Recombinant Mouse IL-18/IL-1F4 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interleukin-18 (IL-18) is a proinflammatory cytokine in the IL-1 family that exerts distinct immune effects depending on the local cytokine environment. It is expressed as a 24 kDa precursor by endothelial and epithelial cells, keratinocytes, gamma δ T cells, and phagocytes. The precursor is activated intracellularly by Caspase-1 mediated proteolysis to release the 17 kDa mature cytokine. The precursor can also be released by necrotic cells for extracellular cleavage by multiple proteases.
IL-18 activation is induced by infection or tissue damage and contributes to disease pathology in chronic inflammation (1-3). IL-18 binds to the widely expressed IL-18 R alpha which recruits IL-18 R beta to form the signaling receptor complex (4, 5). Its bioactivity is negatively regulated by interactions with IL-18 binding proteins and virally encoded IL-18BP homologs (6). In the presence of IL-12 or IL-15, IL-18 enhances anti-viral Th1 immune responses by inducing IFN-gamma production and the cytolytic activity of CD8⁺ T cells and NK cells (7, 8). In the absence of IL-12 or IL-15, however, IL-18 promotes production of the Th2 cytokines IL-4 and IL-13 by CD4⁺ T cells and basophils (9, 10). In the presence of IL-1 beta or IL-23, IL-18 induces the antigen-independent production of IL-17 by gamma δ T cells and CD4⁺ T cells (11). IL-18 also promotes myeloid dendritic cell maturation and triggers neutrophil respiratory burst (12, 13). In cancer, IL-18 exhibits diverse activities including enhancing anti-tumor immunity, inhibiting or promoting angiogenesis, and promoting tumor cell metastasis (14). Mature mouse IL-18 shares 63% and 91% amino acid sequence identity with mouse and rat IL-18, respectively (15).

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 3 applications: Bioassay, Cell Culture, In Vivo.

Showing Publications 1 - 9 of 9.

Publications using 9139-IL/CF	Applications	Species
CM Schafer, S Martin-Alm, K Kurylowicz, N Dufton, L Osuna-Alma, ML Wu, CF Johnson, AV Shah, DO Haskard, A Buxton, E Willis, K Wheeler, S Turner, M Chlebicz, RP Scott, S Kovats, A Cleuren, GM Birdsey, AM Randi, CT Griffin Cytokine-Mediated Degradation of the Transcription Factor ERG Impacts the Pulmonary Vascular Response to Systemic Inflammatory Challenge bioRxiv : the preprint server for biology, 2023-02-11;0(0):. 2023-02-11 [PMID: 36798267] (Bioassay, Mouse)	Bioassay	Mouse
X Zhao, T Peng, X Cao, Y Hou, R Li, T Han, Z Fan, M Zhao, Y Chang, H Chen, C Li, X Huang In�vivo G-CSF treatment activates the GR-SOCS1 axis to suppress IFN-gamma secretion by natural killer cells Cell Reports, 2022-09-13;40(11):111342. 2022-09-13 [PMID: 36103837] (Bioassay, Mouse)	Bioassay	Mouse
HY Chiang, HH Lu, JN Sudhakar, YW Chen, NS Shih, YT Weng, JW Shui IL-22 initiates an IL-18-dependent epithelial response circuit to enforce intestinal host defence Nature Communications, 2022-02-15;13(1):874. 2022-02-15 [PMID: 35169117] (Bioassay, Mouse)	Bioassay	Mouse
G Zhao, H Zhang, S Zhu, S Wang, K Zhu, Y Zhao, L Xu, P Zhang, J Xie, A Sun, Y Zou, J Ge Interleukin-18 accelerates cardiac inflammation and dysfunction during ischemia/reperfusion injury by transcriptional activation of CXCL16 Cellular Signalling, 2021-09-04;0(0):110141. 2021-09-04 [PMID: 34487815] (In Vivo, Mouse)	In Vivo	Mouse
PT Rudak, J Choi, KM Parkins, KL Summers, DN Jackson, PJ Foster, AI Skaro, K Leslie, VC McAlister, VK Kuchroo, W Inoue, O Lantz, SMM Haeryfar Chronic stress physically spares but functionally impairs innate-like invariant T�cells Cell Reports, 2021-04-13;35(2):108979. 2021-04-13 [PMID: 33852855] (In Vivo, Mouse)	In Vivo	Mouse
JA Moral, J Leung, LA Rojas, J Ruan, J Zhao, Z Sethna, A Ramnarain, B Gasmi, M Gururajan, D Redmond, G Askan, U Bhanot, E Elyada, Y Park, DA Tuveson, M Gönen, SD Leach, JD Wolchok, RP DeMatteo, T Merghoub, VP Balachandr ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity Nature, 2020-02-19;0(0):. 2020-02-19 [PMID: 32076273] (In Vivo, Mouse)	In Vivo	Mouse
C Ge, IR Monk, A Pizzolla, N Wang, JG Bedford, TP Stinear, GP Westall, LM Wakim Bystander Activation of Pulmonary Trm Cells Attenuates the Severity of Bacterial Pneumonia by Enhancing Neutrophil Recruitment Cell Rep, 2019-12-24;29(13):4236-4244.e3. 2019-12-24 [PMID: 31875535] (Cell Culture, Mouse)	Cell Culture	Mouse
IJ Jensen, CS Winborn, MG Fosdick, P Shao, MM Tremblay, Q Shan, SK Tripathy, CM Snyder, HH Xue, TS Griffith, JC Houtman, VP Badovinac Polymicrobial sepsis influences NK-cell-mediated immunity by diminishing NK-cell-intrinsic receptor-mediated effector responses to viral ligands or infections PLoS Pathog., 2018-10-31;14(10):e1007405. 2018-10-31 [PMID: 30379932] (Bioassay, Mouse)	Bioassay	Mouse
Jonas J Staudacher, Cemal Yazici, Timothy Carroll, Jessica Bauer, Jingbo Pang, Nancy Krett, Yinglin Xia, Annette Wilson, Georgios Papachris, Andrea Dirmeier, Claudia Kunst, David C Whitcomb, Giamila Fantuzzi, Barbara Jung Activin in acute pancreatitis: Potential risk-stratifying marker and novel therapeutic target. Scientific Reports, 2017-10-06;0(0):2045-2322. 2017-10-06 [PMID: 28986573] (In Vivo, Mouse)	In Vivo	Mouse

Array 9139-IL/CF

• IL-18/IL-1F4 Antibodies
• IL-18/IL-1F4 Antibody Pairs
• IL-18/IL-1F4 ELISA Kits
• IL-18/IL-1F4 Lysate
• IL-18/IL-1F4 Protein
• IL-18/IL-1F4 ELISAs
• IL-18/IL-1F4 Proteins and Enzymes