Recombinant Human PDGF-BB Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Platelet-derived growth factor (PDGF) was discovered as a major mitogenic factor present in serum but absent from plasma. It was found to be secreted from the alpha ‑granules of platelets activated during the coagulation of blood to form serum. Subsequent studies have demonstrated that PDGF is not one molecule but three, each a dimeric combination of two distinct but structurally related peptide chains designated A and B. The dimeric isoforms PDGF-AA, AB and BB are differentially expressed in various cell types and their effects are mediated through two distinct receptors, termed alpha and beta . Differences exist in isoform binding to each receptor. In general, PDGF isoforms are potent mitogens for connective tissue cells, including dermal fibroblasts, glial cells, arterial smooth muscle cells and some epithelial and endothelial cells. In addition to its activity as a mitogen, PDGF is chemotactic for fibroblasts, smooth muscle cells, neutrophils and mononuclear cells. Other reported activities for PDGF include stimulation of granule release by neutrophils and monocytes, facilitation of steroid synthesis by Leydig cells, stimulation of neutrophil phagocytosis, inhibition of natural killer (NK) cell activity, stimulation of collagen synthesis, modulation of thrombospondin expression and secretion, stimulation of collagenase activity and secretion, induction of contraction of rat aorta strips in vitro, and transient induction of T cell IL-2 secretion accompanied by a down-regulation of IL-4 and IFN-gamma production, temporary effects that may allow clonal expansion of antigen-activated B and T helper lymphocytes prior to differentiation. PDGF also appears to be ubiquitous in neurons throughout the CNS, where it is suggested to play an important role in neuron survival and regeneration, and in mediation of glial cell proliferation and differentiation.

We have publications tested in 11 confirmed species: Human, Mouse, Rat, Avian, Canine, N/A, Porcine, Primate - Chlorocebus aethiops (African Green Monkey), Primate - Chlorocebus pygerythrus (Vervet Monkey), Rabbit, Transgenic Mouse.

We have publications tested in 8 applications: Binding Assay, Bioassay, Cell Culture, ELISA (Standard), ELISA Standard, In Vivo, Migration Bioassay, Surface Plasmon Resonance.

Showing Publications 1 - 10 of 174. Show All 174 Publications. Collapse Publications.

Publications using 220-BB	Applications	Species
Xiao, W;Shrimali, N;Oldham, WM;Clish, CB;He, H;Wong, SJ;Wertheim, BM;Arons, E;Haigis, MC;Leopold, JA;Loscalzo, J; Branched chain ?-ketoacids aerobically activate HIF1? signaling in vascular cells bioRxiv : the preprint server for biology 2024-05-30 [PMID: 38853866] (Bioassay, Human)	Bioassay	Human
Guo, T;Pei, F;Zhang, M;Yamada, T;Feng, J;Jing, J;Ho, TV;Chai, Y; Vascular architecture regulates mesenchymal stromal cell heterogeneity via P53-PDGF signaling in the mouse incisor Cell stem cell 2024-04-30 [PMID: 38703771] (Bioassay, Transgenic Mouse)	Bioassay	Transgenic Mouse
Okada, A;Shimizu, K;Kawashima, A;Kayahara, T;Itani, M;Kurita, H;Miyamoto, S;Kataoka, H;Aoki, T; C5a-C5AR1 axis as a potential trigger of the rupture of intracranial aneurysms Scientific reports 2024-02-07 [PMID: 38326494] (Bioassay, Mouse)	Bioassay	Mouse
Voisin, T;Joannes, A;Morzadec, C;Lagadic-Gossmann, D;Naoures, CL;De Latour, BR;Rouze, S;Jouneau, S;Vernhet, L; Antifibrotic effects of vitamin D3 on human lung fibroblasts derived from patients with idiopathic pulmonary fibrosis The Journal of nutritional biochemistry 2024-01-05 [PMID: 38185349] (Bioassay, Human)	Bioassay	Human
Otsuka, T;Kan, HM;Mengsteab, PY;Tyson, B;Laurencin, CT; Fibroblast growth factor 8b (FGF-8b) enhances myogenesis and inhibits adipogenesis in rotator cuff muscle cell populations in vitro Proceedings of the National Academy of Sciences of the United States of America 2024-01-02 [PMID: 38147545] (Bioassay, Rat)	Bioassay	Rat
Xu, Y;Zhang, H;Pober, J;Min, W;Zhou, H; SRF SUMOylation modulates smooth muscle phenotypic switch and vascular remodeling Research square 2023-05-22 [PMID: 37292911] (Bioassay, Mouse)	Bioassay	Mouse
Li, X;Quan, H;He, J;Li, H;Zhu, Q;Wang, Y;Zhu, Y;Ge, RS; The role of platelet-derived growth factor BB signaling pathway in the regulation of stem and progenitor Leydig cell proliferation and steroidogenesis in male rats The Journal of steroid biochemistry and molecular biology 2023-06-05 [PMID: 37286111] (Bioassay, Rat)	Bioassay	Rat
HM Yang, JE Lee, JY Kim, J You, J Kim, HS Lee, HM Yoo, MG Kong, JK Han, HJ Cho, KW Park, HJ Kang, BK Koo, YB Park, HS Kim Identification of cell-biologic mechanisms of coronary artery spasm and its ex vivo diagnosis using peripheral blood-derived iPSCs Biomaterials research, 2023-02-18;27(1):16. 2023-02-18 [PMID: 36803875] (Bioassay, Human)	Bioassay	Human
S Wenhua, T Tsunematsu, M Umeda, H Tawara, N Fujiwara, Y Mouri, R Arakaki, N Ishimaru, Y Kudo Cancer cell-derived novel periostin isoform promotes invasion in head and neck squamous cell carcinoma Cancer Medicine, 2023-01-23;0(0):. 2023-01-23 [PMID: 36691359] (Bioassay, Human)	Bioassay	Human
X Cai, Y Mao, X Shen, H Li, J He, M Zhang The extract from Hyssopus cuspidatus Boriss. Prevents bronchial airway remodeling by inhibiting mouse bronchial wall thickening and hASMC proliferation and migration Journal of ethnopharmacology, 2022-12-14;0(0):116047. 2022-12-14 [PMID: 36528211] (Bioassay, Human)	Bioassay	Human
AA Widjaja, S Viswanatha, SG Shekeran, E Adami, WW Lim, S Chothani, J Tan, JWT Goh, HM Chen, SY Lim, CM Boustany-K, J Hawkins, E Petretto, N Hübner, S Schafer, TM Coffman, SA Cook Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease Nature Communications, 2022-12-05;13(1):7497. 2022-12-05 [PMID: 36470928] (Bioassay, Human)	Bioassay	Human
A Dos Santos, N Lyu, A Balayan, R Knight, KS Zhuo, Y Sun, J Xu, ML Funderburg, JL Funderburg, SX Deng Generation of Functional Immortalized Human Corneal Stromal Stem Cells International Journal of Molecular Sciences, 2022-11-02;23(21):. 2022-11-02 [PMID: 36362184] (Bioassay, Human)	Bioassay	Human
S Gc, K Tuy, L Rickenback, R Jones, A Chakrabort, CR Miller, EA Beierle, VS Hanumanthu, AN Tran, JA Mobley, SL Bellis, AB Hjelmeland alpha2,6 Sialylation mediated by ST6GAL1 promotes glioblastoma growth JCI Insight, 2022-11-08;7(21):. 2022-11-08 [PMID: 36345944] (Bioassay, Human)	Bioassay	Human
W He, X Zhu, A Xin, H Zhang, Y Sun, H Xu, H Li, T Yang, D Zhou, H Yan, X Sun Long-term maintenance of human endometrial epithelial stem cells and their therapeutic effects on intrauterine adhesion Cell & bioscience, 2022-10-18;12(1):175. 2022-10-18 [PMID: 36258228] (Bioassay, Human)	Bioassay	Human
M Tobiume, A Mitsuhashi, A Saijo, H Ogino, T Afroj, H Ogawa, H Goto, S Sato, A Abe, K Haji, R Ozaki, H Takizawa, Y Nishioka Analysis of the chemotactic factors for tumor-infiltrating fibrocytes and their prognostic significances in lung cancer Oncology Letters, 2022-09-30;24(5):417. 2022-09-30 [PMID: 36245829] (Bioassay, Human)	Bioassay	Human
