Recombinant Human Ubiquitin Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Ubiquitin is a 76 amino acid (aa) protein that is ubiquitously expressed in all eukaryotic organisms. Ubiquitin is highly conserved with 96% aa sequence identity shared between human and yeast Ubiquitin, and 100% aa sequence identity shared between human and mouse Ubiquitin (1). In mammals, four Ubiquitin genes encode for two Ubiquitin-ribosomal fusion proteins and two poly-Ubiquitin proteins. Cleavage of the Ubiquitin precursors by deubiquitinating enzymes gives rise to identical Ubiquitin monomers each with a predicted molecular weight of 8.6 kDa. Conjugation of Ubiquitin to target proteins involves the formation of an isopeptide bond between the C-terminal glycine residue of Ubiquitin and a lysine residue in the target protein. This process of conjugation, referred to as ubiquitination or ubiquitylation, is a multi-step process that requires three enzymes: a Ubiquitin-activating (E1) enzyme, a Ubiquitin-conjugating (E2) enzyme, and a Ubiquitin ligase (E3). Ubiquitination is classically recognized as a mechanism to target proteins for degradation and as a result, Ubiquitin was originally named ATP-dependent Proteolysis Factor 1 (APF-1) (2,3). In addition to protein degradation, ubiquitination has been shown to mediate a variety of biological processes such as signal transduction, endocytosis, and post-endocytic sorting (4-7).

The Ubiquitin product was processed to eliminate glycine and buffer salts which can interfere with chemical and in vitro reactions.

We have publications tested in 13 confirmed species: Human, Mouse, Bacteria, Bacteria - E. Coli, Bacteria - Escherichia coli, E. coli, N/A, Parasite - Plasmodium falciparum, Plant - Oryza sativa (Rice), Spodoptera frugiperda, Virus - HPV, Xenopus, Yeast - Saccharomyces cerevisiae.

We have publications tested in 7 applications: Binding Assay, Bioassay, ELISA, Enzyme Assay, Ubiquitination, Ubiquitylation, Western Blot.

Showing Publications 1 - 10 of 137. Show All 137 Publications. Collapse Publications.

Publications using U-100H	Applications	Species
Chan, A;Haley, RM;Najar, MA;Gonzalez-Martinez, D;Bugaj, LJ;Burslem, GM;Mitchell, MJ;Tsourkas, A; Lipid-mediated intracellular delivery of recombinant bioPROTACs for the rapid degradation of undruggable proteins Nature communications 2024-07-10 [PMID: 38987546] (Bioassay, Human)	Bioassay	Human
Wang, S;Li, H;Liu, X;Yin, T;Li, T;Zheng, M;Liu, M;Meng, X;Zhou, J;Wang, Y;Chen, Y; VHL suppresses UBE3B-mediated breast tumor growth and metastasis Cell death & disease 2024-06-24 [PMID: 38914543] (Bioassay, N/A)	Bioassay	N/A
Kubori, T;Arasaki, K;Oide, H;Kitao, T;Nagai, H; Multi-tiered actions of Legionella effectors to modulate host Rab10 dynamics eLife 2024-05-21 [PMID: 38771316] (Bioassay, N/A)	Bioassay	N/A
Radko-Juettner, S;Yue, H;Myers, JA;Carter, RD;Robertson, AN;Mittal, P;Zhu, Z;Hansen, BS;Donovan, KA;Hunkeler, M;Rosikiewicz, W;Wu, Z;McReynolds, MG;Roy Burman, SS;Schmoker, AM;Mageed, N;Brown, SA;Mobley, RJ;Partridge, JF;Stewart, EA;Pruett-Miller, SM;Nabet, B;Peng, J;Gray, NS;Fischer, ES;Roberts, CWM; Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF Nature 2024-03-27 [PMID: 38538798] (Bioassay, N/A)	Bioassay	N/A
Wang, JCK;Baddock, HT;Mafi, A;Foe, IT;Bratkowski, M;Lin, TY;Jensvold, ZD;Preciado López, M;Stokoe, D;Eaton, D;Hao, Q;Nile, AH; Structure of the p53 degradation complex from HPV16 Nature communications 2024-02-28 [PMID: 38418456] (Bioassay, Bacteria - Escherichia coli)	Bioassay	Bacteria - Escherichia coli
Wu, K;DeVita, RJ;Pan, ZQ; Mono-ubiquitination empowers ubiquitin chain elongation The Journal of biological chemistry 2024-02-12 [PMID: 38354782] (Bioassay, Human)	Bioassay	Human
Zhu, K;Suskiewicz, MJ;Chatrin, C;Strømland, Ø;Dorsey, BW;Aucagne, V;Ahel, D;Ahel, I; DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on nucleic acids Nucleic acids research 2023-11-24 [PMID: 38000390] (Bioassay, N/A)	Bioassay	N/A
Tian, T;Xie, X;Yi, W;Zhou, Y;Xu, Y;Wang, Z;Zhang, J;Lin, M;Zhang, R;Lv, Z;Li, X;Lv, L;Xu, Y; FBXO38 mediates FGL1 ubiquitination and degradation to enhance cancer immunity and suppress inflammation Cell reports 2023-11-28 [PMID: 37938970] (Bioassay, N/A)	Bioassay	N/A
Li, P;Zhen, Y;Kim, C;Liu, Z;Hao, J;Deng, H;Deng, H;Zhou, M;Wang, XD;Qin, T;Yu, Y; Nimbolide targets RNF114 to induce the trapping of PARP1 and synthetic lethality in BRCA-mutated cancer Science advances 2023-10-27 [PMID: 37878693] (Bioassay, Human)	Bioassay	Human
VanDyke, D;Xu, L;Sargunas, PR;Gilbreth, RN;Baca, M;Gao, C;Hunt, J;Spangler, JB; Redirecting the specificity of tripartite motif containing-21 scaffolds using a novel discovery and design approach The Journal of biological chemistry 2023-10-20 [PMID: 37866632] (Bioassay, N/A)	Bioassay	N/A
Sun, J;Huang, S;Lu, Q;Li, S;Zhao, S;Zheng, X;Zhou, Q;Zhang, W;Li, J;Wang, L;Zhang, K;Zheng, W;Feng, X;Liu, B;Kong, F;Xiang, F; UV-B irradiation-activated E3 ligase GmILPA1 modulates gibberellin catabolism to increase plant height in soybean Nature communications 2023-10-07 [PMID: 37805547] (Bioassay, N/A)	Bioassay	N/A
