Recombinant Human Biglycan Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Biglycan, also known as PG I, is a secreted chondroitin/dermatan sulfate proteoglycan in the small leucine-rich proteoglycan (SLRP) family. SLRP family members are characterized by N-terminal and C-terminal cysteine-rich domains that flank the central region containing 10-12 tandem leucine-rich repeats (LRRs). Biglycan function is important in the development and maintenance of many tissues (1). The human Biglycan cDNA encodes a 368 amino acid (aa) precursor with a 19 aa signal sequence and a 18 aa propeptide that is cleaved by BMP-1 (2). Mature human Biglycan shares 97% aa sequence identity with bovine, mouse, and rat Biglycan. The mature protein can be further cleaved by proteases, which compromises its inability to bind to other molecules (3, 4). The 45 kDa core protein is approximately one third the molecular weight of the fully glycanated form and can assemble into noncovalently-associated dimers (5). Biglycan binds, crosslinks, and stabilizes several proteins in the collagen matrix (6). It also binds and modulates the activity of a variety of non-matrix proteins, including C1q, collectins, TGF-beta , and Wnt3a (3, 7, 8). Biglycan binds to TLR2, TLR4, P2X4, and P2X7, leading to the increased production of inflammatory mediators, the migration of vascular endothelial cells, and the enhancement of oxidized LDL induced aortic valve calcification (9 - 11). Biglycan also blocks the uptake and degradation of acetylated LDL in atherosclerotic plaques by binding to SR-A (12). It stabilizes the neuromuscular junction through interactions with MuSK as well as alpha- and gamma-Sarcoglycan (13).

We have publications tested in 4 confirmed species: Human, Mouse, N/A, Snake.

We have publications tested in 2 applications: Antibody Absorption, Bioassay.

Showing Publications 1 - 10 of 11. Show All 11 Publications. Collapse Publications.

Publications using 2667-CM	Applications	Species
Li, Y;Wei, Y;Ultsch, M;Li, W;Tang, W;Tombling, B;Gao, X;Dimitrova, Y;Gampe, C;Fuhrmann, J;Zhang, Y;Hannoush, RN;Kirchhofer, D; Cystine-knot peptide inhibitors of HTRA1 bind to a cryptic pocket within the active site region Nature communications 2024-05-22 [PMID: 38777835] (N/A, Bioassay)	Bioassay	N/A
S Gerhardy, M Ultsch, W Tang, E Green, JK Holden, W Li, A Estevez, C Arthur, I Tom, A Rohou, D Kirchhofer Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration Nature Communications, 2022-09-05;13(1):5222. 2022-09-05 [PMID: 36064790] (Bioassay, Human)	Bioassay	Human
H Hoermann, I Krueger, N Maurus, F Reusswig, Y Sun, C Kohlmorgen, M Grandoch, JW Fischer, M Elvers The Proteoglycan Biglycan Modulates Platelet Adhesion and Thrombus Formation in a GPVI-Dependent Manner International Journal of Molecular Sciences, 2021-11-10;22(22):. 2021-11-10 [PMID: 34830059] (Bioassay, Mouse)	Bioassay	Mouse
DG Bisson, K Sheng, S Kocabas, E Krock, A Teles, N Saran, JA Ouellet, L Haglund Toll-like receptor involvement in adolescent scoliotic facet joint degeneration J. Cell. Mol. Med., 2020-08-27;0(0):. 2020-08-27 [PMID: 32853438] (Bioassay, Human)	Bioassay	Human
AF Asega, MC Menezes, D Trevisan-S, D Cajado-Car, L Bertholim, AK Oliveira, A Zelanis, SMT Serrano Cleavage of proteoglycans, plasma proteins and the platelet-derived growth factor receptor in the hemorrhagic process induced by snake venom metalloproteinases Sci Rep, 2020-07-31;10(1):12912. 2020-07-31 [PMID: 32737331] (Bioassay, Snake)	Bioassay	Snake
DA Ferraro, F Patella, S Zanivan, C Donato, N Aceto, M Giannotta, E Dejana, M Diepenbruc, G Christofor, M Buess Endothelial cell-derived nidogen-1 inhibits migration of SK-BR-3 breast cancer cells BMC Cancer, 2019-04-04;19(1):312. 2019-04-04 [PMID: 30947697] (Bioassay, Human)	Bioassay	Human
P Jongwattan, M Terajima, PA Miguez, W Querido, H Nagaoka, N Sumida, EG Gurysh, KM Ainslie, N Pleshko, L Perera, M Yamauchi Identification of the effector domain of biglycan that facilitates BMP-2 osteogenic function Sci Rep, 2018-05-04;8(1):7022. 2018-05-04 [PMID: 29728612] (Bioassay, Mouse)	Bioassay	Mouse
Sterile inflammation as a factor in human male infertility: Involvement of Toll like receptor 2, biglycan and peritubular cells Sci Rep, 2016-11-16;6(0):37128. 2016-11-16 [PMID: 27849015] (Bioassay, Human)	Bioassay	Human
Rzeniewicz K, Newe A, Rey Gallardo A, Davies J, Holt M, Patel A, Charras G, Stramer B, Molenaar C, Tedder T, Parsons M, Ivetic A L-selectin shedding is activated specifically within transmigrating pseudopods of monocytes to regulate cell polarity in vitro. Proc Natl Acad Sci U S A, 2015-03-09;112(12):E1461-70. 2015-03-09 [PMID: 25775539] (Bioassay, Human)	Bioassay	Human
Roy A, Ganesh G, Sippola H, Bolin S, Sawesi O, Dagalv A, Schlenner S, Feyerabend T, Rodewald H, Kjellen L, Hellman L, Abrink M Mast cell chymase degrades the alarmins heat shock protein 70, biglycan, HMGB1, and interleukin-33 (IL-33) and limits danger-induced inflammation. J Biol Chem, 2013-11-20;289(1):237-50. 2013-11-20 [PMID: 24257755] (Bioassay, Mouse)	Bioassay	Mouse
Kitaya K, Yasuo T Dermatan sulfate proteoglycan biglycan as a potential selectin L/CD44 ligand involved in selective recruitment of peripheral blood CD16(-) natural killer cells into human endometrium. J. Leukoc. Biol., 2008-12-16;85(3):391-400. 2008-12-16 [PMID: 19088176] (Antibody Absorption)	Antibody Absorption
Show All 11 Publications. Collapse Publications.

Array 2667-CM

• Biglycan Antibodies
• Biglycan ELISA Kit
• Biglycan Lysate
• Biglycan Protein
• Biglycan Proteins and Enzymes