Recombinant Human SCF Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

What is Stem cell factor?

Stem cell factor (SCF) is a potent hematopoietic growth factor required in regulating both embryonic and adult hematopoiesis. SCF protein promotes the survival, differentiation, and mobilization of multiple cell types including myeloid, erythroid, megakaryocytic, lymphoid, germ cell, and melanocyte progenitors (1 7). SCF is a primary growth and activation factor for mast cells and eosinophils (8). And SCF assists in the recovery of cardiac function following myocardial infarction by increasing the number of cardiomyocytes and vascular channels (9). Stem cell factor is an important cytokine for ex vivo clinical applications. Along with other cytokines, SCF is used in the culture and expansion of hematopoietic stem cells (HSCs) as well as for proliferation and differentiation of both myeloid and erythroid progenitor cells.

Mature stem cell factor consists of a 189 amino acid (aa) extracellular domain (ECD), a 23 aa transmembrane domain, and a 36 aa cytoplasmic tail (10). The ECD shows both N linked and O-linked glycosylation (11). SCF protein exists in two forms, a membrane-bound form and a proteolytically processed soluble form that lacks the transmembrane domain and cytoplasmic tail. The soluble form is created by proteolytic cleavage at two alternate sites in the extracellular juxtamembrane region releasing a 25 kDa soluble SCF protein which is comparable to the only form produced by Steel-dickie mutant mice (12, 13). There is also an alternately spliced isoform of human SCF that lacks 28 amino acids that encompasses the primary proteolytic recognition site (14). This form cannot be cleaved and is only membrane bound.

SCF binds to C-kit (CD117). C-kit is expressed on many different cell types including HSCs, mast cells, germ cells, and melanocytes. Binding of SCF to C-kit induces receptor dimerization and autophosphorylation of tyrosine residues in the cytoplasmic domain (15). Tyrosine phosphorylation initiates multiple signaling pathways including RAS, PI3 kinase, Src, and JAK/STAT. Stem cell factor is highly conserved among mammals. Human SCF protein shares 79% 87% aa sequence identity with dog, cat, mouse, and rat SCF. Rat SCF is active on mouse and human cells, but human SCF is only weakly active on mouse cells (10).

We have publications tested in 7 confirmed species: Human, Mouse, Hamster, Porcine, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque), Primate - Macaca mulatta (Rhesus Macaque), Primate - Papio anubis (Olive Baboon).

We have publications tested in 4 applications: Bioassay, Cell Culture, Differentiation, ELISA (Standard).

Showing Publications 1 - 10 of 189. Show All 189 Publications. Collapse Publications.

Publications using 255-SC/CF	Applications	Species
AA Almad, L Garcia, A Takanohash, A Gagne, W Yang, J Ann McGuir, D French, A Vanderver Generation of three induced Pluripotent Stem Cell lines from individuals with Hypomyelination with Atrophy of Basal Ganglia and Cerebellum caused by a c.745G>A (p.D249N) autosomal dominant mutation in TUBB4A Stem Cell Research, 2023-03-26;69(0):103083. 2023-03-26 [PMID: 37003180] (Bioassay, Human)	Bioassay	Human
S Li, CS Wang, A Montel-Hag, HC Chen, S Lopez, O Zhou, K Dai, S Tsai, W Satyadi, C Botero, C Wong, D Casero, GM Crooks, CS Seet Strength of CAR signaling determines T�cell versus ILC differentiation from pluripotent stem cells Cell Reports, 2023-03-11;42(3):112241. 2023-03-11 [PMID: 36906850] (Bioassay, Human)	Bioassay	Human
Y Fan, J Hackland, A Baggiolini, LY Hung, H Zhao, P Zumbo, P Oberst, AP Minotti, E Hergenrede, S Najjar, Z Huang, NM Cruz, A Zhong, M Sidharta, T Zhou, E de Stanchi, D Betel, RM White, M Gershon, KG Margolis, L Studer hPSC-derived sacral neural crest enables rescue in a severe model of Hirschsprung's disease Cell Stem Cell, 2023;30(3):264-282.e9. 2023 [PMID: 36868194] (Bioassay, Human)	Bioassay	Human
Y Fan, J Hackland, A Baggiolini, LY Hung, H Zhao, P Zumbo, P Oberst, AP Minotti, E Hergenrede, S Najjar, Z Huang, NM Cruz, A Zhong, M Sidharta, T Zhou, E de Stanchi, D Betel, RM White, M Gershon, KG Margolis, L Studer hPSC-derived sacral neural crest enables rescue in a severe model of Hirschsprung's disease Cell Stem Cell, 2023-03-02;30(3):264-282.e9. 2023-03-02 [PMID: 36868194] (Bioassay, Human)	Bioassay	Human
L Feige, T Kozaki, G Dias de Me, V Guillemot, F Larrous, F Ginhoux, H Bourhy Susceptibilities of CNS Cells towards Rabies Virus Infection Is Linked to Cellular Innate Immune Responses Viruses, 2022-12-29;15(1):. 2022-12-29 [PMID: 36680128] (Bioassay, Human)	Bioassay	Human
JP Borges, RSR Sætra, A Volchuk, M Bugge, P Devant, B Sporsheim, BR Kilburn, CL Evavold, JC Kagan, NM Goldenberg, TH Flo, BE Steinberg Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death Elife, 2022-12-05;11(0):. 2022-12-05 [PMID: 36468682] (Cell Culture, Mouse)	Cell Culture	Mouse
PY Su, W Lee, J Zernant, SH Tsang, T Nagasaki, B Corneo, R Allikmets Establishment of the iPSC line CUIMCi005-A from a patient with Stargardt disease for retinal organoid culture Oncogene, 2022-11-14;65(0):102973. 2022-11-14 [PMID: 36455383] (Bioassay, Human)	Bioassay	Human
X Liu, N Sato, T Yabushita, J Li, Y Jia, M Tamura, S Asada, T Fujino, T Fukushima, T Yonezawa, Y Tanaka, T Fukuyama, A Tsuchiya, S Shikata, H Iwamura, C Kinouchi, K Komatsu, S Yamasaki, T Shibata, AT Sasaki, J Schibler, M Wunderlich, E O'Brien, B Mizukawa, JC Mulloy, Y Sugiura, H Takizawa, T Shibata, K Miyake, T Kitamura, S Goyama IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia Embo Molecular Medicine, 2022-12-01;0(0):e15631. 2022-12-01 [PMID: 36453131] (Cell Culture, Human)	Cell Culture	Human
