Recombinant Mouse Desmoglein-2 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Desmoglein-2 (DSG2) is a 160 kDa transmembrane glycoprotein in the cadherin family of calcium dependent adhesion molecules. It is a major protein component of desmosomal contacts between epithelial cells (1, 2). Mature mouse Desmoglein‑2 consists of a 564 amino acid (aa) extracellular domain (ECD) with four cadherin domains, a 21 aa transmembrane segment, and a 483 aa cytoplasmic domain with six desmoglein repeats (3, 4). Within the ECD, mouse Desmoglein‑2 shares 81% and 93% aa sequence identity with human and rat Desmoglein‑2, respectively. A 60 kDa ECD fragment can be proteolytically shed, and this is enhanced by EGF R activation (5‑7). The cytoplasmic domain is cleaved during apoptosis, leaving the transmembrane segment and ECD as a cell‑associated fragment (8). Desmoglein‑2 is widely expressed in epithelia and is required for maintenance of the epithelial barrier (1, 2, 9). It can be either up- or down‑regulated in a variety of carcinomas during tumor progression (10). Desmoglein‑2 also functions as a cell adhesion receptor for several adenovirus serotypes (11). This binding disrupts intercellular junctions between epithelial cells and promotes epithelial‑mesenchymal transition (EMT) (11). Mutations in Desmoglein‑2 cause cardiac dysfunction typical of arrythmogenic right ventricular cardiomyopathy (ARVC) (12).

Array 7699-DM

• Desmoglein-2 Antibodies
• Desmoglein-2 ELISA Kits
• Desmoglein-2 Lysate
• Desmoglein-2 Protein
• Desmoglein-2 Proteins and Enzymes