Recombinant Mouse IFN-gamma Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interferon-gamma (IFN-gamma ), also known as type II or immune interferon, exerts a wide range of immunoregulatory activities and is considered to be the prototype proinflammatory cytokine (1, 2). Mature mouse IFN-gamma exists as a noncovalently linked homodimer of 20-25 kDa variably glycosylated subunits (3). It shares 86% amino acid sequence identity with rat IFN-gamma and 38%-44% with bovine, canine, cotton rat, equine, feline, human, porcine, and rhesus IFN-gamma . IFN-gamma dimers bind to IFN‑ gamma RI (alpha subunits) which then interact with IFN-gamma RII (beta subunits) to form the functional receptor complex of two alpha and two beta subunits. Inclusion of IFN-gamma RII increases the binding affinity for ligand and the efficiency of signal transduction (4, 5). IFN-gamma is produced by a variety of immune cells under inflammatory conditions, notably by T cells and NK cells (6). It plays a key role in host defense by promoting the development and activation of Th1 cells, chemoattraction and activation of monocytes and macrophages, up-regulation of antigen presentation molecules, and immunoglobulin class switching in B cells. It also exhibits antiviral, antiproliferative, and apoptotic effects (6, 7). In addition, IFN-gamma functions as an anti-inflammatory mediator by promoting the development of regulatory T cells and inhibiting Th17 cell differentiation (8, 9). The pleiotropic effects of IFN-gamma contribute to the development of multiple aspects of atherosclerosis (7).

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Transgenic Mouse.

We have publications tested in 8 applications: Bioassay, Cell Cultulre, Cell Culture, Differentiation, ELISA (Standard), ELISA Control, In Vivo, Stimulation.

Showing Publications 1 - 10 of 404. Show All 404 Publications. Collapse Publications.

Publications using 485-MI/CF	Applications	Species
BD Hobson, AT Stanley, MB De Los San, B Culbertson, EV Mosharov, PA Sims, D Sulzer Conserved and cell type-specific transcriptional responses to IFN-gamma in the ventral midbrain Brain, Behavior, and Immunity, 2023-04-24;0(0):. 2023-04-24 [PMID: 37100211] (Bioassay, Mouse)	Bioassay	Mouse
V Göser, N Sander, M Schulte, F Scharte, R Franzkoch, V Liss, OE Psathaki, M Hensel Single molecule analyses reveal dynamics of Salmonella translocated effector proteins in host cell endomembranes Nature Communications, 2023;14(1):1240. 2023 [PMID: 36870997] (Bioassay, Mouse)	Bioassay	Mouse
V Göser, N Sander, M Schulte, F Scharte, R Franzkoch, V Liss, OE Psathaki, M Hensel Single molecule analyses reveal dynamics of Salmonella translocated effector proteins in host cell endomembranes Nature Communications, 2023-03-04;14(1):1240. 2023-03-04 [PMID: 36870997] (Bioassay, Mouse)	Bioassay	Mouse
Y Liao, L Sun, M Nie, J Li, X Huang, S Heng, W Zhang, T Xia, Z Guo, Q Zhao, LJ Zhang Modulation of Skin Inflammatory Responses by Aluminum Adjuvant Pharmaceutics, 2023-02-08;15(2):. 2023-02-08 [PMID: 36839900] (Mouse)		Mouse
CY Hsieh, JN Lin, TY Kang, YH Wen, SH Yu, CC Wu, HP Wu Otoprotective Effects of Fucoidan Reduce Cisplatin-Induced Ototoxicity in Mouse Cochlear UB/OC-2 Cells International Journal of Molecular Sciences, 2023-02-10;24(4):. 2023-02-10 [PMID: 36834972] (Bioassay, Mouse)	Bioassay	Mouse
EG Foerster, DKL Tsang, S Goyal, SJ Robertson, LM Robert, H Maughan, CJ Streutker, SE Girardin, DJ Philpott ATG16L1 protects from interferon-gamma-induced cell death in the small intestinal crypt Mucosal Immunology, 2023-02-14;0(0):. 2023-02-14 [PMID: 36792009] (Bioassay, Transgenic Mouse)	Bioassay	Transgenic Mouse
WH Lee, GE Kim, KJ Hong, HS Kim, GR Lee Insulin Receptor Substrate 1 Signaling Inhibits Foxp3 Expression and Suppressive Functions in Treg Cells through the mTORC1 Pathway International Journal of Molecular Sciences, 2023;24(3):. 2023 [PMID: 36768873] (Bioassay, Mouse)	Bioassay	Mouse
WH Lee, GE Kim, KJ Hong, HS Kim, GR Lee Insulin Receptor Substrate 1 Signaling Inhibits Foxp3 Expression and Suppressive Functions in Treg Cells through the mTORC1 Pathway International Journal of Molecular Sciences, 2023-01-29;24(3):. 2023-01-29 [PMID: 36768873] (Bioassay, Mouse)	Bioassay	Mouse
J Yu, Y Shen, J Luo, J Jin, P Li, P Feng, H Guan Upadacitinib inhibits corneal inflammation and neovascularization by suppressing M1 macrophage infiltration in the corneal alkali burn model International immunopharmacology, 2023-02-03;116(0):109680. 2023-02-03 [PMID: 36739832] (Bioassay, Mouse)	Bioassay	Mouse