Kunitomi A, Hirohata R, Arreola V, Osawa M, Kato T, Nomura M, Kawaguchi J, Hara H, Kusano K, Takashima Y, Takahashi K, Fukuda K, Takasu N, Yamanaka S Improved Sendai viral system for reprogramming to naive pluripotency. Cell Rep Methods, 2022-10-17;2(11):100317. 2022-10-17 [PMID: 36447645] (Bioassay, Human)	Bioassay	Human
Z Li, F Fang, Y Long, Q Zhao, X Wang, Z Ye, T Meng, X Gu, W Xiang, C Xiong, H Li The balance between NANOG and SOX17 mediated by TET proteins regulates specification of human primordial germ cell fate Cell & bioscience, 2022-11-04;12(1):181. 2022-11-04 [PMID: 36333732] (Bioassay, Human)	Bioassay	Human
JC Huang, SC Chen, WA Chang, WW Hung, PH Wu, LY Wu, JM Chang, YL Hsu, YC Tsai KITLG Promotes Glomerular Endothelial Cell Injury in Diabetic Nephropathy by an Autocrine Effect International Journal of Molecular Sciences, 2022-10-03;23(19):. 2022-10-03 [PMID: 36233032] (Cell Culture, Human)	Cell Culture	Human
R Feng, T Mayuranath, P Huang, PA Doerfler, Y Li, Y Yao, J Zhang, LE Palmer, K Mayberry, GE Christakop, P Xu, C Li, Y Cheng, GA Blobel, MC Simon, MJ Weiss Activation of gamma-globin expression by hypoxia-inducible factor 1alpha Nature, 2022-10-12;0(0):. 2022-10-12 [PMID: 36224385] (Bioassay, Human)	Bioassay	Human
N Vilaplana-, V Cuminetti, R Almaghrabi, G Papatzikas, AK Rout, M Jeeves, E González, Y Alyahyawi, A Cunningham, A Erdem, F Schnütgen, M Raghavan, S Potluri, JB Cazier, JJ Schuringa, MAC Reed, L Arranz, UL Günther, P Garcia Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells Elife, 2022-09-02;11(0):. 2022-09-02 [PMID: 36052997] (Bioassay, Human)	Bioassay	Human
YS Michaels, JM Edgar, MC Major, EL Castle, C Zimmerman, T Yin, A Hagner, C Lau, HH Hsu, MI Ibañez-Rio, LJ Durland, DJHF Knapp, PW Zandstra DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells Science Advances, 2022-08-24;8(34):eabn5522. 2022-08-24 [PMID: 36001668] (Bioassay, Human)	Bioassay	Human
R Jing, I Scarfo, MA Najia, E Lummertz d, A Han, M Sanborn, T Bingham, C Kubaczka, DK Jha, M Falchetti, TM Schlaeger, TE North, MV Maus, GQ Daley EZH1 repression generates mature iPSC-derived CAR T�cells with enhanced antitumor activity Cell Stem Cell, 2022-08-04;29(8):1181-1196.e6. 2022-08-04 [PMID: 35931029] (Bioassay, Human)	Bioassay	Human
D Ávila-Gonz, W Portillo, CP Barragán-Á, G Hernandez-, E Flores-Gar, A Molina-Her, NE Díaz-Martí, NF Díaz The human amniotic epithelium confers a bias to differentiate toward the neuroectoderm lineage in human embryonic stem cells Elife, 2022-07-11;11(0):. 2022-07-11 [PMID: 35815953] (Bioassay, Human)	Bioassay	Human
L Liu, A Vujovic, NP Deshpande, S Sathe, G Anande, HTT Chen, J Xu, MD Minden, GW Yeo, A Unnikrishn, KJ Hope, Y Lu The splicing factor RBM17 drives leukemic stem cell maintenance by evading nonsense-mediated decay of pro-leukemic factors Nature Communications, 2022-07-04;13(1):3833. 2022-07-04 [PMID: 35781533] (Bioassay, Human)	Bioassay	Human
J Skokowa, B Hernandez, M Coles, M Ritter, M Nasri, J Haaf, N Aghaallaei, Y Xu, P Mir, AC Krahl, KW Rogers, K Maksymenko, B Bajoghli, K Welte, AN Lupas, P Müller, M ElGamacy A topological refactoring design strategy yields highly stable granulopoietic proteins Nature Communications, 2022-05-26;13(1):2948. 2022-05-26 [PMID: 35618709] (Bioassay, Human)	Bioassay	Human
JH Hong, JH Kim, KW Kang, BH Lee, Y Park, BS Kim Generation of a human induced pluripotent stem cell line KUMi006 from a patient with multiple myeloma Stem Cell Research, 2022-03-28;61(0):102767. 2022-03-28 [PMID: 35397398] (Bioassay, Human)	Bioassay	Human
Y Liu, Y Liu, Y Jia, J Lv, D Sun, Y Yin, N Liu, B Su, G Sun Generation of an induced pluripotent stem cell (iPSC) line from a diabetic patient with glucagon receptor (GCGR) p.W83X mutation Stem Cell Research, 2022-03-11;61(0):102745. 2022-03-11 [PMID: 35381520] (Bioassay, Human)	Bioassay	Human
G Iannello, A Patel, D Sirabella, B Corneo, VV Thaker Derivation and characterization of the induced pluripotent stem cell line CUIMCi004-A from a patient with a novel frameshift variant in exon 18a of OCRL Stem Cell Research, 2021-12-23;59(0):102635. 2021-12-23 [PMID: 35074682] (Bioassay, Human)	Bioassay	Human
M Sone, S Nakamura, S Umeda, H Ginya, M Oshima, MA Kanashiro, SK Paul, K Hashimoto, E Nakamura, Y Harada, K Tsujimura, A Saraya, T Yamaguchi, N Sugimoto, A Sawaguchi, A Iwama, K Eto, N Takayama Silencing of p53 and CDKN1A establishes sustainable immortalized megakaryocyte progenitor cells from human iPSCs Stem Cell Reports, 2021-12-02;0(0):. 2021-12-02 [PMID: 34861163] (Bioassay, Human)	Bioassay	Human
AF de Souza, FF Bressan, NCG Pieri, RC Botigelli, T Revay, SK Haddad, DT Covas, ES Ramos, WA King, FV Meirelles Generation of Primordial Germ Cell-like Cells from iPSCs Derived from Turner Syndrome Patients Cells, 2021-11-10;10(11):. 2021-11-10 [PMID: 34831322] (Bioassay, Human)	Bioassay	Human
SS Sahoo, VB Pastor, C Goodings, RK Voss, EJ Kozyra, A Szvetnik, P Noellke, M Dworzak, J Starý, F Locatelli, R Masetti, M Schmugge, B De Moerloo, A Catala, K Kállay, D Turkiewicz, H Hasle, J Buechner, K Jahnukaine, M Ussowicz, S Polychrono, OP Smith, O Fabri, S Barzilai, V de Haas, I Baumann, S Schwarz-Fu, European W, MR Niewisch, MG Sauer, B Burkhardt, P Lang, P Bader, R Beier, I Müller, MH Albert, R Meisel, A Schulz, G Cario, PK Panda, J Wehrle, S Hirabayash, M Derecka, R Durruthy-D, G Göhring, A Yoshimi-No, M Ku, D Lebrecht, M Erlacher, C Flotho, B Strahm, CM Niemeyer, MW Wlodarski Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes Nature Medicine, 2021-10-07;27(10):1806-1817. 2021-10-07 [PMID: 34621053] (Bioassay, Human)	Bioassay	Human
S Yu, C Di, S Chen, M Guo, J Yan, Z Zhu, L Liu, R Feng, Y Xie, R Zhang, J Chen, M Wang, D Wei, H Fang, T Yin, J Huang, S Chen, H Lu, J Zhu, J Qu Distinct immune signatures discriminate between asymptomatic and presymptomatic SARS-CoV-2pos subjects Cell Research, 2021-09-24;0(0):. 2021-09-24 [PMID: 34561618] (Bioassay, Human)	Bioassay	Human
