Recombinant Human TDP-43/TARDBP Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

TDP-43 (TAR DNA binding protein of 43 kDa; gene name TARDBP) is a 414 amino acid (aa) nuclear RNA/DNA binding phosphoprotein that regulates transcription and splicing.  TDP-43 is aberrantly expressed in most forms of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration.  In these cases it is absent from the nucleus and accumulates, along with a truncated 20-28 kDa form, in the Ubiquitin-containing inclusion bodies.  TDP-43 can also influence CFTR exon 9 skipping in cystic fibrosis.  Human TDP-43 is 96% identical to the mouse ortholog.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Bioassay.

Showing Publications 1 - 3 of 3.

Publications using AP-190	Applications	Species
T Liu, JA Woo, MZ Bukhari, X Wang, Y Yan, SC Buosi, A Ermekbaeva, A Sista, P Kotsiviras, P LePochat, A Chacko, X Zhao, DE Kang Modulation of synaptic plasticity, motor unit physiology, and TDP-43 pathology by CHCHD10 Acta neuropathologica communications, 2022-07-04;10(1):95. 2022-07-04 [PMID: 35787294] (Bioassay, Human)	Bioassay	Human
H Quek, C Cuní-López, R Stewart, T Colletti, A Notaro, TH Nguyen, Y Sun, CC Guo, MK Lupton, TL Roberts, YC Lim, LE Oikari, V La Bella, AR White ALS monocyte-derived microglia-like cells reveal cytoplasmic TDP-43 accumulation, DNA damage, and cell-specific impairment of phagocytosis associated with disease progression Journal of Neuroinflammation, 2022-02-28;19(1):58. 2022-02-28 [PMID: 35227277] (Bioassay, Human)	Bioassay	Human
N Ouassil, RL Pinals, JT Del Bonis-, JW Wang, MP Landry Supervised learning model predicts protein adsorption to carbon nanotubes Science Advances, 2022-01-07;8(1):eabm0898. 2022-01-07 [PMID: 34995109] (Bioassay, Human)	Bioassay	Human

Array AP-190

• TDP-43/TARDBP Antibodies
• TDP-43/TARDBP ELISA Kits
• TDP-43/TARDBP Lysate
• TDP-43/TARDBP Proteins
• TDP-43/TARDBP Proteins and Enzyme