Yuan, F;Gollapudi, S;Day, KJ;Ashby, G;Sangani, A;Malady, BT;Wang, L;Lafer, EM;Huibregtse, JM;Stachowiak, JC; Ubiquitin-driven protein condensation promotes clathrin-mediated endocytosis bioRxiv : the preprint server for biology 2023-08-22 [PMID: 37662320] (Bioassay, N/A)	Bioassay	N/A
Mueller, S;Bialas, J;Ryu, S;Catone, N;Aichem, A; The ubiquitin-like modifier FAT10 covalently modifies HUWE1 and strengthens the interaction of AMBRA1 and HUWE1 PloS one 2023-08-14 [PMID: 37578983] (Bioassay, N/A)	Bioassay	N/A
Li, Y;Wang, H;Sun, B;Su, G;Cang, Y;Zhao, L;Zhao, S;Li, Y;Mao, B;Ma, P; Smurf1 and Smurf2 mediated polyubiquitination and degradation of RNF220 suppresses Shh-group medulloblastoma Cell death & disease 2023-08-03 [PMID: 37537194] (Bioassay, N/A)	Bioassay	N/A
Chen, M;Wang, K;Han, Y;Yan, S;Yuan, H;Liu, Q;Li, L;Li, N;Zhu, H;Lu, D;Wang, K;Liu, F;Luo, D;Zhang, Y;Jiang, J;Li, D;Zhang, L;Ji, H;Zhou, H;Chen, Y;Qin, J;Gao, D; Identification of XAF1 as an endogenous AKT inhibitor Cell reports 2023-06-27 [PMID: 37384528] (Bioassay, N/A)	Bioassay	N/A
Ardah, MT;Radwan, N;Khan, E;Kitada, T;Haque, ME; Parkin Precipitates on Mitochondria via Aggregation and Autoubiquitination International journal of molecular sciences 2023-05-19 [PMID: 37240373] (Bioassay, N/A)	Bioassay	N/A
Monda, JK;Ge, X;Hunkeler, M;Donovan, KA;Ma, MW;Jin, CY;Leonard, M;Fischer, ES;Bennett, EJ; HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways Cell reports 2023-05-09 [PMID: 37167062] (Bioassay, N/A)	Bioassay	N/A
L Kong, C Sui, T Chen, L Zhang, W Zhao, Y Zheng, B Liu, X Cheng, C Gao The ubiquitin E3 ligase TRIM10 promotes STING aggregation and activation in the Golgi apparatus Cell Reports, 2023-03-26;42(4):112306. 2023-03-26 [PMID: 36972172] (Ubiquitination, Human)	Ubiquitination	Human
J Sharma, S Mulherkar, UI Chen, Y Xiong, L Bajaj, BK Cho, YA Goo, HE Leung, KF Tolias, M Sardiello Calpain activity is negatively regulated by a KCTD7-Cullin-3 complex via non-degradative ubiquitination Cell Discovery, 2023-03-24;9(1):32. 2023-03-24 [PMID: 36964131] (Ubiquitination, Human)	Ubiquitination	Human
J Sharma, S Mulherkar, UI Chen, Y Xiong, L Bajaj, BK Cho, YA Goo, HE Leung, KF Tolias, M Sardiello Calpain activity is negatively regulated by a KCTD7-Cullin-3 complex via non-degradative ubiquitination Cell Discovery, 2023;9(1):32. 2023 [PMID: 36964131] (Ubiquitination, Human)	Ubiquitination	Human
TET Mevissen, AV Prasad, JC Walter TRIM21-dependent target protein ubiquitination mediates cell-free Trim-Away Cell Reports, 2023-02-18;42(2):112125. 2023-02-18 [PMID: 36807144] (Bioassay, N/A)	Bioassay	N/A
Y Fan, F Xu, R Wang, J He Lysine 222 in PPAR gamma1 functions as the key site of MuRF2-mediated ubiquitination modification Scientific Reports, 2023-02-03;13(1):1999. 2023-02-03 [PMID: 36737649] (Ubiquitination, Human)	Ubiquitination	Human
PK Shukla, JE Bissell, S Kumar, S Pokhrel, S Palani, KS Radmall, O Obidi, TJ Parnell, J Brasch, DC Shrieve, MB Chandrasek Structure and functional determinants of Rad6-Bre1 subunits in the histone H2B ubiquitin-conjugating complex Nucleic Acids Research, 2023-03-21;0(0):. 2023-03-21 [PMID: 36715322] (Bioassay, N/A)	Bioassay	N/A
X Du, J Pang, B Gu, T Si, Y Chang, T Li, M Wu, Z Wang, Y Wang, J Feng, N Wu, J Man, H Li, A Li, T Zhang, B Wang, X Duan A bio-orthogonal linear ubiquitin probe identifies STAT3 as a direct substrate of OTULIN in glioblastoma Nucleic Acids Research, 2023-02-22;0(0):. 2023-02-22 [PMID: 36660824] (Bioassay, N/A)	Bioassay	N/A
W Wei, YY Yang, JY Chen, P Lakshmanan, JF Kuang, WJ Lu, W Shan MaNAC029 modulates ethylene biosynthesis and fruit quality and undergoes MaXB3-mediated proteasomal degradation during banana ripening Journal of advanced research, 2022-12-15;0(0):. 2022-12-15 [PMID: 36529351] (Bioassay, Human)	Bioassay	Human
W Wei, YY Yang, JY Chen, P Lakshmanan, JF Kuang, WJ Lu, W Shan MaNAC029 modulates ethylene biosynthesis and fruit quality and undergoes MaXB3-mediated proteasomal degradation during banana ripening Journal of advanced research, 2022;0(0):. 2022 [PMID: 36529351] (Bioassay, Human)	Bioassay	Human
L Doblas, PM Hägglund, E Fuentes-Le, MJ Davies The cysteine residue in beta-lactoglobulin reacts with oxidized tyrosine residues in beta-casein to give casein-lactoglobulin dimers Archives of biochemistry and biophysics, 2022-11-28;733(0):109482. 2022-11-28 [PMID: 36457258] (Bioassay, Human)	Bioassay	Human
X Li, DE Anderson, YY Chang, M Jarnik, MP Machner VpdC is a ubiquitin-activated phospholipase effector that regulates Legionella vacuole expansion during infection Proceedings of the National Academy of Sciences of the United States of America, 2022-11-21;119(48):e2209149119. 2022-11-21 [PMID: 36413498] (Bioassay, N/A)	Bioassay	N/A
TT Liu, H Yang, FF Zhuo, Z Yang, MM Zhao, Q Guo, Y Liu, D Liu, KW Zeng, PF Tu Atypical E3 ligase ZFP91 promotes small-molecule-induced E2F2 transcription factor degradation for cancer therapy EBioMedicine, 2022-11-11;86(0):104353. 2022-11-11 [PMID: 36375317] (Bioassay, Human)	Bioassay	Human
OV Kochenova, S Mukkavalli, M Raman, JC Walter Cooperative assembly of p97 complexes involved in replication termination Nature Communications, 2022-11-03;13(1):6591. 2022-11-03 [PMID: 36329031] (Bioassay, Human)	Bioassay	Human
