Recombinant Human IL-15 Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interleukin 15 (IL-15) is a widely expressed 14 kDa cytokine that is structurally and functionally related to IL-2 and plays an important role in many immunological diseases (1, 2). Mature human IL-15 shares 70% amino acid sequence identity with mouse and rat IL-15. Alternative splicing generates isoforms of IL-15 with either a long or short signal peptide (LSP or SSP), and the SSP isoform is retained intracellularly (3). IL-15 binds with high affinity to IL-15 R alpha (4). It binds with lower affinity to a complex of IL-2 R beta and the common gamma chain ( gamma c) which are also subunits of the IL-2 receptor complex (5). IL-15 associates with IL-15 R alpha in the endoplasmic reticulum, and this complex is expressed on the cell surface (6). The dominant mechanism of IL-15 action is known as transpresentation in which IL-15 and IL-15 R alpha are coordinately expressed on the surface of one cell and interact with complexes of IL-2 R beta / gamma c on adjacent cells (7). This enables cells to respond to IL-15 even if they do not express IL-15 R alpha (6). In human and mouse, soluble IL-15-binding forms of IL-15 R alpha can be generated by proteolytic shedding and bind up nearly all the IL-15 in circulation (8-10). Soluble IL-15 R alpha functions as an inhibitor that limits IL-15 action (4, 9). Ligation of membrane-associated IL-15/IL-15 R alpha complexes also induces reverse signaling that promotes activation of the IL-15/IL-15 R alpha expressing cells (11). IL-15 induces or enhances the differentiation, maintenance, or activation of multiple T cell subsets including NK, NKT, Th17, Treg, and CD8⁺ memory cells (12-16). An important component of these functions is the ability of IL‑15 to induce dendritic cell differentiation and inflammatory activation (11, 14). IL-15 exhibits anti-tumor activity independent of its actions on NK cells or CD8⁺ T cells (17). It also inhibits the deposition of lipid in adipocytes, and its circulating levels are decreased in obesity (18).

We have publications tested in 6 confirmed species: Human, Mouse, Bovine, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque), Primate - Macaca mulatta (Rhesus Macaque), Xenograft.

We have publications tested in 7 applications: Bioassay, CAR-T (Bioassay), Cell Culture, ELISA (Standard), Flow Cytometry, In Vivo, Western Blot.

Showing Publications 1 - 10 of 161. Show All 161 Publications. Collapse Publications.

Publications using 247-IL	Applications	Species
T Tate, S Matsumoto, K Nemoto, M Leisegang, S Nagayama, K Obama, Y Nakamura, K Kiyotani Identification of T Cell Receptors Targeting a Neoantigen Derived from Recurrently Mutated FGFR3 Cancers, 2023-02-06;15(4):. 2023-02-06 [PMID: 36831375] (Bioassay, Human)	Bioassay	Human
YS Michaels, JM Edgar, MC Major, EL Castle, C Zimmerman, T Yin, A Hagner, C Lau, HH Hsu, MI Ibañez-Rio, LJ Durland, DJHF Knapp, PW Zandstra DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells Science Advances, 2022-08-24;8(34):eabn5522. 2022-08-24 [PMID: 36001668] (Bioassay, Human)	Bioassay	Human
F Nadeu, R Royo, R Massoni-Ba, H Playa-Albi, B Garcia-Tor, M Duran-Ferr, KJ Dawson, M Kulis, A Diaz-Navar, N Villamor, JL Melero, V Chapapriet, A Dueso-Barr, J Delgado, R Moia, S Ruiz-Gil, D Marchese, A Giró, N Verdaguer-, M Romo, G Clot, M Rozman, G Frigola, A Rivas-Delg, T Baumann, M Alcoceba, M González, F Climent, P Abrisqueta, J Castellví, F Bosch, M Aymerich, A Enjuanes, S Ruiz-Gaspà, A López-Guil, P Jares, S Beà, S Capella-Gu, JL Gelpí, N López-Biga, D Torrents, PJ Campbell, I Gut, D Rossi, G Gaidano, XS Puente, PM Garcia-Rov, D Colomer, H Heyn, F Maura, JI Martín-Sub, E Campo Detection of early seeding of Richter transformation in chronic lymphocytic leukemia Nature Medicine, 2022-08-11;28(8):1662-1671. 2022-08-11 [PMID: 35953718] (Bioassay, Human)	Bioassay	Human
K Hagemann, K Riecken, JM Jung, H Hildebrand, S Menzel, MJ Bunders, B Fehse, F Koch-Nolte, F Heinrich, S Peine, J Schulze Zu, TT Brehm, MM Addo, M Lütgehetma, M Altfeld Natural killer cell-mediated ADCC in SARS-CoV-2-infected individuals and vaccine recipients European Journal of Immunology, 2022-04-22;0(0):. 2022-04-22 [PMID: 35416291] (Bioassay, Human)	Bioassay	Human