A Filliol, Y Saito, A Nair, DH Dapito, LX Yu, A Ravichandr, S Bhattachar, S Affo, N Fujiwara, H Su, Q Sun, TM Savage, JR Wilson-Kan, JM Caviglia, L Chin, D Chen, X Wang, S Caruso, JK Kang, AD Amin, S Wallace, R Dobie, D Yin, OM Rodriguez-, C Yin, A Mehal, B Izar, RA Friedman, RG Wells, UB Pajvani, Y Hoshida, HE Remotti, N Arpaia, J Zucman-Ros, M Karin, NC Henderson, I Tabas, RF Schwabe Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis Nature, 2022-10-05;0(0):. 2022-10-05 [PMID: 36198802] (Bioassay, Human)	Bioassay	Human
R Chandrasek, C Mathieu, R Sheth, AP Cheng, D Fong, R McCormack, H El-Gabalaw, S Alishetty, M Paige, CD Hoemann UDP-glucose dehydrogenase (UGDH) activity is suppressed by peroxide and promoted by PDGF in fibroblast-like synoviocytes: Evidence of a redox control mechanism PLoS ONE, 2022-09-15;17(9):e0274420. 2022-09-15 [PMID: 36107941] (Bioassay, Human)	Bioassay	Human
G Ishikawa, C Kwon, Y Fujii Peficitinib inhibits fibroblast-like synoviocyte activation and angiogenic vascular endothelial tube formation via inhibitory effects on PDGF and VEGF signaling in addition to JAK Journal of pharmacological sciences, 2022-07-31;150(2):74-80. 2022-07-31 [PMID: 36055754] (Bioassay, Human)	Bioassay	Human
A Radwanska, CT Cottage, A Piras, C Overed-Say, C Sihlbom, R Budida, C Wrench, J Connor, S Monkley, P Hazon, H Schluter, MJ Thomas, CM Hogaboam, LA Murray Increased expression and accumulation of GDF15 in IPF extracellular matrix contribute to fibrosis JCI Insight, 2022-08-22;7(16):. 2022-08-22 [PMID: 35993367] (Migration Bioassay, Mouse)	Migration Bioassay	Mouse
F Das, N Ghosh-Chou, S Maity, BS Kasinath, GG Choudhury Oncoprotein DJ-1 interacts with mTOR complexes to effect transcription factor Hif1alpha-dependent expression of collagen I (alpha2) during renal fibrosis The Journal of Biological Chemistry, 2022-07-11;0(0):102246. 2022-07-11 [PMID: 35835217] (Bioassay, Human)	Bioassay	Human
SF Mause, E Ritzel, A Deck, F Vogt, EA Liehn Engagement of the CXCL12-CXCR4 Axis in the Interaction of Endothelial Progenitor Cell and Smooth Muscle Cell to Promote Phenotype Control and Guard Vascular Homeostasis International Journal of Molecular Sciences, 2022-01-14;23(2):. 2022-01-14 [PMID: 35055054] (Bioassay, Human)	Bioassay	Human
MC Beer, H Kuhrt, L Kohen, P Wiedemann, A Bringmann, M Hollborn Kir4.2 Potassium Channels in Retinal Pigment Epithelial Cells In Vitro: Contribution to Cell Viability and Proliferation, and Down-Regulation by Vascular Endothelial Growth Factor Biomolecules, 2022-06-18;12(6):. 2022-06-18 [PMID: 35740973] (Bioassay, Human)	Bioassay	Human
I Nanda, C Steinlein, T Haaf, EM Buhl, DG Grimm, SL Friedman, SK Meurer, SK Schröder, R Weiskirche Genetic Characterization of Rat Hepatic Stellate Cell Line HSC-T6 for In Vitro Cell Line Authentication Cells, 2022-05-29;11(11):. 2022-05-29 [PMID: 35681478] (Bioassay, Rat)	Bioassay	Rat
R Boi, K Ebefors, M Henricsson, J Borén, J Nyström Modified lipid metabolism and cytosolic phospholipase A2 activation in mesangial cells under pro-inflammatory conditions Scientific Reports, 2022-05-05;12(1):7322. 2022-05-05 [PMID: 35513427] (Cell Culture, Human)	Cell Culture	Human
X Zhou, J Liu, Y Zheng, Z Zhang, Y Wu, W Yang, J Liu, Y Huang, Y Yi, Z Zhao, H Xiao, X Mo, J Wang SM22alpha-lineage niche cells regulate intramembranous bone regeneration via PDGFRbeta-triggered hydrogen sulfide production Cell Reports, 2022-05-03;39(5):110750. 2022-05-03 [PMID: 35508129] (Bioassay, Human)	Bioassay	Human
Salokas K, Liu X, Ohman T, Chowdhury I, Gawriyski L, Keskitalo S, Varjosalo M Physical and functional interactome atlas of human receptor tyrosine kinases. EMBO Rep, 2022-04-05;23(6):e54041. 2022-04-05 [PMID: 35384245] (Bioassay, Human)	Bioassay	Human
Kim E, Cha Y, Jeong S, Chang Y Overexpression of CEACAM6 activates Src-FAK signaling and inhibits anoikis, through homophilic interactions in lung adenocarcinomas. Transl Oncol, 2022-03-28;20(0):101402. 2022-03-28 [PMID: 35358791] (Bioassay, Human)	Bioassay	Human
A Joannes, C Morzadec, M Duclos, FL Gutierrez, DC Chiforeanu, C Le Naoures, B De Latour, S Rouzé, L Wollin, S Jouneau, L Vernhet Arsenic trioxide inhibits the functions of lung fibroblasts derived from patients with idiopathic pulmonary fibrosis Toxicology and Applied Pharmacology, 2022-03-09;441(0):115972. 2022-03-09 [PMID: 35276128] (Cell Culture, Human)	Cell Culture	Human
M Culenova, A Nicodemou, ZV Novakova, M Debreova, V Smolinská, S Bernatova, D Ivanisova, O Novotna, J Vasicek, I Varga, S Ziaran, L Danisovic Isolation, Culture and Comprehensive Characterization of Biological Properties of Human Urine-Derived Stem Cells International Journal of Molecular Sciences, 2021-11-19;22(22):. 2021-11-19 [PMID: 34830384] (Bioassay, Human)	Bioassay	Human
Y Li, J Shao, J Song, S Yu, J Wang, K Sun MiR-34a-3p suppresses pulmonary vascular proliferation in acute pulmonary embolism rat by targeting DUSP1 Bioscience Reports, 2022-01-28;0(0):. 2022-01-28 [PMID: 34778900] (Bioassay, Human)	Bioassay	Human
S Looprasert, A Sereemaspu, N Kitkumthor, K Sooklert, T Sarachana, D Jindatip Gold Nanoparticles Affect Pericyte Biology and Capillary Tube Formation Pharmaceutics, 2021-05-17;13(5):. 2021-05-17 [PMID: 34067883] (Bioassay, Human)	Bioassay	Human
YJ Liao, YH Wang, CY Wu, FY Hsu, CY Chien, YC Lee Ketogenic Diet Enhances the Cholesterol Accumulation in Liver and Augments the Severity of CCl4 and TAA-Induced Liver Fibrosis in Mice International Journal of Molecular Sciences, 2021-03-13;22(6):. 2021-03-13 [PMID: 33805788] (Bioassay, Human)	Bioassay	Human
S Yang, H Li, H Yao, Y Zhang, H Bao, L Wu, C Zhang, M Li, L Feng, J Zhang, Z Zheng, G Xu, F Wang Long noncoding RNA ERLR mediates epithelial-mesenchymal transition of retinal pigment epithelial cells and promotes experimental proliferative vitreoretinopathy Cell Death and Differentiation, 2021-03-04;0(0):. 2021-03-04 [PMID: 33664479] (Bioassay, Rabbit)	Bioassay	Rabbit
R Beckmann, K Jensen, S Fenn, J Speck, K Krause, A Meier, M Röth, S Fauser, R Kimbung, DT Logan, M Steegmaier, H Kettenberg DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously Nature Communications, 2021-01-29;12(1):708. 2021-01-29 [PMID: 33514724] (ELISA Standard, Human)	ELISA Standard	Human
T Otsuka, PY Mengsteab, CT Laurencin Control of mesenchymal cell fate via application of FGF-8b in vitro Stem Cell Research, 2021-01-07;51(0):102155. 2021-01-07 [PMID: 33445073] (Bioassay, Rat)	Bioassay	Rat
Z Al-Bakri, M Ishige-Wad, N Fukuda, C Yoshida-No, N Nagoshi, H Okano, H Mugishima, T Matsumoto Isolation and characterization of neural crest-like progenitor cells in human umbilical cord blood Regenerative Therapy, 2020-07-18;15(0):53-63. 2020-07-18 [PMID: 33426202] (Bioassay, Human)	Bioassay	Human
L Fang, M Roth, C Teck S'ng, M Tamm, B Han, BX Hoang Zinc salicylate reduces airway smooth muscle cells remodelling by blocking mTOR and activating p21(Waf1/Cip1) The Journal of nutritional biochemistry, 2020-12-14;0(0):108563. 2020-12-14 [PMID: 33326841] (Bioassay, Human)	Bioassay	Human
