Recombinant Mouse LAMP-2/CD107b Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Lysosomal associated membrane protein 2 (LAMP-2), also known as CD107b and LGP110, is an approximately 110 kDa transmembrane glycoprotein that is a major component of lysosomal membranes (1). Mature mouse LAMP-2 consists of a 354 amino acid (aa) intralumenal domain, a 25 aa transmembrane segment, and a 11 aa cytoplasmic tail (2). Its lumenal domain is organized into two heavily N-glycosylated regions separated by a Ser/Pro-rich linker that carries a minor amount of O‑linked glycosylation (2, 3). Alternate splicing generates two additional mouse LAMP-2 isoforms (LAMP-2B and LAMP-2C) with a substituted juxtamembrane lumenal region, transmembrane segment, and cytoplasmic tail (4). Within the lumenal domain, mouse LAMP-2 shares approximately 64% and 81% aa sequence identity with human and rat LAMP-2, repectively. LAMP-2 itself is subject to lysosomal degradation following cleavage of its lumenal domain (5). It mediates the lysosomal uptake of the chaperone HSC73 in complex with cargo proteins and is required for the lysosomal destruction of autophagic vacuoles (6, 7). In cytotoxic T cells and mast cells, LAMP-2 is expressed in the membranes of intracellular granules that contain effector molecules such as perforin, granzymes, eicosanoids, and histamine (8-10). Up‑regulated LAMP-2 at the plasma membrane serves as an indicator of cell activation of CD8+ T cells, mast cells, monocytes, and platelets (9-12). LAMP-2 is a native ligand for lectins Galectin-1 and Galectin-3 (13‑15).

We have publications tested in 2 confirmed species: Human, N/A.

We have publications tested in 1 application: ELISA Capture.

Showing Publication 1 - 1 of 1.

Publication using 10552-LM	Applications	Species
Akbaba, TH;Toor, KK;Mann, SK;Gibson, KM;Alfaro, GA;Balci-Peynircioglu, B;Cabral, DA;Morishita, KA;Brown, KL;PedVas Investigator’s Network, ; Anti-LAMP-2 Antibody Seropositivity in Children with Primary Systemic Vasculitis Affecting Medium- and Large-Sized Vessels International journal of molecular sciences 2024-03-28 [PMID: 38612581] (ELISA Capture, Human, N/A)	ELISA Capture	Human, N/A

Array 10552-LM

• LAMP-2/CD107b Antibodies
• LAMP-2/CD107b Lysate
• LAMP-2/CD107b Proteins
• LAMP-2/CD107b Proteins and Enzymes