TH Chu, MC Vo, TJ Lakshmi, SY Ahn, M Kim, GY Song, DH Yang, JS Ahn, HJ Kim, SH Jung, JJ Lee Novel IL-15 dendritic cells have a potent immunomodulatory effect in immunotherapy of multiple myeloma Translational Oncology, 2022-04-09;20(0):101413. 2022-04-09 [PMID: 35413499] (Bioassay, Human)	Bioassay	Human
P Sekhri, DK Ledezma, A Shukla, EE Sweeney, R Fernandes The Thermal Dose of Photothermal Therapy Generates Differential Immunogenicity in Human Neuroblastoma Cells Cancers, 2022-03-11;14(6):. 2022-03-11 [PMID: 35326601] (Cell Culture, Human)	Cell Culture	Human
HC Liang, M Costanza, N Prutsch, MW Zimmerman, E Gurnhofer, IA Montes-Moj, BJ Abraham, N Prokoph, S Stoiber, S Tangermann, C Lobello, J Oppelt, I Anagnostop, T Hielscher, S Pervez, W Klapper, F Zammarchi, DA Silva, KC Garcia, D Baker, M Janz, N Schleussne, F Fend, Š Pospíšilov, A Janiková, J Wallwitz, D Stoiber, I Simonitsch, L Cerroni, S Pileri, L de Leval, D Sibon, V Fataccioli, P Gaulard, C Assaf, F Knörr, C Damm-Welk, W Woessmann, SD Turner, AT Look, S Mathas, L Kenner, O Merkel Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma Nature Communications, 2021-09-22;12(1):5577. 2021-09-22 [PMID: 34552066] (Cell Culture, Human)	Cell Culture	Human
M Pino, S Pereira Ri, A Pagliuzza, K Ghneim, A Khan, E Ryan, JL Harper, CT King, S Welbourn, L Micci, S Aldrete, KA Delman, T Stuart, M Lowe, JM Brenchley, CA Derdeyn, K Easley, RP Sekaly, N Chomont, M Paiardini, VC Marconi Increased homeostatic cytokines and stability of HIV-infected memory CD4 T-cells identify individuals with suboptimal CD4 T-cell recovery on-ART PloS Pathogens, 2021-08-27;17(8):e1009825. 2021-08-27 [PMID: 34449812] (Bioassay, Human)	Bioassay	Human
G David, C Willem, N Legrand, Z Djaoud, P Mérieau, A Walencik, T Guillaume, K Gagne, P Chevallier, C Retière Deciphering the biology of KIR2DL3+ T lymphocytes that are associated to relapse in haploidentical HSCT Scientific Reports, 2021-08-04;11(1):15782. 2021-08-04 [PMID: 34349169] (Bioassay, Human)	Bioassay	Human
AS Bear, T Blanchard, J Cesare, MJ Ford, LP Richman, C Xu, ML Baroja, S McCuaig, C Costeas, K Gabunia, J Scholler, AD Posey, MH O'Hara, A Smole, DJ Powell, BA Garcia, RH Vonderheid, GP Linette, BM Carreno Biochemical and functional characterization of mutant KRAS epitopes validates this oncoprotein for immunological targeting Nature Communications, 2021-07-16;12(1):4365. 2021-07-16 [PMID: 34272369] (Bioassay, Human)	Bioassay	Human
R Basar, N Uprety, E Ensley, M Daher, K Klein, F Martinez, F Aung, M Shanley, B Hu, E Gokdemir, AK Nunez Cort, M Mendt, F Reyes Silv, S Acharya, T Laskowski, L Muniz-Feli, PP Banerjee, Y Li, S Li, L Melo Garci, P Lin, H Shaim, SG Yates, D Marin, I Kaur, S Rao, D Mak, A Lin, Q Miao, J Dou, K Chen, RE Champlin, EJ Shpall, K Rezvani Generation of glucocorticoid-resistant SARS-CoV-2 T�cells for adoptive cell therapy Cell Reports, 2021-07-07;36(3):109432. 2021-07-07 [PMID: 34270918] (Bioassay, Human)	Bioassay	Human
DKJ Pieren, NAM Smits, J Hoeboer, V Kandiah, RJ Postel, R Mariman, J van Beek, D van Baarle, J de Wit, T Guichelaar Regulatory KIR+ RA+ T cells accumulate with age and are highly activated during viral respiratory disease Aging Cell, 2021-05-27;0(0):e13372. 2021-05-27 [PMID: 34043881] (Bioassay, Human)	Bioassay	Human
ED Rossignol, AS Dugast, H Compere, CA Cottrell, J Copps, S Lin, D Cizmeci, MS Seaman, ME Ackerman, AB Ward, G Alter, B Julg Mining HIV controllers for broad and functional antibodies to recognize and eliminate HIV-infected cells Cell Reports, 2021-05-25;35(8):109167. 2021-05-25 [PMID: 34038720] (Bioassay, Human)	Bioassay	Human
F Hasan, Y Chiu, RM Shaw, J Wang, C Yee Hypoxia acts as an environmental cue for the human tissue-resident memory T cell differentiation program JCI Insight, 2021-05-24;6(10):. 2021-05-24 [PMID: 34027895] (Bioassay, Human)	Bioassay	Human