Y Yamamoto, A Mukai, T Ikushima, Y Urata, S Kinoshita, J Hamuro, M Ueno, C Sotozono Pluripotent epigenetic regulator OBP-801 maintains filtering blebs in glaucoma filtration surgery model Scientific Reports, 2020-12-01;10(1):20936. 2020-12-01 [PMID: 33262357] (Cell Culture, Human)	Cell Culture	Human
L Song, Z Liu, HH Hu, Y Yang, TY Li, ZZ Lin, J Ye, J Chen, X Huang, DT Liu, J Zhou, Y Shi, H Zhao, C Xie, L Chen, E Song, SY Lin, SC Lin Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy Nat Commun, 2020-11-17;11(1):5842. 2020-11-17 [PMID: 33203880] (Cell Culture, Human)	Cell Culture	Human
YY Liang, XB Deng, XT Lin, LL Jiang, XT Huang, ZW Mo, YW Yuan, MT Teh RASSF1A inhibits PDGFB-driven malignant phenotypes of nasopharyngeal carcinoma cells in a YAP1-dependent manner Cell Death Dis, 2020-10-14;11(10):855. 2020-10-14 [PMID: 33057010] (Bioassay, Human)	Bioassay	Human
K Song, Y Qing, Q Guo, EK Peden, C Chen, WE Mitch, L Truong, J Cheng PDGFRA in vascular adventitial MSCs promotes neointima formation in arteriovenous fistula in chronic kidney disease JCI Insight, 2020-11-05;0(0):. 2020-11-05 [PMID: 33001865] (Bioassay, Mouse)	Bioassay	Mouse
SK Meurer, O Tezcan, T Lammers, R Weiskirche Differential regulation of Lipocalin 2 (LCN2) in doxorubicin-resistant 4T1 triple negative breast cancer cells Cell. Signal., 2020-08-03;74(0):109731. 2020-08-03 [PMID: 32758668] (Bioassay, Human)	Bioassay	Human
S Maity, F Das, BS Kasinath, N Ghosh-Chou, G Ghosh Chou TGFb acts through PDGFRb to activate mTORC1 via the Akt/PRAS40 axis and causes glomerular mesangial cell hypertrophy and matrix protein expression J. Biol. Chem., 2020-07-30;0(0):. 2020-07-30 [PMID: 32732288] (Bioassay, Human)	Bioassay	Human
X Li, S Shao, H Li, Z Bi, S Zhang, Y Wei, J Bai, R Zhang, X Ma, B Ma, L Zhang, C Xie, W Ning, H Zhou, C Yang Byakangelicin protects against carbon tetrachloride-induced liver injury and fibrosis in mice J. Cell. Mol. Med., 2020-07-09;0(0):. 2020-07-09 [PMID: 32643868] (Cell Culture, Human)	Cell Culture	Human
K Wei, I Korsunsky, JL Marshall, A Gao, GFM Watts, T Major, AP Croft, J Watts, PE Blazar, JK Lange, TS Thornhill, A Filer, K Raza, LT Donlin, CW Siebel, CD Buckley, S Raychaudhu, MB Brenner Notch signalling drives synovial fibroblast identity and arthritis pathology Nature, 2020-04-22;582(7811):259-264. 2020-04-22 [PMID: 32499639] (Bioassay, Human)	Bioassay	Human
M Oka, S Shimo, N Ohno, H Imai, Y Abekura, H Koseki, H Miyata, K Shimizu, M Kushamae, I Ono, K Nozaki, A Kawashima, T Kawamata, T Aoki Dedifferentiation of smooth muscle cells in intracranial aneurysms and its potential contribution to the pathogenesis Sci Rep, 2020-05-20;10(1):8330. 2020-05-20 [PMID: 32433495] (Bioassay, Human)	Bioassay	Human
M Aliabouzar, A Jivani, X Lu, OD Kripfgans, JB Fowlkes, ML Fabiilli Standing wave-assisted acoustic droplet vaporization for single and dual payload release in acoustically-responsive scaffolds Ultrason Sonochem, 2020-03-26;66(0):105109. 2020-03-26 [PMID: 32248042] (Bioassay, N/A)	Bioassay	N/A
B Wang, M Zhang, G Urabe, Y Huang, G Chen, D Wheeler, DJ Dornbos, A Huttinger, SM Nimjee, S Gong, LW Guo, KC Kent PERK Inhibition Mitigates Restenosis and�Thrombosis: A Potential Low-Thrombogenic Antirestenotic Paradigm JACC Basic Transl Sci, 2020-02-19;5(3):245-263. 2020-02-19 [PMID: 32215348] (Cell Culture, Human)	Cell Culture	Human
J Heo, HC Yang, WJ Rhee, H Kang Vascular Smooth Muscle Cell-Derived Exosomal MicroRNAs Regulate Endothelial Cell Migration Under PDGF Stimulation Cells, 2020-03-06;9(3):. 2020-03-06 [PMID: 32155804] (Cell Culture, Human)	Cell Culture	Human
W Chen, J Lin, B Li, S Cao, H Li, J Zhao, K Liu, Y Li, Y Li, S Sun Screening and functional prediction of differentially expressed circRNAs in proliferative human aortic smooth muscle cells J. Cell. Mol. Med., 2020-03-10;0(0):. 2020-03-10 [PMID: 32155686] (Cell Culture, Human)	Cell Culture	Human
NA Agabalyan, HD Sparks, S Tarraf, NL Rosin, K Anker, G Yoon, LN Burnett, D Nickerson, ES Di Martino, VA Gabriel, J Biernaskie Adult Human Dermal Progenitor Cell Transplantation Modulates the Functional Outcome of Split-Thickness Skin Xenografts Stem Cell Reports, 2019-11-14;13(6):1068-1082. 2019-11-14 [PMID: 31735655] (Cell Culture, Human)	Cell Culture	Human
K Wang, J Yu, B Wang, H Wang, Z Shi, G Li miR-29a Regulates the Proliferation and Migration of Human Arterial Smooth Muscle Cells in Arteriosclerosis Obliterans of the Lower Extremities Kidney Blood Press. Res., 2019-10-15;44(5):1219-1232. 2019-10-15 [PMID: 31614351] (Bioassay, Human)	Bioassay	Human
TN Vu, X Chen, HD Foda, GC Smaldone, NA Hasaneen Interferon-γ enhances the antifibrotic effects of pirfenidone by attenuating IPF lung fibroblast activation and differentiation Respir. Res., 2019-09-11;20(1):206. 2019-09-11 [PMID: 31511015] (Bioassay, Human)	Bioassay	Human
L Messerschm, S Fischer, P Wiedemann, A Bringmann, M Hollborn Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation Mol. Vis., 2019-06-30;25(0):329-344. 2019-06-30 [PMID: 31341381] (Bioassay, Human)	Bioassay	Human
P Luan, W Jian, X Xu, W Kou, Q Yu, H Hu, D Li, W Wang, MW Feinberg, J Zhuang, Y Xu, W Peng NLRC5 inhibits neointima formation following vascular injury and directly interacts with PPARgamma Nat Commun, 2019-06-28;10(1):2882. 2019-06-28 [PMID: 31253783] (Bioassay, Human)	Bioassay	Human
H Gan, J Wu, H Ju Proximity hybridization-induced on particle DNA walker for ultrasensitive protein detection Anal. Chim. Acta, 2019-05-08;1074(0):142-149. 2019-05-08 [PMID: 31159934] (Bioassay, N/A)	Bioassay	N/A
T Muraguchi, D Nanba, EK Nishimura, T Tashiro IGF-1R deficiency in human keratinocytes disrupts epidermal homeostasis and stem cell maintenance J. Dermatol. Sci., 2019-05-11;0(0):. 2019-05-11 [PMID: 31122679] (Bioassay, Human)	Bioassay	Human
T Emi, K Michaud, E Orton, G Santilli, C Linh, M O'Connell, F Issa, S Kennedy Ultrasonic Generation of Pulsatile and Sequential Therapeutic Delivery Profiles from Calcium-Crosslinked Alginate Hydrogels Molecules, 2019-03-16;24(6):. 2019-03-16 [PMID: 30884862] (Bioassay)	Bioassay
T Colunga, M Hayworth, S Kre beta , DM Reynolds, L Chen, KL Nazor, J Baur, AM Singh, JF Loring, M Metzger, S Dalton Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair Cell Rep, 2019-03-05;26(10):2566-2579.e10. 2019-03-05 [PMID: 30840882] (Bioassay, Human)	Bioassay	Human
MFM Gerli, LA Moyle, S Benedetti, G Ferrari, E Ucuncu, M Ragazzi, C Constantin, I Louca, H Sakai, P Ala, P De Coppi, S Tajbakhsh, G Cossu, FS Tedesco Combined Notch and PDGF Signaling Enhances Migration and Expression of Stem Cell Markers while Inducing Perivascular Cell Features in Muscle Satellite Cells Stem Cell Reports, 2019-02-07;0(0):. 2019-02-07 [PMID: 30745033] (Bioassay, Human)	Bioassay	Human
