Recombinant Human GM-CSF (CHO-expressed) Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

GM‑CSF was initially characterized as a factor that can support the in vitro colony formation of granulocyte‑macrophage progenitors. It is also a growth factor for erythroid, megakaryocyte, and eosinophil progenitors. GM‑CSF is produced by a number of different cell types (including T cells, B cells, macrophages, mast cells, endothelial cells, fibroblasts, and adipocytes) in response to cytokine or inflammatory stimuli. On mature hematopoietic cells, GM‑CSF is a survival factor for and activates the effector functions of granulocytes, monocytes/macrophages, and eosinophils (1, 2). GM‑CSF promotes a Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity (3‑5). It shows clinical effectiveness in ameliorating chemotherapy‑induced neutropenia, and GM‑CSF transfected tumor cells are utilized as cancer vaccines (6, 7). The 22 kDa glycosylated GM‑CSF, similar to IL‑3 and IL‑5, is a cytokine with a core of four bundled alpha ‑helices (8‑12). Mature human GM‑CSF shares 63%‑70% amino acid sequence identity with canine, feline, porcine, and rat GM‑CSF and 54% with mouse GM‑CSF. GM‑CSF exerts its biological effects through a heterodimeric receptor complex composed of GM‑CSF R alpha /CD116 and the signal transducing common beta  chain (CD131) which is also a component of the high‑affinity receptors for IL‑3 and IL‑5 (13, 14). In addition, GM‑CSF binds a naturally occurring soluble form of GM‑CSF R alpha (15). Human GM‑CSF is active on canine and feline cells but not on murine cells (16‑18).

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: Bioassay, Cell Culture.

Showing Publications 1 - 6 of 6.

Publications using 7954-GM	Applications	Species
Moore, KM;Pelletier, AN;Lapp, S;Metz, A;Tharp, GK;Lee, M;Bhasin, SS;Bhasin, M;Sékaly, RP;Bosinger, SE;Suthar, MS; Single cell analysis reveals an antiviral network that controls Zika virus infection in human dendritic cells bioRxiv : the preprint server for biology 2024-01-21 [PMID: 38293140] (Bioassay, Human)	Bioassay	Human
Martins, C;Rasbach, E;Heppt, MV;Singh, P;Kulcsar, Z;Holzgruber, J;Chakraborty, A;Mucciarone, K;Kleffel, S;Brandenburg, A;Hoetzenecker, W;Rahbari, NN;DeCaprio, JA;Thakuria, M;Murphy, GF;Ramsey, MR;Posch, C;Barthel, SR;Schatton, T; Tumor cell-intrinsic PD-1 promotes Merkel cell carcinoma growth by activating downstream mTOR-mitochondrial ROS signaling Science advances 2024-01-19 [PMID: 38241371] (Bioassay, Human)	Bioassay	Human
Pan, HW;Guo, J;Zhu, L;Leung, SWS;Zhang, C;Lam, JKW; Enhanced powder dispersion of dual-excipient spray-dried powder formulations of a monoclonal antibody and its fragment for local treatment of severe asthma International journal of pharmaceutics 2023-07-25 [PMID: 37499774] (Bioassay, Human)	Bioassay	Human
X Wang, S Cooper, HE Broxmeyer, R Kapur Transient regulation of RNA methylation in human hematopoietic stem cells promotes their homing and engraftment Leukemia, 2022-12-02;0(0):. 2022-12-02 [PMID: 36460765] (Cell Culture, Human)	Cell Culture	Human
J Zhu, Z Chen, X Peng, Z Zheng, A Le, J Guo, L Ma, H Shi, K Yao, S Zhang, J Ge, Z Zheng, Q Wang Extracellular Vesicle-Derived circITGB1 Regulates Dendritic Cell Maturation and Cardiac Inflammation via miR-342-3p/NFAM1 Oxidative Medicine and Cellular Longevity, 2022-05-16;2022(0):8392313. 2022-05-16 [PMID: 35615580] (Bioassay, Human)	Bioassay	Human
M Medelin, V Giacco, A Aldinucci, G Castronovo, E Bonechi, A Sibilla, M Tanturli, M Torcia, L Ballerini, F Cozzolino, C Ballerini Bridging pro-inflammatory signals, synaptic transmission and protection in spinal explants in vitro Mol Brain, 2018-01-15;11(1):3. 2018-01-15 [PMID: 29334986] (Bioassay, Mouse)	Bioassay	Mouse

Array 7954-GM

• GM-CSF Antibodies
• GM-CSF Antibody Pairs
• GM-CSF ELISA Kits
• GM-CSF Lysate
• GM-CSF Proteins
• GM-CSF ELISAs
• GM-CSF Proteins and Enzymes