrum, A Sandelin Characterization of the enhancer and promoter landscape of inflammatory bowel disease from human colon biopsies Nat Commun, 2018-04-25;9(1):1661. 2018-04-25 [PMID: 29695774] (Bioassay, Human)	Bioassay	Human
BA Willems, M Furmanik, MMJ Caron, MLL Chatrou, DHM Kusters, TJM Welting, M Stock, MS Rafael, CSB Viegas, DC Simes, C Vermeer, CPM Reutelings, LJ Schurgers Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell calcification via SMAD-dependent BMP signalling Sci Rep, 2018-03-21;8(1):4961. 2018-03-21 [PMID: 29563538] (Bioassay, Mouse)	Bioassay	Mouse
JJ Brown, SP Short, J Stencel-Ba, K Urbanek, AJ Pruijssers, N McAllister, M Ikizler, G Taylor, P Aravamudha, S Khomandiak, B Jabri, CS Williams, TS Dermody Reovirus-Induced Apoptosis in the Intestine Limits Establishment of Enteric Infection J. Virol., 2018-04-27;0(0):. 2018-04-27 [PMID: 29514905] (Bioassay, Mouse)	Bioassay	Mouse
T Takahashi, A Shiraishi, J Murata The Coordinated Activities of nAChR and Wnt Signaling Regulate Intestinal Stem Cell Function in Mice Int J Mol Sci, 2018-03-05;19(3):. 2018-03-05 [PMID: 29510587] (Bioassay, Mouse)	Bioassay	Mouse
E Järvinen, J Shimomura-, A Balic, M Jussila, I Thesleff Mesenchymal Wnt/?-catenin signaling limits tooth number Development, 2018;0(0):. 2018 [PMID: 29437780] (Tissue Culture, Mouse)	Tissue Culture	Mouse
B Li, C Dorrell, PS Canaday, C Pelz, A Haft, M Finegold, M Grompe Adult Mouse Liver Contains Two Distinct Populations of Cholangiocytes Stem Cell Reports, 2017-07-06;0(0):. 2017-07-06 [PMID: 28689996] (Bioassay, Mouse)	Bioassay	Mouse
O Bernatik, T Radaszkiew, M Behal, Z Dave, F Witte, A Mahl, NH Cernohorsk, P Krejci, S Stricker, V Bryja A Novel Role for the BMP Antagonist Noggin in Sensitizing Cells to Non-canonical Wnt-5a/Ror2/Disheveled Pathway Activation Front Cell Dev Biol, 2017-05-04;5(0):47. 2017-05-04 [PMID: 28523267] (Bioassay, Mouse, Rat)	Bioassay	Mouse, Rat
JR Chao, DA Lamba, TR Klesert, A Torre, A Hoshino, RJ Taylor, A Jayabalu, AL Engel, TH Khuu, RK Wang, M Neitz, J Neitz, TA Reh Transplantation of Human Embryonic Stem Cell-Derived Retinal Cells into the Subretinal Space of a Non-Human Primate Transl Vis Sci Technol, 2017-05-16;6(3):4. 2017-05-16 [PMID: 28516002] (Bioassay, Human)	Bioassay	Human
KB McCauley, F Hawkins, M Serra, DC Thomas, A Jacob, DN Kotton Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling Cell Stem Cell, 2017-03-30;0(0):. 2017-03-30 [PMID: 28366587] (Bioassay, Mouse)	Bioassay	Mouse
J Lee, ER Snyder, Y Liu, X Gu, J Wang, BM Flowers, YJ Kim, S Park, GL Szot, RH Hruban, TA Longacre, SK Kim Reconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells Nat Commun, 2017-03-08;8(0):14686. 2017-03-08 [PMID: 28272465] (Bioassay, Human)	Bioassay	Human
I Espuny-Cam, AM Arranz, M Fiers, A Snellinx, K Ando, S Munck, J Bonnefont, L Lambot, N Corthout, L Omodho, E Vanden Eyn, E Radaelli, I Tesseur, S Wray, A Ebneth, J Hardy, K Leroy, JP Brion, P Vanderhaeg, B De Stroope Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain Neuron, 2017-02-23;0(0):. 2017-02-23 [PMID: 28238547] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
C Barry, MT Schmitz, P Jiang, MP Schwartz, BM Duffin, S Swanson, R Bacher, JM Bolin, AL Elwell, BE McIntosh, R Stewart, JA Thomson Species-specific developmental timing is maintained by pluripotent stem cells ex utero Dev. Biol., 2017-02-06;423(2):101-110. 2017-02-06 [PMID: 28179190] (Differentiation, Differentiation, Mouse)	Differentiation, Differentiation	Mouse