Y Higashi, S Mummidi, S Sukhanov, T Yoshida, M Noda, P Delafontai, B Chandrasek Minocycline inhibits PDGF-BB-induced human aortic smooth muscle cell proliferation and migration by reversing miR-221- and -222-mediated RECK suppression Cell. Signal., 2019-02-01;57(0):20-Oct. 2019-02-01 [PMID: 30716386] (Bioassay, Human)	Bioassay	Human
SI Motegi, C Fujiwara, A Sekiguchi, S Yamazaki, Y Yokoyama, M Yasuda, O Ishikawa Possible contribution of PDGF-BB-induced autophagy in dermatofibrosarcoma protuberans: Autophagy marker Atg5 could be a differential marker between dermatofibrosarcoma protuberans and dermatofibroma J. Dermatol. Sci., 2019-01-16;0(0):. 2019-01-16 [PMID: 30704939] (Bioassay, Human)	Bioassay	Human
H Li, J Zhao, B Liu, J Luo, Z Li, X Qin, Y Wei MicroRNA-320 targeting neuropilin 1 inhibits proliferation and migration of vascular smooth muscle cells and neointimal formation Int J Med Sci, 2019-01-01;16(1):106-114. 2019-01-01 [PMID: 30662334] (Bioassay, Human)	Bioassay	Human
Y Kano, T Gebregiwor, CB Marshall, N Radulovich, BPK Poon, J St-Germain, JD Cook, I Valencia-S, BMM Grant, SG Herrera, J Miao, B Raught, MS Irwin, JE Lee, JJ Yeh, ZY Zhang, MS Tsao, M Ikura, M Ohh Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation Nat Commun, 2019-01-15;10(1):224. 2019-01-15 [PMID: 30644389] (Bioassay, Mouse)	Bioassay	Mouse
M Zhang, G Urabe, C Little, B Wang, AM Kent, Y Huang, KC Kent, LW Guo HDAC6 Regulates the MRTF-A/SRF Axis and Vascular Smooth Muscle Cell Plasticity JACC Basic Transl Sci, 2018-12-31;3(6):782-795. 2018-12-31 [PMID: 30623138] (Bioassay, Mouse)	Bioassay	Mouse
C Lambers, C Kornauth, F Oberndorfe, PM Boehm, M Tamm, W Klepetko, M Roth Mechanism of anti-remodelling action of treprostinil in human pulmonary arterial smooth muscle cells PLoS ONE, 2018-11-01;13(11):e0205195. 2018-11-01 [PMID: 30383775] (Bioassay, Human)	Bioassay	Human
L Delsing, P Dönnes, J Sánchez, M Clausen, D Voulgaris, A Falk, A Herland, G Brolén, H Zetterberg, R Hicks, J Synnergren Barrier properties and transcriptome expression in human iPSC-derived models of the blood-brain barrier Stem Cells, 2018-11-05;0(0):. 2018-11-05 [PMID: 30171748] (Bioassay, Human)	Bioassay	Human
A Dubrac, SE Künzel, SH Künzel, J Li, RR Chandran, K Martin, DM Greif, RH Adams, A Eichmann NCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy Nat Commun, 2018-08-27;9(1):3463. 2018-08-27 [PMID: 30150707] (Cell Culture, Human)	Cell Culture	Human
ACY Chang, ACH Chang, A Kirillova, K Sasagawa, W Su, G Weber, J Lin, V Termglinch, I Karakikes, T Seeger, AM Dainis, JT Hinson, J Seidman, CE Seidman, JW Day, E Ashley, JC Wu, HM Blau Telomere shortening is a hallmark of genetic cardiomyopathies Proc. Natl. Acad. Sci. U.S.A., 2018-08-27;0(0):. 2018-08-27 [PMID: 30150400] (Bioassay, Human)	Bioassay	Human
R Sambathkum, R Akkerman, S Dastidar, P Roelandt, M Kumar, M Bajaj, AR Mestre Ros, N Helsen, V Vanslembro, E Kalo, S Khurana, J Laureys, C Gysemans, MM Faas, P de Vos, CM Verfaillie Generation of hepatocyte- and endocrine pancreatic-like cells from human induced endodermal progenitor cells PLoS ONE, 2018-05-11;13(5):e0197046. 2018-05-11 [PMID: 29750821] (Bioassay, Human)	Bioassay	Human
LR Penke, JM Speth, VL Dommeti, ES White, IL Bergin, M Peters-Gol FOXM1 is a critical driver of lung fibroblast activation and fibrogenesis J. Clin. Invest., 2018-05-07;0(0):. 2018-05-07 [PMID: 29733296] (Bioassay, Human)	Bioassay	Human
Y Zhang, D Zhao, S Yang, H Yao, M Li, C Zhao, J Zhang, GT Xu, H Li, F Wang Protective Effects of Fucoidan on Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells and Progression of Proliferative Vitreoretinopathy Cell. Physiol. Biochem., 2018-04-23;46(4):1704-1715. 2018-04-23 [PMID: 29698960] (In Vivo, Rabbit)	In Vivo	Rabbit
B Bergström, H Carlsten, AH Ekwall Methotrexate inhibits effects of platelet-derived growth factor and interleukin-1? on rheumatoid arthritis fibroblast-like synoviocytes Arthritis Res. Ther., 2018-03-20;20(1):49. 2018-03-20 [PMID: 29554943] (Bioassay, Human)	Bioassay	Human
JM Dave, T Mirabella, SD Weatherbee, DM Greif Pericyte ALK5/TIMP3 Axis Contributes to Endothelial Morphogenesis in the Developing Brain Dev. Cell, 2018-02-15;0(0):. 2018-02-15 [PMID: 29456135] (Bioassay, Human)	Bioassay	Human
VC Pai, IC Lo, YW Huang, IC Tsai, HP Cheng, GY Shi, HL Wu, MJ Jiang The chondroitin sulfate moiety mediates thrombomodulin-enhanced adhesion and migration of vascular smooth muscle cells J. Biomed. Sci., 2018-02-13;25(1):14. 2018-02-13 [PMID: 29439742] (Bioassay, Human)	Bioassay	Human
L Peix, IC Evans, DR Pearce, JK Simpson, TM Maher, RJ McAnulty Diverse functions of clusterin promote and protect against the development of pulmonary fibrosis Sci Rep, 2018-01-30;8(1):1906. 2018-01-30 [PMID: 29382921] (Human)		Human
KB Sugg, JF Markworth, NP Disser, AM Rizzi, JR Talarek, DC Sarver, SV Brooks, CL Mendias Postnatal Tendon Growth and Remodeling Requires Platelet-Derived Growth Factor Receptor Signaling Am. J. Physiol., Cell Physiol., 2017-12-13;0(0):. 2017-12-13 [PMID: 29341790] (Bioassay, Mouse)	Bioassay	Mouse
SB Mamer, S Chen, JC Weddell, A Palasz, A Wittenkell, M Kumar, PI Imoukhuede Discovery of High-Affinity PDGF-VEGFR Interactions: Redefining RTK Dynamics Sci Rep, 2017-11-27;7(1):16439. 2017-11-27 [PMID: 29180757] (Surface Plasmon Resonance, Human)	Surface Plasmon Resonance	Human
H Kitano, Y Kitadai, J Teishima, R Yuge, S Shinmei, K Goto, S Inoue, T Hayashi, K Sentani, W Yasui, A Matsubara Combination therapy using molecular-targeted drugs modulates tumor microenvironment and impairs tumor growth in renal cell carcinoma Cancer Med, 2017-08-23;0(0):. 2017-08-23 [PMID: 28834289] (Bioassay, Human)	Bioassay	Human
TM Wang, KC Chen, PY Hsu, HF Lin, YS Wang, CY Chen, YC Liao, SH Juo microRNA let-7g suppresses PDGF-induced conversion of vascular smooth muscle cell into the synthetic phenotype J. Cell. Mol. Med., 2017-07-12;0(0):. 2017-07-12 [PMID: 28699690] (Bioassay, Human)	Bioassay	Human
M Dagnell, PE Pace, Q Cheng, J Frijhoff, A Östman, ESJ Arnér, MB Hampton, CC Winterbour Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H2O2 exposure J. Biol. Chem., 2017-07-06;0(0):. 2017-07-06 [PMID: 28684416] (Bioassay, Mouse)	Bioassay	Mouse
P Piñol-Jura, E Gallardo, N de Luna, X Suárez-Cal, C Sánchez-Ri, E Fernández-, C Gomis, I Illa, J Díaz-Maner Platelet-Derived Growth Factor BB Influences Muscle Regeneration in Duchenne Muscle Dystrophy Am. J. Pathol., 2017-06-12;0(0):. 2017-06-12 [PMID: 28618254] (Bioassay, Human)	Bioassay	Human
TH Su, CW Shiau, P Jao, NJ Yang, WT Tai, CJ Liu, TC Tseng, HC Yang, CH Liu, KW Huang, TC Hu, YJ Huang, YM Wu, LJ Chen, PJ Chen, DS Chen, KF Chen, JH Kao Src-homology protein tyrosine phosphatase-1 agonist, SC-43, reduces liver fibrosis Sci Rep, 2017-05-11;7(1):1728. 2017-05-11 [PMID: 28496142] (Bioassay, Mouse)	Bioassay	Mouse
R Núñez-Told, E Martínez-S, C Gil-Recio, MÁ Carrasco, A Al Madhoun, S Montori, M Atari Dental pulp pluripotent-like stem cells (DPPSC), a new stem cell population with chromosomal stability and osteogenic capacity for biomaterials evaluation BMC Cell Biol., 2017-04-21;18(1):21. 2017-04-21 [PMID: 28427322] (Bioassay, Human)	Bioassay	Human