Sudo K, Yamazaki S, Wilkinson A, Nakauchi H, Nakamura Y Polyvinyl alcohol hydrolysis rate and molecular weight influence human and murine HSC activity ex vivo. Stem Cell Res, 2021-09-03;56(0):102531. 2021-09-03 [PMID: 34509158] (Bioassay, Human)	Bioassay	Human
GB Schwartz, H Kubo, MM Laronda Generation of two human induced pluripotent stem cell lines from a patient with complete androgen insensitivity syndrome with a hemizygous single nucleotide variant in the androgen receptor (AR) gene Stem Cell Research, 2021-06-30;55(0):102441. 2021-06-30 [PMID: 34233262] (Bioassay, Human)	Bioassay	Human
H Kato, Y Maezawa, Y Ouchi, N Takayama, M Sone, K Sone, A Takada-Wat, K Tsujimura, M Koshizaka, S Nagasawa, H Saitoh, M Ohtaka, M Nakanishi, H Tahara, A Shimamoto, A Iwama, K Eto, K Yokote Generation of disease-specific and CRISPR/Cas9-mediated gene-corrected iPS cells from a patient with adult progeria Werner syndrome Stem Cell Research, 2021-04-23;53(0):102360. 2021-04-23 [PMID: 34087989] (Cell Culture, Human)	Cell Culture	Human
GA Newby, JS Yen, KJ Woodard, T Mayuranath, CR Lazzarotto, Y Li, H Sheppard-T, SN Porter, Y Yao, K Mayberry, KA Everette, Y Jang, CJ Podracky, E Thaman, C Lechauve, A Sharma, JM Henderson, MF Richter, KT Zhao, SM Miller, T Wang, LW Koblan, AP McCaffrey, JF Tisdale, TA Kalfa, SM Pruett-Mil, SQ Tsai, MJ Weiss, DR Liu Base editing of haematopoietic stem cells rescues sickle cell disease in mice Nature, 2021-06-02;0(0):. 2021-06-02 [PMID: 34079130] (Bioassay, Human)	Bioassay	Human
JC Reid, D Golubeva, AL Boyd, CG Hollands, C Henly, L Orlando, A Leber, J Hébert, F Morabito, G Cutrona, L Agnelli, M Gentile, M Ferrarini, A Neri, B Leber, M Bhatia Human pluripotent stem cells identify molecular targets of trisomy 12 in chronic lymphocytic leukemia patients Cell Reports, 2021-03-16;34(11):108845. 2021-03-16 [PMID: 33730576] (Bioassay, Human)	Bioassay	Human
W Yuan, Z Yao, V Veerapandi, X Yang, X Wang, D Chen, L Ma, C Li, Y Zheng, F Luo, XY Zhao The histone demethylase KDM2B regulates human primordial germ cell-like cells specification International journal of biological sciences, 2021-01-01;17(2):527-538. 2021-01-01 [PMID: 33613110] (Bioassay, Human)	Bioassay	Human
T Wang, AR Pine, AG Kotini, H Yuan, L Zamparo, DT Starczynow, C Leslie, EP Papapetrou Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets Cell Stem Cell, 2021-02-10;0(0):. 2021-02-10 [PMID: 33571445] (Bioassay, Human)	Bioassay	Human
Q Jiang, J Isquith, L Ladel, A Mark, F Holm, C Mason, Y He, P Mondala, I Oliver, J Pham, W Ma, E Reynoso, S Ali, IJ Morris, R Diep, C Nasamran, G Xu, R Sasik, SB Rosenthal, A Birmingham, S Coso, G Pineda, L Crews, ME Donohoe, JC Venter, T Whisenant, RA Mesa, LB Alexandrov, KM Fisch, C Jamieson Inflammation-driven deaminase deregulation fuels human pre-leukemia stem cell evolution Cell Reports, 2021-01-26;34(4):108670. 2021-01-26 [PMID: 33503434] (Bioassay, Human)	Bioassay	Human
S Iriguchi, Y Yasui, Y Kawai, S Arima, M Kunitomo, T Sato, T Ueda, A Minagawa, Y Mishima, N Yanagawa, Y Baba, Y Miyake, K Nakayama, M Takiguchi, T Shinohara, T Nakatsura, M Yasukawa, Y Kassai, A Hayashi, S Kaneko A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy Nature Communications, 2021-01-18;12(1):430. 2021-01-18 [PMID: 33462228] (Bioassay, Human)	Bioassay	Human
YS Hwang, S Suzuki, Y Seita, J Ito, Y Sakata, H Aso, K Sato, BP Hermann, K Sasaki Reconstitution of prospermatogonial specification in vitro from human induced pluripotent stem cells Nat Commun, 2020-11-09;11(1):5656. 2020-11-09 [PMID: 33168808] (Cell Culture, Human)	Cell Culture	Human
H Zhu, RH Blum, D Bernareggi, EH Ask, Z Wu, HJ Hoel, Z Meng, C Wu, KL Guan, KJ Malmberg, DS Kaufman Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In�Vivo Persistence and Enhances Anti-tumor Activity Cell Stem Cell, 2020-06-11;0(0):. 2020-06-11 [PMID: 32531207] (Bioassay, Human)	Bioassay	Human
J Wesely, AG Kotini, F Izzo, H Luo, H Yuan, J Sun, M Georgomano, A Zviran, AG Deslaurier, N Dusaj, SD Nimer, C Leslie, DA Landau, MG Kharas, EP Papapetrou Acute Myeloid Leukemia iPSCs Reveal a Role for RUNX1 in the Maintenance of Human Leukemia Stem Cells Cell Rep, 2020-06-02;31(9):107688. 2020-06-02 [PMID: 32492433] (Cell Culture, Human)	Cell Culture	Human
P Norbnop, P Ingrungrua, N Israsena, K Suphapeeti, V Shotelersu Generation and characterization of HLA-universal platelets derived from induced pluripotent stem cells Sci Rep, 2020-05-21;10(1):8472. 2020-05-21 [PMID: 32439978] (Cell Culture, Human)	Cell Culture	Human
S Demirci, B Gudmundsdo, Q Li, JJ Haro-Mora, T Nassehi, C Drysdale, M Yapundich, J Gamer, F Seifuddin, JF Tisdale, N Uchida &betaT87Q-Globin Gene Therapy Reduces Sickle Hemoglobin Production, Allowing for Ex�Vivo Anti-sickling Activity in Human Erythroid Cells Mol Ther Methods Clin Dev, 2020-04-18;17(0):912-921. 2020-04-18 [PMID: 32405513] (Cell Culture, Human)	Cell Culture	Human
C Yamashiro, K Sasaki, S Yokobayash, Y Kojima, M Saitou Generation of human oogonia from induced pluripotent stem cells in culture Nat Protoc, 2020-03-30;15(4):1560-1583. 2020-03-30 [PMID: 32231324] (Bioassay, Human)	Bioassay	Human
A Leonard, M Yapundich, T Nassehi, J Gamer, CM Drysdale, JJ Haro-Mora, S Demirci, MM Hsieh, N Uchida, JF Tisdale Low-Dose Busulfan Reduces Human CD34+ Cell Doses Required for Engraftment in c-kit Mutant Immunodeficient Mice Mol Ther Methods Clin Dev, 2019-11-11;15(0):430-437. 2019-11-11 [PMID: 31890735] (Bioassay, Human)	Bioassay	Human
D Suzuki, C Flahou, N Yoshikawa, I Stirblyte, Y Hayashi, A Sawaguchi, M Akasaka, S Nakamura, N Higashi, H Xu, T Matsumoto, K Fujio, MG Manz, A Hotta, H Takizawa, K Eto, N Sugimoto iPSC-Derived Platelets Depleted of HLA Class I Are Inert to Anti-HLA Class I and Natural Killer Cell Immunity Stem Cell Reports, 2019-12-26;0(0):. 2019-12-26 [PMID: 31883921] (Bioassay, Human)	Bioassay	Human