L Nigmatulli, M Norkin, MM Dzama, B Messner, S Sayols, N Soshnikova Id2 controls specification of Lgr5+ intestinal stem cell progenitors during gut development EMBO J., 2017-01-11;36(7):869-885. 2017-01-11 [PMID: 28077488] (Bioassay, Mouse)	Bioassay	Mouse
Electrical stimulation drives chondrogenesis of mesenchymal stem cells in the absence of exogenous growth factors Sci Rep, 2016-12-22;6(0):39302. 2016-12-22 [PMID: 28004813] (Bioassay, Mouse)	Bioassay	Mouse
Divya Varun A robust vitronectin-derived peptide for the scalable long-term expansion and neuronal differentiation of human pluripotent stem cell (hPSC)-derived neural progenitor cells (hNPCs) Acta Biomater, 2016-10-27;0(0):. 2016-10-27 [PMID: 27989923] (Bioassay, Human)	Bioassay	Human
Toru Nakata Indispensable role of Notch ligand-dependent signaling in the proliferation and stem cell niche maintenance of APC-deficient intestinal tumors Biochem. Biophys. Res. Commun, 2016-12-08;0(0):. 2016-12-08 [PMID: 27939883] (Bioassay)	Bioassay
J Lee, S Kang, KC Lilja, KJ Colletier, CJ Scheitz, YV Zhang, T Tumbar Signalling couples hair follicle stem cell quiescence with reduced histone H3 K4/K9/K27me3 for proper tissue homeostasis Nat Commun, 2016-04-15;7(0):11278. 2016-04-15 [PMID: 27080563] (In Vivo, Mouse)	In Vivo	Mouse
Carthy J, Engstrom U, Heldin C, Moustakas A Commercially Available Preparations of Recombinant Wnt3a Contain Non-Wnt Related Activities Which May Activate TGF-beta Signaling. J Cell Biochem, 2015-09-22;117(4):938-45. 2015-09-22 [PMID: 26369756] (Bioassay, Mouse)	Bioassay	Mouse
Barrett C, Reddy V, Short S, Motley A, Lintel M, Bradley A, Freeman T, Vallance J, Ning W, Parang B, Poindexter S, Fingleton B, Chen X, Washington M, Wilson K, Shroyer N, Hill K, Burk R, Williams C Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage. J Clin Invest, 2015-06-08;125(7):2646-60. 2015-06-08 [PMID: 26053663] (Bioassay, Mouse)	Bioassay	Mouse
Shojaie S, Ermini L, Ackerley C, Wang J, Chin S, Yeganeh B, Bilodeau M, Sambi M, Rogers I, Rossant J, Bear C, Post M Acellular lung scaffolds direct differentiation of endoderm to functional airway epithelial cells: requirement of matrix-bound HS proteoglycans. Stem Cell Reports, 2015-02-05;4(3):419-30. 2015-02-05 [PMID: 25660407] (Bioassay, Mouse)	Bioassay	Mouse
Gottle P, Sabo J, Heinen A, Venables G, Torres K, Tzekova N, Parras C, Kremer D, Hartung H, Cate H, Kury P Oligodendroglial maturation is dependent on intracellular protein shuttling. J Neurosci, 2015-01-21;35(3):906-19. 2015-01-21 [PMID: 25609610] (In Vivo, Mouse)	In Vivo	Mouse
McElroy S, Castle S, Bernard J, Almohazey D, Hunter C, Bell B, Al Alam D, Wang L, Ford H, Frey M The ErbB4 ligand neuregulin-4 protects against experimental necrotizing enterocolitis. Am J Pathol, 2014-09-09;184(10):2768-78. 2014-09-09 [PMID: 25216938] (Bioassay, Mouse)	Bioassay	Mouse
Fukuda M, Mizutani T, Mochizuki W, Matsumoto T, Nozaki K, Sakamaki Y, Ichinose S, Okada Y, Tanaka T, Watanabe M, Nakamura T Small intestinal stem cell identity is maintained with functional Paneth cells in heterotopically grafted epithelium onto the colon. Genes Dev, 2014-08-15;28(16):1752-7. 2014-08-15 [PMID: 25128495] (Bioassay, Mouse)	Bioassay	Mouse
Capaldo C, Farkas A, Hilgarth R, Krug S, Wolf M, Benedik J, Fromm M, Koval M, Parkos C, Nusrat A Proinflammatory cytokine-induced tight junction remodeling through dynamic self-assembly of claudins. Mol Biol Cell, 2014-07-16;25(18):2710-9. 2014-07-16 [PMID: 25031428] (Bioassay, Mouse)	Bioassay	Mouse
Poh Y, Chen J, Hong Y, Yi H, Zhang S, Chen J, Wu D, Wang L, Jia Q, Singh R, Yao W, Tan Y, Tajik A, Tanaka T, Wang N Generation of organized germ layers from a single mouse embryonic stem cell. Nat Commun, 2014-05-30;5(0):4000. 2014-05-30 [PMID: 24873804] (Bioassay, Mouse)	Bioassay	Mouse