Y Wu, A Prager, S Boos, M Resch, I Brizic, M Mach, S Wildner, L Scrivano, B Adler Human cytomegalovirus glycoprotein complex gH/gL/gO uses PDGFR-? as a key for entry PLoS Pathog., 2017-04-12;13(4):e1006281. 2017-04-12 [PMID: 28403202] (Bioassay, Human)	Bioassay	Human
S Pan, H Lin, H Luo, F Gao, L Meng, C Zhou, C Jiang, Y Guo, Z Ji, J Chi, H Guo Folic acid inhibits dedifferentiation of PDGF-BB-induced vascular smooth muscle cells by suppressing mTOR/P70S6K signaling Am J Transl Res, 2017-03-15;9(3):1307-1316. 2017-03-15 [PMID: 28386356] (Bioassay, Rat)	Bioassay	Rat
Y Liu, W Ma, B Liu, Y Wang, J Chu, G Xiong, L Shen, C Long, T Lin, D He, D Butnaru, L Alexey, Y Zhang, D Zhang, G Wei Urethral reconstruction with autologous urine-derived stem cells seeded in three-dimensional porous small intestinal submucosa in a rabbit model Stem Cell Res Ther, 2017-03-09;8(1):63. 2017-03-09 [PMID: 28279224] (Bioassay, Human)	Bioassay	Human
D Pap, E Sziksz, Z Kiss, R Rokonay, A Veres-Szék, R Lippai, IM Takács, É Kis, A Fekete, G Reusz, A Vannay, AJ Szabó Microarray Analysis Reveals Increased Expression of Matrix Metalloproteases and Cytokines of Interleukin-20 Subfamily in the Kidneys of Neonate Rats Underwent Unilateral Ureteral Obstruction: A Potential Role of IL-24 in the Regulation of Inflammation and Tissue Remodeling Kidney Blood Press. Res, 2017-02-28;42(1):16-32. 2017-02-28 [PMID: 28253513] (Bioassay, Human)	Bioassay	Human
DH Heiland, R Ferrarese, R Claus, F Dai, AP Masilamani, E Kling, A Weyerbrock, T Kling, S Nelander, MS Carro c-Jun-N-terminal phosphorylation regulates DNMT1 expression and genome wide methylation in gliomas Oncotarget, 2017-01-24;0(0):. 2017-01-24 [PMID: 28036297] (Bioassay, Human)	Bioassay	Human
Huimin Mao Zedoarondiol Inhibits Platelet-Derived Growth Factor-Induced Vascular Smooth Muscle Cells Proliferation via Regulating AMP-Activated Protein Kinase Signaling Pathway Cell. Physiol. Biochem, 2016-12-21;40(6):1506-1520. 2016-12-21 [PMID: 27997894] (Bioassay, Rat)	Bioassay	Rat
Xiaoming Wei Biological characteristics of embryonic epicardial cells in vitro correlate with embryonic day Acta Biochim. Biophys. Sin. (Shanghai), 2016-12-07;0(0):. 2016-12-07 [PMID: 27932393] (Bioassay, Mouse)	Bioassay	Mouse
Haipeng Guo Isoquercitrin protects against pulmonary hypertension via inhibiting PASMCs proliferation Clin. Exp. Pharmacol. Physiol., 2017-03-01;0(0):. 2017-03-01 [PMID: 27873355] (Bioassay, Human)	Bioassay	Human
Robert M Lavker miR-184 exhibits angiostatic properties via regulation of Akt and VEGF signaling pathways FASEB J., 2016-10-07;0(0):. 2016-10-07 [PMID: 27825105] (Bioassay, Human)	Bioassay	Human
Interferon-? blocks signalling through PDGFR? in human brain pericytes J Neuroinflammation, 2016-09-21;13(1):249. 2016-09-21 [PMID: 27654972] (Bioassay, Human)	Bioassay	Human
Pericyte-fibroblast transition promotes tumor growth and metastasis Proc Natl Acad Sci USA, 2016-09-07;113(38):E5618-E5627. 2016-09-07 [PMID: 27608497] (Bioassay, Mouse)	Bioassay	Mouse
Mesenchymal Stem Cells Reshape and Provoke Proliferation of Articular Chondrocytes by Paracrine Secretion Sci Rep, 2016-09-06;6(0):32705. 2016-09-06 [PMID: 27596239] (Bioassay, Rabbit)	Bioassay	Rabbit
Mesenchymal stem cells from cortical bone demonstrate increased clonal incidence, potency, and developmental capacity compared to their bone marrow-derived counterparts J Tissue Eng, 2016-08-16;7(0):2041731416661. 2016-08-16 [PMID: 27579159] (Bioassay, Rat)	Bioassay	Rat
Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci Nat Commun, 2016-07-08;7(0):12092. 2016-07-08 [PMID: 27386823] (Bioassay, Human)	Bioassay	Human
Platelet-Derived Growth Factor in the Ovarian Follicle Attracts the Stromal Cells of the Fallopian Tube Fimbriae PLoS ONE, 2016-07-05;11(7):e0158266. 2016-07-05 [PMID: 27379403] (Bioassay, Human)	Bioassay	Human
Bogershausen N, Tsai I, Pohl E, Kiper P, Beleggia F, Percin E, Keupp K, Matchan A, Milz E, Alanay Y, Kayserili H, Liu Y, Banka S, Kranz A, Zenker M, Wieczorek D, Elcioglu N, Prontera P, Lyonnet S, Meitinger T, Stewart A, Donnai D, Strom T, Boduroglu K, Yigit G, Li Y, Katsanis N, Wollnik B RAP1-mediated MEK/ERK pathway defects in Kabuki syndrome. J Clin Invest, 2015-08-17;125(9):3585-99. 2015-08-17 [PMID: 26280580] (Bioassay, Human)	Bioassay	Human
Amarachintha S, Sertorio M, Wilson A, Li X, Pang Q Fanconi Anemia Mesenchymal Stromal Cells-Derived Glycerophospholipids Skew Hematopoietic Stem Cell Differentiation Through Toll-Like Receptor Signaling. Stem Cells, 2015-07-24;33(11):3382-96. 2015-07-24 [PMID: 26212365] (Bioassay, Mouse)	Bioassay	Mouse
Wilson J, Yu J, Taylor L, Polgar P Hyperplastic Growth of Pulmonary Artery Smooth Muscle Cells from Subjects with Pulmonary Arterial Hypertension Is Activated through JNK and p38 MAPK. 2015-04-23;0(0):. 2015-04-23 [PMID: 25905460] (Bioassay, Human)	Bioassay	Human
Jia D, Duan F, Peng P, Sun L, Ruan Y, Gu J Pyrroloquinoline-quinone suppresses liver fibrogenesis in mice. PLoS ONE, 2015-03-30;10(3):e0121939. 2015-03-30 [PMID: 25822822] (Bioassay, Mouse)	Bioassay	Mouse
Huang , Yi-Hsun, I , Ching-Ch, Kuo , Cheng-Hs, Hsu , Yun-Yan, Lee , Fang-Tzu, Shi , Guey-Yue, Tseng , Sung-Hue, Wu , Hua-Lin Thrombomodulin promotes corneal epithelial wound healing. PLoS ONE, 2015-03-27;10(3):e0122491. 2015-03-27 [PMID: 25816372] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
Jayaprakash P, Dong H, Zou M, Bhatia A, O'Brien K, Chen M, Woodley D, Li W Hsp90alpha and Hsp90beta together operate a hypoxia and nutrient paucity stress-response mechanism during wound healing. J Cell Sci, 2015-03-03;128(8):1475-80. 2015-03-03 [PMID: 25736295] (Bioassay, Human)	Bioassay	Human
Zhang F, Hao F, An D, Zeng L, Wang Y, Xu X, Cui M The matricellular protein Cyr61 is a key mediator of platelet-derived growth factor-induced cell migration. J Biol Chem, 2015-01-26;290(13):8232-42. 2015-01-26 [PMID: 25623072] (Bioassay, Mouse)	Bioassay	Mouse
Hostettler K, Zhong J, Papakonstantinou E, Karakiulakis G, Tamm M, Seidel P, Sun Q, Mandal J, Lardinois D, Lambers C, Roth M Anti-fibrotic effects of nintedanib in lung fibroblasts derived from patients with idiopathic pulmonary fibrosis. Respir Res, 2014-12-12;15(1):157. 2014-12-12 [PMID: 25496490] (Bioassay, Human)	Bioassay	Human
Kureshi A, Funderburgh J, Daniels J Human corneal stromal stem cells exhibit survival capacity following isolation from stored organ-culture corneas. Invest Ophthalmol Vis Sci, 2014-10-21;55(11):7583-8. 2014-10-21 [PMID: 25335980] (Bioassay, Human)	Bioassay	Human
Niu F, Yao H, Zhang W, Sutliff R, Buch S Tat 101-mediated enhancement of brain pericyte migration involves platelet-derived growth factor subunit B homodimer: implications for human immunodeficiency virus-associated neurocognitive disorders. J Neurosci, 2014-08-27;34(35):11812-25. 2014-08-27 [PMID: 25164676] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