J Li, N Liu, H Zhou, P Xian, Y Song, X Tang, Y Li, M Basler Immunoproteasome inhibition prevents progression of castration-resistant prostate cancer British Journal of Cancer, 2023-01-21;0(0):. 2023-01-21 [PMID: 36681728] (Bioassay, Mouse)	Bioassay	Mouse
L Tang, M Zhu, X Che, X Yang, Y Xu, Q Ma, M Zhang, Z Ni, X Shao, S Mou Astragaloside IV Targets Macrophages to Alleviate Renal Ischemia-Reperfusion Injury via the Crosstalk between Hif-1alpha and NF-kappaB (p65)/Smad7 Pathways Journal of personalized medicine, 2022-12-27;13(1):. 2022-12-27 [PMID: 36675720] (Bioassay, Mouse)	Bioassay	Mouse
G Spiaggia, P Taladriz-B, S Hengsberge, D Septiadi, C Geers, A Lee, B Rothen-Rut, A Petri-Fink A Near-Infrared Mechanically Switchable Elastomeric Film as a Dynamic Cell Culture Substrate Biomedicines, 2022-12-22;11(1):. 2022-12-22 [PMID: 36672538] (ELISA Control, Mouse)	ELISA Control	Mouse
YS Song, N Jamali, CM Sorenson, N Sheibani Vitamin D Receptor Expression Limits the Angiogenic and Inflammatory Properties of Retinal Endothelial Cells Cells, 2023-01-16;12(2):. 2023-01-16 [PMID: 36672270] (Bioassay, Mouse)	Bioassay	Mouse
M De Burghgr, C Lourenço, C Berthault, V Aiello, A Villalba, A Fouque, M Diedisheim, S You, M Oshima, R Scharfmann Pancreatic Islet Cells Response to IFNgamma Relies on Their Spatial Location within an Islet Cells, 2022-12-28;12(1):. 2022-12-28 [PMID: 36611907] (Bioassay, Mouse)	Bioassay	Mouse
X Yang, D Nishimiya, S Löchte, KM Jude, M Borowska, CS Savvides, M Dougan, L Su, X Zhao, J Piehler, KC Garcia Facile repurposing of peptide-MHC-restricted antibodies for cancer immunotherapy Nature Biotechnology, 2023-01-02;0(0):. 2023-01-02 [PMID: 36593402] (Bioassay, Mouse)	Bioassay	Mouse
X Yang, D Nishimiya, S Löchte, KM Jude, M Borowska, CS Savvides, M Dougan, L Su, X Zhao, J Piehler, KC Garcia Facile repurposing of peptide-MHC-restricted antibodies for cancer immunotherapy Nature Biotechnology, 2023;0(0):. 2023 [PMID: 36593402] (Bioassay, Mouse)	Bioassay	Mouse
YK Kim, JA Walters, ND Moss, KL Wells, R Sheridan, JG Miranda, RKP Benninger, LL Pyle, RM O'Brien, L Sussel, HW Davidson Zinc Transporter 8 Haploinsufficiency Protects Against Beta Cell Dysfunction in Type 1 Diabetes by Increasing Mitochondrial Respiration Molecular Metabolism, 2022-11-05;66(0):101632. 2022-11-05 [PMID: 36347424] (Bioassay, Mouse)	Bioassay	Mouse
P Wang, Z Huang, Y Peng, H Li, T Lin, Y Zhao, Z Hu, Z Zhou, W Zhou, Y Liu, FF Hou Circular RNA circBNC2 inhibits epithelial cell G2-M arrest to prevent fibrotic maladaptive repair Nature Communications, 2022-10-31;13(1):6502. 2022-10-31 [PMID: 36316334] (Bioassay, Mouse)	Bioassay	Mouse
KK Myo Min, D Rojas-Cana, D Penko, M DeNichilo, MP Cockshell, CB Ffrench, EJ Thompson, O Asplund, CJ Drogemulle, RB Prasad, L Groop, ST Grey, HE Thomas, T Loudovaris, TW Kay, MG Mahoney, CF Jessup, PT Coates, CS Bonder Desmoglein-2 is important for islet function and beta-cell survival Cell Death & Disease, 2022-10-29;13(10):911. 2022-10-29 [PMID: 36309486] (Bioassay, Mouse)	Bioassay	Mouse
F Babaeijand, A Paiero, R Long, LW Tung, SP Smith, R Cheng, J Smandych, N Kajabadi, CK Chang, A Ghassemi, WDM Kennedy, H Soliman, PW Schutz, FMV Rossi TNFalpha and IFNgamma cooperate for efficient pro- to anti-inflammatory transition of macrophages during muscle regeneration Proceedings of the National Academy of Sciences of the United States of America, 2022-10-24;119(44):e2209976119. 2022-10-24 [PMID: 36279473] (Bioassay, Mouse)	Bioassay	Mouse
AP Shaik, AS Shaik, M Abudawood, A Al Faraj Detection of Radiolabeled Inflammatory Cell Macrophage Subpopulations in Chronic Respiratory Diseases: Results from Preliminary Analyses BioMed Research International, 2022-10-06;2022(0):9470845. 2022-10-06 [PMID: 36246991] (Bioassay, Mouse)	Bioassay	Mouse
H Cho, HY Kwon, A Sharma, SH Lee, X Liu, N Miyamoto, JJ Kim, SH Im, NY Kang, YT Chang Visualizing inflammation with an M1 macrophage selective probe via GLUT1 as the gating target Nature Communications, 2022-10-10;13(1):5974. 2022-10-10 [PMID: 36216803] (Bioassay, Mouse)	Bioassay	Mouse
N Zoellner, N Coesfeld, FH De Vos, J Denter, HC Xu, E Zimmer, B Knebel, H Al-Hasani, S Mossner, PA Lang, DM Floss, J Scheller Synthetic mimetics assigned a major role to IFNAR2 in type I interferon signaling Frontiers in Microbiology, 2022-09-02;13(0):947169. 2022-09-02 [PMID: 36118237] (Bioassay, Mouse)	Bioassay	Mouse