Park J, Jang S, Park D, Lim N, Deng C, Kim D, Green J, Kim H Cooperativity of E-cadherin and Smad4 loss to promote diffuse-type gastric adenocarcinoma and metastasis. Mol Cancer Res, 2014-04-30;12(8):1088-99. 2014-04-30 [PMID: 24784840] (Bioassay, Mouse)	Bioassay	Mouse
Takemura N, Kawasaki T, Kunisawa J, Sato S, Lamichhane A, Kobiyama K, Aoshi T, Ito J, Mizuguchi K, Karuppuchamy T, Matsunaga K, Miyatake S, Mori N, Tsujimura T, Satoh T, Kumagai Y, Kawai T, Standley D, Ishii K, Kiyono H, Akira S, Uematsu S Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome. Nat Commun, 2014-03-18;5(0):3492. 2014-03-18 [PMID: 24637670] (Bioassay, Mouse)	Bioassay	Mouse
Yap C, Goh H, Familari M, Rathjen P, Rathjen J The formation of proximal and distal definitive endoderm populations in culture requires p38 MAPK activity. J Cell Sci, 2014-01-30;127(0):2204-16. 2014-01-30 [PMID: 24481813] (Bioassay, Mouse)	Bioassay	Mouse
Singh A, Chappell J, Trost R, Lin L, Wang T, Tang J, Matlock B, Weller K, Wu H, Zhao S, Jin P, Dalton S Cell-cycle control of developmentally regulated transcription factors accounts for heterogeneity in human pluripotent cells. Stem Cell Reports, 2013-12-05;1(6):532-44. 2013-12-05 [PMID: 24371808] (Bioassay, Human)	Bioassay	Human
Brafman D, Moya N, Allen-Soltero S, Fellner T, Robinson M, McMillen Z, Gaasterland T, Willert K Analysis of SOX2-expressing cell populations derived from human pluripotent stem cells. Stem Cell Reports, 2013-10-31;1(5):464-78. 2013-10-31 [PMID: 24286033] (Bioassay, Mouse)	Bioassay	Mouse
Lee J, Sugiyama T, Liu Y, Wang J, Gu X, Lei J, Markmann J, Miyazaki S, Miyazaki J, Szot G, Bottino R, Kim S Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells. Elife, 2013-11-19;2(0):e00940. 2013-11-19 [PMID: 24252877]
Guan J, Li H, Lv T, Chen D, Yuan Y, Qu S Bone morphogenetic protein-7 (BMP-7) mediates ischemic preconditioning-induced ischemic tolerance via attenuating apoptosis in rat brain. Biochem Biophys Res Commun, 2013-10-30;441(3):560-6. 2013-10-30 [PMID: 24184479] (Rat)		Rat
Lewis , Christop, Mardaryev , Andrei N, Poterlowicz , Krzyszto, Sharova , Tatyana, Aziz , Ahmar, Sharpe , David T, Botchkareva , Natalia, Sharov , Andrey A Bone morphogenetic protein signaling suppresses wound-induced skin repair by inhibiting keratinocyte proliferation and migration. J Invest Dermatol, 2013-10-14;134(3):827-37. 2013-10-14 [PMID: 24126843] (Bioassay, Mouse)	Bioassay	Mouse
Wang , Yidong, Wu , Bingruo, Chamberlain , Alyssa A, Lui , Wendy, Koirala , Pratisth, Susztak , Katalin, Klein , Diana, Taylor , Verdon, Zhou , Bin Endocardial to myocardial notch-wnt-bmp axis regulates early heart valve development. PLoS ONE, 2013-04-01;8(4):e60244. 2013-04-01 [PMID: 23560082] (Bioassay, Mouse)	Bioassay	Mouse
Li S, Meyer N, Quarto N, Longaker M Integration of multiple signaling regulates through apoptosis the differential osteogenic potential of neural crest-derived and mesoderm-derived Osteoblasts. PLoS ONE, 2013-03-25;8(3):e58610. 2013-03-25 [PMID: 23536803] (Bioassay, Mouse)	Bioassay	Mouse
Huegel J, Mundy C, Sgariglia F, Nygren P, Billings P, Yamaguchi Y, Koyama E, Pacifici M Perichondrium phenotype and border function are regulated by Ext1 and heparan sulfate in developing long bones: a mechanism likely deranged in Hereditary Multiple Exostoses. Dev Biol, 2013-03-01;377(1):100-12. 2013-03-01 [PMID: 23458899] (Bioassay, Mouse)	Bioassay	Mouse