Su C, Chan C, Chen H, Wu C, Hsiao C, Lee P, Lin V, Hung C Lutein inhibits the migration of retinal pigment epithelial cells via cytosolic and mitochondrial Akt pathways (lutein inhibits RPE cells migration). Int J Mol Sci, 2014-08-08;15(8):13755-67. 2014-08-08 [PMID: 25110866] (Bioassay, Human)	Bioassay	Human
Oleinik N, Helke K, Kistner-Griffin E, Krupenko N, Krupenko S Rho GTPases RhoA and Rac1 mediate effects of dietary folate on metastatic potential of A549 cancer cells through the control of cofilin phosphorylation. J Biol Chem, 2014-08-01;289(38):26383-94. 2014-08-01 [PMID: 25086046] (Bioassay, Human)	Bioassay	Human
Yang , Wei, Ramachandran , Aruna, You , Sungyong, Jeong , HyoBin, Morley , Samantha, Mulone , Michelle, Logvinenko , Tanya, Kim , Jayoung, Hwang , Daehee, Freeman , Michael, Adam , Rosalyn Integration of proteomic and transcriptomic profiles identifies a novel PDGF-MYC network in human smooth muscle cells. Cell Commun Signal, 2014-08-01;12(1):44. 2014-08-01 [PMID: 25080971] (Bioassay, Human)	Bioassay	Human
Zhao C, Pavicic P, Datta S, Sun D, Novotny M, Hamilton T Cellular stress amplifies TLR3/4-induced CXCL1/2 gene transcription in mononuclear phagocytes via RIPK1. J Immunol, 2014-06-11;193(2):879-88. 2014-06-11 [PMID: 24920846] (Bioassay, Human)	Bioassay	Human
Tsai T, Shih S, Ho T, Ma H, Liu M, Chen S, Tsao Y Pigment epithelium-derived factor 34-mer peptide prevents liver fibrosis and hepatic stellate cell activation through down-regulation of the PDGF receptor. PLoS ONE, 2014-04-24;9(4):e95443. 2014-04-24 [PMID: 24763086] (Bioassay, Rat)	Bioassay	Rat
Kondo , Shunya, Bottos , Alessia, Allegood , Jeremy C, Masson , Regis, Maurer , Francisc, Genoud , Christel, Kaeser , Patrick, Huwiler , Andrea, Murakami , Masato, Spiegel , Sarah, Hynes , Nancy E Memo has a novel role in S1P signaling and is [corrected] crucial for vascular development. PLoS ONE, 2014-04-08;9(4):e94114. 2014-04-08 [PMID: 24714781] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
Miller C, Haas U, Diaz R, Leeper N, Kundu R, Patlolla B, Assimes T, Kaiser F, Perisic L, Hedin U, Maegdefessel L, Schunkert H, Erdmann J, Quertermous T, Sczakiel G Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation. PLoS Genet, 2014-03-27;10(3):e1004263. 2014-03-27 [PMID: 24676100] (Bioassay, Human)	Bioassay	Human
Hayes B, Riehle K, Shimizu-Albergine M, Bauer R, Hudkins K, Johansson F, Yeh M, Mahoney W, Yeung R, Campbell J Activation of platelet-derived growth factor receptor alpha contributes to liver fibrosis. PLoS ONE, 2014-03-25;9(3):e92925. 2014-03-25 [PMID: 24667490] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
Gobin B, Moriceau G, Ory B, Charrier C, Brion R, Blanchard F, Redini F, Heymann D Imatinib mesylate exerts anti-proliferative effects on osteosarcoma cells and inhibits the tumour growth in immunocompetent murine models. PLoS ONE, 2014-03-05;9(3):e90795. 2014-03-05 [PMID: 24599309] (Bioassay, Human, Rat)	Bioassay	Human, Rat
Camorani S, Esposito C, Rienzo A, Catuogno S, Iaboni M, Condorelli G, de Franciscis V, Cerchia L Inhibition of receptor signaling and of glioblastoma-derived tumor growth by a novel PDGFRbeta aptamer. Mol Ther, 2014-01-02;22(4):828-41. 2014-01-02 [PMID: 24566984] (Bioassay, Human)	Bioassay	Human
Wollin L, Maillet I, Quesniaux V, Holweg A, Ryffel B Antifibrotic and anti-inflammatory activity of the tyrosine kinase inhibitor nintedanib in experimental models of lung fibrosis. J Pharmacol Exp Ther, 2014-02-20;349(2):209-20. 2014-02-20 [PMID: 24556663] (Bioassay, Human)	Bioassay	Human
Lo H, Lai T, Li C, Wu W TNF-alpha induces CXCL1 chemokine expression and release in human vascular endothelial cells in vitro via two distinct signaling pathways. Acta Pharmacol Sin, 2014-02-03;35(3):339-50. 2014-02-03 [PMID: 24487964] (Bioassay, Human)	Bioassay	Human
Zhang , Y, Kim , J, Mueller , A C, Dey , B, Yang , Y, Lee , D-h, Hachmann , J, Finderle , S, Park , D M, Christensen , J, Schiff , D, Purow , B, Dutta , A, Abounader , R Multiple receptor tyrosine kinases converge on microRNA-134 to control KRAS, STAT5B, and glioblastoma. Cell Death Differ, 2014-01-17;21(5):720-34. 2014-01-17 [PMID: 24440911] (Bioassay, Human)	Bioassay	Human
Bastiaans J, van Meurs J, van Holten-Neelen C, Nagtzaam N, van Hagen P, Chambers R, Hooijkaas H, Dik W Thrombin induces epithelial-mesenchymal transition and collagen production by retinal pigment epithelial cells via autocrine PDGF-receptor signaling. Invest Ophthalmol Vis Sci, 2013-12-19;54(13):8306-14. 2013-12-19 [PMID: 24302586] (Bioassay, Human)	Bioassay	Human
Gottlieb-Abraham , Efrat, Shvartsman , Dmitry E, Donaldson , John C, Ehrlich , Marcelo, Gutman , Orit, Martin , G Steven, Henis , Yoav I Src-mediated caveolin-1 phosphorylation affects the targeting of active Src to specific membrane sites. Mol Biol Cell, 2013-10-16;24(24):3881-95. 2013-10-16 [PMID: 24131997] (Bioassay, Primate - Chlorocebus aethiops (African Green Monkey))	Bioassay	Primate - Chlorocebus aethiops (African Green Monkey)
Gadepalli R, Kotla S, Heckle M, Verma S, Singh N, Rao G Novel role for p21-activated kinase 2 in thrombin-induced monocyte migration. J Biol Chem, 2013-09-11;288(43):30815-31. 2013-09-11 [PMID: 24025335] (Bioassay, Human)	Bioassay	Human
Karki R, Kim S, Kim D Magnolol inhibits migration of vascular smooth muscle cells via cytoskeletal remodeling pathway to attenuate neointima formation. Exp Cell Res, 2013-07-29;319(20):3238-50. 2013-07-29 [PMID: 23906924] (Bioassay, Human)	Bioassay	Human
Hollborn M, Chen R, Wiedemann P, Reichenbach A, Bringmann A, Kohen L Cytotoxic effects of curcumin in human retinal pigment epithelial cells. PLoS ONE, 2013-03-26;8(3):e59603. 2013-03-26 [PMID: 23555722] (Bioassay, Human)	Bioassay	Human
Li , Wei, Li , Qingle, Qin , Lingfeng, Ali , Rahmat, Qyang , Yibing, Tassabehji , May, Pober , Barbara, Sessa , William, Giordano , Frank J, Tellides , George Rapamycin inhibits smooth muscle cell proliferation and obstructive arteriopathy attributable to elastin deficiency. Arterioscler Thromb Vasc Biol, 2013-03-14;33(5):1028-35. 2013-03-14 [PMID: 23493289] (Bioassay, Human)	Bioassay	Human
Song S, Jung W, Kim K, Hong W, Kim H, Lee K, Lee K, Suh W Distinct transcriptional profiles of angioblasts derived from human embryonic stem cells. Exp Cell Res, 2013-02-28;319(8):1136-45. 2013-02-28 [PMID: 23458169] (Bioassay, Human)	Bioassay	Human
Silvestre-Roig C, Fernandez P, Esteban V, Pello O, Indolfi C, Rodriguez C, Rodriguez-Calvo R, Lopez-Maderuelo M, Bauriedel G, Hutter R, Fuster V, Ibanez B, Redondo J, Martinez-Gonzalez J, Andres V Inactivation of nuclear factor-Y inhibits vascular smooth muscle cell proliferation and neointima formation. Arterioscler Thromb Vasc Biol, 2013-02-21;33(5):1036-45. 2013-02-21 [PMID: 23430616] (Bioassay, Human, Rat)	Bioassay	Human, Rat
Cheng J, Cheng H, Tsai I, Jiang M ROS-mediated downregulation of MYPT1 in smooth muscle cells: a potential mechanism for the aberrant contractility in atherosclerosis. Lab Invest, 2013-02-18;93(4):422-33. 2013-02-18 [PMID: 23419712] (Bioassay, Human)	Bioassay	Human