TR Emmons, T Giridharan, KL Singel, ANH Khan, J Ricciuti, K Howard, SL Silva-Del, IL Debreceni, CEM Aarts, MC Brouwer, S Suzuki, TW Kuijpers, I Jongerius, LH Allen, VP Ferreira, A Schubart, H Sellner, J Eder, SM Holland, S Ram, JA Lederer, KH Eng, KB Moysich, K Odunsi, MB Yaffe, E Zsiros, BH Segal Mechanisms Driving Neutrophil-Induced T-cell Immunoparalysis in Ovarian Cancer Cancer Immunology Research, 2021-05-14;9(7):790-810. 2021-05-14 [PMID: 33990375] (Bioassay, Human)	Bioassay	Human
OB Bakker, AD Ramírez-Sá, ZA Borek, N de Klein, Y Li, R Modderman, Y Kooy-Winke, MK Johannesen, F Matarese, JHA Martens, V Kumar, J van Bergen, SW Qiao, KEA Lundin, LM Sollid, F Koning, C Wijmenga, S Withoff, IH Jonkers Potential impact of celiac disease genetic risk factors on T cell receptor signaling in gluten-specific CD4+ T cells Scientific Reports, 2021-04-29;11(1):9252. 2021-04-29 [PMID: 33927210] (Bioassay, Human)	Bioassay	Human
AM Farhat, AC Weiner, C Posner, ZS Kim, B Orcutt-Jah, SM Carlson, AS Meyer Modeling cell-specific dynamics and regulation of the common gamma chain cytokines Cell Reports, 2021-04-27;35(4):109044. 2021-04-27 [PMID: 33910015] (Bioassay, Human)	Bioassay	Human
S Jung, E Appleton, M Ali, GM Church, A Del Sol A computer-guided design tool to increase the efficiency of cellular conversions Nature Communications, 2021-03-12;12(1):1659. 2021-03-12 [PMID: 33712564] (Bioassay, Human)	Bioassay	Human
AK Singh, E Schetzen, SK Yadav, EB Lustig, WH Liu, RK Yadav, RP Gale, K McGinnis, Y Reisner Correction of murine sickle cell disease by allogeneic haematopoietic cell transplantation with anti-3rd party veto cells Bone marrow transplantation, 2021-03-03;0(0):. 2021-03-03 [PMID: 33658643] (Bioassay, Mouse)	Bioassay	Mouse
N Gimenez, R Tripathi, A Giró, L Rosich, M López-Guer, I López-Orej, H Playa-Albi, F Arenas, JM Mas, P Pérez-Galá, J Delgado, E Campo, J Farrés, D Colomer Systems biology drug screening identifies statins as enhancers of current therapies in chronic lymphocytic leukemia Scientific Reports, 2020-12-17;10(1):22153. 2020-12-17 [PMID: 33335123] (Cell Culture, Human)	Cell Culture	Human
KK Naidoo, ZB Shangase, T Rashid, A Ngubane, N Ismail, T Ndung'u, CF Thobakgale The DARC-null trait is associated with moderate modulation of NK cell profiles and unaltered cytolytic T cell profiles in black South Africans PLoS ONE, 2020-11-19;15(11):e0242448. 2020-11-19 [PMID: 33211774] (Bioassay, Human)	Bioassay	Human
B Mbiribindi, JK Pena, MP Arvedson, C Moreno Rom, SR McCarthy, OL Hatton, CO Esquivel, OM Martinez, SM Krams Epstein-Barr virus peptides derived from latent cycle proteins alter NKG2A?+?NK cell effector function Sci Rep, 2020-11-17;10(1):19973. 2020-11-17 [PMID: 33203899] (Bioassay, Human)	Bioassay	Human
S Panigrahi, B Chen, M Fang, D Potashniko, AA Komissarov, A Lebedeva, GM Michaelson, JM Wyrick, SR Morris, SF Sieg, M Paiardini, FJ Villinger, K Harth, VS Kashyap, MJ Cameron, CM Cameron, E Vasilieva, L Margolis, SA Younes, NT Funderburg, DA Zidar, MM Lederman, ML Freeman CX3CL1 and IL-15 Promote CD8 T cell chemoattraction in HIV and in atherosclerosis PLoS Pathog, 2020-09-25;16(9):e1008885. 2020-09-25 [PMID: 32976527] (Cell Culture, Flow Cytometry, Human)	Cell Culture, Flow Cytometry	Human
J Aram, N Frakich, E Morandi, M Alrouji, A Samaraweer, D Onion, I Spendlove, SL Colombo, R Tanasescu, B Gran, CS Constantin Increased IL-2 and Reduced TGF-&beta Upon T-Cell Stimulation are Associated with GM-CSF Upregulation in Multiple Immune Cell Types in Multiple Sclerosis Biomedicines, 2020-07-18;8(7):. 2020-07-18 [PMID: 32708498] (Cell Culture, Human)	Cell Culture	Human
SJ Schober, M Thiede, H Gassmann, C Prexler, B Xue, D Schirmer, D Wohlleber, S Stein, TGP Grünewald, DH Busch, GHS Richter, SEG Burdach, U Thiel MHC Class I-Restricted TCR-Transgenic CD4+ T Cells Against STEAP1 Mediate Local Tumor Control of Ewing Sarcoma In Vivo Cells, 2020-06-29;9(7):. 2020-06-29 [PMID: 32610710] (Cell Culture, Human)	Cell Culture	Human
H Zhu, RH Blum, D Bernareggi, EH Ask, Z Wu, HJ Hoel, Z Meng, C Wu, KL Guan, KJ Malmberg, DS Kaufman Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In�Vivo Persistence and Enhances Anti-tumor Activity Cell Stem Cell, 2020-06-11;0(0):. 2020-06-11 [PMID: 32531207] (Bioassay, Human)	Bioassay	Human
