Recombinant Human IL-21R Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interleukin-21 Receptor (IL-21 R) is a type I transmembrane glycoprotein within the class I cytokine receptor family (1). IL-21 R associates with the common  gamma  chain ( gamma _c) which is also a component of the receptors for IL-2, IL-4, IL-7, IL-9, IL-13, and IL-15 (2, 3). Mature human IL-21 R consists of a 213 amino acid (aa) extracellular domain (ECD) with 4 conserved cysteine residues, a fibronectin type III domain, and a WSxWS motif, followed by a 21 aa transmembrane domain and a 253 aa cytoplasmic domain with a Box 1 motif, a kinase domain, and several sites for tyrosine phosphorylation (4, 5). Within the ECD, human IL-21 R shares 69% aa identity with mouse and rat IL-21 R, respectively. IL-21 R is expressed mainly on B cells (highest on mature, activated, follicular and germinal center B cells), NK cells, and activated T cells, but is also found on dendritic cells, alternatively activated macrophages, intestinal lamina propria fibroblasts and epithelial cells, and keratinocytes (1, 4, 5). Both IL-21 and IL-4 are necessary for efficient B cell IgG1 production and normal germinal center architecture (6). B cell IL-21 R engagement induces Blimp-1 (which mediates plasma cell differentiation) and is important for memory responses (7, 8). IL-21 R engagement enhances NK cell mediated cytotoxic activity and IFN-gamma production (4, 9), control of viral infection and tumor growth by CD8⁺ T cells (10), development of regulatory T cells (11), IL-23 responsiveness of encephalitogenic Th17 cells (12), but suppresses the accumulation of IL-17 secreting gamma δ T cells in the airway (13). IL-21 R expression is often upregulated in allergic skin inflammation, systemic lupus erythematosus and diffuse large B cell lymphoma (DLBCL) (14, 15).

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: Bioassay, Cell Culture, Flow Cytometry, IHC.

Showing Publications 1 - 10 of 15. Show All 15 Publications. Collapse Publications.

