mGluR1 Antibody - BSA Free

The Metabotropic Glutamate Receptor mGluR1 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. mGluR1 and mGluR5 are group I receptors that have been shown to activate phospholipase C. Alternative splice variants of the mGluR1 gene have been described, but their full-length nature has not been determined. Inflammation results in the activation of mGluR1 and mGluR5 in dorsal horn neurons of the spinal cord, leading to extracellular signal-regulated kinase (ERK) activation, which is required for nociceptive plasticity and enhanced pain. mGluR1 has been reported in various regions of the brain and spinal cord. ESTs have been isolated from brain and eye libraries. Caution: GRIA1 refers to Ionotropic Glutamate Receptor 1, not to Metabotropic Glutamate Receptor 1 (mGLUR1).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 2 applications: ICC/IF, IHC-P.

Showing Publications 1 - 3 of 3.

Publications using NB110-39033	Applications	Species
Liang D, Xue Z, Xue J et al. Sinoatrial node pacemaker cells share dominant biological properties with glutamatergic neurons Protein & cell 2021-02-06 [PMID: 33548033] (IHC-P, ICC/IF, Mouse)	IHC-P, ICC/IF	Mouse
Tang Y, Liu L, Xu D et al. Interaction between astrocytic colony stimulating factor and its receptor on microglia mediates central sensitization and behavioral hypersensitivity in chronic post ischemic pain model. Brain Behav Immun 2018-02-01 [PMID: 29080683] (Rat)		Rat
Hirdes W, Napp N, Wulfsen I et al. Erg K+ currents modulate excitability in mouse mitral/tufted neurons. Pflugers Arch 2009-11-01 [PMID: 19688350] (ICC/IF, Mouse)	ICC/IF	Mouse

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Janosch Heller	ICC	Rat	03/27/2017	View Summary Application Immunocytochemistry Sample Tested Primary rat cortical neurons Species Rat Comments Comments Fixation: 4% paraformaldehyde (TAAB) in PBS, 15 minutes RT Quenching: 0.1% NaBH4 in PBS, 7 minutes RT Blocking: 3% BSA in PBS, 30 minutes RT Permeabilization: 0.1% Triton-X100, 10 minutes RT Primary Antibody: 1:500 in 3% BSA in PBS, overnight, 4°C Wash: three times wash with PBS, 10 min each Secondary Antibody: Invitrogen goat anti-mouse Alexa568, 1:1800 in PBS with 1% BSA, 2 hours, RT Wash: three times wash with PBS, 10 min each Microscope: Bruker Vutara 350 The antibody labels clusters of metabotropic receptors along the whole cell.

Array NB110-39033

• mGluR1 Antibodies
• mGluR1 ELISA Kit
• mGluR1 Lysate
• mGluR1 Protein