KA Meerschaer, BS Edwards, AY Epouhe, B Jefferson, R Friedman, OL Babyok, JK Moy, F Kehinde, C Liu, CJ Workman, DAA Vignali, KM Albers, HR Koerber, MS Gold, BM Davis, NN Scheff, JL Saloman Neuronally expressed PDL1, not PD1, suppresses acute nociception Brain, Behavior, and Immunity, 2022-09-08;106(0):233-246. 2022-09-08 [PMID: 36089217] (Bioassay, Mouse)	Bioassay	Mouse
I Mhatre-Win, A Eid, Y Han, K Tieu, JR Richardson Sex and APOE Genotype Alter the Basal and Induced Inflammatory States of Primary Microglia from APOE Targeted Replacement Mice International Journal of Molecular Sciences, 2022-08-29;23(17):. 2022-08-29 [PMID: 36077227] (Bioassay, Mouse)	Bioassay	Mouse
T Otsuki, N Fukuda, L Chen, A Tsunemi, M Abe Twist-related protein 1 induces epithelial-mesenchymal transition and renal fibrosis through the upregulation of complement 3 PLoS ONE, 2022-08-26;17(8):e0272917. 2022-08-26 [PMID: 36018840] (Bioassay, Mouse)	Bioassay	Mouse
T Meyer, D Shimon, S Youssef, G Yankovitz, A Tessler, T Chernobyls, A Gaoni-Yoge, R Perelroize, N Budick-Har, L Steinman, L Mayo NAD+ metabolism drives astrocyte proinflammatory reprogramming in central nervous system autoimmunity Proceedings of the National Academy of Sciences of the United States of America, 2022-08-22;119(35):e2211310119. 2022-08-22 [PMID: 35994674] (Cell Culture, Mouse)	Cell Culture	Mouse
S Ng, S Lim, ACN Sim, R Mangadu, A Lau, C Zhang, SB Martinez, A Chandramoh, UM Lim, SSW Ho, SC Chang, P Gopal, LZ Hong, A Schwaid, AZ Fernandis, A Loboda, C Li, U Phan, B Henry, AW Partridge STUB1 is an intracellular checkpoint for interferon gamma sensing Scientific Reports, 2022-08-18;12(1):14087. 2022-08-18 [PMID: 35982220] (Bioassay, Human)	Bioassay	Human
S Chandrasek, JA Kochanowsk, EF Merritt, JS Lagas, A Swannigan, AA Koshy IFN-gamma stimulated murine and human neurons mount anti-parasitic defenses against the intracellular parasite Toxoplasma gondii Nature Communications, 2022-08-08;13(1):4605. 2022-08-08 [PMID: 35941154] (Bioassay, Mouse)	Bioassay	Mouse
EG Vasquez, N Nasreddin, GN Valbuena, EJ Mulholland, HL Belnoue-Da, HR Eggington, RO Schenck, VM Wouters, P Wirapati, K Gilroy, TRM Lannagan, DJ Flanagan, AK Najumudeen, S Omwenga, AMB McCorry, A Easton, VH Koelzer, JE East, D Morton, L Trusolino, T Maughan, AD Campbell, MB Loughrey, PD Dunne, P Tsantoulis, DJ Huels, S Tejpar, OJ Sansom, SJ Leedham Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia Cell Stem Cell, 2022-08-04;29(8):1213-1228.e8. 2022-08-04 [PMID: 35931031] (Bioassay, Mouse)	Bioassay	Mouse
R Guo, X Jia, Z Ding, G Wang, M Jiang, B Li, S Chen, B Xia, Q Zhang, J Liu, R Zheng, Z Gao, X Xie Loss of MLKL ameliorates liver fibrosis by inhibiting hepatocyte necroptosis and hepatic stellate cell activation Theranostics, 2022-07-04;12(11):5220-5236. 2022-07-04 [PMID: 35836819] (Bioassay, Mouse)	Bioassay	Mouse
MB Bayazit, C Jacovetti, C Cosentino, J Sobel, K Wu, F Brozzi, A Rodriguez-, L Stoll, C Guay, R Regazzi Small RNAs derived from tRNA fragmentation regulate the functional maturation of neonatal beta cells Cell Reports, 2022-07-12;40(2):111069. 2022-07-12 [PMID: 35830789] (Bioassay, Rat)	Bioassay	Rat
MK Ameka, WN Beavers, CM Shaver, LB Ware, VE Kerchberge, KQ Schoenfelt, L Sun, T Koyama, EP Skaar, L Becker, AH Hasty An Iron Refractory Phenotype in Obese Adipose Tissue Macrophages Leads to Adipocyte Iron Overload International Journal of Molecular Sciences, 2022-07-03;23(13):. 2022-07-03 [PMID: 35806422] (Bioassay, Mouse)	Bioassay	Mouse
H Qu, R Heinbäck, H Salo, E Ewing, A Espinosa, C Aulin, H Erlandsson Transcriptomic Profiling Reveals That HMGB1 Induces Macrophage Polarization Different from Classical M1 Biomolecules, 2022-06-02;12(6):. 2022-06-02 [PMID: 35740904] (Bioassay, Mouse)	Bioassay	Mouse
G Coquant, D Aguanno, L Brot, C Belloir, J Delugeard, N Roger, HP Pham, L Briand, M Moreau, L de Sordi, V Carrière, JP Grill, S Thenet, P Seksik 3-oxo-C12:2-HSL, quorum sensing molecule from human intestinal microbiota, inhibits pro-inflammatory pathways in immune cells via bitter taste receptors Oncogene, 2022-06-08;12(1):9440. 2022-06-08 [PMID: 35676403] (Bioassay, Mouse)	Bioassay	Mouse
H Kamei, T Ishii, Y Nishii Semaphorin 3A regulates alveolar bone remodeling on orthodontic tooth movement Oncogene, 2022-06-02;12(1):9243. 2022-06-02 [PMID: 35654941] (Bioassay, Mouse)	Bioassay	Mouse