Z Li, F Fang, Q Zhao, H Li, C Xiong Supplementation of vitamin C promotes early germ cell specification from human embryonic stem cells Stem Cell Res Ther, 2019-11-15;10(1):324. 2019-11-15 [PMID: 31730021] (Cell Culture, Human)	Cell Culture	Human
JP Ruiz, G Chen, JJ Haro Mora, K Keyvanfar, C Liu, J Zou, J Beers, H Bloomer, H Qanash, N Uchida, JF Tisdale, M Boehm, A Larochelle Robust generation of erythroid and multilineage hematopoietic progenitors from human iPSCs using a scalable monolayer culture system Stem Cell Res, 2019-10-15;41(0):101600. 2019-10-15 [PMID: 31710911] (Cell Culture, Mouse)	Cell Culture	Mouse
T Ikuno, S Ito, T Inoue Human induced pluripotent stem cell-derived mast cells useful for in vitro mast cell activation assay exhibiting phenotypes and morphological characteristics of human mast cells J Toxicol Sci, 2019-01-01;44(11):789-797. 2019-01-01 [PMID: 31708535] (Cell Culture, Human)	Cell Culture	Human
J Chagraoui, B Lehnertz, S Girard, JF Spinella, I Fares, E Tomellini, N Mayotte, S Corneau, T MacRae, L Simon, G Sauvageau UM171 induces a homeostatic inflammatory-detoxification response supporting human HSC self-renewal PLoS ONE, 2019-11-08;14(11):e0224900. 2019-11-08 [PMID: 31703090] (Cell Culture, Human)	Cell Culture	Human
J Grajcarek, J Monlong, Y Nishinaka-, M Nakamura, M Nagai, S Matsuo, D Lougheed, H Sakurai, MK Saito, G Bourque, K Woltjen Genome-wide microhomologies enable precise template-free editing of biologically relevant deletion mutations Nat Commun, 2019-10-24;10(1):4856. 2019-10-24 [PMID: 31649251] (Bioassay, Human)	Bioassay	Human
WR Proto, SV Siegel, S Dankwa, W Liu, A Kemp, S Marsden, ZA Zenonos, S Unwin, PM Sharp, GJ Wright, BH Hahn, MT Duraisingh, JC Rayner Adaptation of Plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand Nat Commun, 2019-10-04;10(1):4512. 2019-10-04 [PMID: 31586047] (Cell Culture, Human)	Cell Culture	Human
N Uchida, MM Hsieh, L Raines, JJ Haro-Mora, S Demirci, AC Bonifacino, AE Krouse, ME Metzger, RE Donahue, JF Tisdale Development of a forward-oriented therapeutic lentiviral vector for hemoglobin disorders Nat Commun, 2019-10-02;10(1):4479. 2019-10-02 [PMID: 31578323] (Cell Culture, Human)	Cell Culture	Human
GL Rogers, HY Chen, H Morales, PM Cannon Homologous Recombination-Based Genome Editing by Clade F AAVs Is Inefficient in the Absence of a Targeted DNA Break Mol. Ther., 2019-09-09;27(10):1726-1736. 2019-09-09 [PMID: 31540849] (Bioassay, Human)	Bioassay	Human
M Ly, S Rentas, A Vujovic, N Wong, S Moreira, J Xu, N Holzapfel, S Bhatia, D Tran, MD Minden, JS Draper, KJ Hope Diminished AHR signaling drives human acute myeloid leukemia stem cell maintenance Cancer Res., 2019-09-13;0(0):. 2019-09-13 [PMID: 31519687] (Bioassay, Human)	Bioassay	Human
MD McKenzie, M Ghisi, EP Oxley, S Ngo, L Cimmino, C Esnault, R Liu, JM Salmon, CC Bell, N Ahmed, M Erlichster, MT Witkowski, GJ Liu, M Chopin, A Dakic, E Simankowic, G Pomilio, T Vu, P Krsmanovic, S Su, L Tian, TM Baldwin, DA Zalcenstei, L DiRago, S Wang, D Metcalf, RW Johnstone, BA Croker, GI Lancaster, AJ Murphy, SH Naik, SL Nutt, V Pospisil, T Schroeder, M Wall, MA Dawson, AH Wei, H de Thé, ME Ritchie, J Zuber, RA Dickins Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia Cell Stem Cell, 2019-08-01;25(2):258-272.e9. 2019-08-01 [PMID: 31374198] (Cell Culture, Human)	Cell Culture	Human
MA Kinney, LT Vo, JM Frame, J Barragan, AJ Conway, S Li, KK Wong, JJ Collins, P Cahan, TE North, DA Lauffenbur, GQ Daley A systems biology pipeline identifies regulatory networks for stem cell engineering Nat. Biotechnol., 2019-07-01;37(7):810-818. 2019-07-01 [PMID: 31267104] (Cell Culture, Human)	Cell Culture	Human
Ohta R, Sugimura R, Niwa A, Saito M Hemogenic Endothelium Differentiation from Human Pluripotent Stem Cells in A Feeder- and Xeno-free Defined Condition. J Vis Exp, 2019-06-16;0(148):. 2019-06-16 [PMID: 31259914] (Bioassay, Human)	Bioassay	Human
M Nasri, M Ritter, P Mir, B Dannenmann, N Aghaallaei, D Amend, V Makaryan, Y Xu, B Fletcher, R Bernhard, I Steiert, K Hahnel, J Berger, I Koch, B Sailer, K Hipp, C Zeidler, M Klimiankou, B Bajoghli, DC Dale, K Welte, J Skokowa CRISPR/Cas9 mediated ELANE knockout enables neutrophilic maturation of primary hematopoietic stem and progenitor cells and induced pluripotent stem cells of severe congenital neutropenia patients Haematologica, 2019-06-27;0(0):. 2019-06-27 [PMID: 31248972] (Bioassay, Human)	Bioassay	Human
YL Chang, Z Wang, S Igawa, JE Choi, T Werbel, A Di Nardo Lipocalin 2: A New Antimicrobial in Mast Cells Int J Mol Sci, 2019-05-14;20(10):. 2019-05-14 [PMID: 31091692] (Cell Culture, Human)	Cell Culture	Human
B Mair, J Tomic, SN Masud, P Tonge, A Weiss, M Usaj, AHY Tong, JJ Kwan, KR Brown, E Titus, M Atkins, KSK Chan, L Munsie, A Habsid, H Han, M Kennedy, B Cohen, G Keller, J Moffat Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies Cell Rep, 2019-04-09;27(2):599-615.e12. 2019-04-09 [PMID: 30970261] (Differentiation, Differentiation, Human)	Differentiation, Differentiation	Human
A Tobío, G Bandara, DA Morris, DK Kim, MP O'Connell, HD Komarow, MC Carter, D Smrz, DD Metcalfe, A Olivera Oncogenic D816V-KIT signaling in mast cells causes persistent IL-6 production Haematologica, 2019-04-04;0(0):. 2019-04-04 [PMID: 30948489] (Bioassay, Human)	Bioassay	Human
AK Seneviratn, M Xu, JJA Henao, VA Fajardo, Z Hao, V Voisin, GW Xu, R Hurren, S Kim, N MacLean, X Wang, M Gronda, D Jeyaraju, Y Jitkova, T Ketela, M Mullokando, D Sharon, G Thomas, R Chouinard-, JR Hawley, C Schafer, HL Yau, Z Khuchua, A Aman, R Al-Awar, A Gross, SM Claypool, R Bazinet, M Lupien, S Chan, DD De Carvalh, MD Minden, GD Bader, KD Stark, P LeBlanc, AD Schimmer The Mitochondrial Transacylase, Tafazzin, Regulates for AML Stemness by Modulating Intracellular Levels of Phospholipids Cell Stem Cell, 2019-03-28;0(0):. 2019-03-28 [PMID: 30930145] (Bioassay, Human)	Bioassay	Human
