Recombinant Mouse IL-1ra/IL-1F3 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

IL-1ra was originally isolated from the urine of patients with monocytic leukemia and has also been purified from adherent monocytes. The naturally-occurring, fully glycosylated form has an apparent molecular weight of about 25,000 Daltons. The protein shows 26% amino acid homology to IL-1 beta and 19% homology to IL-1 alpha . It will compete with either factor for receptor binding, but does not interact with either one. Human IL-1ra will bind to both types of IL-1 receptor (I and II) on human cells. In mouse, IL-1 RII does not bind IL-1ra. The recombinant, non-glycosylated form of IL-1ra blocks binding of IL-1 to its receptor equally as well as the naturally-occurring, glycosylated form. The IL-1ra has been shown to block the inflammatory responses induced by IL-1 both in vitro and in vivo. Currently, pre-clinical and clinical studies are underway to test possible therapeutic applications for IL-1ra in the treatment of sepsis, rheumatoid arthritis and chronic myelogenous leukemia.

We have publications tested in 4 confirmed species: Human, Mouse, Rat, N/A.

We have publications tested in 5 applications: Bioassay, ELISA, ELISA (Standard), In Vivo, Western Blot.

Showing Publications 1 - 10 of 32. Show All 32 Publications. Collapse Publications.

Publications using 480-RM/CF	Applications	Species
L Goksøyr, AB Funch, AK Okholm, TG Theander, WA de Jongh, CM Bonefeld, AF Sander Preclinical Efficacy of a Capsid Virus-like Particle-Based Vaccine Targeting IL-1beta for Treatment of Allergic Contact Dermatitis Vaccines, 2022-05-23;10(5):. 2022-05-23 [PMID: 35632584] (Western Blot, N/A)	Western Blot	N/A
KMJ McMurray, A Winter, R Ahlbrand, A Wilson, S Shukla, R Sah Subfornical organ interleukin 1 receptor: a novel regulator of spontaneous and conditioned fear associated behaviors in mice Brain, Behavior, and Immunity, 2022-01-12;0(0):. 2022-01-12 [PMID: 35032573] (In Vivo, Mouse)	In Vivo	Mouse
A Takahashi, H Aleyasin, MA Stavarache, L Li, F Cathomas, LF Parise, HY Lin, CJ Burnett, A Aubry, ME Flanigan, A Brancato, C Menard, ML Pfau, V Kana, J Wang, GE Hodes, T Sasaki, MG Kaplitt, S Ogawa, BS McEwen, SJ Russo Neuromodulatory effect of interleukin 1&beta in the dorsal raphe nucleus on individual differences in aggression Molecular Psychiatry, 2021-04-30;0(0):. 2021-04-30 [PMID: 33931727] (Bioassay, Mouse)	Bioassay	Mouse
F Namai, S Shigemori, T Ogita, T Sato, T Shimosato Microbial therapeutics for acute colitis based on genetically modified Lactococcus lactis hypersecreting IL-1Ra in mice Exp Mol Med, 2020-09-28;0(0):. 2020-09-28 [PMID: 32989233] (Bioassay, Mouse)	Bioassay	Mouse
Y Dong, S Li, Y Lu, X Li, Y Liao, Z Peng, Y Li, L Hou, Z Yuan, J Cheng Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice J Neuroinflammation, 2020-07-07;17(1):205. 2020-07-07 [PMID: 32635937] (In Vivo, Mouse)	In Vivo	Mouse
Z Julier, R Karami, B Nayer, YZ Lu, AJ Park, K Maruyama, GA Kuhn, R Müller, S Akira, MM Martino Enhancing the regenerative effectiveness of growth factors by local inhibition of interleukin-1 receptor signaling Sci Adv, 2020-06-12;6(24):eaba7602. 2020-06-12 [PMID: 32582857] (ELISA, Mouse)	ELISA	Mouse
Z Julier, R Karami, B Nayer, YZ Lu, AJ Park, K Maruyama, GA Kuhn, R Müller, S Akira, MM Martino Enhancing the regenerative effectiveness of growth factors by local inhibition of interleukin-1 receptor signaling Sci Adv, 2020;6(24):eaba7602. 2020 [PMID: 32582857] (ELISA, Mouse)	ELISA	Mouse