Di Maggio N, Mehrkens A, Papadimitropoulos A, Schaeren S, Heberer M, Banfi A, Martin I Fibroblast growth factor-2 maintains a niche-dependent population of self-renewing highly potent non-adherent mesenchymal progenitors through FGFR2c. Stem Cells, 2012-07-01;30(7):1455-64. 2012-07-01 [PMID: 22495904] (Bioassay, Human)	Bioassay	Human
Davis-Dusenbery BN, Chan MC, Reno KE, Weisman AS, Layne MD, Lagna G, Hata A Down-regulation of Kruppel-like Factor-4 (KLF4) by MicroRNA-143/145 Is Critical for Modulation of Vascular Smooth Muscle Cell Phenotype by Transforming Growth Factor-{beta} and Bone Morphogenetic Protein 4. J. Biol. Chem., 2011-06-13;286(32):28097-110. 2011-06-13 [PMID: 21673106] (Bioassay, Human)	Bioassay	Human
Roobrouck VD, Clavel C, Jacobs SA, Ulloa-Montoya F, Crippa S, Sohni A, Roberts SJ, Luyten FP, Van Gool SW, Sampaolesi M, Delforge M, Luttun A, Verfaillie CM Differentiation potential of human postnatal mesenchymal stem cells, mesoangioblasts, and multipotent adult progenitor cells reflected in their transcriptome and partially influenced by the culture conditions. Stem Cells, 2011-05-01;29(5):871-82. 2011-05-01 [PMID: 21433224] (Bioassay, Human)	Bioassay	Human
Chang Y, Al-Alwan L, Risse PA, Roussel L, Rousseau S, Halayko AJ, Martin JG, Hamid Q, Eidelman DH TH17 cytokines induce human airway smooth muscle cell migration. J. Allergy Clin. Immunol., 2011-02-22;127(4):1046-53.e1-2. 2011-02-22 [PMID: 21345484] (Bioassay, Human)	Bioassay	Human
Evans IM, Yamaji M, Britton G, Pellet-Many C, Lockie C, Zachary IC, Frankel P Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells. Mol. Cell. Biol., 2011-01-18;31(6):1174-85. 2011-01-18 [PMID: 21245381] (Bioassay, Human)	Bioassay	Human
Roelandt P, Pauwelyn KA, Sancho-Bru P Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells. PLoS ONE, 2010-08-11;5(8):e12101. 2010-08-11 [PMID: 20711405] (Cell Culture, Human)	Cell Culture	Human
Lorquet S, Berndt S, Blacher S, Gengoux E, Peulen O, Maquoi E, Noel A, Foidart JM, Munaut C, Pequeux C Soluble forms of VEGF receptor-1 and -2 promote vascular maturation via mural cell recruitment. FASEB J., 2010-05-19;24(10):3782-95. 2010-05-19 [PMID: 20484670] (Bioassay, Human)	Bioassay	Human
Shan L, Redhu NS, Saleh A Thymic stromal lymphopoietin receptor-mediated IL-6 and CC/CXC chemokines expression in human airway smooth muscle cells: role of MAPKs (ERK1/2, p38, and JNK) and STAT3 pathways. J. Immunol., 2010-05-14;184(12):7134-43. 2010-05-14 [PMID: 20483734] (Bioassay, Human)	Bioassay	Human
Nilsson MB, Zage PE, Zeng L, Xu L, Cascone T, Wu HK, Saigal B, Zweidler-McKay PA, Heymach JV Multiple receptor tyrosine kinases regulate HIF-1alpha and HIF-2alpha in normoxia and hypoxia in neuroblastoma: implications for antiangiogenic mechanisms of multikinase inhibitors. Oncogene, 2010-03-08;29(20):2938-49. 2010-03-08 [PMID: 20208561] (Bioassay, Human)	Bioassay	Human
Ball SG, Bayley C, Shuttleworth CA, Kielty CM Neuropilin-1 regulates platelet-derived growth factor receptor signalling in mesenchymal stem cells. Biochem. J., 2010-03-15;427(1):29-40. 2010-03-15 [PMID: 20102335] (Bioassay, Human)	Bioassay	Human
Liu R, Li X, Tulpule A, Zhou Y, Scehnet JS, Zhang S, Lee JS, Chaudhary PM, Jung J, Gill PS KSHV-induced notch components render endothelial and mural cell characteristics and cell survival. Blood, 2009-11-24;115(4):887-95. 2009-11-24 [PMID: 19965636] (Cell Culture, Human)	Cell Culture	Human
Kobayashi T, Furukawa Y, Kikuchi J, Ito C, Miyata Y, Muto S, Tanaka A, Kusano E Transactivation of RON receptor tyrosine kinase by interaction with PDGF receptor beta during steady-state growth of human mesangial cells. Kidney Int., 2009-02-25;75(11):1173-83. 2009-02-25 [PMID: 19242504] (Cell Culture, Human)	Cell Culture	Human
van Steensel L, Paridaens D, Schrijver B, Dingjan GM, van Daele PL, van Hagen PM, van den Bosch WA, Drexhage HA, Hooijkaas H, Dik WA Imatinib mesylate and AMN107 inhibit PDGF-signaling in orbital fibroblasts: a potential treatment for Graves' ophthalmopathy. Invest. Ophthalmol. Vis. Sci., 2009-02-21;50(7):3091-8. 2009-02-21 [PMID: 19234339] (Bioassay, Human)	Bioassay	Human
Rice JW, Veal JM, Fadden RP, Barabasz AF, Partridge JM, Barta TE, Dubois LG, Huang KH, Mabbett SR, Silinski MA, Steed PM, Hall SE Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis. Arthritis Rheum., 2008-12-01;58(12):3765-75. 2008-12-01 [PMID: 19035474] (Bioassay, Mouse)	Bioassay	Mouse
Jiang M, Bujo H, Ohwaki K, Unoki H, Yamazaki H, Kanaki T, Shibasaki M, Azuma K, Harigaya K, Schneider WJ, Saito Y Ang II-stimulated migration of vascular smooth muscle cells is dependent on LR11 in mice. J. Clin. Invest., 2008-08-01;118(8):2733-46. 2008-08-01 [PMID: 18618022] (Bioassay, Mouse)	Bioassay	Mouse
Wagsater D, Zhu C, Bjorck HM, Eriksson P Effects of PDGF-C and PDGF-D on monocyte migration and MMP-2 and MMP-9 expression. Atherosclerosis, 2008-05-22;202(2):415-23. 2008-05-22 [PMID: 18573494] (Bioassay, Human)	Bioassay	Human
Nedeau AE, Bauer RJ, Gallagher K, Chen H, Liu ZJ, Velazquez OC A CXCL5- and bFGF-dependent effect of PDGF-B-activated fibroblasts in promoting trafficking and differentiation of bone marrow-derived mesenchymal stem cells. Exp. Cell Res., 2008-04-25;314(11):2176-86. 2008-04-25 [PMID: 18570917] (Bioassay, Mouse)	Bioassay	Mouse
Hilberg F, Roth GJ, Krssak M, Kautschitsch S, Sommergruber W, Tontsch-Grunt U, Garin-Chesa P, Bader G, Zoephel A, Quant J, Heckel A, Rettig WJ BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res., 2008-06-15;68(12):4774-82. 2008-06-15 [PMID: 18559524] (Bioassay, Human)	Bioassay	Human
He S, Chen Y, Khankan R, Barron E, Burton R, Zhu D, Ryan SJ, Oliver N, Hinton DR Connective tissue growth factor as a mediator of intraocular fibrosis. Invest. Ophthalmol. Vis. Sci., 2008-04-30;49(9):4078-88. 2008-04-30 [PMID: 18450591] (In Vivo, Rabbit)	In Vivo	Rabbit
Tomanek RJ, Hansen HK, Christensen LP Temporally expressed PDGF and FGF-2 regulate embryonic coronary artery formation and growth. Arterioscler. Thromb. Vasc. Biol., 2008-04-17;28(7):1237-43. 2008-04-17 [PMID: 18420995] (Bioassay, Avian)	Bioassay	Avian
Gang EJ, Bosnakovski D, Simsek T, To K, Perlingeiro RC Pax3 activation promotes the differentiation of mesenchymal stem cells toward the myogenic lineage. Exp. Cell Res., 2008-03-05;314(8):1721-33. 2008-03-05 [PMID: 18395202] (Bioassay, Mouse)	Bioassay	Mouse
Li R, Maminishkis A, Wang FE, Miller SS PDGF-C and -D induced proliferation/migration of human RPE is abolished by inflammatory cytokines. Invest. Ophthalmol. Vis. Sci., 2007-12-01;48(12):5722-32. 2007-12-01 [PMID: 18055825] (Bioassay, Human)	Bioassay	Human
Schweizer PA, Krause U, Becker R, Seckinger A, Bauer A, Hardt C, Eckstein V, Ho AD, Koenen M, Katus HA, Zehelein J Atrial-radiofrequency catheter ablation mediated targeting of mesenchymal stromal cells. Stem Cells, 2007-06-01;25(6):1546-51. 2007-06-01 [PMID: 17548531] (Bioassay, Canine)	Bioassay	Canine
