Recombinant Human Decorin Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Decorin, also known as PG40 and PGS2, is a secreted chondroitin/dermatan sulfate proteoglycan in the family of small leucine‑rich proteoglycans (SLRPs). SLRP family members are characterized by N‑terminal and C‑terminal cysteine‑rich regions which flank the central region containing 10 ‑ 12 tandem leucine‑rich repeats (LRR) (1). The human Decorin cDNA encodes a 359 amino acid (aa) precursor that includes a 16 aa signal sequence and a 14 aa propeptide (2). Mature human Decorin contains twelve tandem LRR and shares 80% and 78% aa sequence identity with mouse and rat Decorin, respectively. Alternate splicing of human Decorin generates five isoforms with variable length deletions. Decorin is an N‑glycosylated protein that also carries a variably‑sized hybrid chondroitin/dermatan sulfate chain at Ser34 (3, 4). Naturally occurring Decorin proteoglycan has a molecular mass of approximately 100 kDa, and the deglycosylated Decorin core protein has a mass of approximately 40 kDa (5). Decorin regulates assembly of the extracellular collagen matrix and the bioactivity of the matrix associated growth factors FGF‑2, GDF‑8/Myostatin, TGF‑ beta , and WISP‑1 (4, 6 ‑ 9). It also binds and activates EGF R, ErbB4, and IGF‑I R (10 ‑ 12). In vivo, Decorin promotes myoblast differentiation, supports angiogenesis, and inhibits tumor progression (13 ‑ 16). Decorin is cleared from the extracellular space by LRP‑mediated endocytosis (17).

We have publications tested in 5 confirmed species: Human, Mouse, Rat, Bovine, N/A.

We have publications tested in 7 applications: Antibody Absorption, Array Development, Bioassay, Cell Culture, Control, ELISA (Standard), In Vivo.

Showing Publications 1 - 10 of 16. Show All 16 Publications. Collapse Publications.