Y Jin, Y Liu, L Xu, J Xu, Y Xiong, Y Peng, K Ding, S Zheng, N Yang, Z Zhang, L Li, L Tan, H Song, J Fu Novel role for caspase 1 inhibitor VX765 in suppressing NLRP3 inflammasome assembly and atherosclerosis via promoting mitophagy and efferocytosis Cell Death & Disease, 2022-05-31;13(5):512. 2022-05-31 [PMID: 35641492] (Bioassay, Mouse)	Bioassay	Mouse
R Mary, F Chalmin, T Accogli, M Bruchard, C Hibos, J Melin, C Truntzer, E Limagne, V Derangère, M Thibaudin, E Humblin, R Boidot, S Chevrier, L Arnould, C Richard, Q Klopfenste, A Bernard, Y Urade, JA Harker, L Apetoh, F Ghiringhel, F Végran Hematopoietic Prostaglandin D2 Synthase Controls Tfh/Th2 Communication and Limits Tfh Antitumor Effects Cancer Immunology Research, 2022-07-01;0(0):OF1-OF17. 2022-07-01 [PMID: 35612500] (Bioassay, Mouse)	Bioassay	Mouse
SO Vasudevan, AJ Russo, P Kumari, SK Vanaja, VA Rathinam A TLR4-independent critical role for CD14 in intracellular LPS sensing Cell Reports, 2022-05-03;39(5):110755. 2022-05-03 [PMID: 35508125] (Bioassay, Mouse)	Bioassay	Mouse
A Steiner, K Hrovat-Sch, I Prigione, CH Yu, P Laohamonth, CR Harapas, RRJ Low, D De Nardo, LF Dagley, MJ Mlodzianos, KL Rogers, T Zillinger, G Hartmann, MP Gantier, M Gattorno, M Geyer, S Volpi, S Davidson, SL Masters Deficiency in coatomer complex I causes aberrant activation of STING signalling Nature Communications, 2022-04-28;13(1):2321. 2022-04-28 [PMID: 35484149] (Bioassay, Human)	Bioassay	Human
W Piao, L Li, V Saxena, J Iyyathurai, R Lakhan, Y Zhang, IT Lape, C Paluskievi, KL Hippen, Y Lee, E Silverman, MW Shirkey, LV Riella, BR Blazar, JS Bromberg PD-L1 signaling selectively regulates T cell lymphatic transendothelial migration Nature Communications, 2022-04-21;13(1):2176. 2022-04-21 [PMID: 35449134] (Bioassay, Mouse)	Bioassay	Mouse
ML Yang, S Horstman, R Gee, P Guyer, TT Lam, J Kanyo, AL Perdigoto, C Speake, CJ Greenbaum, A Callebaut, L Overbergh, RG Kibbey, KC Herold, EA James, MJ Mamula Citrullination of glucokinase is linked to autoimmune diabetes Nature Communications, 2022-04-06;13(1):1870. 2022-04-06 [PMID: 35388005] (Bioassay, Rat)	Bioassay	Rat
L Liu, RM Lucas, JD Nanson, Y Li, J Whitfield, JEB Curson, N Tuladhar, K Alexandrov, M Mobli, MJ Sweet, B Kobe, J Stow, L Luo The transmembrane adaptor SCIMP recruits tyrosine kinase Syk to phosphorylate Toll-like receptors to mediate selective inflammatory outputs The Journal of Biological Chemistry, 2022-03-22;0(0):101857. 2022-03-22 [PMID: 35337798] (Bioassay, Mouse)	Bioassay	Mouse
A Stancic, T Saksida, M Markelic, M Vucetic, I Grigorov, V Martinovic, D Gajic, A Ivanovic, K Velickovic, N Savic, V Otasevic Ferroptosis as a Novel Determinant of beta-Cell Death in Diabetic Conditions Oxidative Medicine and Cellular Longevity, 2022-03-14;2022(0):3873420. 2022-03-14 [PMID: 35320979] (Cell Culture, Rat)	Cell Culture	Rat
A Fedoriw, L Shi, S O'Brien, KN Smitheman, Y Wang, J Hou, C Sherk, S Rajapurkar, J Laraio, LJ Williams, C Xu, G Han, Q Feng, MT Bedford, L Wang, O Barbash, RG Kruger, P Hwu, HP Mohammad, W Peng Inhibiting Type I arginine methyltransferase activity promotes the T cell mediated antitumor immune response Cancer Immunology Research, 2022-04-01;0(0):. 2022-04-01 [PMID: 35181787] (Bioassay, Human)	Bioassay	Human
SW Tuffs, MI Goncheva, SX Xu, HC Craig, KJ Kasper, J Choi, RS Flannagan, SM Kerfoot, DE Heinrichs, JK McCormick Superantigens promote Staphylococcus aureus bloodstream infection by eliciting pathogenic interferon-gamma production Proceedings of the National Academy of Sciences of the United States of America, 2022-02-22;119(8):. 2022-02-22 [PMID: 35165181] (Bioassay, Mouse)	Bioassay	Mouse
J Jin, I Sivakumar, Y Mironchik, B Krishnamac, F Wildes, JD Barnett, CF Hung, S Nimmagadda, H Kobayashi, ZM Bhujwalla, MF Penet PD-L1 near Infrared Photoimmunotherapy of Ovarian Cancer Model Cancers, 2022-01-26;14(3):. 2022-01-26 [PMID: 35158887] (Bioassay, Mouse)	Bioassay	Mouse
EI Arafa, AT Shenoy, KA Barker, NS Etesami, IM Martin, C Lyon De An, E Na, CV Odom, WN Goltry, FT Korkmaz, AK Wooten, AC Belkina, A Guillon, EC Forsberg, MR Jones, LJ Quinton, JP Mizgerd Recruitment and training of alveolar macrophages after pneumococcal pneumonia JCI Insight, 2022-03-08;0(0):. 2022-03-08 [PMID: 35133985] (Bioassay, Mouse)	Bioassay	Mouse
Z Wang, K Huang, J Xu, J Liu, Y Zheng Insights from Dysregulated mRNA Expression Profile of beta-Cells in Response to Proinflammatory Cytokines Journal of Immunology Research, 2022-01-22;2022(0):4542487. 2022-01-22 [PMID: 35103245] (Bioassay, Mouse)	Bioassay	Mouse