YH Xiang, JJ Yu, B Liao, JX Shan, WW Ye, NQ Dong, T Guo, Y Kan, H Zhang, YB Yang, YC Li, HY Zhao, HX Yu, ZQ Lu, HX Lin An alpha/beta hydrolase family member negatively regulates salt tolerance but promotes flowering through three distinct functions in rice Molecular plant, 2022-10-27;0(0):. 2022-10-27 [PMID: 36303433] (Bioassay, Plant - Oryza sativa (Rice))	Bioassay	Plant - Oryza sativa (Rice)
K Zhu, MJ Suskiewicz, A Hloušek-Ka, H Meudal, A Miko?, V Aucagne, D Ahel, I Ahel DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on protein substrates Science Advances, 2022-10-05;8(40):eadd4253. 2022-10-05 [PMID: 36197986] (Bioassay, Human)	Bioassay	Human
L Zhang, L Jiang, L Yu, Q Li, X Tian, J He, L Zeng, Y Yang, C Wang, Y Wei, X Jiang, J Li, X Ge, Q Gu, J Li, D Wu, AJ Sadler, D Yu, D Xu, Y Gao, X Yuan, B He Inhibition of UBA6 by inosine augments tumour immunogenicity and responses Nature Communications, 2022-09-15;13(1):5413. 2022-09-15 [PMID: 36109526] (Bioassay, Human)	Bioassay	Human
X Ma, X Ma, L Zhu, Y Zhao, M Chen, T Li, Y Lin, D Ma, C Sun, L Han The E3 ubiquitin ligase MG53 inhibits hepatocellular carcinoma by targeting RAC1 signaling Oncogenesis, 2022-07-20;11(1):40. 2022-07-20 [PMID: 35858925] (Bioassay, Human)	Bioassay	Human
S Zhang, S Zou, D Yin, L Zhao, D Finley, Z Wu, Y Mao USP14-regulated allostery of the human proteasome by time-resolved cryo-EM Nature, 2022-04-27;605(7910):567-574. 2022-04-27 [PMID: 35477760] (Bioassay, Human)	Bioassay	Human
D Deshmukh, J Xu, X Yang, H Shimelis, S Fang, Y Qiu Regulation of p27 (Kip1) by Ubiquitin E3 Ligase RNF6 Pharmaceutics, 2022-04-06;14(4):. 2022-04-06 [PMID: 35456636] (Bioassay, N/A)	Bioassay	N/A
SB Lee, L Garofano, A Ko, F D'Angelo, B Frangaj, D Sommer, Q Gan, K Kim, T Cardozo, A Iavarone, A Lasorella Regulated interaction of ID2 with the anaphase-promoting complex links progression through mitosis with reactivation of cell-type-specific transcription Nature Communications, 2022-04-19;13(1):2089. 2022-04-19 [PMID: 35440621] (Bioassay, Human)	Bioassay	Human
OT Johnson, CM Nadel, EC Carroll, T Arhar, JE Gestwicki Two distinct classes of co-chaperones compete for the EEVD motif in heat shock protein 70 (Hsp70) to tune its chaperone activities The Journal of Biological Chemistry, 2022-02-09;0(0):101697. 2022-02-09 [PMID: 35148989] (Bioassay, Human)	Bioassay	Human
Y Zhou, R Zheng, S Liu, C Disoma, A Du, S Li, Z Chen, Z Dong, Y Zhang, S Li, P Liu, A Razzaq, X Chen, Y Liao, S Tao, Y Liu, L Xu, Q Zhang, J Peng, X Deng, S Li, T Jiang, Z Xia Host E3 ligase HUWE1 attenuates the pro-apoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation The Journal of Biological Chemistry, 2022-01-13;0(0):101584. 2022-01-13 [PMID: 35032548] (Bioassay, Human)	Bioassay	Human
S Yoon, K Bogdanov, D Wallach Site-specific ubiquitination of MLKL targets it to endosomes and targets Listeria and Yersinia to the lysosomes Cell Death and Differentiation, 2022-01-09;0(0):. 2022-01-09 [PMID: 34999730] (Bioassay, Human)	Bioassay	Human
E Fuentes-Le, JS Reyes, LF Gamon, C López-Alar, MJ Davies Effect of macromolecular crowding on protein oxidation: Consequences on the rate, extent and oxidation pathways Redox Biology, 2021-11-27;48(0):102202. 2021-11-27 [PMID: 34856437] (Bioassay, Human)	Bioassay	Human
H Zhou, MS Zaher, JC Walter, A Brown Structure of CRL2Lrr1, the E3 ubiquitin ligase that promotes DNA replication termination in vertebrates Nucleic Acids Research, 2021-12-16;49(22):13194-13206. 2021-12-16 [PMID: 34850944] (Bioassay, N/A)	Bioassay	N/A
M Won, KA Park, S Kim, E Ju, Y Ko, H Yoo, H Ro, J Lee, J Oh, EG Lee, SY Kim, SW Nam, HM Shen, MK Yeo, JM Kim, GM Hur ANKRD13a controls early cell-death checkpoint by interacting with RIP1 independent of NF-kappaB Cell Death and Differentiation, 2021-11-27;0(0):. 2021-11-27 [PMID: 34839354] (Bioassay, Human)	Bioassay	Human
R Ibarra, HR Borror, B Hart, RG Gardner, G Kleiger The San1 Ubiquitin Ligase Avidly Recognizes Misfolded Proteins through Multiple Substrate Binding Sites Biomolecules, 2021-11-02;11(11):. 2021-11-02 [PMID: 34827617] (Bioassay, Human)	Bioassay	Human
C Mukhopadhy, C Yang, L Xu, D Liu, Y Wang, D Huang, LD Deonarine, J Cyrta, E Davicioni, A Sboner, BD Robinson, AM Chinnaiyan, MA Rubin, CE Barbieri, P Zhou G3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer Nature Communications, 2021-11-18;12(1):6662. 2021-11-18 [PMID: 34795264] (Bioassay, Human)	Bioassay	Human
Q Zhu, J Huang, H Huang, H Li, P Yi, JA Kloeber, J Yuan, Y Chen, M Deng, K Luo, M Gao, G Guo, X Tu, P Yin, Y Zhang, J Su, J Chen, Z Lou RNF19A-mediated ubiquitination of BARD1 prevents BRCA1/BARD1-dependent homologous recombination Nature Communications, 2021-11-17;12(1):6653. 2021-11-17 [PMID: 34789768] (Bioassay, Human)	Bioassay	Human
T Mahlokozer, B Patel, H Chen, P Desouza, X Qu, DD Mao, D Hafez, W Yang, R Taiwo, M Paturu, A Salehi, AD Gujar, GP Dunn, N Mosammapar, AA Petti, H Yano, AH Kim Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma Nature Communications, 2021-11-03;12(1):6321. 2021-11-03 [PMID: 34732716] (Bioassay, Human)	Bioassay	Human