Mehta V, Schmitz C, Keil K, Joshi P, Abler L, Lin T, Taketo M, Sun X, Vezina C Beta-catenin (CTNNB1) induces Bmp expression in urogenital sinus epithelium and participates in prostatic bud initiation and patterning. Dev Biol, 2013-02-08;376(2):125-35. 2013-02-08 [PMID: 23396188] (Bioassay, Mouse)	Bioassay	Mouse
Tucker B, Anfinson K, Mullins R, Stone E, Young M Use of a synthetic xeno-free culture substrate for induced pluripotent stem cell induction and retinal differentiation. Stem Cells Transl Med, 2012-12-27;2(1):16-24. 2012-12-27 [PMID: 23283489] (Bioassay, Mouse)	Bioassay	Mouse
Chen , Jiekai, Liu , He, Liu , Jing, Qi , Jing, Wei , Bei, Yang , Jiaqi, Liang , Hanquan, Chen , You, Chen , Jing, Wu , Yaran, Guo , Lin, Zhu , Jieying, Zhao , Xiangjie, Peng , Tianran, Zhang , Yixin, Chen , Shen, Li , Xuejia, Li , Dongwei, Wang , Tao, Pei , Duanqing H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs. Nat Genet, 2012-12-02;45(1):34-42. 2012-12-02 [PMID: 23202127] (Bioassay, Mouse)	Bioassay	Mouse
Brafman D, Phung C, Kumar N, Willert K Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions. Cell Death Differ, 2012-11-16;20(3):369-81. 2012-11-16 [PMID: 23154389] (Bioassay, Human)	Bioassay	Human
Sneddon , Julie B, Borowiak , Malgorza, Melton , Douglas Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme. Nature, 2012-10-07;491(7426):765-8. 2012-10-07 [PMID: 23041930] (Cell Culture, Human)	Cell Culture	Human
Ueki Y, Reh TA Activation of BMP-Smad1/5/8 signaling promotes survival of retinal ganglion cells after damage in vivo. PLoS ONE, 2012-06-06;7(6):e38690. 2012-06-06 [PMID: 22701694] (In Vivo, Mouse)	In Vivo	Mouse
Chen T, Heller E, Beronja S, Oshimori N, Stokes N, Fuchs E An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regeneration. Nature, 2012-04-04;485(7396):104-8. 2012-04-04 [PMID: 22495305] (In Vivo, Mouse)	In Vivo	Mouse
Wang P, McKnight K, Wong D, Rodriguez R, Sugiyama T, Gu X, Ghodasara A, Qu K, Chang H, Kim S A molecular signature for purified definitive endoderm guides differentiation and isolation of endoderm from mouse and human embryonic stem cells. Stem Cells Dev, 2012-02-29;21(12):2273-87. 2012-02-29 [PMID: 22236333] (Bioassay, Mouse)	Bioassay	Mouse
Kawaguchi J, Nichols J, Gierl MS, Faial T, Smith A Isolation and propagation of enteric neural crest progenitor cells from mouse embryonic stem cells and embryos. Development, 2010-03-01;137(5):693-704. 2010-03-01 [PMID: 20147374] (Bioassay, Mouse)	Bioassay	Mouse
Du Y, Xiao Q, Yip HK Regulation of retinal progenitor cell differentiation by bone morphogenetic protein 4 is mediated by the smad/id cascade. Invest. Ophthalmol. Vis. Sci., 2010-02-03;51(7):3764-73. 2010-02-03 [PMID: 20130285] (Bioassay, Mouse)	Bioassay	Mouse
Hayashi K, Surani MA Self-renewing epiblast stem cells exhibit continual delineation of germ cells with epigenetic reprogramming in vitro. Development, 2009-09-30;136(21):3549-56. 2009-09-30 [PMID: 19793888] (Bioassay, Mouse)	Bioassay	Mouse
Sellers DL, Maris DO, Horner PJ Postinjury niches induce temporal shifts in progenitor fates to direct lesion repair after spinal cord injury. J. Neurosci., 2009-05-20;29(20):6722-33. 2009-05-20 [PMID: 19458241] (In Vivo, Mouse)	In Vivo	Mouse
Kelley R, Ren R, Pi X, Wu Y, Moreno I, Willis M, Moser M, Ross M, Podkowa M, Attisano L, Patterson C A concentration-dependent endocytic trap and sink mechanism converts Bmper from an activator to an inhibitor of Bmp signaling. J. Cell Biol., 2009-02-16;184(4):597-609. 2009-02-16 [PMID: 19221194] (Bioassay, Mouse)	Bioassay	Mouse