JG Miranda, WE Schleicher, KL Wells, DG Ramirez, SP Landgrave, RK Benninger Dynamic changes in beta-cell [Ca2+] regulates NFAT activation, gene transcription and islet gap junction communication Oncogene, 2021-12-31;0(0):101430. 2021-12-31 [PMID: 34979329] (Bioassay, Mouse)	Bioassay	Mouse
H Mo, Q Ren, D Song, B Xu, D Zhou, X Hong, FF Hou, L Zhou, Y Liu CXCR4 induces podocyte injury and proteinuria by activating beta-catenin signaling Theranostics, 2022-01-01;12(2):767-781. 2022-01-01 [PMID: 34976212] (Bioassay, Mouse)	Bioassay	Mouse
HR McMurray, A Ambeskovic, LA Newman, J Aldersley, V Balakrishn, B Smith, HA Stern, H Land, MN McCall Gene network modeling via TopNet reveals functional dependencies between diverse tumor-critical mediator genes Cell Reports, 2021-12-21;37(12):110136. 2021-12-21 [PMID: 34936873] (Bioassay, Mouse)	Bioassay	Mouse
Y Cheng, TR Hall, X Xu, I Yung, D Souza, J Zheng, F Schiele, M Hoffmann, ML Mbow, JP Garnett, J Li Targeting uPA-uPAR interaction to improve intestinal epithelial barrier integrity in inflammatory bowel disease EBioMedicine, 2021-12-18;75(0):103758. 2021-12-18 [PMID: 34933179] (Bioassay, Mouse, Transgenic Mouse)	Bioassay	Mouse, Transgenic Mouse
P Chauhan, WS Sheng, S Hu, S Prasad, JR Lokensgard Differential Cytokine-Induced Responses of Polarized Microglia Brain sciences, 2021-11-10;11(11):. 2021-11-10 [PMID: 34827481] (Bioassay, Mouse)	Bioassay	Mouse
Y Zhang, Y Zheng, F Shu, R Zhou, B Bao, S Xiao, K Li, Q Lin, L Zhu, Z Xia In situ-formed adhesive hyaluronic acid hydrogel with prolonged amnion-derived conditioned medium release for diabetic wound repair Carbohydrate polymers, 2021-10-16;276(0):118752. 2021-10-16 [PMID: 34823781] (Bioassay, Mouse)	Bioassay	Mouse
A Fu, L van Rooyen, L Evans, N Armstrong, D Avizonis, T Kin, GH Bird, A Reddy, ET Chouchani, M Liesa-Roig, LD Walensky, AMJ Shapiro, NN Danial Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets Cell Reports, 2021-11-23;37(8):110037. 2021-11-23 [PMID: 34818536] (Bioassay, Mouse)	Bioassay	Mouse
J Amo-Aparic, J Garcia-Gar, I Francos-Qu, A Urpi, A Esteve-Cod, M Gut, A Quintana, R Lopez-Vale Interleukin-4 and interleukin-13 induce different metabolic profiles in microglia and macrophages that relate with divergent outcomes after spinal cord injury Theranostics, 2021-10-03;11(20):9805-9820. 2021-10-03 [PMID: 34815787] (Bioassay, Mouse)	Bioassay	Mouse
KKL Wu, K Long, H Lin, PMF Siu, RLC Hoo, D Ye, A Xu, KKY Cheng The APPL1-Rab5 axis restricts NLRP3 inflammasome activation through early endosomal-dependent mitophagy in macrophages Nature Communications, 2021-11-17;12(1):6637. 2021-11-17 [PMID: 34789781] (Bioassay, Mouse)	Bioassay	Mouse
P Rozier, M Maumus, ATJ Maria, K Toupet, C Jorgensen, P Guilpain, D Noël Lung Fibrosis Is Improved by Extracellular Vesicles from IFNgamma-Primed Mesenchymal Stromal Cells in Murine Systemic Sclerosis Cells, 2021-10-13;10(10):. 2021-10-13 [PMID: 34685707] (Cell Culture, Mouse)	Cell Culture	Mouse
JM Motta, VM Rumjanek, A Mantovani, M Locati Tumor-Released Products Promote Bone Marrow-Derived Macrophage Survival and Proliferation Biomedicines, 2021-10-04;9(10):. 2021-10-04 [PMID: 34680504] (Differentiation, Differentiation, Mouse)	Differentiation, Differentiation	Mouse
F Progatzky, M Shapiro, SH Chng, B Garcia-Cas, CH Classon, S Sevgi, A Laddach, AC Bon-Frauch, R Lasrado, M Rahim, EM Amaniti, S Boeing, K Shah, LJ Entwistle, A Suárez-Bon, MS Wilson, B Stockinger, V Pachnis Regulation of intestinal immunity and tissue repair by enteric glia Nature, 2021-10-20;599(7883):125-130. 2021-10-20 [PMID: 34671159] (Bioassay, Mouse)	Bioassay	Mouse
G Wang, L Xie, B Li, W Sang, J Yan, J Li, H Tian, W Li, Z Zhang, Y Tian, Y Dai A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis Nature Communications, 2021-09-30;12(1):5733. 2021-09-30 [PMID: 34593794] (Bioassay, Mouse)	Bioassay	Mouse
Z Qian, H Yang, H Li, C Liu, L Yang, Z Qu, X Li The Cholinergic Anti-Inflammatory Pathway Attenuates the Development of Atherosclerosis in Apoe-/- Mice through Modulating Macrophage Functions Biomedicines, 2021-09-03;9(9):. 2021-09-03 [PMID: 34572339] (Bioassay, Mouse)	Bioassay	Mouse
TD Popoola, ST Guetchueng, KJ Ritchie, O Awodele, NM Dempster, O Akinloye, SD Sarker, AA Fatokun Potent Nrf2-inducing, antioxidant, and anti-inflammatory effects and identification of constituents validate the anti-cancer use of Uvaria chamae and Olax subscorpioidea BMC complementary medicine and therapies, 2021-09-18;21(1):234. 2021-09-18 [PMID: 34537049] (Bioassay, Mouse)	Bioassay	Mouse