Ball SG, Shuttleworth CA, Kielty CM Vascular endothelial growth factor can signal through platelet-derived growth factor receptors. J. Cell Biol., 2007-04-30;177(3):489-500. 2007-04-30 [PMID: 17470632] (Bioassay, Human)	Bioassay	Human
Tacke F, Gabele E, Bataille F, Schwabe RF, Hellerbrand C, Klebl F, Straub RH, Luedde T, Manns MP, Trautwein C, Brenner DA, Scholmerich J, Schnabl B Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells. Dig. Dis. Sci., 2007-04-06;52(12):3404-15. 2007-04-06 [PMID: 17415633] (Bioassay, Human)	Bioassay	Human
Dentelli P, Rosso A, Balsamo A, Colmenares Benedetto S, Zeoli A, Pegoraro M, Camussi G, Pegoraro L, Brizzi MF C-KIT, by interacting with the membrane-bound ligand, recruits endothelial progenitor cells to inflamed endothelium. Blood, 2007-02-08;109(10):4264-71. 2007-02-08 [PMID: 17289809] (Bioassay, Human)	Bioassay	Human
Hunter I, Nixon GF Spatial compartmentalization of tumor necrosis factor (TNF) receptor 1-dependent signaling pathways in human airway smooth muscle cells. Lipid rafts are essential for TNF-alpha-mediated activation of RhoA but dispensable for the activation of the NF-kappaB and MAPK pathways. J. Biol. Chem., 2006-09-18;281(45):34705-15. 2006-09-18 [PMID: 16982613] (Bioassay, Human)	Bioassay	Human
Zeng L, Rahrmann E, Hu Q, Lund T, Sandquist L, Felten M, O'Brien TD, O'Brien TD, Zhang J, Verfaillie C Multipotent adult progenitor cells from swine bone marrow. Stem Cells, 2006-08-24;24(11):2355-66. 2006-08-24 [PMID: 16931778] (Bioassay, Porcine)	Bioassay	Porcine
Jiang M, Bujo H, Zhu Y, Yamazaki H, Hirayama S, Kanaki T, Shibasaki M, Takahashi K, Schneider WJ, Saito Y Pitavastatin attenuates the PDGF-induced LR11/uPA receptor-mediated migration of smooth muscle cells. Biochem. Biophys. Res. Commun., 2006-08-10;348(4):1367-77. 2006-08-10 [PMID: 16919601] (Bioassay, Rabbit)	Bioassay	Rabbit
Riggi N, Cironi L, Provero P, Suva ML, Stehle JC, Baumer K, Guillou L, Stamenkovic I Expression of the FUS-CHOP fusion protein in primary mesenchymal progenitor cells gives rise to a model of myxoid liposarcoma. Cancer Res., 2006-07-15;66(14):7016-23. 2006-07-15 [PMID: 16849546] (Bioassay, Mouse)	Bioassay	Mouse
Faraone D, Aguzzi MS, Ragone G, Russo K, Capogrossi MC, Facchiano A Heterodimerization of FGF-receptor 1 and PDGF-receptor-alpha: a novel mechanism underlying the inhibitory effect of PDGF-BB on FGF-2 in human cells. Blood, 2005-12-01;107(5):1896-902. 2005-12-01 [PMID: 16322476] (Bioassay, Human)	Bioassay	Human
Wong AP, Nili N, Strauss BH In vitro differences between venous and arterial-derived smooth muscle cells: potential modulatory role of decorin. Cardiovasc. Res., 2005-02-15;65(3):702-10. 2005-02-15 [PMID: 15664397] (Bioassay, Rabbit)	Bioassay	Rabbit
Nagineni CN, Kutty V, Detrick B, Hooks JJ Expression of PDGF and their receptors in human retinal pigment epithelial cells and fibroblasts: regulation by TGF-beta. J. Cell. Physiol., 2005-04-01;203(1):35-43. 2005-04-01 [PMID: 15368539] (Bioassay, Human)	Bioassay	Human
Tardif G, Hum D, Pelletier JP, Boileau C, Ranger P, Martel-Pelletier J Differential gene expression and regulation of the bone morphogenetic protein antagonists follistatin and gremlin in normal and osteoarthritic human chondrocytes and synovial fibroblasts. Arthritis Rheum., 2004-08-01;50(8):2521-30. 2004-08-01 [PMID: 15334466] (Bioassay, Human)	Bioassay	Human
Wen FQ, Liu X, Kobayashi T, Abe S, Fang Q, Kohyama T, Ertl R, Terasaki Y, Manouilova L, Rennard SI Interferon-gamma inhibits transforming growth factor-beta production in human airway epithelial cells by targeting Smads. Am. J. Respir. Cell Mol. Biol., 2004-01-12;30(6):816-22. 2004-01-12 [PMID: 14722222] (Bioassay, Human)	Bioassay	Human
Lacoste E, Martineau I, Gagnon G Platelet concentrates: effects of calcium and thrombin on endothelial cell proliferation and growth factor release. J. Periodontol., 2003-10-01;74(10):1498-507. 2003-10-01 [PMID: 14653397] (ELISA (Standard))	ELISA (Standard)
Nili N, Cheema AN, Giordano FJ, Barolet AW, Babaei S, Hickey R, Eskandarian MR, Smeets M, Butany J, Pasterkamp G, Strauss BH Decorin inhibition of PDGF-stimulated vascular smooth muscle cell function: potential mechanism for inhibition of intimal hyperplasia after balloon angioplasty. Am. J. Pathol., 2003-09-01;163(3):869-78. 2003-09-01 [PMID: 12937128] (Binding Assay, Bioassay, Rabbit)	Binding Assay, Bioassay	Rabbit
Kovalenko D, Yang X, Nadeau RJ, Harkins LK, Friesel R Sef inhibits fibroblast growth factor signaling by inhibiting FGFR1 tyrosine phosphorylation and subsequent ERK activation. J. Biol. Chem., 2003-02-24;278(16):14087-91. 2003-02-24 [PMID: 12604616] (Bioassay, Mouse, Primate - Chlorocebus pygerythrus (Vervet Monkey))	Bioassay	Mouse, Primate - Chlorocebus pygerythrus (Vervet Monkey)
Huaux F, Liu T, McGarry B, Ullenbruch M, Phan SH Dual roles of IL-4 in lung injury and fibrosis. Proteins containing BRCA1 C-terminal (BRCT) domains play crucial roles in response to and repair of DNA damage. Epithelial cell transforming factor ECT2 is a member of the BRCT protein family, but it , 2003-02-15;170(4):2083-92. 2003-02-15 [PMID: 12574379] (Bioassay, Human)	Bioassay	Human
Huaux F, 107322, Arras M, Tomasi D, Barbarin V, Delos M, Coutelier JP, Vink A, Phan SH, Renauld JC, Lison D A profibrotic function of IL-12p40 in experimental pulmonary fibrosis. Interferon-gamma modulates articular chondrocyte and osteoblast metabolism through protein kinase R-independent and dependent mechanisms, 2002-09-01;169(5):2653-61. 2002-09-01 [PMID: 12193738] (Bioassay, Mouse)	Bioassay	Mouse
Desfaits AC, 48971, Raymond J, Muizelaar JP Growth factors stimulate neointimal cells in vitro and increase the thickness of the neointima formed at the neck of porcine aneurysms treated by embolization. Cigarette smoke attenuates phagocytic ability of macrophages through down-regulating Milk fat globule-EGF factor 8 (MFG-E8) expressions, 2000-02-01;31(0):498-507. 2000-02-01 [PMID: 10657429] (Bioassay, In Vivo, Canine, Porcine)	Bioassay, In Vivo	Canine, Porcine
Akagi Y, Liu W, Zebrowski B, Xie K, Ellis LM Regulation of vascular endothelial growth factor expression in human colon cancer by insulin-like growth factor-I. Cancer Res., 1998-09-01;58(17):4008-14. 1998-09-01 [PMID: 9731515] (Bioassay, Human)	Bioassay	Human
Show All 174 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Steven Moore	Immunoassay Standard		10/13/2020	View Summary Application Immunoassay Standard Lot Recombinant Human PDGF-BB Protein, CF, 10 UG QXB0815111 Comments Good (publishable, would use again) Comments Comments HMW high intact molecular weight LMW Super low molecular weight
Enlarge	4 reviewed by: Steven Moore	Stem/Immune cell maintenance or differentiation		10/13/2020	View Summary Application Stem/Immune cell maintenance or differentiation Lot N/A Comments Good (publishable, would use again)

Array 220-BB

• PDGF-BB Antibodies
• PDGF-BB ELISA Kits
• PDGF-BB Proteins
• PDGF-BB Proteins and Enzymes
• PDGF-BB ELISAs