BS Gerstenber, ME Banker, JD Clark, ME Dowty, A Fensome, R Gifford, MC Griffor, M Hegen, BD Hollingshe, JD Knafels, TH Lin, JF Smith, FF Vajdos Demonstration of In Vitro to In Vivo Translation of a TYK2 Inhibitor That Shows Cross Species Potency Differences Sci Rep, 2020-06-02;10(1):8974. 2020-06-02 [PMID: 32488071] (Bioassay, Human)	Bioassay	Human
SR Morris, B Chen, JC Mudd, S Panigrahi, CL Shive, SF Sieg, CM Cameron, DA Zidar, NT Funderburg, SA Younes, B Rodriguez, S Gianella, MM Lederman, ML Freeman "Inflammescent" CX3CR1+CD57+ CD8 T cells are generated and expanded by IL-15 JCI Insight, 2020-06-04;0(0):. 2020-06-04 [PMID: 32369455] (Bioassay, Human)	Bioassay	Human
R Fonseca, LK Beura, CF Quarnstrom, HE Ghoneim, Y Fan, CC Zebley, MC Scott, NJ Fares-Fred, S Wijeyesing, EA Thompson, H Borges da, V Vezys, B Youngblood, D Masopust Developmental plasticity allows outside-in immune responses by resident memory T cells Nat. Immunol., 2020-02-17;0(0):. 2020-02-17 [PMID: 32066954] (Cell Culture, Human)	Cell Culture	Human
JB McBrien, M Mavigner, L Franchitti, SA Smith, E White, GK Tharp, H Walum, K Busman-Suh, CR Aguilera-S, WO Thayer, RA Spagnuolo, M Kovarova, A Wahl, B Cervasi, DM Margolis, TH Vanderford, DG Carnathan, M Paiardini, JD Lifson, JH Lee, JT Safrit, SE Bosinger, JD Estes, CA Derdeyn, JV Garcia, DA Kulpa, A Chahroudi, G Silvestri Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells Nature, 2020-01-22;0(0):. 2020-01-22 [PMID: 31969705] (Cell Culture, Mouse)	Cell Culture	Mouse
L Swadling, LJ Pallett, MO Diniz, JM Baker, OE Amin, KA Stegmann, AR Burton, NM Schmidt, A Jeffery-Sm, N Zakeri, K Suveizdyte, F Froghi, G Fusai, WM Rosenberg, BR Davidson, A Schurich, AK Simon, MK Maini Human Liver Memory CD8+ T Cells Use Autophagy for Tissue Residence Cell Rep, 2020-01-21;30(3):687-698.e6. 2020-01-21 [PMID: 31968246] (Cell Culture, Human)	Cell Culture	Human
DN Nguyen, TL Roth, PJ Li, PA Chen, R Apathy, MR Mamedov, LT Vo, VR Tobin, D Goodman, E Shifrut, JA Bluestone, JM Puck, FC Szoka, A Marson Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency Nat. Biotechnol., 2019-12-09;0(0):. 2019-12-09 [PMID: 31819258] (Cell Culture, Human)	Cell Culture	Human
JD Ventura, J Beloor, E Allen, T Zhang, KA Haugh, PD Uchil, C Ochsenbaue, C Kieffer, P Kumar, TJ Hope, W Mothes Longitudinal bioluminescent imaging of HIV-1 infection during antiretroviral therapy and treatment interruption in humanized mice PLoS Pathog., 2019-12-05;15(12):e1008161. 2019-12-05 [PMID: 31805155] (Cell Culture, Human)	Cell Culture	Human
C Quintarell, S Sivori, S Caruso, S Carlomagno, M Falco, I Boffa, D Orlando, M Guercio, Z Abbaszadeh, M Sinibaldi, S Di Cecca, A Camera, B Cembrola, A Pitisci, M Andreani, L Vinti, S Gattari, F Del Bufalo, M Algeri, G Li Pira, A Moseley, B De Angelis, L Moretta, F Locatelli Efficacy of third-party chimeric antigen receptor modified peripheral blood natural killer cells for adoptive cell therapy of B-cell precursor acute lymphoblastic leukemia Leukemia, 2019-11-19;0(0):. 2019-11-19 [PMID: 31745215] (Cell Culture, Human)	Cell Culture	Human
ZY Li, JJ Zhou, CL Luo, LM Zhang Activation of TGR5 alleviates inflammation in rheumatoid arthritis peripheral blood mononuclear cells and in mice with collagen II?induced arthritis Mol Med Rep, 2019-09-26;20(5):4540-4550. 2019-09-26 [PMID: 31702035] (Cell Culture, Human)	Cell Culture	Human
R Eyre, DG Alférez, A Santiago-G, K Spence, JC McConnell, C Hart, BM Simões, D Lefley, C Tulotta, J Storer, A Gurney, N Clarke, M Brown, SJ Howell, AH Sims, G Farnie, PD Ottewell, RB Clarke Microenvironmental IL1beta promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling Nat Commun, 2019-11-01;10(1):5016. 2019-11-01 [PMID: 31676788] (Cell Culture, Human)	Cell Culture	Human
M López-Guer, S Xargay-Tor, P Fuentes, J Roldán, B González-F, L Rosich, E Silkensted, MJ García-Leó, E Lee-Vergés, N Giménez, A Giró, M Aymerich, N Villamor, J Delgado, A López-Guil, XS Puente, E Campo, ML Toribio, D Colomer Specific NOTCH1 antibody targets DLL4-induced proliferation, migration, and angiogenesis in NOTCH1-mutated CLL cells Oncogene, 2019-10-15;0(0):. 2019-10-15 [PMID: 31616059] (Bioassay, Human)	Bioassay	Human