S Lee, G Kalugotla, H Ingle, R Rodgers, C Wu, Y Wang, Y Li, X Yang, J Zhang, NR Borella, H Deng, L Droit, R Hill, ST Peterson, C Desai, D Lawrence, Q Lu, MT Baldridge Intestinal antiviral signaling is controlled by autophagy gene Epg5 independent of the microbiota Autophagy, 2021-09-14;0(0):1-16. 2021-09-14 [PMID: 34520306] (Bioassay, Mouse)	Bioassay	Mouse
M Choi, JA Bonanno Mitochondrial Targeting of the Ammonia-Sensitive Uncoupler SLC4A11 by the Chaperone-Mediated Carrier Pathway in Corneal Endothelium Investigative Ophthalmology & Visual Science, 2021-09-02;62(12):4. 2021-09-02 [PMID: 34499705] (Bioassay, Mouse)	Bioassay	Mouse
A Gluschko, A Farid, M Herb, D Grumme, M Krönke, M Schramm Macrophages target Listeria monocytogenes by two discrete non-canonical autophagy pathways Autophagy, 2021-09-05;0(0):1-15. 2021-09-05 [PMID: 34482812] (Bioassay, Mouse)	Bioassay	Mouse
A Osman, B Yan, Y Li, KD Pavelko, J Quandt, A Saadalla, MP Singh, M Kazemian, F Gounari, K Khazaie TCF-1 controls Treg cell functions that regulate inflammation, CD8+ T cell cytotoxicity and severity of colon cancer Nature Immunology, 2021-08-12;0(0):. 2021-08-12 [PMID: 34385712] (Bioassay, Mouse)	Bioassay	Mouse
K Sumi, M Sakuda, K Munakata, K Nakamura, K Ashida alpha-Hydroxyisocaproic Acid Decreases Protein Synthesis but Attenuates TNFalpha/IFNgamma Co-Exposure-Induced Protein Degradation and Myotube Atrophy via Suppression of iNOS and IL-6 in Murine C2C12 Myotube Nutrients, 2021-07-13;13(7):. 2021-07-13 [PMID: 34371902] (Bioassay, Mouse)	Bioassay	Mouse
JH Kim, J Han, K Suk Protective Effects of Complement Component 8 Gamma Against Blood-Brain Barrier Breakdown Frontiers in Physiology, 2021-06-03;12(0):671250. 2021-06-03 [PMID: 34149451] (Cell Cultulre, Mouse)	Cell Cultulre	Mouse
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AS Chitre, MG Kattah, YY Rosli, M Pao, M Deswal, SG Deeks, PW Hunt, M Abdel-Mohs, LJ Montaner, CC Kim, A Ma, M Somsouk, JM McCune A20 upregulation during treated HIV disease is associated with intestinal epithelial cell recovery and function PLoS Pathog., 2018-03-05;14(3):e1006806. 2018-03-05 [PMID: 29505600] (Bioassay, Mouse)	Bioassay	Mouse
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JF Ma, BJ Sanchez, DT Hall, AK Tremblay, S Di Marco, IE Gallouzi STAT3 promotes IFN?/TNF?-induced muscle wasting in an NF-?B-dependent and IL-6-independent manner EMBO Mol Med, 2017-05-01;0(0):. 2017-05-01 [PMID: 28264935] (Bioassay, In Vivo, Mouse)	Bioassay, In Vivo	Mouse
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Ofer Guttman Context-Specific and Immune Cell-Dependent Antitumor Activities of ?1-Antitrypsin Front Immunol, 2016-12-07;7(0):559. 2016-12-07 [PMID: 28003813] (Bioassay, Mouse)	Bioassay	Mouse
Oksana Dmytriyeva Epobis is a Nonerythropoietic and Neuroprotective Agonist of the Erythropoietin Receptor with Anti-Inflammatory and Memory Enhancing Effects Mediators Inflamm, 2016-11-21;2016(0):1346390. 2016-11-21 [PMID: 27990061] (Bioassay, Mouse)	Bioassay	Mouse
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Th1 cells downregulate connexin 43 gap junctions in astrocytes via microglial activation Sci Rep, 2016-12-08;6(0):38387. 2016-12-08 [PMID: 27929069] (Bioassay, Mouse)	Bioassay	Mouse
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Mechanisms Underlying Interferon-?-Induced Priming of Microglial Reactive Oxygen Species Production PLoS ONE, 2016-09-06;11(9):e0162497. 2016-09-06 [PMID: 27598576] (Bioassay, Mouse)	Bioassay	Mouse
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Cui W, Joshi NS, Jiang A, Kaech SM Effects of Signal 3 during CD8 T cell priming: Bystander production of IL-12 enhances effector T cell expansion but promotes terminal differentiation. Vaccine, 2009-02-06;27(15):2177-87. 2009-02-06 [PMID: 19201385] (In Vivo, Mouse)	In Vivo	Mouse
Bhowmick S, Mazumdar T, Ali N Vaccination route that induces transforming growth factor beta production fails to elicit protective immunity against Leishmania donovani infection. Infect. Immun., 2009-01-21;77(4):1514-23. 2009-01-21 [PMID: 19168736] (Bioassay, Mouse)	Bioassay	Mouse
Dienz O, Eaton SM, Bond JP, Neveu W, Moquin D, Noubade R, Briso EM, Charland C, Leonard WJ, Ciliberto G, Teuscher C, Haynes L, Rincon M The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells. J. Exp. Med., 2009-01-12;206(1):69-78. 2009-01-12 [PMID: 19139170] (Bioassay, Mouse)	Bioassay	Mouse