P Pan, Q Zhang, W Liu, W Wang, Z Yu, Z Lao, W Zhang, M Shen, P Wan, F Xiao, MA Shereen, W Zhang, Q Tan, Y Liu, X Liu, K Wu, Y Liu, G Li, J Wu Dengue Virus Infection Activates Interleukin-1beta to Induce Tissue Injury and Vascular Leakage Front Microbiol, 2019-11-22;10(0):2637. 2019-11-22 [PMID: 31824450] (In Vivo, Mouse)	In Vivo	Mouse
E Mirabelli, L Ni, L Li, C Acioglu, RF Heary, S Elkabes Pathological pain processing in mouse models of multiple sclerosis and spinal cord injury: contribution of plasma membrane calcium ATPase 2 (PMCA2) J Neuroinflammation, 2019-11-08;16(1):207. 2019-11-08 [PMID: 31703709] (In Vivo, Mouse)	In Vivo	Mouse
HG Lee, JU Lee, DH Kim, S Lim, I Kang, JM Choi Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis Nat Commun, 2019-02-12;10(1):709. 2019-02-12 [PMID: 30755603] (Bioassay, Mouse)	Bioassay	Mouse
HC Xiang, LX Lin, XF Hu, H Zhu, HP Li, RY Zhang, L Hu, WT Liu, YL Zhao, Y Shu, HL Pan, M Li AMPK activation attenuates inflammatory pain through inhibiting NF-?B activation and IL-1? expression J Neuroinflammation, 2019-02-12;16(1):34. 2019-02-12 [PMID: 30755236] (In Vivo, Mouse)	In Vivo	Mouse
Y Kang, H Zhang, Y Zhao, Y Wang, W Wang, Y He, W Zhang, W Zhang, X Zhu, Y Zhou, L Zhang, Z Ju, L Shi Telomere Dysfunction Disturbs Macrophage Mitochondrial Metabolism and the NLRP3 Inflammasome through the PGC-1?/TNFAIP3 Axis Cell Rep, 2018-03-27;22(13):3493-3506. 2018-03-27 [PMID: 29590618] (In Vivo, Mouse)	In Vivo	Mouse
MX Li, HL Zheng, Y Luo, JG He, W Wang, J Han, L Zhang, X Wang, L Ni, HY Zhou, ZL Hu, PF Wu, Y Jin, LH Long, H Zhang, G Hu, JG Chen, F Wang Gene deficiency and pharmacological inhibition of caspase-1 confers resilience to chronic social defeat stress via regulating the stability of surface AMPARs Mol. Psychiatry, 2017-04-18;0(0):. 2017-04-18 [PMID: 28416811] (In Vivo, Mouse)	In Vivo	Mouse
Interaction between interleukin-1? and type-1 cannabinoid receptor is involved in anxiety-like behavior in experimental autoimmune encephalomyelitis J Neuroinflammation, 2016-09-02;13(1):231. 2016-09-02 [PMID: 27589957] (In Vivo, Mouse)	In Vivo	Mouse
Reed M, Morris S, Owczarczyk A, Lukacs N Deficiency of autophagy protein Map1-LC3b mediates IL-17-dependent lung pathology during respiratory viral infection via ER stress-associated IL-1. Mucosal Immunol, 2015-02-11;8(5):1118-30. 2015-02-11 [PMID: 25669150] (In Vivo, Mouse)	In Vivo	Mouse
Shaw A, Pickup M, Chytil A, Aakre M, Owens P, Moses H, Novitskiy S TGFbeta signaling in myeloid cells regulates mammary carcinoma cell invasion through fibroblast interactions. PLoS ONE, 2015-01-28;10(1):e0117908. 2015-01-28 [PMID: 25629162] (Bioassay, Mouse)	Bioassay	Mouse
Cowardin C, Kuehne S, Buonomo E, Marie C, Minton N, Petri W Inflammasome activation contributes to interleukin-23 production in response to Clostridium difficile. MBio, 2015-01-27;6(1):. 2015-01-27 [PMID: 25626905] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
Moyon S, Dubessy A, Aigrot M, Trotter M, Huang J, Dauphinot L, Potier M, Kerninon C, Melik Parsadaniantz S, Franklin R, Lubetzki C Demyelination causes adult CNS progenitors to revert to an immature state and express immune cues that support their migration. J Neurosci, 2015-01-07;35(1):4-20. 2015-01-07 [PMID: 25568099] (Bioassay, Mouse)	Bioassay	Mouse
Rossi S, Motta C, Studer V, Macchiarulo G, Volpe E, Barbieri F, Ruocco G, Buttari F, Finardi A, Mancino R, Weiss S, Battistini L, Martino G, Furlan R, Drulovic J, Centonze D Interleukin-1beta causes excitotoxic neurodegeneration and multiple sclerosis disease progression by activating the apoptotic protein p53. Mol Neurodegener, 2014-12-12;9(0):56. 2014-12-12 [PMID: 25495224] (In Vivo, Mouse)	In Vivo	Mouse
