45 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publications using AP-190 in the following applications:
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
6 months from date of receipt, -70 °C as supplied.
3 months, -70 °C under sterile conditions after opening.
Buffer
Supplied
as a solution in HEPES, NaCl, DTT, Glycerol and Urea.
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Recombinant Human TDP-43/TARDBP Protein, CF
ALS10
ALS10TAR DNA-binding protein-43
TAR DNA binding protein
TARDBP
TDP43
TDP-43
TDP-43TAR DNA-binding protein 43
Background
TDP-43 (TAR DNA binding protein of 43 kDa; gene name TARDBP) is a 414 amino acid (aa) nuclear RNA/DNA binding phosphoprotein that regulates transcription and splicing. TDP-43 is aberrantly expressed in most forms of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration. In these cases it is absent from the nucleus and accumulates, along with a truncated 20-28 kDa form, in the Ubiquitin-containing inclusion bodies. TDP-43 can also influence CFTR exon 9 skipping in cystic fibrosis. Human TDP-43 is 96% identical to the mouse ortholog.
Buratti E. et al. (2001) EMBO J. 20: 1774.
Chen-Plotkin A.S. et al. (2010) Nat. Rev. Neurol. 6: 211.
Johnson B.S. et al. (2009) J. Biol. Chem. 284: 20329.
Strong M.J. et al. (2007) Mol. Cell Neurosci. 35: 320.
The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.
=
÷
Review this Product
Be the first to review our Recombinant Human TDP-43/TARDBP Protein, CF and receive a gift card or discount.