14-3-3 zeta Antibody (818515) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

14-3-3 proteins are a highly conserved family of homo- and heterodimeric phosphoserine/threonine-binding proteins present in high abundance in all eukaryotic cells. 14-3-3 proteins were the first polypeptides shown to have pSer/Thr binding properties, generally recognizing the consensus sequences RSXpSXP and RXY/FXpSXP (where X is any amino acid). 14-3-3 proteins act as key regulators of intracellular signal transduction through their ability to bind specific motifs phosphorylated on serine or threonine. For example, the binding of 14-3-3 to phosphorylated BAD blocks its proapoptotic association with Bcl-XL. There are at least seven distinct 14-3-3 genes in vertebrates, alpha/beta, epsilon, eta, gamma, theta, sigma and zeta ( alpha / beta , epsilon , eta , gamma , tau / theta , sigma , and zeta /δ). 14-3-3 zeta, also known as Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, zeta isoform (gene name YWHAZ) is a 245 amino acid, 27 kDa protein.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publication 1 - 1 of 1.

Publication using MAB2669	Applications	Species
Jake E. Thistle, Ylva Hellberg, Kristina Mortensen, Stephen Hamilton–Dutoit, Anders Kjærsgaard, Deirdre Cronin–Fenton et al. The effect of 14-3-3 zeta expression on tamoxifen resistance and breast cancer recurrence: a Danish population-based study Breast Cancer Research and Treatment 2017-10-01 [PMID: 28643021]

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Yongkang Yang	WB	Human	03/20/2021	View Summary Application Western Blot Sample Tested 293T and MCF-7 cells-whole cell lysate,MDA-231 cell lysate Species Human Lot CHGN0220021
Enlarge	5 reviewed by: Michal Dibus	WB	Human	08/02/2017	View Summary Application Western Blot Sample Tested Human recombinant protein from E. Coli Species Human Lot CHGN0115081

Array MAB2669

• 14-3-3 zeta Antibodies
• 14-3-3 zeta Lysate
• 14-3-3 zeta Proteins and Enzyme