Publications using 991-R2	Applications	Species
K Szabó, I Jámbor, K Pázmándi, N Nagy, G Papp, T Tarr Altered Circulating Follicular T Helper Cell Subsets and Follicular T Regulatory Cells Are Indicators of a Derailed B Cell Response in Lupus, Which Could Be Modified by Targeting IL-21R International Journal of Molecular Sciences, 2022-10-13;23(20):. 2022-10-13 [PMID: 36293075] (Cell Culture, Human)	Cell Culture	Human
E Janssen, M Tohme, J Butts, SS Giguere, PT Sage, FE Velázquez, C Kam, E Milin, M Das, A Sobh, S Al-Tamemi, FW Luscinskas, F Batista, RS Geha DOCK8 is essential for LFA-1 dependent positioning of T follicular helper cells in germinal centers JCI Insight, 2020-08-06;0(0):. 2020-08-06 [PMID: 32573493] (Bioassay, Human)	Bioassay	Human
A Aljurayyan, S Puksuriwon, M Ahmed, R Sharma, M Krishnan, S Sood, K Davies, D Rajashekar, S Leong, PS McNamara, S Gordon, Q Zhang Activation and induction of antigen-specific T follicular helper cells (TFH) play a critical role in LAIV-induced human mucosal anti-influenza antibody response J. Virol., 2018-05-14;0(0):. 2018-05-14 [PMID: 29563292] (Bioassay, Human)	Bioassay	Human
O Désy, S Béland, P Vallin, J Riopel, E Latulippe, E Wagner, SA De Serres Allogeneic dendritic cells stimulated with antibodies against HLA class II polarize naive T cells in a follicular helper phenotype Sci Rep, 2018-03-05;8(1):4025. 2018-03-05 [PMID: 29507364] (Bioassay, Human)	Bioassay	Human
YM Kooy-Winke, D Bouwer, GM Janssen, A Thompson, MH Brugman, F Schmitz, AH de Ru, T van Gils, G Bouma, JJ van Rood, PA van Veelen, ML Mearin, CJ Mulder, F Koning, J van Bergen CD4 T-cell cytokines synergize to induce proliferation of malignant and nonmalignant innate intraepithelial lymphocytes Proc. Natl. Acad. Sci. U.S.A, 2017-01-03;0(0):. 2017-01-03 [PMID: 28049849] (Bioassay)	Bioassay
Augmentation of Circulating Follicular Helper T Cells and Their Impact on Autoreactive B Cells in Myasthenia Gravis J Immunol, 2016-08-19;0(0):. 2016-08-19 [PMID: 27543617] (Bioassay, Human)	Bioassay	Human
Xing R, Yang L, Jin Y, Sun L, Li C, Li Z, Zhao J, Liu X Interleukin-21 Induces Proliferation and Proinflammatory Cytokine Profile of Fibroblast-like Synoviocytes of Patients with Rheumatoid Arthritis. Scand J Immunol, 2016-01-01;83(1):64-71. 2016-01-01 [PMID: 26482544] (Bioassay, Human)	Bioassay	Human
Harker J, Wong K, Dolgoter A, Zuniga E Cell-Intrinsic gp130 Signaling on CD4+ T Cells Shapes Long-Lasting Antiviral Immunity. J Immunol, 2015-06-17;195(3):1071-81. 2015-06-17 [PMID: 26085685] (IHC, Mouse)	IHC	Mouse
Kaltenmeier C, Gawanbacht A, Beyer T, Lindner S, Trzaska T, van der Merwe J, Harter G, Gruner B, Fabricius D, Lotfi R, Schwarz K, Schutz C, Honig M, Schulz A, Kern P, Bommer M, Schrezenmeier H, Kirchhoff F, Jahrsdorfer B CD4+ T cell-derived IL-21 and deprivation of CD40 signaling favor the in vivo development of granzyme B-expressing regulatory B cells in HIV patients. J Immunol, 2015-03-16;194(8):3768-77. 2015-03-16 [PMID: 25780036] (Bioassay, Human)	Bioassay	Human
Parmigiani A, Alcaide M, Freguja R, Pallikkuth S, Frasca D, Fischl M, Pahwa S Impaired antibody response to influenza vaccine in HIV-infected and uninfected aging women is associated with immune activation and inflammation. PLoS ONE, 2013-11-13;8(11):e79816. 2013-11-13 [PMID: 24236161] (Bioassay, Human)	Bioassay	Human
Mazerolles F, Picard C, Kracker S, Fischer A, Durandy A Blood CD4+CD45RO+CXCR5+ T cells are decreased but partially functional in signal transducer and activator of transcription 3 deficiency. J Allergy Clin Immunol, 2013-02-10;131(4):1146-56, 1156. 2013-02-10 [PMID: 23403044] (Bioassay, Human)	Bioassay	Human
Kasagi S, Kawano S, Okazaki T, Honjo T, Morinobu A, Hatachi S, Shimatani K, Tanaka Y, Minato N, Kumagai S Anti-programmed cell death 1 antibody reduces CD4+PD-1+ T cells and relieves the lupus-like nephritis of NZB/W F1 mice. J. Immunol., 2010-02-05;184(5):2337-47. 2010-02-05 [PMID: 20139271] (Flow Cytometry, Human)	Flow Cytometry	Human
Eid RE, Rao DA, Zhou J, Lo SF, Ranjbaran H, Gallo A, Sokol SI, Pfau S, Pober JS, Tellides G Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells. Circulation, 2009-03-02;119(10):1424-32. 2009-03-02 [PMID: 19255340] (Bioassay, Human)	Bioassay	Human
Cerboni C, Ardolino M, Santoni A, Zingoni A Detuning CD8+ T lymphocytes by down-regulation of the activating receptor NKG2D: role of NKG2D ligands released by activated T cells. Blood, 2009-01-05;113(13):2955-64. 2009-01-05 [PMID: 19124832] (Bioassay, Human)	Bioassay	Human
Monteleone G, Caruso R, Fina D, Peluso I, Gioia V, Stolfi C, Fantini MC, Caprioli F, Tersigni R, Alessandroni L, MacDonald TT, Pallone F Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21. Gut, 2006-05-08;55(12):1774-80. 2006-05-08 [PMID: 16682426] (Bioassay, Human)	Bioassay	Human
Show All 15 Publications. Collapse Publications.

Array 991-R2

• IL-21R Antibodies
• IL-21R ELISA Kits
• IL-21R Lysates
• IL-21R Protein
• IL-21R Proteins and Enzymes