T Hochdörfer, C Winkler, K Pardali, J Mjösberg Expression of c-Kit discriminates between two functionally distinct subsets of human type 2 innate lymphoid cells Eur. J. Immunol., 2019-03-28;0(0):. 2019-03-28 [PMID: 30892687] (Bioassay, Human)	Bioassay	Human
H Xu, B Wang, M Ono, A Kagita, K Fujii, N Sasakawa, T Ueda, P Gee, M Nishikawa, M Nomura, F Kitaoka, T Takahashi, K Okita, Y Yoshida, S Kaneko, A Hotta Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility Cell Stem Cell, 2019-03-07;0(0):. 2019-03-07 [PMID: 30853558] (Bioassay, Human)	Bioassay	Human
M Suga, T Kondo, K Imamura, R Shibukawa, Y Okanishi, Y Sagara, K Tsukita, T Enami, M Furujo, K Saijo, Y Nakamura, M Osawa, MK Saito, S Yamanaka, H Inoue Generation of a human induced pluripotent stem cell line, BRCi001-A, derived from a patient with mucopolysaccharidosis type I Stem Cell Res, 2019-02-12;36(0):101406. 2019-02-12 [PMID: 30849633] (Bioassay, Human)	Bioassay	Human
N Uchida, T Nassehi, CM Drysdale, J Gamer, M Yapundich, S Demirci, JJ Haro-Mora, A Leonard, MM Hsieh, JF Tisdale High-Efficiency Lentiviral Transduction of Human CD34+ Cells in High-Density Culture with Poloxamer and Prostaglandin E2 Mol Ther Methods Clin Dev, 2019-01-25;13(0):187-196. 2019-01-25 [PMID: 30788387] (Bioassay, Human)	Bioassay	Human
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A Camgoz, M Paszkowski, S Satpathy, M Wermke, MV Hamann, M von Bonin, C Choudhary, S Knapp, F Buchholz STK3 is a therapeutic target for a subset of acute myeloid leukemias Oncotarget, 2018-05-22;9(39):25458-25473. 2018-05-22 [PMID: 29876001] (Bioassay, Human)	Bioassay	Human
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P Shen, S Yang, H Sun, G Li, B Wu, F Ji, T Sun, D Zhou SCF/c-KIT Signaling Increased Mucin2 Production by Maintaining Atoh1 Expression in Mucinous Colorectal Adenocarcinoma Int J Mol Sci, 2018-05-22;19(5):. 2018-05-22 [PMID: 29786668] (Bioassay, Human)	Bioassay	Human
MC Allenby, A Tahlawi, JCF Morais, K Li, N Panoskalts, A Mantalaris Ceramic Hollow Fibre Constructs for Continuous Perfusion and Cell Harvest from 3D Hematopoietic Organoids Stem Cells Int, 2018-04-02;2018(0):6230214. 2018-04-02 [PMID: 29760729] (Bioassay, Human)	Bioassay	Human
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CM Ferrer, M Alders, AV Postma, S Park, MA Klein, M Cetinbas, E Pajkrt, A Glas, S van Koning, VM Christoffe, MMAM Mannens, L Knegt, JP Etchegaray, RI Sadreyev, JM Denu, G Mostoslavs, MC van Maarle, R Mostoslavs An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality Genes Dev., 2018-03-19;32(5):373-388. 2018-03-19 [PMID: 29555651] (Bioassay, Human)	Bioassay	Human
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YE Bar-Ephrai, F Cornelisse, N Papazian, T Konijn, RM Hoogenboez, MA Sanders, BA Westerman, M Gönültas, J Kwekkeboom, JMM Den Haan, RM Reijmers, RE Mebius, T Cupedo Cross-Tissue Transcriptomic Analysis of Human Secondary Lymphoid Organ-Residing ILC3s Reveals a Quiescent State in the Absence of Inflammation Cell Rep, 2017-10-17;21(3):823-833. 2017-10-17 [PMID: 29045847] (Bioassay, Human)	Bioassay	Human
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W Jeong, S Jung, FW Bazer, J Kim Stem Cell Factor-Induced AKT Cell Signaling Pathway: Effects on Porcine Trophectoderm and Uterine Luminal Epithelial Cells Gen. Comp. Endocrinol., 2017-05-24;0(0):. 2017-05-24 [PMID: 28551414] (Bioassay, Human)	Bioassay	Human
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Williams M, Yousafzai Y, Cox C, Blair A, Carmody R, Sai S, Chapman K, McAndrew R, Thomas A, Spence A, Gibson B, Graham G, Halsey C Interleukin-15 enhances cellular proliferation and upregulates CNS homing molecules in pre-B acute lymphoblastic leukemia. Blood, 2014-04-03;123(20):3116-27. 2014-04-03 [PMID: 24700781] (Bioassay, Human)	Bioassay	Human
Levescot A, Flamant S, Basbous S, Jacomet F, Feraud O, Anne Bourgeois E, Bonnet M, Giraud C, Roy L, Barra A, Chomel J, Turhan A, Guilhot F, Girard J, Gombert J, Herbelin A BCR-ABL-induced deregulation of the IL-33/ST2 pathway in CD34+ progenitors from chronic myeloid leukemia patients. Cancer Res, 2014-03-27;74(10):2669-76. 2014-03-27 [PMID: 24675360] (Bioassay, Human)	Bioassay	Human
Vannucchi , A M, Rotunno , G, Bartalucci , N, Raugei , G, Carrai , V, Balliu , M, Mannarelli , C, Pacilli , A, Calabresi , L, Fjerza , R, Pieri , L, Bosi , A, Manfredini , R, Guglielmelli , P Calreticulin mutation-specific immunostaining in myeloproliferative neoplasms: pathogenetic insight and diagnostic value. Leukemia, 2014-03-12;28(9):1811-8. 2014-03-12 [PMID: 24618731] (Bioassay, Human)	Bioassay	Human
Reynolds , C, Roderick , J E, LaBelle , J L, Bird , G, Mathieu , R, Bodaar , K, Colon , D, Pyati , U, Stevenson , K E, Qi , J, Harris , M, Silverman , L B, Sallan , S E, Bradner , J E, Neuberg , D S, Look , A T, Walensky , L D, Kelliher , M A, Gutierrez , A Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia. Leukemia, 2014-02-20;28(9):1819-27. 2014-02-20 [PMID: 24552990] (Bioassay, Human)	Bioassay	Human
Nakamura S, Takayama N, Hirata S, Seo H, Endo H, Ochi K, Fujita K, Koike T, Harimoto K, Dohda T, Watanabe A, Okita K, Takahashi N, Sawaguchi A, Yamanaka S, Nakauchi H, Nishimura S, Eto K Expandable megakaryocyte cell lines enable clinically applicable generation of platelets from human induced pluripotent stem cells. Cell Stem Cell, 2014-02-13;14(4):535-48. 2014-02-13 [PMID: 24529595] (Bioassay, Human)	Bioassay	Human