H Bunch, J Jeong, K Kang, DS Jo, ATQ Cong, D Kim, D Kim, DH Cho, YM Lee, BPC Chen, MJ Schellenbe, SK Calderwood BRCA1-BARD1 regulates transcription through modulating topoisomerase IIbeta Open Biology, 2021-10-06;11(10):210221. 2021-10-06 [PMID: 34610268] (Enzyme Assay, Human)	Enzyme Assay	Human
RK Manne, Y Agrawal, SK Malonia, S Banday, S Edachery, A Patel, A Kumar, P Shetty, MK Santra FBXL20 promotes breast cancer malignancy by inhibiting apoptosis through degradation of PUMA and BAX The Journal of Biological Chemistry, 2021-09-26;0(0):101253. 2021-09-26 [PMID: 34587475] (Bioassay, Human)	Bioassay	Human
Y Liu, C Qin, Y Rao, C Ngo, JJ Feng, J Zhao, S Zhang, TY Wang, J Carriere, AC Savas, M Zarinfar, S Rice, H Yang, W Yuan, JA Camarero, J Yu, XS Chen, C Zhang, P Feng SARS-CoV-2 Nsp5 Demonstrates Two Distinct Mechanisms Targeting RIG-I and MAVS To Evade the Innate Immune Response MBio, 2021-09-21;0(0):e0233521. 2021-09-21 [PMID: 34544279] (Bioassay, E. coli, Human)	Bioassay	E. coli, Human
G Kokic, FR Wagner, A Chernev, H Urlaub, P Cramer Structural basis of human transcription-DNA repair coupling Nature, 2021-09-15;0(0):. 2021-09-15 [PMID: 34526721] (Bioassay, Human)	Bioassay	Human
Y Sun, J Chen, SN Huang, YP Su, W Wang, K Agama, S Saha, LM Jenkins, JM Pascal, Y Pommier PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation Nature Communications, 2021-08-18;12(1):5010. 2021-08-18 [PMID: 34408146] (Bioassay, Human)	Bioassay	Human
CW Davies, SE Vidal, L Phu, J Sudhamsu, TB Hinkle, S Chan Rosen, FR Schumacher, YJ Zeng, C Schwerdtfe, AS Peterson, JR Lill, CM Rose, AS Shaw, IE Wertz, DS Kirkpatric, JT Koerber Antibody toolkit reveals N-terminally ubiquitinated substrates of UBE2W Nature Communications, 2021-07-29;12(1):4608. 2021-07-29 [PMID: 34326324] (Bioassay, Human)	Bioassay	Human
W Li, Y Wang, L Zhu, S Du, J Mao, Y Wang, S Wang, Q Bo, Y Tu, Q Yi The P300/XBP1s/Herpud1 axis promotes macrophage M2 polarization and the development of choroidal neovascularization Journal of Cellular and Molecular Medicine, 2021-05-31;0(0):. 2021-05-31 [PMID: 34057287] (Bioassay, Human)	Bioassay	Human
W El Manaa, E Duplan, T Goiran, I Lauritzen, L Vaillant B, S Lacas-Gerv, VA Morais, H You, L Qi, M Salazar, U Ozcan, M Chami, F Checler, C Alves da C Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology Autophagy, 2021-05-24;0(0):1-23. 2021-05-24 [PMID: 34030589] (Bioassay, Human)	Bioassay	Human
P Gao, X Ma, M Yuan, Y Yi, G Liu, M Wen, W Jiang, R Ji, L Zhu, Z Tang, Q Yu, J Xu, R Yang, S Xia, M Yang, J Pan, H Yuan, H An E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3 Nature Communications, 2021-02-19;12(1):1194. 2021-02-19 [PMID: 33608556] (Ubiquitination, Human)	Ubiquitination	Human
S Zhao, A Kieser, HY Li, HK Reinking, P Weickert, S Euteneuer, D Yaneva, AC Acampora, MJ Götz, R Feederle, J Stingele A ubiquitin switch controls autocatalytic inactivation of the DNA-protein crosslink repair protease SPRTN Nucleic Acids Research, 2021-01-25;0(0):. 2021-01-25 [PMID: 33348378] (Bioassay, Human)	Bioassay	Human
JO Watzlawik, X Hou, D Fricova, C Ramnarine, SK Barodia, TF Gendron, MG Heckman, M DeTure, J Siuda, ZK Wszolek, CR Scherzer, OA Ross, G Bu, DW Dickson, MS Goldberg, FC Fiesel, W Springer Sensitive ELISA-based detection method for the mitophagy marker p-S65-Ub in human cells, autopsy brain, and blood samples Autophagy, 2020-10-28;0(0):1-16. 2020-10-28 [PMID: 33112198] (Western Blot, Human)	Western Blot	Human
M Deng, J Lin, S Nowsheen, T Liu, Y Zhao, PW Villalta, D Sicard, DJ Tschumperl, S Lee, J Kim, Z Lou Extracellular matrix stiffness determines DNA repair efficiency and cellular sensitivity to genotoxic agents Science Advances, 2020-09-11;6(37):. 2020-09-11 [PMID: 32917705] (Bioassay, Human)	Bioassay	Human
MC Albert, K Brinkmann, W Pokrzywa, SD Günther, M Krönke, T Hoppe, H Kashkar CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage Cell Death & Disease, 2020-09-10;11(9):740. 2020-09-10 [PMID: 32913203] (Ubiquitylation, Human)	Ubiquitylation	Human
ST Fukai, R Hibi, T Naganuma, M Sakai, S Saijo, N Shimizu, M Matsumoto, T Shimizu Crystal structure of GCN5 PCAF�N-terminal domain reveals atypical ubiquitin ligase structure J. Biol. Chem., 2020-08-19;0(0):. 2020-08-19 [PMID: 32820047] (Bioassay, Ubiquitination, Human, Mouse)	Bioassay, Ubiquitination	Human, Mouse
AM Cathcart, GH Bird, TE Wales, HD Herce, EP Harvey, ZJ Hauseman, CE Newman, U Adhikary, MS Prew, T Oo, S Lee, JR Engen, LD Walensky Targeting a helix-in-groove interaction between E1 and E2 blocks ubiquitin transfer Nat. Chem. Biol., 2020-08-17;0(0):. 2020-08-17 [PMID: 32807965] (Bioassay, E. coli, Human, N/A)	Bioassay	E. coli, Human, N/A
M Gatti, R Imhof, Q Huang, M Baudis, M Altmeyer The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency Cell Rep, 2020-08-04;32(5):107985. 2020-08-04 [PMID: 32755579] (Bioassay, Human)	Bioassay	Human
CR Kim, T Noda, H Kim, G Kim, S Park, Y Na, S Oura, K Shimada, I Bang, JY Ahn, YR Kim, SK Oh, HJ Choi, JS Kim, I Jung, H Lee, Y Okada, M Ikawa, SH Baek PHF7 Modulates BRDT Stability and Histone-to-Protamine Exchange during Spermiogenesis Cell Rep, 2020-07-28;32(4):107950. 2020-07-28 [PMID: 32726616] (Bioassay, Mouse)	Bioassay	Mouse