Publications using 143-DE	Applications	Species
Li, Y;Wei, Y;Ultsch, M;Li, W;Tang, W;Tombling, B;Gao, X;Dimitrova, Y;Gampe, C;Fuhrmann, J;Zhang, Y;Hannoush, RN;Kirchhofer, D; Cystine-knot peptide inhibitors of HTRA1 bind to a cryptic pocket within the active site region Nature communications 2024-05-22 [PMID: 38777835] (Bioassay, N/A)	Bioassay	N/A
Wang, S;Qu, Y;Fang, X;Ding, Q;Zhao, H;Yu, X;Xu, T;Lu, R;Jing, S;Liu, C;Wu, H;Liu, Y; Decorin: a potential therapeutic candidate for ligamentum flavum hypertrophy by antagonizing TGF-beta 1 Experimental & molecular medicine 2023-07-03 [PMID: 37394592] (Bioassay, In Vivo, Human, Rat)	Bioassay, In Vivo	Human, Rat
S Gerhardy, M Ultsch, W Tang, E Green, JK Holden, W Li, A Estevez, C Arthur, I Tom, A Rohou, D Kirchhofer Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration Nature Communications, 2022-09-05;13(1):5222. 2022-09-05 [PMID: 36064790] (Bioassay, Human)	Bioassay	Human
Q Ding, Q Wei, G Sheng, S Wang, S Jing, T Ma, R Zhang, T Wang, W Li, X Tang, H Wu, C Liu The Preventive Effect of Decorin on Epidural Fibrosis and Epidural Adhesions After Laminectomy Frontiers in Pharmacology, 2021-12-16;12(0):774316. 2021-12-16 [PMID: 34975478] (Bioassay, Human)	Bioassay	Human
S Du, J Shao, D Xie, F Zhang Decorin inhibits glucose-induced lens epithelial cell apoptosis via suppressing p22phox-p38 MAPK signaling pathway PLoS ONE, 2020-04-27;15(4):e0224251. 2020-04-27 [PMID: 32339204] (Cell Culture, Human)	Cell Culture	Human
N Jiang, Q Zhang, MK Chau, MS Yip, SL Lui, S Liu, KM Chu, HY Ngan, TM Chan, S Yung Anti-fibrotic effect of decorin in peritoneal dialysis and PD-associated peritonitis EBioMedicine, 2020-02-12;52(0):102661. 2020-02-12 [PMID: 32062358] (Bioassay, Human)	Bioassay	Human
AD Kolb, AB Shupp, D Mukhopadhy, FC Marini, KM Bussard Osteoblasts are "educated" by crosstalk with metastatic breast cancer cells in the bone tumor microenvironment Breast Cancer Res., 2019-02-27;21(1):31. 2019-02-27 [PMID: 30813947] (Bioassay, Human)	Bioassay	Human
Y Shen, MR Zeglinski, CT Turner, SA Raithatha, Z Wu, V Russo, C Oram, S Hiroyasu, L Nabai, H Zhao, T Bozin, K Westendorf, I Kopko, R Huang, S Arns, J Tan, H Zeng, A Boey, R Liggins, J Jaquith, DR Cameron, A Papp, DJ Granville Topical small molecule�granzyme B�inhibitor improves remodeling in a�murine model of impaired burn wound healing Exp. Mol. Med., 2018-05-30;50(5):68. 2018-05-30 [PMID: 29849046] (Bioassay, In Vivo, Mouse)	Bioassay, In Vivo	Mouse
S Gogalic, U Sauer, S Doppler, C Preininger Investigating Colorimetric Protein Array Assay Schemes for Detection of Recurrence of Bladder Cancer Biosensors (Basel), 2018-01-24;8(1):. 2018-01-24 [PMID: 29364182] (Array Development, Human)	Array Development	Human
Y Ishikawa, P Holden, HP Bachinger Heat shock protein 47 and 65 KDa FK506 binding protein weakly but synergistically interact during collagen folding in the endoplasmic reticulum J. Biol. Chem., 2017-08-31;0(0):. 2017-08-31 [PMID: 28860186] (Control)	Control
Kelc R, Trapecar M, Gradisnik L, Rupnik M, Vogrin M Platelet-rich plasma, especially when combined with a TGF-beta inhibitor promotes proliferation, viability and myogenic differentiation of myoblasts in vitro. PLoS ONE, 2015-02-13;10(2):e0117302. 2015-02-13 [PMID: 25679956] (Bioassay, Human)	Bioassay	Human
Rottenberger Z, Komorowicz E, Szabo L, Bota A, Varga Z, Machovich R, Longstaff C, Kolev K Lytic and mechanical stability of clots composed of fibrin and blood vessel wall components. J Thromb Haemost, 2013-03-01;11(3):529-38. 2013-03-01 [PMID: 23279194] (Bioassay, Bovine)	Bioassay	Bovine
Zhang Y, Conrad AH, Conrad GW Effects of Ultraviolet-A and Riboflavin on the Interaction of Collagen and Proteoglycans during Corneal Cross-linking. J. Biol. Chem., 2011-02-18;286(15):13011-22. 2011-02-18 [PMID: 21335557] (Bioassay, Bovine)	Bioassay	Bovine
Kitaya K, Yasuo T Dermatan sulfate proteoglycan biglycan as a potential selectin L/CD44 ligand involved in selective recruitment of peripheral blood CD16(-) natural killer cells into human endometrium. J. Leukoc. Biol., 2008-12-16;85(3):391-400. 2008-12-16 [PMID: 19088176] (Antibody Absorption)	Antibody Absorption
Bolton K, Segal D, McMillan J, Jowett J, Heilbronn L, Abberton K, Zimmet P, Chisholm D, Collier G, Walder K Decorin is a secreted protein associated with obesity and type 2 diabetes. Int J Obes (Lond), 2008-04-15;32(7):1113-21. 2008-04-15 [PMID: 18414424] (ELISA (Standard))	ELISA (Standard)
Barkho BZ, Song H, Aimone JB Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation. Stem Cells Dev., 2006-06-01;15(3):407-21. 2006-06-01 [PMID: 16846377] (Bioassay, Rat)	Bioassay	Rat
Show All 16 Publications. Collapse Publications.

Array 143-DE

• Decorin Antibodies
• Decorin ELISA Kits
• Decorin Lysates
• Decorin Proteins
• Decorin ELISAs
• Decorin Proteins and Enzymes