Yamada A, Suzuki D, Miyazono A, Oshima K, Kamiya A, Zhao B, Takami M, Donnelly RP, Itabe H, Yamamoto M, Kimura S, Kamijo R IFN-gamma down-regulates Secretoglobin 3A1 gene expression. Biochem. Biophys. Res. Commun., 2009-01-09;379(4):964-8. 2009-01-09 [PMID: 19135978] (Bioassay, Mouse)	Bioassay	Mouse
Smith KE, Fritzell S, Badn W, Eberstal S, Janelidze S, Visse E, Darabi A, Siesjo P Cure of established GL261 mouse gliomas after combined immunotherapy with GM-CSF and IFNgamma is mediated by both CD8+ and CD4+ T-cells. Int. J. Cancer, 2009-02-01;124(3):630-7. 2009-02-01 [PMID: 18972433] (Bioassay, In Vivo, Mouse)	Bioassay, In Vivo	Mouse
Liu T, Huang Y, Likhotvorik RI, Keshvara L, Hoyt DG Protein Never in Mitosis Gene A Interacting-1 (PIN1) regulates degradation of inducible nitric oxide synthase in endothelial cells. Am. J. Physiol., Cell Physiol., 2008-07-23;295(3):C819-27. 2008-07-23 [PMID: 18650263] (Bioassay, Mouse)	Bioassay	Mouse
Nairz M, Fritsche G, Brunner P, Talasz H, Hantke K, Weiss G Interferon-gamma limits the availability of iron for intramacrophage Salmonella typhimurium. Eur. J. Immunol., 2008-07-01;38(7):1923-36. 2008-07-01 [PMID: 18581323] (Bioassay, Mouse)	Bioassay	Mouse
Wieland CW, van der Windt GJ, Wiersinga WJ, Florquin S, van der Poll T CD14 contributes to pulmonary inflammation and mortality during murine tuberculosis. Immunology, 2008-04-03;125(2):272-9. 2008-04-03 [PMID: 18393969] (ELISA (Standard))	ELISA (Standard)
Lee YM, Miyahara N, Takeda K, Prpich J, Oh A, Balhorn A, Joetham A, Gelfand EW, Dakhama A IFN-gamma production during initial infection determines the outcome of reinfection with respiratory syncytial virus. Am. J. Respir. Crit. Care Med., 2007-10-25;177(2):208-18. 2007-10-25 [PMID: 17962634] (In Vivo, Mouse)	In Vivo	Mouse
Smith SE, Li J, Garbett K, Mirnics K, Patterson PH Maternal immune activation alters fetal brain development through interleukin-6. J. Neurosci., 2007-10-03;27(40):10695-702. 2007-10-03 [PMID: 17913903] (In Vivo, Mouse)	In Vivo	Mouse
Schell JB, Crane CA, Smith MF, Roberts MR Differential ex vivo nitric oxide production by acutely isolated neonatal and adult microglia. J. Neuroimmunol., 2007-08-15;189(1):75-87. 2007-08-15 [PMID: 17698208] (Bioassay, Mouse)	Bioassay	Mouse
Fujita H, Asahina A, Komine M, Tamaki K The direct action of 1alpha,25(OH)2-vitamin D3 on purified mouse Langerhans cells. Cell. Immunol., 2007-05-15;245(2):70-9. 2007-05-15 [PMID: 17507001] (Bioassay, Mouse)	Bioassay	Mouse
Chitnis T, Imitola J, Wang Y, Elyaman W, Chawla P, Sharuk M, Raddassi K, Bronson RT, Khoury SJ Elevated neuronal expression of CD200 protects Wlds mice from inflammation-mediated neurodegeneration. Am. J. Pathol., 2007-05-01;170(5):1695-712. 2007-05-01 [PMID: 17456775] (Bioassay, Mouse)	Bioassay	Mouse
Watanabe H, Kubo M, Numata K, Takagi K, Mizuta H, Okada S, Ito T, Matsukawa A Overexpression of suppressor of cytokine signaling-5 in T cells augments innate immunity during septic peritonitis. J. Immunol., 2006-12-15;177(12):8650-7. 2006-12-15 [PMID: 17142765] (ELISA (Standard))	ELISA (Standard)
Henke PK, Pearce CG, Moaveni DM, Moore AJ, Lynch EM, Longo C, Varma M, Dewyer NA, Deatrick KB, Upchurch GR, Wakefield TW, Hogaboam C, Kunkel SL Targeted deletion of CCR2 impairs deep vein thombosis resolution in a mouse model. J. Immunol., 2006-09-01;177(5):3388-97. 2006-09-01 [PMID: 16920980] (In Vivo, Mouse)	In Vivo	Mouse
Butovsky O, Koronyo-Hamaoui M, Kunis G, Ophir E, Landa G, Cohen H, Schwartz M Glatiramer acetate fights against Alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1. Proc. Natl. Acad. Sci. U.S.A., 2006-07-24;103(31):11784-9. 2006-07-24 [PMID: 16864778] (Bioassay, Mouse)	Bioassay	Mouse
Butovsky O, Landa G, Kunis G, Ziv Y, Avidan H, Greenberg N, Schwartz A, Smirnov I, Pollack A, Jung S, Schwartz M Induction and blockage of oligodendrogenesis by differently activated microglia in an animal model of multiple sclerosis. J. Clin. Invest., 2006-03-23;116(4):905-15. 2006-03-23 [PMID: 16557302] (Bioassay, Mouse)	Bioassay	Mouse
An HJ, Jeong HJ, Um JY, Kim HM, Hong SH Glechoma hederacea inhibits inflammatory mediator release in IFN-gamma and LPS-stimulated mouse peritoneal macrophages. J Ethnopharmacol, 2006-03-10;106(3):418-24. 2006-03-10 [PMID: 16530364] (Bioassay, In Vivo, Mouse)	Bioassay, In Vivo	Mouse
Zhang F, Lee J, Wang D, Dong Z Differential Growth of IFN-beta-Engineered Tumor Cells in Nude and IFN Receptor-Null Mice. J. Interferon Cytokine Res., 2006-02-01;26(2):108-18. 2006-02-01 [PMID: 16487031] (Bioassay, Mouse)	Bioassay	Mouse