ME Matyskiela, T Clayton, X Zheng, C Mayne, E Tran, A Carpenter, B Pagarigan, J McDonald, M Rolfe, LG Hamann, G Lu, PP Chamberlai Crystal structure of the SALL4-pomalidomide-cereblon-DDB1 complex Nat. Struct. Mol. Biol., 2020-04-06;27(4):319-322. 2020-04-06 [PMID: 32251415] (Ubiquitination, Spodoptera frugiperda)	Ubiquitination	Spodoptera frugiperda
F Li, P Yuan, M Rao, CH Jin, W Tang, YF Rong, YP Hu, F Zhang, T Wei, Q Yin, T Liang, L Wu, J Li, D Li, Y Liu, W Lou, S Zhao, MF Liu piRNA-independent function of PIWIL1 as a co-activator for anaphase promoting complex/cyclosome to drive pancreatic cancer metastasis Nat. Cell Biol., 2020-03-16;0(0):. 2020-03-16 [PMID: 32203416] (Bioassay, Human)	Bioassay	Human
YS Yoo, YJ Park, HS Lee, NTK Oanh, MY Cho, J Heo, ES Lee, H Cho, YY Park, H Cho Mitochondria ubiquitin ligase, MARCH5 resolves hepatitis B virus X protein aggregates in the liver pathogenesis Cell Death Dis, 2019-12-09;10(12):938. 2019-12-09 [PMID: 31819032] (Bioassay, Human)	Bioassay	Human
X Li, M Guo, L Cai, T Du, Y Liu, HF Ding, H Wang, J Zhang, X Chen, C Yan Competitive ubiquitination activates the tumor suppressor p53 Cell Death Differ., 2019-12-02;0(0):. 2019-12-02 [PMID: 31796886] (Bioassay, Human)	Bioassay	Human
TC Ting, M Goralski, K Klein, B Wang, J Kim, Y Xie, D Nijhawan Aryl Sulfonamides Degrade RBM39 and RBM23 by Recruitment to CRL4-DCAF15 Cell Rep, 2019-11-05;29(6):1499-1510.e6. 2019-11-05 [PMID: 31693891] (Bioassay, Human)	Bioassay	Human
J Sitz, SA Blanchet, SF Gameiro, E Biquand, TM Morgan, M Galloy, J Dessapt, EG Lavoie, A Blondeau, BC Smith, JS Mymryk, CA Moody, A Fradet-Tur Human papillomavirus E7 oncoprotein targets RNF168 to hijack the host DNA damage response Proc. Natl. Acad. Sci. U.S.A., 2019-09-09;116(39):19552-19562. 2019-09-09 [PMID: 31501315] (Bioassay, Virus - HPV)	Bioassay	Virus - HPV
HB Rycenga, KB Wolfe, ES Yeh, DT Long Uncoupling of p97 ATPase activity has a dominant negative effect on protein extraction Sci Rep, 2019-07-17;9(1):10329. 2019-07-17 [PMID: 31316150] (Bioassay, Xenopus)	Bioassay	Xenopus
MS Liyasova, K Ma, D Voeller, PE Ryan, J Chen, RE Klevit, S Lipkowitz Cbl interacts with multiple E2s in vitro and in cells PLoS ONE, 2019-05-23;14(5):e0216967. 2019-05-23 [PMID: 31120930] (Ubiquitination, Human)	Ubiquitination	Human
Q Yin, T Han, B Fang, G Zhang, C Zhang, ER Roberts, V Izumi, M Zheng, S Jiang, X Yin, M Kim, J Cai, EB Haura, JM Koomen, KSM Smalley, L Wan K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling Nat Commun, 2019-04-23;10(1):1870. 2019-04-23 [PMID: 31015455] (Ubiquitination, Human)	Ubiquitination	Human
OE Akande, PK Damle, M Pop, NE Sherman, BB Szomju, LV Litovchick, SR Grossman DBC1 Regulates p53 Stability via Inhibition of CBP-Dependent p53 Polyubiquitination Cell Rep, 2019-03-19;26(12):3323-3335.e4. 2019-03-19 [PMID: 30893604] (Bioassay)	Bioassay
CM Xie, M Tan, XT Lin, D Wu, Y Jiang, Y Tan, H Li, Y Ma, X Xiong, Y Sun The FBXW7-SHOC2-Raptor Axis Controls the Cross-Talks between the RAS-ERK and mTORC1 Signaling Pathways Cell Rep, 2019-03-12;26(11):3037-3050.e4. 2019-03-12 [PMID: 30865892] (Bioassay)	Bioassay
B Liu, J Yi, X Yang, L Liu, X Lou, Z Zhang, H Qi, Z Wang, J Zou, WG Zhu, W Gu, J Luo MDM2-mediated degradation of WRN promotes cellular senescence in a p53-independent manner Oncogene, 2018-12-07;0(0):. 2018-12-07 [PMID: 30532073] (Bioassay, Human)	Bioassay	Human
Y Dong, S Zhang, Z Wu, X Li, WL Wang, Y Zhu, S Stoilova-M, Y Lu, D Finley, Y Mao Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome Nature, 2018-11-12;0(0):. 2018-11-12 [PMID: 30479383] (Bioassay, Human)	Bioassay	Human
X Huang, XN Wang, XD Yuan, WY Wu, PE Lobie, Z Wu XIAP facilitates breast and colon carcinoma growth via promotion of p62 depletion through ubiquitination-dependent proteasomal degradation Oncogene, 2018-10-01;0(0):. 2018-10-01 [PMID: 30275562] (Bioassay, Human)	Bioassay	Human
ME Matyskiela, S Couto, X Zheng, G Lu, J Hui, K Stamp, C Drew, Y Ren, M Wang, A Carpenter, CW Lee, T Clayton, W Fang, CC Lu, M Riley, P Abdubek, K Blease, J Hartke, G Kumar, R Vessey, M Rolfe, LG Hamann, PP Chamberlai SALL4 mediates teratogenicity as a thalidomide-dependent cereblon substrate Nat. Chem. Biol., 2018-09-06;0(0):. 2018-09-06 [PMID: 30190590] (Ubiquitination, Human)	Ubiquitination	Human
KA Donovan, J An, RP Nowak, JC Yuan, EC Fink, BC Berry, BL Ebert, ES Fischer Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome Elife, 2018-08-01;7(0):. 2018-08-01 [PMID: 30067223] (Ubiquitination, Human)	Ubiquitination	Human
X Hou, FC Fiesel, D Truban, M Castanedes, WL Lin, AI Soto, P Tacik, LG Rousseau, NN Diehl, MG Heckman, O Lorenzo-Be, I Ferrer, JM Arbelo, JC Steele, MJ Farrer, M Cornejo-Ol, L Torres, IF Mata, NR Graff-Radf, ZK Wszolek, OA Ross, ME Murray, DW Dickson, W Springer Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease Autophagy, 2018-07-28;14(8):1404-1418. 2018-07-28 [PMID: 29947276] (Bioassay)	Bioassay