Jensen B, Frandsen P, Raaby E, Schiotz P, Skov P, Poulsen L Molecular and stimulus-response profiles illustrate heterogeneity between peripheral and cord blood-derived human mast cells. J Leukoc Biol, 2014-02-03;95(6):893-901. 2014-02-03 [PMID: 24493825] (Bioassay, Human)	Bioassay	Human
Kamat V, Paluru P, Myint M, French D, Gadue P, Diamond S MicroRNA screen of human embryonic stem cell differentiation reveals miR-105 as an enhancer of megakaryopoiesis from adult CD34+ cells. Stem Cells, 2014-05-01;32(5):1337-46. 2014-05-01 [PMID: 24446170] (Bioassay, Human)	Bioassay	Human
Smith A, Bowers S, Stratman A, Davis G Hematopoietic stem cell cytokines and fibroblast growth factor-2 stimulate human endothelial cell-pericyte tube co-assembly in 3D fibrin matrices under serum-free defined conditions. PLoS ONE, 2013-12-31;8(12):e85147. 2013-12-31 [PMID: 24391990] (Bioassay, Human)	Bioassay	Human
Klimenkova O, Ellerbeck W, Klimiankou M, Unalan M, Kandabarau S, Gigina A, Hussein K, Zeidler C, Welte K, Skokowa J A lack of secretory leukocyte protease inhibitor (SLPI) causes defects in granulocytic differentiation. Blood, 2013-12-18;123(8):1239-49. 2013-12-18 [PMID: 24352879] (Bioassay, Human)	Bioassay	Human
Tolar J, McGrath J, Xia L, Riddle M, Lees C, Eide C, Keene D, Liu L, Osborn M, Lund T, Blazar B, Wagner J Patient-specific naturally gene-reverted induced pluripotent stem cells in recessive dystrophic epidermolysis bullosa. J Invest Dermatol, 2013-12-06;134(5):1246-54. 2013-12-06 [PMID: 24317394] (Bioassay, Human)	Bioassay	Human
Sjeklocha L, Wong P, Belcher J, Vercellotti G, Steer C beta-Globin sleeping beauty transposon reduces red blood cell sickling in a patient-derived CD34(+)-based in vitro model. PLoS ONE, 2013-11-18;8(11):e80403. 2013-11-18 [PMID: 24260386] (Bioassay, Cell Culture, Human)	Bioassay, Cell Culture	Human
Uchida N, Weitzel R, Evans M, Green R, Bonifacino A, Krouse A, Metzger M, Hsieh M, Donahue R, Tisdale J Evaluation of engraftment and immunological tolerance after reduced intensity conditioning in a rhesus hematopoietic stem cell gene therapy model. Gene Ther, 2013-11-21;21(2):148-57. 2013-11-21 [PMID: 24257347] (Bioassay, Primate - Macaca mulatta (Rhesus Macaque))	Bioassay	Primate - Macaca mulatta (Rhesus Macaque)
Csaszar , Elizabet, Wang , Weijia, Usenko , Tatiana, Qiao , Wenlian, Delaney , Colleen, Bernstein , Irwin D, Zandstra , Peter W Blood stem cell fate regulation by Delta-1-mediated rewiring of IL-6 paracrine signaling. Blood, 2013-11-15;123(5):650-8. 2013-11-15 [PMID: 24243972] (Bioassay, Human)	Bioassay	Human
Doulatov S, Vo L, Chou S, Kim P, Arora N, Li H, Hadland B, Bernstein I, Collins J, Zon L, Daley G Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors. Cell Stem Cell, 2013-10-03;13(4):459-70. 2013-10-03 [PMID: 24094326] (Bioassay, Human)	Bioassay	Human
Morishima , Tatsuya, Watanabe , Ken-ichi, Niwa , Akira, Hirai , Hideyo, Saida , Satoshi, Tanaka , Takayuki, Kato , Itaru, Umeda , Katsutsu, Hiramatsu , Hidefumi, Saito , Megumu K, Matsubara , Kousaku, Adachi , Souichi, Kobayashi , Masao, Nakahata , Tatsutos, Heike , Toshio Genetic correction of HAX1 in induced pluripotent stem cells from a patient with severe congenital neutropenia improves defective granulopoiesis. Haematologica, 2013-08-23;99(1):19-27. 2013-08-23 [PMID: 23975175] (Bioassay, Human)	Bioassay	Human
Bachet J, Tabone-Eglinger S, Dessaux S, Besse A, Brahimi-Adouane S, Emile J, Blay J, Alberti L Gene expression patterns of hemizygous and heterozygous KIT mutations suggest distinct oncogenic pathways: a study in NIH3T3 cell lines and GIST samples. PLoS ONE, 2013-04-12;8(4):e61103. 2013-04-12 [PMID: 23593401] (Bioassay, Mouse)	Bioassay	Mouse
Yu , Jianhua, Peng , Yong, Wu , Lai-Chu, Xie , Zhiliang, Deng , Youcai, Hughes , Tiffany, He , Shun, Mo , XiaoKui, Chiu , Ming, Wang , Qi-En, He , Xiaoming, Liu , Shujun, Grever , Michael, Chan , Kenneth, Liu , Zhongfa Curcumin down-regulates DNA methyltransferase 1 and plays an anti-leukemic role in acute myeloid leukemia. PLoS ONE, 2013-02-13;8(2):e55934. 2013-02-13 [PMID: 23457487] (Bioassay, Human)	Bioassay	Human
Farrer R, Farrer J, DeVries G Platelet-derived growth factor-BB activates calcium/calmodulin-dependent and -independent mechanisms that mediate Akt phosphorylation in the neurofibromin-deficient human Schwann cell line ST88-14. J Biol Chem, 2013-03-01;288(16):11066-73. 2013-03-01 [PMID: 23457304] (Bioassay, Human)	Bioassay	Human
Giannoni F, Hardee C, Wherley J, Gschweng E, Senadheera S, Kaufman M, Chan R, Bahner I, Gersuk V, Wang X, Gjertson D, Baltimore D, Witte O, Economou J, Ribas A, Kohn D Allelic exclusion and peripheral reconstitution by TCR transgenic T cells arising from transduced human hematopoietic stem/progenitor cells. Mol Ther, 2013-02-05;21(5):1044-54. 2013-02-05 [PMID: 23380815] (Bioassay, Human)	Bioassay	Human
Lee M, Prasain N, Chae H, Kim Y, Mantel C, Yoder M, Broxmeyer H Epigenetic regulation of NANOG by miR-302 cluster-MBD2 completes induced pluripotent stem cell reprogramming. Stem Cells, 2013-04-01;31(4):666-81. 2013-04-01 [PMID: 23255147] (Bioassay, Human)	Bioassay	Human
Todd J, Scurr L, Becker T, Kefford R, Rizos H The MAPK pathway functions as a redundant survival signal that reinforces the PI3K cascade in c-Kit mutant melanoma. Oncogene, 2012-12-17;33(2):236-45. 2012-12-17 [PMID: 23246970] (Bioassay, Human)	Bioassay	Human
Targeting of CD34+CD38- cells using Gemtuzumab ozogamicin (Mylotarg) in combination with tipifarnib (Zarnestra) in Acute Myeloid Leukaemia. BMC Cancer, 2012-09-26;12(0):431. 2012-09-26 [PMID: 23013471] (Bioassay, Human)	Bioassay	Human
Stromal cells expressing hedgehog-interacting protein regulate the proliferation of myeloid neoplasms. Blood Cancer J, 2012-09-07;2(0):e87. 2012-09-07 [PMID: 22961059] (Bioassay, Human)	Bioassay	Human
