Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Recombinant Human TIMP-1 Western Blot Standard Protein
CLGI
Collagenase inhibitor
collagenase inhibitor)
EPATIMP-1
EPO
erythroid potentiating activity
Erythroid-potentiating activity
Fibroblast collagenase inhibitor
FLJ90373
HCI
metalloproteinase inhibitor 1
TIMP metallopeptidase inhibitor 1
TIMP1
TIMP-1
TIMPtissue inhibitor of metalloproteinase 1 (erythroid potentiating activity
Tissue inhibitor of metalloproteinases 1
Background
TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.
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