S Ito, A Ueno, T Ueda, H Nakagawa, H Taniguchi, N Kayukawa, A Fujihara-I, F Hongo, K Okihara, O Ukimura CNPY2 inhibits MYLIP-mediated AR protein degradation in prostate cancer cells Oncotarget, 2018-04-03;9(25):17645-17655. 2018-04-03 [PMID: 29707137] (Bioassay)	Bioassay
D Valleau, AT Quaile, H Cui, X Xu, E Evdokimova, C Chang, ME Cuff, ML Urbanus, S Houliston, CH Arrowsmith, AW Ensminger, A Savchenko Discovery of Ubiquitin Deamidases in the Pathogenic Arsenal of Legionella pneumophila Cell Rep, 2018-04-10;23(2):568-583. 2018-04-10 [PMID: 29642013] (Bioassay)	Bioassay
TR de Moura, S Mozaffari-, CZK Szabó, J Schmitzová, O Dybkov, C Cretu, M Kachala, D Svergun, H Urlaub, R Lührmann, V Pena Prp19/Pso4 Is an Autoinhibited Ubiquitin Ligase Activated by Stepwise Assembly of Three Splicing Factors Mol. Cell, 2018-03-15;69(6):979-992.e6. 2018-03-15 [PMID: 29547724] (Bioassay, Bacteria)	Bioassay	Bacteria
LJ Albee, HM LaPorte, X Gao, JM Eby, YH Cheng, AM Nevins, BF Volkman, V Gaponenko, M Majetschak Identification and functional characterization of arginine vasopressin receptor 1A : atypical chemokine receptor 3 heteromers in vascular smooth muscle Open Biol, 2018-01-01;8(1):. 2018-01-01 [PMID: 29386406] (Bioassay, Human)	Bioassay	Human
M Higa, K Tanaka, M Saijo Inhibition of UVSSA ubiquitination suppresses transcription-coupled nucleotide excision repair deficiency caused by dissociation from USP7 FEBS J., 2018-01-25;0(0):. 2018-01-25 [PMID: 29323787] (Bioassay)	Bioassay
X Chen, Z He, M Fu, Y Wang, H Wu, X Li, H Cao, SJ Zheng The E3 ubiquitin ligase Siah-1 suppresses avian reovirus infection by targeting p10 for degradation J. Virol., 2018-02-26;0(0):. 2018-02-26 [PMID: 29321312] (Bioassay)	Bioassay
SY Kim, HJ Kim, HJ Kim, DH Kim, CH Kim, JH Han, HK Byeon, K Lee HSPA5 negatively regulates lysosomal activity through ubiquitination of MUL1 in head and neck cancer Autophagy, 2018-02-21;0(0):1-89. 2018-02-21 [PMID: 29260979] (Bioassay, Human)	Bioassay	Human
C Yang, W Zang, Z Tang, Y Ji, R Xu, Y Yang, A Luo, B Hu, Z Zhang, Z Liu, X Zheng A20 regulates the DNA damage response and mediates tumor cell resistance to DNA damaging therapy Cancer Res., 2017-12-12;0(0):. 2017-12-12 [PMID: 29233925] (Bioassay, Human)	Bioassay	Human
JB Hein, EPT Hertz, DH Garvanska, T Kruse, J Nilsson Distinct kinetics of serine and threonine dephosphorylation are essential for mitosis Nat. Cell Biol., 2017-10-30;19(12):1433-1440. 2017-10-30 [PMID: 29084198] (Bioassay, Human)	Bioassay	Human
M Boselli, BH Lee, J Robert, MA Prado, SW Min, C Cheng, MC Silva, C Seong, S Elsasser, KM Hatle, TC Gahman, SP Gygi, SJ Haggarty, L Gan, RW King, D Finley An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons J. Biol. Chem., 2017-09-26;0(0):. 2017-09-26 [PMID: 28972160] (Enzyme Assay, Human)	Enzyme Assay	Human
BA Osuna, CJ Howard, S Kc, A Frost, DE Weinberg In vitro analysis of RQC activities provides insights into the mechanism and function of CAT tailing Elife, 2017-07-18;6(0):. 2017-07-18 [PMID: 28718767] (Bioassay, Yeast - Saccharomyces cerevisiae)	Bioassay	Yeast - Saccharomyces cerevisiae
Y Kagami, M Ono, K Yoshida Plk1 phosphorylation of CAP-H2 triggers chromosome condensation by condensin II at the early phase of mitosis Sci Rep, 2017-07-17;7(1):5583. 2017-07-17 [PMID: 28717250] (Bioassay, Human)	Bioassay	Human
ZQ Fan, JY Chen, JF Kuang, WJ Lu, W Shan The Banana Fruit SINA Ubiquitin Ligase MaSINA1 Regulates the Stability of MaICE1 to be Negatively Involved in Cold Stress Response Front Plant Sci, 2017-06-12;8(0):995. 2017-06-12 [PMID: 28659946] (Bioassay)	Bioassay
B Lin, Q Ke, H Li, NS Pheifer, DC Velliquett, DW Leaman Negative regulation of the RLH signaling by the E3 ubiquitin ligase RNF114 Cytokine, 2017-07-29;0(0):. 2017-07-29 [PMID: 28625874] (Bioassay, Human)	Bioassay	Human
A Bononi, C Giorgi, S Patergnani, D Larson, K Verbruggen, M Tanji, L Pellegrini, V Signorato, F Olivetto, S Pastorino, M Nasu, A Napolitano, G Gaudino, P Morris, G Sakamoto, LK Ferris, A Danese, A Raimondi, C Tacchetti, S Kuchay, HI Pass, EB Affar, H Yang, P Pinton, M Carbone BAP1 regulates IP3R3-mediated Ca(2+) flux to mitochondria suppressing cell transformation Nature, 2017-06-14;546(7659):549-553. 2017-06-14 [PMID: 28614305] (Bioassay)	Bioassay
S Inano, K Sato, Y Katsuki, W Kobayashi, H Tanaka, K Nakajima, S Nakada, H Miyoshi, K Knies, A Takaori-Ko, D Schindler, M Ishiai, H Kurumizaka, M Takata RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination Mol. Cell, 2017-06-01;66(5):622-634.e8. 2017-06-01 [PMID: 28575658] (Enzyme Assay, Human)	Enzyme Assay	Human
V Glorian, J Allègre, J Berthelet, B Dumetier, PM Boutanquoi, N Droin, C Kayaci, J Cartier, S Gemble, G Marcion, D Gonzalez, R Boidot, C Garrido, O Michaud, E Solary, L Dubrez DNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residues Cell Death Dis, 2017-05-25;8(5):e2816. 2017-05-25 [PMID: 28542143] (Bioassay, Bacteria - E. Coli, Human)	Bioassay	Bacteria - E. Coli, Human
J An, CM Ponthier, R Sack, J Seebacher, MB Stadler, KA Donovan, ES Fischer pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4(CRBN) ubiquitin ligase Nat Commun, 2017-05-22;8(0):15398. 2017-05-22 [PMID: 28530236] (Bioassay)	Bioassay