ER Wonderlich, K Subramania, B Cox, A Wiegand, C Lackman-Sm, MJ Bale, M Stone, R Hoh, MF Kearney, F Maldarelli, SG Deeks, MP Busch, RG Ptak, DA Kulpa Effector memory differentiation increases detection of replication-competent HIV-l in resting CD4+ T cells from virally suppressed individuals PLoS Pathog., 2019-10-14;15(10):e1008074. 2019-10-14 [PMID: 31609991] (Bioassay, Human)	Bioassay	Human
K Renner, C Bruss, A Schnell, G Koehl, HM Becker, M Fante, AN Menevse, N Kauer, R Blazquez, L Hacker, SM Decking, T Bohn, S Faerber, K Evert, L Aigle, S Amslinger, M Landa, O Krijgsman, EA Rozeman, C Brummer, PJ Siska, K Singer, S Pektor, M Miederer, K Peter, E Gottfried, W Herr, I Marchiq, J Pouyssegur, WR Roush, S Ong, S Warren, T Pukrop, P Beckhove, SA Lang, T Bopp, CU Blank, JL Cleveland, PJ Oefner, K Dettmer, M Selby, M Kreutz Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy Cell Rep, 2019-10-01;29(1):135-150.e9. 2019-10-01 [PMID: 31577944] (Bioassay, Human)	Bioassay	Human
A Gras Navar, H Espedal, JV Joseph, L Trachsel-M, M Bahador, B Tore Gjert, E Klæboe Kri, A Simonsen, H Miletic, P Øyvind Eng, MA Rahman, M Chekenya Pretreatment of Glioblastoma with Bortezomib Potentiates Natural Killer Cell Cytotoxicity through TRAIL/DR5 Mediated Apoptosis and Prolongs Animal Survival Cancers (Basel), 2019-07-17;11(7):. 2019-07-17 [PMID: 31319548] (Bioassay, Human)	Bioassay	Human
VC Lam, L Folkersen, OA Aguilar, LL Lanier KLF12 Regulates Mouse NK Cell Proliferation J. Immunol., 2019-07-12;0(0):. 2019-07-12 [PMID: 31300511] (Bioassay, Mouse)	Bioassay	Mouse
EW Kim, A De Leon, Z Jiang, RA Radu, AR Martineau, ED Chan, X Bai, WL Su, DJ Montoya, RL Modlin, PT Liu Vitamin A Metabolism by Dendritic Cells Triggers an Antimicrobial Response against Mycobacterium tuberculosis mSphere, 2019-06-05;4(3):. 2019-06-05 [PMID: 31167948] (Bioassay, Human)	Bioassay	Human
HJ Yoo, Y Liu, L Wang, ML Schubert, JM Hoffmann, S Wang, B Neuber, A Hückelhove, U Gern, A Schmitt, C Müller-Tid, P Dreger, A Mokhir, M Schmitt, L Sellner Tumor-Specific Reactive Oxygen Species Accelerators Improve Chimeric Antigen Receptor T Cell Therapy in B Cell Malignancies Int J Mol Sci, 2019-05-18;20(10):. 2019-05-18 [PMID: 31109083] (CAR-T (Bioassay), Human)	CAR-T (Bioassay)	Human
W Yang, KW Lee, RM Srivastava, F Kuo, C Krishna, D Chowell, V Makarov, D Hoen, MG Dalin, L Wexler, R Ghossein, N Katabi, Z Nadeem, MA Cohen, SK Tian, N Robine, K Arora, H Geiger, P Agius, N Bouvier, K Huberman, K Vanness, JJ Havel, JS Sims, RM Samstein, R Mandal, J Tepe, I Ganly, AL Ho, N Riaz, RJ Wong, N Shukla, TA Chan, LGT Morris Immunogenic neoantigens derived from gene fusions stimulate T cell responses Nat. Med., 2019-04-22;0(0):. 2019-04-22 [PMID: 31011208] (Bioassay, Human)	Bioassay	Human
K Kuranda, S Caillat-Zu, S You, R Mallone In�Vitro Expansion of Anti-viral T Cells from Cord Blood by Accelerated Co-cultured Dendritic Cells Mol Ther Methods Clin Dev, 2018-12-31;13(0):112-120. 2018-12-31 [PMID: 30740473] (Bioassay, Human)	Bioassay	Human
C Solà-Riera, S Gupta, HG Ljunggren, J Klingström Orthohantaviruses belonging to three phylogroups all inhibit apoptosis in infected target cells Sci Rep, 2019-01-29;9(1):834. 2019-01-29 [PMID: 30696898] (Bioassay, Human)	Bioassay	Human
C Schleiss, W Ilias, O Tahar, Y Güler, L Miguet, C Mayeur-Rou, L Mauvieux, LM Fornecker, E Toussaint, R Herbrecht, F Bertrand, M Maumy-Bert, T Martin, S Fournel, P Georgel, S Bahram, L Vallat BCR-associated factors driving chronic lymphocytic leukemia cells proliferation ex vivo Sci Rep, 2019-01-24;9(1):701. 2019-01-24 [PMID: 30679590] (Bioassay, Human)	Bioassay	Human
SR Kim, JM Lewis, BM Cyrenne, PF Monico, FN Mirza, KR Carlson, FM Foss, M Girardi BET inhibition in advanced cutaneous T cell lymphoma is synergistically potentiated by BCL2 inhibition or HDAC inhibition Oncotarget, 2018-06-26;9(49):29193-29207. 2018-06-26 [PMID: 30018745] (Bioassay, Human)	Bioassay	Human
X Zhao, S Sankaran, J Yap, CT Too, ZZ Ho, G Dolton, M Legut, EC Ren, AK Sewell, A Bertoletti, PA MacAry, J Brzostek, NRJ Gascoigne Nonstimulatory peptide-MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling Nat Commun, 2018-07-13;9(1):2716. 2018-07-13 [PMID: 30006605] (Bioassay, Human)	Bioassay	Human
