Recombinant Human mGluR2 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Metabotropic glutamate receptors (mGluRs) are coupled to effector systems through GTP-binding proteins and modulate glutamate neurotransmission in the central and peripheral nervous systems (1). Structurally, members from this family are characterized by a large N-terminal extracellular domain (ECD), seven transmembrane domains, and a cytoplasmic carboxyl-terminal domain variable in length. Two ECDs dimerize together and large conformational changes are induced when agonists bind to one or both domains (3). Intracellularly, a short C-terminus interacts directly with a G-protein (2). The receptors are subdivided into three groups (I–III) based on sequence homology, signal transduction and pharmacological properties (1). The Group II receptors comprise mGLuR2 and mGLuR3, which share high sequence homology. mGLuR2 is a presynaptic receptor expressed on both neurons and glia, and its activation regulates cAMP accumulation (1). Mature human mGluR2 is 854 amino acids in length, including a 549 amino acid (aa) N-terminal ECD. Within N-terminal ECD, human mGluR2 shares 98% aa sequence identity with mouse and rat mGluR2.

Array 9526-UR

• mGluR2 Antibodies
• mGluR2 Lysate
• mGluR2 Protein
• mGluR2 Proteins and Enzyme