Recombinant Human NKG2E Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Human NKG2E (NK cell Group 2 isoform E; Killer cell lectin-like receptor subfamily C, member 3) is a member of the C-type lectin-like superfamily of proteins. Natural killer (NK) receptors are expressed in both NK cells and cytotoxic CD8⁺ T cells and have both activating and inhibitory members (1-3). Regulation of the balance between the activating and inhibitory receptors is important and lack of such regulation has been implicated in autoimmunity (4). The NKG2 family includes seven receptors: NKG2A, -B, -C, -D, -E, -F, and -H, which is the longer isoform of NKG2E. Except for NKG2D and NKG2F, the NKG2 family members form heterodimers with CD94 (5, 6). Human NKG2E consist of a 70 aa cytoplasmic domain, a 23 aa transmembrane segment, and a 147 aa extracellular domain (ECD). Within the ECD, human NKG2E shares 40% sequence identity with mouse NKG2E. NKG2E-CD94 heterodimers bind to the widely expressed nonclassical MHC-I molecule, HLA-E (Qa-1^b in mouse), which presents a peptide derived from the signal peptide of classical MHC-I molecules (7, 8). Triggering the NKG2E-CD94 complex may activate the cytolytic activity and cytokine production of NK and CD8⁺ T cells (1, 7, 9). Over-expression of KLRC3/NKG2E in glioblastomas may play a major role in glioblastoma aggressiveness and recurrence (10).

Array 9759-NK

• NKG2E/KLRC3 Antibodies
• NKG2E/KLRC3 Lysate
• NKG2E/KLRC3 Proteins
• NKG2E/KLRC3 Proteins and Enzyme