EW Kim, RMB Teles, S Haile, PT Liu, RL Modlin Vitamin D status contributes to the antimicrobial activity of macrophages against Mycobacterium leprae PLoS Negl Trop Dis, 2018-07-02;12(7):e0006608. 2018-07-02 [PMID: 29965969] (Bioassay, Human)	Bioassay	Human
MP Correia, A Stojanovic, K Bauer, D Juraeva, LO Tykocinski, HM Lorenz, B Brors, A Cerwenka Distinct human circulating NKp30+Fc?RI?+CD8+ T cell population exhibiting high natural killer-like antitumor potential Proc. Natl. Acad. Sci. U.S.A., 2018-06-12;0(0):. 2018-06-12 [PMID: 29895693] (Cell Culture, Human)	Cell Culture	Human
Y Rodríguez-, A Cabrales-R, A Perera-Pin, A Prats-Capo, HE Garay-Pére, O Reyes-Acos, E Pérez-Garc, A Chico-Capo, A Santos-Sav In vitro and in vivo characterization of an interleukin-15 antagonist peptide by metabolic stability, 99m Tc-labeling, and biological activity assays J. Pept. Sci., 2018-04-15;24(4):e3078. 2018-04-15 [PMID: 29656472] (Bioassay, Mouse)	Bioassay	Mouse
L Golden-Mas, RH McMahan, MS Kriss, AL Kilgore, L Cheng, RJ Dran, A Wieland, HR Rosen Early and late changes in natural killer cells in response to ledipasvir/sofosbuvir treatment Hepatol Commun, 2018-03-01;2(4):364-375. 2018-03-01 [PMID: 29619416] (Bioassay, Human)	Bioassay	Human
R Liu, J Merola, TD Manes, L Qin, GT Tietjen, F López-Girá, V Broecker, C Fang, C Xie, PM Chen, NC Kirkiles-S, D Jane-Wit, JS Pober Interferon-? converts human microvascular pericytes into negative regulators of alloimmunity through induction of indoleamine 2,3-dioxygenase 1 JCI Insight, 2018-03-08;3(5):. 2018-03-08 [PMID: 29515027] (Bioassay, Human)	Bioassay	Human
T Oth, THPM Habets, WTV Germeraad, MI Zonneveld, GMJ Bos, J Vanderloch Pathogen recognition by NK cells amplifies the pro-inflammatory cytokine production of monocyte-derived DC via IFN-? BMC Immunol., 2018-02-13;19(1):8. 2018-02-13 [PMID: 29433450] (Bioassay, Human)	Bioassay	Human
C Thepmalee, A Panya, M Junking, T Chieochans, PT Yenchitsom Inhibition of IL-10 and TGF-? receptors on dendritic cells enhances activation of effector T-cells to kill cholangiocarcinoma cells Hum Vaccin Immunother, 2018-02-21;0(0):0. 2018-02-21 [PMID: 29420117] (Bioassay, Human)	Bioassay	Human
M Felices, AJ Lenvik, R McElmurry, S Chu, P Hinderlie, L Bendzick, MA Geller, J Tolar, BR Blazar, JS Miller Continuous treatment with IL-15 exhausts human NK cells via a metabolic defect JCI Insight, 2018-02-08;3(3):. 2018-02-08 [PMID: 29415897] (Bioassay, Human)	Bioassay	Human
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Ramana Rao PV, Rajasekaran S, Raja A Natural killer cell-mediated cytokine response among HIV-positive south Indians with pulmonary tuberculosis. J. Interferon Cytokine Res., 2010-01-01;30(1):33-42. 2010-01-01 [PMID: 20028198] (Bioassay, Human)	Bioassay	Human
Kwant-Mitchell A, Pek EA, Rosenthal KL Development of functional human NK cells in an immunodeficient mouse model with the ability to provide protection against tumor challenge. PLoS ONE, 2009-12-21;4(12):e8379. 2009-12-21 [PMID: 20027308] (Bioassay, Human)	Bioassay	Human
Erlendsson LS, Muench MO, Hellman U, Hrafnkelsdottir SM, Jonsson A, Balmer Y, Mantyla E, Orvar BL Barley as a green factory for the production of functional Flt3 ligand. Biotechnol J, 2010-02-01;5(2):163-71. 2010-02-01 [PMID: 19844912] (Bioassay, Human)	Bioassay	Human
Duluc D, Corvaisier M, Blanchard S, Catala L, Descamps P, Gamelin E, Ponsoda S, Delneste Y, Hebbar M, Jeannin P Interferon-gamma reverses the immunosuppressive and protumoral properties and prevents the generation of human tumor-associated macrophages. Int. J. Cancer, 2009-07-15;125(2):367-73. 2009-07-15 [PMID: 19378341] (Bioassay, Human)	Bioassay	Human
Giron-Michel J, Menard F, Negrini S, Devocelle A, Azzarone B, Besson C EBV-associated mononucleosis does not induce long-term global deficit in T-cell responsiveness to IL-15. Blood, 2009-03-04;113(19):4541-7. 2009-03-04 [PMID: 19264676] (Bioassay, Human)	Bioassay	Human
Eid RE, Rao DA, Zhou J, Lo SF, Ranjbaran H, Gallo A, Sokol SI, Pfau S, Pober JS, Tellides G Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells. Circulation, 2009-03-02;119(10):1424-32. 2009-03-02 [PMID: 19255340] (Bioassay, Human)	Bioassay	Human