Butovsky O, Ziv Y, Schwartz A, Landa G, Talpalar AE, Pluchino S, Martino G, Schwartz M Microglia activated by IL-4 or IFN-gamma differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells. Mol. Cell. Neurosci., 2005-11-16;31(1):149-60. 2005-11-16 [PMID: 16297637] (Bioassay, Mouse)	Bioassay	Mouse
Best SM, Morris KL, Shannon JG, Robertson SJ, Mitzel DN, Park GS, Boer E, Wolfinbarger JB, Bloom ME Inhibition of interferon-stimulated JAK-STAT signaling by a tick-borne flavivirus and identification of NS5 as an interferon antagonist. J. Virol., 2005-10-01;79(20):12828-39. 2005-10-01 [PMID: 16188985] (Bioassay, Mouse)	Bioassay	Mouse
Osuchowski MF, Siddiqui J, Copeland S, Remick DG Sequential ELISA to profile multiple cytokines from small volumes. J. Immunol. Methods, 2005-07-01;302(1):172-81. 2005-07-01 [PMID: 16023134] (ELISA (Standard))	ELISA (Standard)
Kamath AT, Sheasby CE, Tough DF Dendritic cells and NK cells stimulate bystander T cell activation in response to TLR agonists through secretion of IFN-alpha beta and IFN-gamma. J. Immunol., 2005-01-15;174(2):767-76. 2005-01-15 [PMID: 15634897] (Bioassay, Mouse)	Bioassay	Mouse
Murphey ED, Herndon DN, Sherwood ER Gamma interferon does not enhance clearance of Pseudomonas aeruginosa but does amplify a proinflammatory response in a murine model of postseptic immunosuppression. Infect. Immun., 2004-12-01;72(12):6892-901. 2004-12-01 [PMID: 15557610] (In Vivo, Mouse)	In Vivo	Mouse
Zamboni DS, Campos MA, Torrecilhas AC, Kiss K, Samuel JE, Golenbock DT, Lauw FN, Roy CR, Almeida IC, Gazzinelli RT Stimulation of toll-like receptor 2 by Coxiella burnetii is required for macrophage production of pro-inflammatory cytokines and resistance to infection. J. Biol. Chem., 2004-10-13;279(52):54405-15. 2004-10-13 [PMID: 15485838] (Bioassay, Mouse)	Bioassay	Mouse
Wolk K, Kunz S, Witte E, Friedrich M, Asadullah K, Sabat R IL-22 increases the innate immunity of tissues. Immunity, 2004-08-01;21(2):241-54. 2004-08-01 [PMID: 15308104] (In Vivo, Mouse)	In Vivo	Mouse
Bleier JI, Pillarisetty VG, Shah AB, DeMatteo RP Increased and long-term generation of dendritic cells with reduced function from IL-6-deficient bone marrow. J. Immunol., 2004-06-15;172(12):7408-16. 2004-06-15 [PMID: 15187118] (Bioassay, Mouse)	Bioassay	Mouse
Sharif MN, Tassiulas I, Hu Y, Mecklenbrauker I, Tarakhovsky A, Ivashkiv LB IFN-alpha priming results in a gain of proinflammatory function by IL-10: implications for systemic lupus erythematosus pathogenesis. J. Immunol., 2004-05-15;172(10):6476-81. 2004-05-15 [PMID: 15128840] (Bioassay, Mouse)	Bioassay	Mouse
Gough PJ, Garton KJ, Wille PT, Rychlewski M, Dempsey PJ, Raines EW A disintegrin and metalloproteinase 10-mediated cleavage and shedding regulates the cell surface expression of CXC chemokine ligand 16. J. Immunol., 2004-03-15;172(6):3678-85. 2004-03-15 [PMID: 15004171] (Bioassay, Mouse)	Bioassay	Mouse
Asselin-Paturel C, Brizard G, Pin JJ, Briere F, Trinchieri G Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibody. J. Immunol., 2003-12-15;171(12):6466-77. 2003-12-15 [PMID: 14662846] (Bioassay, Mouse)	Bioassay	Mouse
Monick MM, Samavati L, Butler NS, Mohning M, Powers LS, Yarovinsky T, Spitz DR, Hunninghake GW Intracellular thiols contribute to Th2 function via a positive role in IL-4 production. J. Immunol., 2003-11-15;171(10):5107-15. 2003-11-15 [PMID: 14607909] (Bioassay, Mouse)	Bioassay	Mouse
Shin T, Kennedy G, Gorski K, Tsuchiya H, Koseki H, Azuma M, Yagita H, Chen L, Powell J, Pardoll D, Housseau F Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor. J. Exp. Med., 2003-07-07;198(1):31-8. 2003-07-07 [PMID: 12847135] (Bioassay, Mouse)	Bioassay	Mouse
Jakubzick C, Choi ES, Kunkel SL, Joshi BH, Puri RK, Hogaboam CM Impact of interleukin-13 responsiveness on the synthetic and proliferative properties of Th1- and Th2-type pulmonary granuloma fibroblasts. Am. J. Pathol., 2003-05-01;162(5):1475-86. 2003-05-01 [PMID: 12707030] (Bioassay, Mouse)	Bioassay	Mouse
Shi ZO, Fischer MJ, De Sanctis GT, Schuyler MR, Tesfaigzi Y IFN-gamma, but not Fas, mediates reduction of allergen-induced mucous cell metaplasia by inducing apoptosis. J. Immunol., 2002-05-01;168(9):4764-71. 2002-05-01 [PMID: 11971027] (In Vivo, Mouse)	In Vivo	Mouse
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Array 485-MI/CF

• IFN-gamma Antibodies
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