Recombinant Human E-Cadherin Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

E-Cadherin/Cadherin-1, also known as Uvomorulin in the mouse and rat, is a 120 kDa member of the Cadherin family of cell surface glycoproteins that mediate cell adhesion (1). Human E-Cadherin shares 81% amino acid sequence identity with the rat and mouse proteins (2). It is a single-pass transmembrane protein that mediates calcium-dependent epithelial cell adhesion. E-Cadherin has five extracellular EC domains that form homophilic cis-clusters between adjacent epithelial cells and trans-clusters within the same cell. E-Cadherin clusters are critical components of adherens junctions between epithelial cells and act in the formation and maintenance of the epithelial cell barrier (3, 4). The intracellular domain of E-Cadherin binds to the Catenin cytoskeletal complex, which includes p120 Catenin, beta-Catenin, alpha-Catenin, and Vinculin. E-Cadherin expression is critical for epithelial tissue homeostasis. Decreased E-Cadherin is associated with physiological and pathological epithelial-to-mesenchymal transition and cell migration, and E-Cadherin loss contributes to cancer metastasis (5). The extracellular E-Cadherin N-terminal domain can be cleaved by several proteases and is released as a soluble factor that enhances cancer cell motility and EGFR-dependent survival and proliferation (6).

We have publications tested in 3 confirmed species: Human, Bacteria, N/A.

We have publications tested in 2 applications: Bioassay, Western Blot Control.

Showing Publications 1 - 9 of 9.

Publications using 8505-EC	Applications	Species
Carriquí-Madroñal, B;Sheldon, J;Duven, M;Stegmann, C;Cirksena, K;Wyler, E;Zapatero-Belinchón, FJ;Vondran, FWR;Gerold, G; The matrix metalloproteinase ADAM10 supports hepatitis C virus entry and cell-to-cell spread via its sheddase activity PLoS pathogens 2023-11-01 [PMID: 37967063] (Bioassay, Human)	Bioassay	Human
Souralova, T;Hulinova, D;Jeseta, M;Ventruba, P;Hampl, A;Koutna, I; Truncated vitronectin with E-cadherin enables the xeno-free derivation of human embryonic stem cells Scientific reports 2023-09-12 [PMID: 37700192] (Bioassay, Human)	Bioassay	Human
X Zhang, Y Lin, X Xu, S Wen, Z Wang, J Gu, Q He, X Cai HtrA is involved in stress response and adhesion in Glaesserella parasuis serovar 5 strain Nagasaki Veterinary Microbiology, 2023-04-18;282(0):109748. 2023-04-18 [PMID: 37120968] (Bioassay, N/A)	Bioassay	N/A
II Ceschin, AP Ceschin, MS Joya, TG Mitsugi, LK Nishikawa, AC Krepischi, OK Okamoto Functional assessment of donated human embryos for the generation of pluripotent embryonic stem cell lines Reproductive biomedicine online, 2022-12-02;0(0):. 2022-12-02 [PMID: 36737274] (Bioassay, Human)	Bioassay	Human
M Kwak, KM Southard, WR Kim, A Lin, NH Kim, R Gopalappa, HJ Lee, M An, SH Choi, Y Jung, K Noh, J Farlow, A Georgakopo, NK Robakis, MK Kang, ML Kutys, D Seo, HH Kim, YH Kim, J Cheon, ZJ Gartner, YW Jun Adherens junctions organize size-selective proteolytic hotspots critical for Notch signalling Nature Cell Biology, 2022-12-01;24(12):1739-1753. 2022-12-01 [PMID: 36456828] (Bioassay, Human)	Bioassay	Human
DS Micalizzi, D Che, BT Nicholson, JF Edd, N Desai, ER Lang, M Toner, S Maheswaran, DT Ting, DA Haber Targeting breast and pancreatic cancer metastasis using a dual-cadherin antibody Proceedings of the National Academy of Sciences of the United States of America, 2022-10-18;119(43):e2209563119. 2022-10-18 [PMID: 36256815] (Western Blot Control, Human)	Western Blot Control	Human
ED Tabdanov, VV Puram, Z Win, A Alamgir, PW Alford, PP Provenzano Bimodal sensing of guidance cues in mechanically distinct microenvironments Nat Commun, 2018;9(1):4891. 2018 [PMID: 30459308] (Bioassay, Human)	Bioassay	Human
M Yamada, N Takahashi, Y Matsuda, K Sato, M Yokoji, B Sulijaya, T Maekawa, T Ushiki, Y Mikami, M Hayatsu, Y Mizutani, S Kishino, J Ogawa, M Arita, K Tabeta, T Maeda, K Yamazaki A bacterial metabolite ameliorates periodontal pathogen-induced gingival epithelial barrier disruption via GPR40 signaling Sci Rep, 2018-06-13;8(1):9008. 2018-06-13 [PMID: 29899364] (Bioassay, Bacteria)	Bioassay	Bacteria
JM Caldwell, MH Collins, KA Kemme, JD Sherrill, T Wen, M Rochman, EM Stucke, L Amin, H Tai, PE Putnam, MJ Jim‚nez-Da, MR Wormald, A Porollo, JP Abonia, ME Rothenberg Cadherin 26 is an alpha integrin-binding epithelial receptor regulated during allergic inflammation Mucosal Immunol, 2017-01-04;0(0):. 2017-01-04 [PMID: 28051089] (Bioassay, Human)	Bioassay	Human

Array 8505-EC

• E-Cadherin Antibodies
• E-Cadherin Antibody Pair
• E-Cadherin ELISA Kits
• E-Cadherin Lysate
• E-Cadherin Proteins
• E-Cadherin ELISAs
• E-Cadherin Proteins and Enzymes