Li Q, Ramirez-Bergeron D, Dunwoodie S, Yang Y Cited2 gene controls pluripotency and cardiomyocyte differentiation of murine embryonic stem cells through Oct4 gene. J Biol Chem, 2012-07-03;287(34):29088-100. 2012-07-03 [PMID: 22761414] (Bioassay, Human)	Bioassay	Human
Ichii , Michiko, Frank , Mark Bar, Iozzo , Renato V, Kincade , Paul W The canonical Wnt pathway shapes niches supportive of hematopoietic stem/progenitor cells. Blood, 2011-11-23;119(7):1683-92. 2011-11-23 [PMID: 22117039] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
Cross-presentation of tumour antigens by human induced pluripotent stem cell-derived CD141(+)XCR1+ dendritic cells. Gene Ther, 2011-11-10;19(10):1035-40. 2011-11-10 [PMID: 22071967] (Bioassay, Human)	Bioassay	Human
Torrano V, Procter J, Cardus P ETV6-RUNX1 promotes survival of early B lineage progenitor cells via a dysregulated erythropoietin receptor. Blood, 2011-09-07;118(18):4910-8. 2011-09-07 [PMID: 21900195] (Bioassay, Human)	Bioassay	Human
Niwa A, Heike T, Umeda K A novel serum-free monolayer culture for orderly hematopoietic differentiation of human pluripotent cells via mesodermal progenitors. PLoS ONE, 2011-07-27;6(7):e22261. 2011-07-27 [PMID: 21818303] (Bioassay, Human)	Bioassay	Human
Uchida N, Hsieh MM, Hayakawa J, Madison C, Washington KN, Tisdale JF Optimal conditions for lentiviral transduction of engrafting human CD34+ cells. Gene Ther., 2011-05-05;18(11):1078-86. 2011-05-05 [PMID: 21544097] (Bioassay, Human)	Bioassay	Human
Tolar J, Park I, Xia L, Lees C, Peacock B, Webber B, McElmurry R, Eide C, Orchard P, Kyba M, Osborn M, Lund T, Wagner J, Daley G, Blazar B Hematopoietic differentiation of induced pluripotent stem cells from patients with mucopolysaccharidosis type I (Hurler syndrome). Blood, 2010-10-29;117(3):839-47. 2010-10-29 [PMID: 21037085] (Bioassay, Human)	Bioassay	Human
Kirouac DC, Ito C, Csaszar E, Roch A, Yu M, Sykes EA, Bader GD, Zandstra PW Dynamic interaction networks in a hierarchically organized tissue. Mol. Syst. Biol., 2010-10-05;6(0):417. 2010-10-05 [PMID: 20924352] (Bioassay, Human)	Bioassay	Human
Stratman AN, Malotte KM, Mahan RD, Davis MJ, Davis GE Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation. Blood, 2009-10-12;114(24):5091-101. 2009-10-12 [PMID: 19822899] (Bioassay, Human)	Bioassay	Human
Duraisingham SS, Hornig J, Gotch F, Patterson S TLR-stimulated CD34 stem cell-derived human skin-like and monocyte-derived dendritic cells fail to induce Th17 polarization of naive T cells but do stimulate Th1 and Th17 memory responses. J. Immunol., 2009-07-22;183(4):2242-51. 2009-07-22 [PMID: 19625644] (Bioassay, Human)	Bioassay	Human
Margulis A, Nocka KH, Brennan AM, Deng B, Fleming M, Goldman SJ, Kasaian MT Mast cell-dependent contraction of human airway smooth muscle cell-containing collagen gels: influence of cytokines, matrix metalloproteases, and serine proteases. J. Immunol., 2009-07-10;183(3):1739-50. 2009-07-10 [PMID: 19592653] (Bioassay, Human)	Bioassay	Human
Ye L, Chang JC, Lin C, Sun X, Yu J, Kan YW Induced pluripotent stem cells offer new approach to therapy in thalassemia and sickle cell anemia and option in prenatal diagnosis in genetic diseases. Proc. Natl. Acad. Sci. U.S.A., 2009-05-29;106(24):9826-30. 2009-05-29 [PMID: 19482945] (Bioassay, Human)	Bioassay	Human
Aerbajinai W, Zhu J, Kumkhaek C, Chin K, Rodgers GP SCF induces gamma-globin gene expression by regulating downstream transcription factor COUP-TFII. Blood, 2009-04-28;114(1):187-94. 2009-04-28 [PMID: 19401563] (Bioassay, Human)	Bioassay	Human
Margulis A, Nocka KH, Wood NL, Wolf SF, Goldman SJ, Kasaian MT MMP dependence of fibroblast contraction and collagen production induced by human mast cell activation in a three-dimensional collagen lattice. Am. J. Physiol. Lung Cell Mol. Physiol., 2008-12-05;296(2):L236-47. 2008-12-05 [PMID: 19060229] (Bioassay, Human)	Bioassay	Human
Hollins F, Kaur D, Yang W, Cruse G, Saunders R, Sutcliffe A, Berger P, Ito A, Brightling CE, Bradding P Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6. J. Immunol., 2008-08-15;181(4):2772-80. 2008-08-15 [PMID: 18684968] (Bioassay, Human)	Bioassay	Human
Kobune M, Kawano Y, Takahashi S, Takada K, Murase K, Iyama S, Sato T, Takimoto R, Niitsu Y, Kato J Interaction with human stromal cells enhances CXCR4 expression and engraftment of cord blood Lin(-)CD34(-) cells. Exp. Hematol., 2008-06-17;36(9):1121-31. 2008-06-17 [PMID: 18562079] (Bioassay, Human)	Bioassay	Human
Sorrentino A, Ferracin M, Castelli G, Biffoni M, Tomaselli G, Baiocchi M, Fatica A, Negrini M, Peschle C, Valtieri M Isolation and characterization of CD146+ multipotent mesenchymal stromal cells. Exp. Hematol., 2008-05-27;36(8):1035-46. 2008-05-27 [PMID: 18504067] (Bioassay, Human)	Bioassay	Human
McCullar V, Oostendorp R, Panoskaltsis-Mortari A, Yun G, Lutz CT, Wagner JE, Miller JS Mouse fetal and embryonic liver cells differentiate human umbilical cord blood progenitors into CD56-negative natural killer cell precursors in the absence of interleukin-15. Exp. Hematol., 2008-03-04;36(5):598-608. 2008-03-04 [PMID: 18295962] (Bioassay, Human)	Bioassay	Human
Gunetti M, Ferrero I, Rustichelli D, Berger M, Gammaitoni L, Timeus F, Piacibello W, Aglietta M, Fagioli F Refreezing of cord blood hematopoietic stem cells for allogenic transplantation: in vitro and in vivo validation of a clinical phase I/II protocol in European and Italian Good Manufacturing Practice conditions. Exp. Hematol., 2008-02-01;36(2):235-43. 2008-02-01 [PMID: 18206730] (Bioassay, Human)	Bioassay	Human
Bogatkevich GS, Ludwicka-Bradley A, Highland KB, Hant F, Nietert PJ, Singleton CB, Feghali-Bostwick CA, Silver RM Impairment of the antifibrotic effect of hepatocyte growth factor in lung fibroblasts from African Americans: possible role in systemic sclerosis. Arthritis Rheum., 2007-07-01;56(7):2432-42. 2007-07-01 [PMID: 17599773] (Bioassay, Human)	Bioassay	Human