Kitaya K, Yasuo T Dermatan sulfate proteoglycan biglycan as a potential selectin L/CD44 ligand involved in selective recruitment of peripheral blood CD16(-) natural killer cells into human endometrium. J. Leukoc. Biol., 2008-12-16;85(3):391-400. 2008-12-16 [PMID: 19088176] (Bioassay, Human)	Bioassay	Human
Vossen MT, Matmati M, Hertoghs KM, Baars PA, Gent MR, Leclercq G, Hamann J, Kuijpers TW, van Lier RA CD27 defines phenotypically and functionally different human NK cell subsets. J. Immunol., 2008-03-15;180(6):3739-45. 2008-03-15 [PMID: 18322179] (Bioassay, Human)	Bioassay	Human
McCullar V, Oostendorp R, Panoskaltsis-Mortari A, Yun G, Lutz CT, Wagner JE, Miller JS Mouse fetal and embryonic liver cells differentiate human umbilical cord blood progenitors into CD56-negative natural killer cell precursors in the absence of interleukin-15. Exp. Hematol., 2008-03-04;36(5):598-608. 2008-03-04 [PMID: 18295962] (Bioassay, Human)	Bioassay	Human
Pfleger C, Schloot N, ter Veld F Effect of serum content and diluent selection on assay sensitivity and signal intensity in multiplex bead-based immunoassays. J. Immunol. Methods, 2007-10-22;329(1):214-8. 2007-10-22 [PMID: 17964594] (ELISA (Standard))	ELISA (Standard)
de Matos CT, Berg L, Michaelsson J, Fellander-Tsai L, Karre K, Soderstrom K Activating and inhibitory receptors on synovial fluid natural killer cells of arthritis patients: role of CD94/NKG2A in control of cytokine secretion. Immunology, 2007-05-22;122(2):291-301. 2007-05-22 [PMID: 17521371] (Bioassay, Human)	Bioassay	Human
Bulanova E, Budagian V, Duitman E, Orinska Z, Krause H, Ruckert R, Reiling N, Bulfone-Paus S Soluble Interleukin IL-15Ralpha is generated by alternative splicing or proteolytic cleavage and forms functional complexes with IL-15. J. Biol. Chem., 2007-02-27;282(18):13167-79. 2007-02-27 [PMID: 17327231] (Bioassay, Human)	Bioassay	Human
Biancotto A, Grivel JC, Iglehart SJ, Vanpouille C, Lisco A, Sieg SF, Debernardo R, Garate K, Rodriguez B, Margolis LB, Lederman MM Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1. Blood, 2007-02-08;109(10):4272-9. 2007-02-08 [PMID: 17289812] (ELISA (Standard))	ELISA (Standard)
Eidenschenk C, Jouanguy E, Alcais A, Mention JJ, Pasquier B, Fleckenstein IM, Puel A, Gineau L, Carel JC, Vivier E, Le Deist F, Casanova JL Familial NK cell deficiency associated with impaired IL-2- and IL-15-dependent survival of lymphocytes. J. Immunol., 2006-12-15;177(12):8835-43. 2006-12-15 [PMID: 17142786] (Bioassay, Human)	Bioassay	Human
Hirahara K, Liu L, Clark RA, Yamanaka K, Fuhlbrigge RC, Kupper TS The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors. J. Immunol., 2006-10-01;177(7):4488-94. 2006-10-01 [PMID: 16982885] (Bioassay, Human)	Bioassay	Human
Ebert EC, Mehta V Human intestinal intraepithelial lymphocytes keep TNF alpha levels low by cell uptake and feedback inhibition of transcription. Cell. Immunol., 2006-08-17;241(1):7-13. 2006-08-17 [PMID: 16914126] (Bioassay, Human)	Bioassay	Human
Goff WL, Storset AK, Johnson WC, Brown WC Bovine splenic NK cells synthesize IFN-gamma in response to IL-12-containing supernatants from Babesia bovis-exposed monocyte cultures. Parasite Immunol., 2006-05-01;28(5):221-8. 2006-05-01 [PMID: 16629708] (Bioassay, Bovine)	Bioassay	Bovine
Cho ML, Min SY, Chang SH, Kim KW, Heo SB, Lee SH, Park SH, Cho CS, Kim HY Transforming growth factor beta 1(TGF-beta1) down-regulates TNFalpha-induced RANTES production in rheumatoid synovial fibroblasts through NF-kappaB-mediated transcriptional repression. Immunol. Lett., 2006-03-03;105(2):159-66. 2006-03-03 [PMID: 16564576] (Bioassay, Human)	Bioassay	Human
Hanabuchi S, Watanabe N, Wang YH, Ito T, Shaw J, Cao W, Qin FX, Liu YJ Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL). Blood, 2006-01-05;107(9):3617-23. 2006-01-05 [PMID: 16397134] (Bioassay, Human)	Bioassay	Human
von Strandmann EP, Hansen HP, Reiners KS, Schnell R, Borchmann P, Merkert S, Simhadri VR, Draube A, Reiser M, Purr I, Hallek M, Engert A A novel bispecific protein (ULBP2-BB4) targeting the NKG2D receptor on natural killer (NK) cells and CD138 activates NK cells and has potent antitumor activity against human multiple myeloma in vitro and in vivo. Blood, 2005-10-06;107(5):1955-62. 2005-10-06 [PMID: 16210338] (Bioassay, Human)	Bioassay	Human