A Paul, B Wang RNF8- and Ube2S-Dependent Ubiquitin Lysine 11-Linkage Modification in Response to DNA Damage Mol. Cell, 2017-05-18;66(4):458-472.e5. 2017-05-18 [PMID: 28525740] (Bioassay)	Bioassay
NO Bodnar, TA Rapoport Molecular Mechanism of Substrate Processing by the Cdc48 ATPase Complex Cell, 2017-05-04;169(4):722-735.e9. 2017-05-04 [PMID: 28475898] (Bioassay)	Bioassay
C Perea-Resa, MA Rodríguez-, E Iniesto, V Rubio, J Salinas Prefoldins Negatively Regulate Cold Acclimation in Arabidopsis Thaliana By Promoting Nuclear Proteasome-Mediated HY5 Degradation Mol Plant, 2017-04-12;0(0):. 2017-04-12 [PMID: 28412546] (Bioassay)	Bioassay
Y Pakdaman, M Sanchez-Gu, R Kleppe, S Erdal, HJ Bustad, L Bjørkhaug, K Haugarvoll, C Tzoulis, K Heimdal, PM Knappskog, S Johansson, I Aukrust In vitro characterization of six STUB1 variants in spinocerebellar ataxia 16 reveals altered structural properties for the encoded CHIP proteins Biosci. Rep., 2017-04-28;37(2):. 2017-04-28 [PMID: 28396517] (Bioassay, Human)	Bioassay	Human
KM Houston, AT Melvin, GS Woss, EL Fayer, ML Waters, NL Allbritton Development of ?-Hairpin Peptides for the Measurement of SCF-Family E3 Ligase Activity in Vitro via Ornithine Ubiquitination ACS Omega, 2017-03-29;2(3):1198-1206. 2017-03-29 [PMID: 28393136] (Bioassay, Human)	Bioassay	Human
X Zhang, B Li, AH Rezaeian, X Xu, PC Chou, G Jin, F Han, BS Pan, CY Wang, J Long, A Zhang, CY Huang, FJ Tsai, CH Tsai, C Logothetis, HK Lin H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis Nat Commun, 2017-03-16;8(0):14799. 2017-03-16 [PMID: 28300060] (Bioassay)	Bioassay
RJ Malonis, W Fu, MJ Jelcic, M Thompson, BS Canter, M Tsikitis, FJ Esteva, I Sánchez RNF11 sequestration of the E3 ligase SMURF2 on membranes antagonizes SMAD7 down-regulation of transforming growth factor ? signaling J. Biol. Chem., 2017-03-14;292(18):7435-7451. 2017-03-14 [PMID: 28292929] (Bioassay)	Bioassay
Q Wang, L Huang, Z Hong, Z Lv, Z Mao, Y Tang, X Kong, S Li, Y Cui, H Liu, L Zhang, X Zhang, L Jiang, C Wang, Q Zhou The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response PLoS Pathog, 2017-03-08;13(3):e1006264. 2017-03-08 [PMID: 28273161] (Bioassay)	Bioassay
S He, Y Cao, P Xie, G Dong, L Zhang The Nedd8 Non-covalent Binding Region in the Smurf HECT Domain is Critical to its Ubiquitn Ligase Function Sci Rep, 2017-02-07;7(0):41364. 2017-02-07 [PMID: 28169289] (Bioassay, Human)	Bioassay	Human
E Hasanov, G Chen, P Chowdhury, J Weldon, Z Ding, E Jonasch, S Sen, CL Walker, R Dere Ubiquitination and regulation of AURKA identifies a hypoxia-independent E3 ligase activity of VHL Oncogene, 2017-01-23;0(0):. 2017-01-23 [PMID: 28114281] (Ubiquitination)	Ubiquitination
Xueting Lang TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity J. Exp. Med, 2016-12-28;0(0):. 2016-12-28 [PMID: 28031478] (Bioassay, Human)	Bioassay	Human
Shengyu Yang Monoubiquitination Inhibits the Actin Bundling Activity of Fascin J. Biol. Chem., 2016-11-22;0(0):. 2016-11-22 [PMID: 27879315] (Bioassay)	Bioassay
Regulation of the MDM2-p53 pathway by the nucleolar protein CSIG in response to nucleolar stress Sci Rep, 2016-11-04;6(0):36171. 2016-11-04 [PMID: 27811966] (Bioassay, Human)	Bioassay	Human
Structural insights into Parkin substrate lysine targeting from minimal Miro substrates Sci Rep, 2016-09-08;6(0):33019. 2016-09-08 [PMID: 27605430] (Bioassay, Human)	Bioassay	Human
Neddylation E2 UBE2F promotes the survival of lung cancer cells by activating CRL5 to degrade NOXA via the K11 linkage Clin Cancer Res, 2016-09-02;0(0):. 2016-09-02 [PMID: 27591266] (Ubiquitination, Human)	Ubiquitination	Human
Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal Nat Commun, 2016-07-28;7(0):12326. 2016-07-28 [PMID: 27465491] (Bioassay)	Bioassay
Mary E Matyskiela A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase Nature, 2016-06-22;0(0):. 2016-06-22 [PMID: 27338790] (Bioassay)	Bioassay
Higher-order oligomerization promotes localization of SPOP to liquid nuclear speckles EMBO J, 2016-05-23;0(0):. 2016-05-23 [PMID: 27220849] (Bioassay, Human)	Bioassay	Human
Q Zhang, D Karnak, M Tan, TS Lawrence, MA Morgan, Y Sun FBXW7 Facilitates Nonhomologous End-Joining via K63-Linked Polyubiquitylation of XRCC4 Mol. Cell, 2016-01-07;61(3):419-33. 2016-01-07 [PMID: 26774286] (Bioassay, Human)	Bioassay	Human
Ardelt P, Ebbing J, Adams F, Reiss C, Arap W, Pasqualini R, Bachmann A, Wetterauer U, Riedmiller H, Kneitz B An anti-ubiquitin antibody response in transitional cell carcinoma of the urinary bladder. PLoS ONE, 2015-03-05;10(3):e0118646. 2015-03-05 [PMID: 25742283] (ELISA, Human)	ELISA	Human
Sandoval D, Hill S, Ziemba A, Lewis S, Kuhlman B, Kleiger G Ubiquitin-conjugating enzyme Cdc34 and ubiquitin ligase Skp1-cullin-F-box ligase (SCF) interact through multiple conformations. J Biol Chem, 2014-11-25;290(2):1106-18. 2014-11-25 [PMID: 25425648] (Bacteria - E. Coli)		Bacteria - E. Coli
Rout , Manoj K, Hodge , Curtis D, Markin , Craig J, Xu , Xin, Glover , J N Mark, Xiao , Wei, Spyracopoulos , Leo Stochastic gate dynamics regulate the catalytic activity of ubiquitination enzymes. J Am Chem Soc, 2014-12-05;136(50):17446-58. 2014-12-05 [PMID: 25423605] (Bioassay)	Bioassay