Riccioni R, Diverio D, Mariani G, Buffolino S, Riti V, Saulle E, Petrucci E, Cedrone M, Lo-Coco F, Foa R, Peschle C, Testa U Expression of Tie-2 and other receptors for endothelial growth factors in acute myeloid leukemias is associated with monocytic features of leukemic blasts. Stem Cells, 2007-04-19;25(8):1862-71. 2007-04-19 [PMID: 17446561] (Bioassay, Human)	Bioassay	Human
Srivastava AS, Nedelcu E, Esmaeli-Azad B, Mishra R, Carrier E Thrombopoietin enhances generation of CD34+ cells from human embryonic stem cells. Stem Cells, 2007-03-22;25(6):1456-61. 2007-03-22 [PMID: 17379761] (Bioassay, Human)	Bioassay	Human
Dentelli P, Rosso A, Balsamo A, Colmenares Benedetto S, Zeoli A, Pegoraro M, Camussi G, Pegoraro L, Brizzi MF C-KIT, by interacting with the membrane-bound ligand, recruits endothelial progenitor cells to inflamed endothelium. Blood, 2007-02-08;109(10):4264-71. 2007-02-08 [PMID: 17289809] (Bioassay, Human)	Bioassay	Human
Hiroyama T, Miharada K, Aoki N, Fujioka T, Sudo K, Danjo I, Nagasawa T, Nakamura Y Long-lasting in vitro hematopoiesis derived from primate embryonic stem cells. Exp. Hematol., 2006-06-01;34(6):760-9. 2006-06-01 [PMID: 16728281] (Bioassay, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))	Bioassay	Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
Yu H, Fang D, Kumar SM, Li L, Nguyen TK, Acs G, Herlyn M, Xu X Isolation of a novel population of multipotent adult stem cells from human hair follicles. Am. J. Pathol., 2006-06-01;168(6):1879-88. 2006-06-01 [PMID: 16723703] (Bioassay, Human)	Bioassay	Human
Kahl CA, Tarantal AF, Lee CI, Jimenez DF, Choi C, Pepper K, Petersen D, Fletcher MD, Leapley AC, Fisher J, Burns TS, Ultsch MN, Dorey FJ, Kohn DB Effects of busulfan dose escalation on engraftment of infant rhesus monkey hematopoietic stem cells after gene marking by a lentiviral vector. Exp. Hematol., 2006-03-01;34(3):369-81. 2006-03-01 [PMID: 16543071] (Bioassay, Primate - Macaca mulatta (Rhesus Macaque))	Bioassay	Primate - Macaca mulatta (Rhesus Macaque)
Gemelli C, Montanari M, Tenedini E, Zanocco Marani T, Vignudelli T, Siena M, Zini R, Salati S, Tagliafico E, Manfredini R, Grande A, Ferrari S Virally mediated MafB transduction induces the monocyte commitment of human CD34+ hematopoietic stem/progenitor cells. Cell Death Differ., 2006-02-03;13(10):1686-96. 2006-02-03 [PMID: 16456583] (Bioassay, Human)	Bioassay	Human
Hsieh FH, Sharma P, Gibbons A, Goggans T, Erzurum SC, Haque SJ Human airway epithelial cell determinants of survival and functional phenotype for primary human mast cells. Proc. Natl. Acad. Sci. U.S.A., 2005-09-26;102(40):14380-5. 2005-09-26 [PMID: 16186496] (Bioassay, Human)	Bioassay	Human
Hanley MB, Napolitano LA, McCune JM Growth hormone-induced stimulation of multilineage human hematopoiesis. Stem Cells, 2005-06-13;23(8):1170-9. 2005-06-13 [PMID: 15955828] (Bioassay, Human)	Bioassay	Human
Femenia F, Arock M, Leriche L, Delouis C, Millet G, Ben Hamouda N, Cote M, Alliot A, Lilin T, Pinton A, Iannucceli N, Parodi AL, Boireau P Establishment and characterization of continuous hematopoietic progenitors-derived pig normal mast cell lines. Life Sci., 2005-07-01;77(7):808-23. 2005-07-01 [PMID: 15896811] (Bioassay, Porcine)	Bioassay	Porcine
Wang J, Roy SK Growth differentiation factor-9 and stem cell factor promote primordial follicle formation in the hamster: modulation by follicle-stimulating hormone. Biol. Reprod., 2003-10-29;70(3):577-85. 2003-10-29 [PMID: 14585807] (Bioassay, Hamster)	Bioassay	Hamster
Manz MG, 107325, Miyamoto T, Akashi K, Weissman IL Prospective isolation of human clonogenic common myeloid progenitors. Ultra-Sensitive and Semi-Quantitative Vertical Flow Assay for the Rapid Detection of Interleukin-6 in Inflammatory Diseases, 2002-08-22;99(18):11872-7. 2002-08-22 [PMID: 12193648] (Bioassay, Human)	Bioassay	Human
Da Silva CA, 2019, Kassel O, Mathieu E, Massard G, Gasser B, Frossard N Inhibition by glucocorticoids of the interleukin-1beta-enhanced expression of the mast cell growth factor SCF. 2002-04-01;135(7):1634-40. 2002-04-01 [PMID: 11934803] (ELISA (Standard))	ELISA (Standard)
Shih CC, Hu MC, Hu J A secreted and LIF-mediated stromal cell-derived activity that promotes ex vivo expansion of human hematopoietic stem cells. Blood, 2000-03-15;95(6):1957-66. 2000-03-15 [PMID: 10706861] (Bioassay, Human)	Bioassay	Human
Gomez-Navarro J, ¯&h~²@á, Contreras JL, Arafat W, Jiang XL, Krisky D, Oligino T, Marconi P, Hubbard B, Glorioso JC, Curiel DT, Thomas JM Genetically modified CD34+ cells as cellular vehicles for gene delivery into areas of angiogenesis in a rhesus model. 2000-01-01;7(1):43-52. 2000-01-01 [PMID: 10680015] (Bioassay, Primate - Macaca mulatta (Rhesus Macaque))	Bioassay	Primate - Macaca mulatta (Rhesus Macaque)
Drouet M, 49153, Mathieu J, Grenier N, Multon E, Sotto JJ, Herodin F The reduction of in vitro radiation-induced Fas-related apoptosis in CD34+ progenitor cells by SCF, FLT-3 ligand, TPO, and IL-3 in combination resulted in CD34+ cell proliferation and differentiation. Circulating NOD1 Activators and Hematopoietic NOD1 Contribute to Metabolic Inflammation and Insulin Resistance, 1999-01-01;17(5):273-85. 1999-01-01 [PMID: 10527462] (Bioassay, Primate - Papio anubis (Olive Baboon))	Bioassay	Primate - Papio anubis (Olive Baboon)
Barcena A, Park SW, Banapour B, Muench MO, Mechetner E Expression of Fas/CD95 and Bcl-2 by primitive hematopoietic progenitors freshly isolated from human fetal liver. Blood, 1996-09-15;88(6):2013-25. 1996-09-15 [PMID: 8822920] (Bioassay, Human)	Bioassay	Human
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Array 255-SC/CF

• SCF/c-kit Ligand Antibodies
• SCF/c-kit Ligand ELISA Kits
• SCF/c-kit Ligand Lysate
• SCF/c-kit Ligand Proteins
• SCF/c-kit Ligand Proteins and Enzymes
• SCF/c-kit Ligand ELISAs