Alves NL, Arosa FA, van Lier RA IL-21 sustains CD28 expression on IL-15-activated human naive CD8+ T cells. J. Immunol., 2005-07-15;175(2):755-62. 2005-07-15 [PMID: 16002671] (Bioassay, Human)	Bioassay	Human
Vasir B, Avigan D, Wu Z, Crawford K, Turnquist S, Ren J, Kufe D Dendritic cells induce MUC1 expression and polarization on human T cells by an IL-7-dependent mechanism. J. Immunol., 2005-02-15;174(4):2376-86. 2005-02-15 [PMID: 15699174] (Bioassay, Human)	Bioassay	Human
Tejman-Yarden N, Zlotnik M, Lewis E, Etzion O, Chaimovitz C, Douvdevani A Renal cells express a functional interleukin-15 receptor. Nephrol. Dial. Transplant., 2005-01-25;20(3):516-23. 2005-01-25 [PMID: 15671076] (Western Blot)	Western Blot
Conklyn M, Andresen C, Changelian P, Kudlacz E The JAK3 inhibitor CP-690550 selectively reduces NK and CD8+ cell numbers in cynomolgus monkey blood following chronic oral dosing. J. Leukoc. Biol., 2004-09-15;76(6):1248-55. 2004-09-15 [PMID: 15371489] (Bioassay, Human, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))	Bioassay	Human, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
Kao CY, Chen Y, Thai P, Wachi S, Huang F, Kim C, Harper RW, Wu R IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways. J. Immunol., 2004-09-01;173(5):3482-91. 2004-09-01 [PMID: 15322213] (Bioassay, Human)	Bioassay	Human
Ciree A, Michel L, Camilleri-Broet S, Jean Louis F, Oster M, Flageul B, Senet P, Fossiez F, Fridman WH, Tartour E Expression and activity of IL-17 in cutaneous T-cell lymphomas (mycosis fungoides and Sezary syndrome). Int. J. Cancer, 2004-10-20;112(1):113-20. 2004-10-20 [PMID: 15305382] (Bioassay, Human)	Bioassay	Human
Yamasaki S, Maeda M, Ohshima K, Kikuchi M, Otsuka T, Harada M Growth and apoptosis of human natural killer cell neoplasms: role of interleukin-2/15 signaling. Leuk. Res., 2004-10-01;28(10):1023-31. 2004-10-01 [PMID: 15289013] (Bioassay, Human)	Bioassay	Human
Brady J, Hayakawa Y, Smyth MJ, Nutt SL IL-21 induces the functional maturation of murine NK cells. J. Immunol., 2004-02-15;172(4):2048-58. 2004-02-15 [PMID: 14764669] (Bioassay, Mouse)	Bioassay	Mouse
Calarota SA, Otero M, Hermanstayne K, Lewis M, Rosati M, Felber BK, Pavlakis GN, Boyer JD, Weiner DB Use of interleukin 15 to enhance interferon-gamma production by antigen-specific stimulated lymphocytes from rhesus macaques. J. Immunol. Methods, 2003-08-01;279(1):55-67. 2003-08-01 [PMID: 12969547] (Bioassay, Primate - Macaca mulatta (Rhesus Macaque))	Bioassay	Primate - Macaca mulatta (Rhesus Macaque)
Groh V, Bruhl A, El-Gabalawy H, Nelson JL, Spies T Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis. Proc. Natl. Acad. Sci. U.S.A., 2003-07-23;100(16):9452-7. 2003-07-23 [PMID: 12878725] (Bioassay, Human)	Bioassay	Human
Wang CR, Liu MF Regulation of CCR5 expression and MIP-1alpha production in CD4+ T cells from patients with rheumatoid arthritis. Clin. Exp. Immunol., 2003-05-01;132(2):371-8. 2003-05-01 [PMID: 12699431] (Bioassay, Human)	Bioassay	Human
Ong PY, Hamid QA, Travers JB, Strickland I, Al Kerithy M, Boguniewicz M, Leung DY Decreased IL-15 may contribute to elevated IgE and acute inflammation in atopic dermatitis. J. Immunol., 2002-01-01;168(1):505-10. 2002-01-01 [PMID: 11751999] (Bioassay, Human)	Bioassay	Human
Searle RF, Bromage SJ, Palmer J, Curry JE, Lang AK Human amniotic fluid lacks interleukin-2 and interleukin-15 but can interact with the beta-chain of the interleukin-2 receptor. Immunology, 2000-03-01;99(3):411-7. 2000-03-01 [PMID: 10712671] (ELISA (Standard))	ELISA (Standard)
Chen YM, Ting CC, Peng JW, Yang WK, Yang KY, Tsai CM, Perng RP Restoration of cytotoxic T lymphocyte function in malignant pleural effusion: interleukin-15 vs. interleukin-2. J. Interferon Cytokine Res., 2000-01-01;20(1):31-9. 2000-01-01 [PMID: 10670650] (Bioassay, Human)	Bioassay	Human
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Array 247-IL

• IL-15 Antibodies
• IL-15 Antibody Pair
• IL-15 ELISA Kits
• IL-15 Lysate
• IL-15 Proteins
• IL-15 ELISAs
• IL-15 Proteins and Enzymes