Sanchez C, Liu C, Mayer S, Nurhasanah A, Cyrklaff M, Mu J, Ferdig M, Stein W, Lanzer M A HECT ubiquitin-protein ligase as a novel candidate gene for altered quinine and quinidine responses in Plasmodium falciparum. PLoS Genet, 2014-05-15;10(5):e1004382. 2014-05-15 [PMID: 24830312] (Ubiquitination, Parasite - Plasmodium falciparum)	Ubiquitination	Parasite - Plasmodium falciparum
Guicciardi , Maria Eu, Werneburg , Nathan W, Bronk , Steven F, Franke , Adrian, Yagita , Hideo, Thomas , Gary, Gores , Gregory Cellular inhibitor of apoptosis (cIAP)-mediated ubiquitination of phosphofurin acidic cluster sorting protein 2 (PACS-2) negatively regulates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity. PLoS ONE, 2014-03-14;9(3):e92124. 2014-03-14 [PMID: 24633224] (Bioassay)	Bioassay
Townley-Tilson , W H Davi, Wu , Yaxu, Ferguson , James E, Patterson , Cam The ubiquitin ligase ASB4 promotes trophoblast differentiation through the degradation of ID2. PLoS ONE, 2014-02-21;9(2):e89451. 2014-02-21 [PMID: 24586788] (Ubiquitination, Human)	Ubiquitination	Human
Sivakumar , Sushama, Daum , John R, Tipton , Aaron R, Rankin , Susannah, Gorbsky , Gary J The spindle and kinetochore-associated (Ska) complex enhances binding of the anaphase-promoting complex/cyclosome (APC/C) to chromosomes and promotes mitotic exit. Mol Biol Cell, 2014-01-08;25(5):594-605. 2014-01-08 [PMID: 24403607] (Bioassay, Human)	Bioassay	Human
Lonskaya I, Desforges N, Hebron M, Moussa C Ubiquitination increases parkin activity to promote autophagic alpha-synuclein clearance. PLoS ONE, 2013-12-26;8(12):e83914. 2013-12-26 [PMID: 24386307] (Enzyme Assay)	Enzyme Assay
Tripathi A, Davis J, Staren D, Volkman B, Majetschak M CXC chemokine receptor 4 signaling upon co-activation with stromal cell-derived factor-1alpha and ubiquitin. Cytokine, 2013-12-24;65(2):121-5. 2013-12-24 [PMID: 24373940] (Bioassay, Human)	Bioassay	Human
Liu , Weixiao, Shang , Yonglian, Zeng , Yan, Liu , Chao, Li , Yanchang, Zhai , Linhui, Wang , Pan, Lou , Jizhong, Xu , Ping, Ye , Yihong, Li , Wei Dimeric Ube2g2 simultaneously engages donor and acceptor ubiquitins to form Lys48-linked ubiquitin chains. EMBO J, 2013-12-23;33(1):46-61. 2013-12-23 [PMID: 24366945] (Bioassay)	Bioassay
Rajbhandari P, Schalper K, Solodin N, Ellison-Zelski S, Ping Lu K, Rimm D, Alarid E Pin1 modulates ERalpha levels in breast cancer through inhibition of phosphorylation-dependent ubiquitination and degradation. Oncogene, 2013-04-01;33(11):1438-47. 2013-04-01 [PMID: 23542176] (Bioassay)	Bioassay
Singer , Alexande, Schulze , Sebastia, Skarina , Tatiana, Xu , Xiaohui, Cui , Hong, Eschen-Lippold , Lennart, Egler , Monique, Srikumar , Tharan, Raught , Brian, Lee , Justin, Scheel , Dierk, Savchenko , Alexei, Bonas , Ulla A pathogen type III effector with a novel E3 ubiquitin ligase architecture. PLoS Pathog, 2013-01-24;9(1):e1003121. 2013-01-24 [PMID: 23359647] (Bioassay)	Bioassay
Hebron , Michaeli, Lonskaya , Irina, Sharpe , Kaydee, Weerasinghe , Puwakdan, Algarzae , Norah K, Shekoyan , Ashot R, Moussa , Charbel Parkin ubiquitinates Tar-DNA binding protein-43 (TDP-43) and promotes its cytosolic accumulation via interaction with histone deacetylase 6 (HDAC6). J Biol Chem, 2012-12-20;288(6):4103-15. 2012-12-20 [PMID: 23258539] (Bioassay)	Bioassay
Lu , Yunzhe, Li , Jiezhi, Cheng , Dongmei, Parameswaran , Balaji, Zhang , Shaohua, Jiang , Zefei, Yew , P Renee, Peng , Junmin, Ye , Qinong, Hu , Yanfen The F-box protein FBXO44 mediates BRCA1 ubiquitination and degradation. J Biol Chem, 2012-10-18;287(49):41014-22. 2012-10-18 [PMID: 23086937] (Ubiquitination)	Ubiquitination
Shibata Y, Oyama M, Kozuka-Hata H, Han X, Tanaka Y, Gohda J, Inoue J p47 negatively regulates IKK activation by inducing the lysosomal degradation of polyubiquitinated NEMO. Nat Commun, 2012-01-01;3(0):1061. 2012-01-01 [PMID: 22990857] (Binding Assay)	Binding Assay
Foster S, Morgan D The APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation. Mol Cell, 2012-08-30;47(6):921-32. 2012-08-30 [PMID: 22940250] (Bioassay)	Bioassay
Sun J, Zhou W, Kaliappan K, Nawaz Z, Slingerland J ERalpha phosphorylation at Y537 by Src triggers E6-AP-ERalpha binding, ERalpha ubiquitylation, promoter occupancy, and target gene expression. Mol Endocrinol, 2012-08-03;26(9):1567-77. 2012-08-03 [PMID: 22865929] (Bioassay, Human)	Bioassay	Human
Varfolomeev , Eugene, Moradi , Elham, Dynek , Jasmin N, Zha , Jiping, Fedorova , Anna V, Deshayes , Kurt, Fairbrother , Wayne J, Newton , Kim, Le Couter , Jennifer, Vucic , Domagoj Characterization of ML-IAP protein stability and physiological role in vivo. Biochem J, 2012-11-01;447(3):427-36. 2012-11-01 [PMID: 22853455] (Bioassay, Human)	Bioassay	Human
Pelisch F, Pozzi B, Risso G, Munoz M, Srebrow A DNA damage-induced heterogeneous nuclear ribonucleoprotein K sumoylation regulates p53 transcriptional activation. J Biol Chem, 2012-07-23;287(36):30789-99. 2012-07-23 [PMID: 22825850] (Bioassay)	Bioassay
Show All 137 Publications. Collapse Publications.

Array U-100H

• Ubiquitin Antibodies
• Ubiquitin Lysate
• Ubiquitin Proteins
• Ubiquitin Proteins and Enzymes