Khare S, Ratsimandresy R, de Almeida L, Cuda C, Rellick S, Misharin A, Wallin M, Gangopadhyay A, Forte E, Gottwein E, Perlman H, Reed J, Greaves D, Dorfleutner A, Stehlik C The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses. Nat Immunol, 2014-02-16;15(4):343-53. 2014-02-16 [PMID: 24531343] (Bioassay, Mouse)	Bioassay	Mouse
Zhao H, Zhao X, Cao X, Wu G Age-Dependent Neuroimmune Modulation of IGF-1R in the Traumatic Mice. Immun Ageing, 2012-05-28;9(1):12. 2012-05-28 [PMID: 22640633] (Bioassay, Mouse)	Bioassay	Mouse
Koo JW, Russo SJ, Ferguson D, Nestler EJ, Duman RS Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior. Proc. Natl. Acad. Sci. U.S.A., 2010-01-26;107(6):2669-74. 2010-01-26 [PMID: 20133768] (In Vivo, Mouse)	In Vivo	Mouse
Osuchowski MF, Connett J, Welch K, Granger J, Remick DG Stratification is the key: inflammatory biomarkers accurately direct immunomodulatory therapy in experimental sepsis. Crit. Care Med., 2009-05-01;37(5):1567-73. 2009-05-01 [PMID: 19325479] (ELISA (Standard))	ELISA (Standard)
Abraham J, Johnson RW Central inhibition of interleukin-1beta ameliorates sickness behavior in aged mice. Brain Behav. Immun., 2008-12-31;23(3):396-401. 2008-12-31 [PMID: 19152833] (In Vivo, Mouse)	In Vivo	Mouse
Ortiz LA, Dutreil M, Fattman C, Pandey AC, Torres G, Go K, Phinney DG Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury. Proc. Natl. Acad. Sci. U.S.A., 2007-06-14;104(26):11002-7. 2007-06-14 [PMID: 17569781] (Bioassay, Mouse)	Bioassay	Mouse
Taki N, Tatro JM, Lowe R, Goldberg VM, Greenfield EM Comparison of the roles of IL-1, IL-6, and TNFalpha in cell culture and murine models of aseptic loosening. Bone, 2006-12-21;40(5):1276-83. 2006-12-21 [PMID: 17236833] (Bioassay, Mouse)	Bioassay	Mouse
Osuchowski MF, Welch K, Siddiqui J, Remick DG Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality. J. Immunol., 2006-08-01;177(3):1967-74. 2006-08-01 [PMID: 16849510] (ELISA (Standard))	ELISA (Standard)
Osuchowski MF, Siddiqui J, Copeland S, Remick DG Sequential ELISA to profile multiple cytokines from small volumes. J. Immunol. Methods, 2005-07-01;302(1):172-81. 2005-07-01 [PMID: 16023134] (ELISA (Standard))	ELISA (Standard)
Park EM, Cho BP, Volpe BT, Cruz MO, Joh TH, Cho S Ibuprofen protects ischemia-induced neuronal injury via up-regulating interleukin-1 receptor antagonist expression. Neuroscience, 2005-01-01;132(3):625-31. 2005-01-01 [PMID: 15837124] (Bioassay, Rat)	Bioassay	Rat
Wei S, Kitaura H, Zhou P, Ross FP, Teitelbaum SL IL-1 mediates TNF-induced osteoclastogenesis. J. Clin. Invest., 2005-02-01;115(2):282-90. 2005-02-01 [PMID: 15668736] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
Yirmiya R, 107313, Winocur G, Goshen I Brain interleukin-1 is involved in spatial memory and passive avoidance conditioning. Minimal Development of Liver Fibrosis in Adult Tolerant Liver Transplant Recipients Late After Immunosuppressive Drug Weaning and Transplantation, 2002-09-01;78(2):379-89. 2002-09-01 [PMID: 12431424] (In Vivo, Rat)	In Vivo	Rat
Borsody MK, Weiss JM Alteration of locus coeruleus neuronal activity by interleukin-1 and the involvement of endogenous corticotropin-releasing hormone. Neuroimmunomodulation, 2003-01-01;10(2):101-21. 2003-01-01 [PMID: 12372984] (In Vivo, Rat)	In Vivo	Rat
Show All 32 Publications. Collapse Publications.

Array 480-RM/CF

• IL-1ra/IL-1F3/IL1RN Antibodies
• IL-1ra/IL-1F3/IL1RN ELISA Kit
• IL-1ra/IL-1F3/IL1RN Lysates
• IL-1ra/IL-1F3/IL1RN Proteins
• IL-1ra/IL-1F3/IL1RN Proteins and Enzymes
• IL-1ra/IL-1F3/IL1RN ELISAs