Kobune M, Kawano Y, Takahashi S, Takada K, Murase K, Iyama S, Sato T, Takimoto R, Niitsu Y, Kato J Interaction with human stromal cells enhances CXCR4 expression and engraftment of cord blood Lin(-)CD34(-) cells. Exp. Hematol., 2008-06-17;36(9):1121-31. 2008-06-17 [PMID: 18562079] (Bioassay, Human)	Bioassay	Human
Matsuura I, Taniguchi J, Hata K, Saeki N, Yamashita T BMP inhibition enhances axonal growth and functional recovery after spinal cord injury. J. Neurochem., 2008-01-24;105(4):1471-9. 2008-01-24 [PMID: 18221366] (In Vivo, Rat)	In Vivo	Rat
Zhang P, Li J, Tan Z, Wang C, Liu T, Chen L, Yong J, Jiang W, Sun X, DU L, Ding M, Deng H Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells. Blood, 2007-11-27;111(4):1933-41. 2007-11-27 [PMID: 18042803] (Bioassay, Human)	Bioassay	Human
Fuller ML, DeChant AK, Rothstein B, Caprariello A, Wang R, Hall AK, Miller RH Bone morphogenetic proteins promote gliosis in demyelinating spinal cord lesions. Ann. Neurol., 2007-09-01;62(3):288-300. 2007-09-01 [PMID: 17696121] (Bioassay, Rat)	Bioassay	Rat
Stavridis MP, Lunn JS, Collins BJ, Storey KG A discrete period of FGF-induced Erk1/2 signalling is required for vertebrate neural specification. Development, 2007-08-01;134(16):2889-94. 2007-08-01 [PMID: 17660197] (Bioassay, Mouse)	Bioassay	Mouse
Lin L, Valore EV, Nemeth E, Goodnough JB, Gabayan V, Ganz T Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Blood, 2007-05-31;110(6):2182-9. 2007-05-31 [PMID: 17540841] (Bioassay, Mouse)	Bioassay	Mouse
Tiecke E, Bangs F, Blaschke R, Farrell ER, Rappold G, Tickle C Expression of the short stature homeobox gene Shox is restricted by proximal and distal signals in chick limb buds and affects the length of skeletal elements. Dev. Biol., 2006-07-12;298(2):585-96. 2006-07-12 [PMID: 16904661] (In Vivo, Chicken)	In Vivo	Chicken
Schlueter J, Manner J, Brand T BMP is an important regulator of proepicardial identity in the chick embryo. Dev. Biol., 2006-04-01;295(2):546-58. 2006-04-01 [PMID: 16677627] (Bioassay, Chicken)	Bioassay	Chicken
Maeshima A, Vaughn DA, Choi Y, Nigam SK Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct. Dev. Biol., 2006-04-27;295(2):473-85. 2006-04-27 [PMID: 16643884] (Bioassay, Rat)	Bioassay	Rat
Yao S, Chen S, Clark J, Hao E, Beattie GM, Hayek A, Ding S Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions. Proc. Natl. Acad. Sci. U.S.A., 2006-04-21;103(18):6907-12. 2006-04-21 [PMID: 16632596] (Bioassay, Human)	Bioassay	Human
Brugmann SA, Pandur PD, Kenyon KL, Pignoni F, Moody SA Six1 promotes a placodal fate within the lateral neurogenic ectoderm by functioning as both a transcriptional activator and repressor. Development, 2004-11-03;131(23):5871-81. 2004-11-03 [PMID: 15525662] (Bioassay, Xenopus)	Bioassay	Xenopus
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Saos‑2 human osteosarcoma cell line was stained with Mouse Anti-Human/Rat Osteocalcin Monoclonal Antibody (Catalog # MAB1419, filled histogram) or isotype control antibody (Catalog # MAB002, open histogram), followed by Allophycocyanin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0101B). To facilitate intracellular staining, cells were fixed with paraformaldehyde and permeabilized with saponin.

Osteocalcin Antibody (190125)
MAB1419

Noggin was detected in immersion fixed frozen sections of embryonic mouse cardiac tissue (11 d.p.c.) using 15 µg/mL Goat Anti-Mouse Noggin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF719) overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.

Noggin Antibody [Unconjugated]
AF719

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Gene Symbol	Nog
Uniprot	P97466()

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

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