Prostaglandin I2 Synthase Antibody (852307) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

PTGIS (Prostacyclin synthase; also CYP8A1, PGIS and Prostaglandin I2 synthase) is a 50-52 kDa (57 kDa predicted) microsomal, integral membrane member of Family 8 in the cytochrome P450 superfamily of molecules. It is expressed by skeletal and smooth muscle, fibroblasts, macrophages and endothelium. Prostaglandin I2/prostacyclin and thromboxane A2/TXA2 are two lipid mediators that are derived from the same precursor (PGH2). Acting upon PGH2, TXA2 is created through the action of TX synthase, while PGI2 is generated through the action of PTGIS/PGIS. Although they share a common precursor, they exhibit opposite effects on the vasculature, with PGI2 reported to block platelet aggregation, induce vasodilation, and inhibit smooth muscle proliferation. It apparently does so by binding to either the IP receptor or PPAR gamma . Human PTGIS is 500 amino acids (aa) in length. It is a single span transmembrane protein that contains an N-terminal transmembrane segment (aa 1-20) coupled to a lengthy 480 aa cytoplasmic region. Over aa 21-500, human PTGIS shares 86% aa sequence identity with mouse PTGIS.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Western Blot.

Showing Publication 1 - 1 of 1.

Publication using MAB7788	Applications	Species
L Sommerfeld, I Knuth, F Finkernage, J Pesek, WA Nockher, JM Jansen, U Wagner, A Nist, T Stiewe, S Müller-Brü, R Müller, S Reinartz Prostacyclin Released by Cancer-Associated Fibroblasts Promotes Immunosuppressive and Pro-Metastatic Macrophage Polarization in the Ovarian Cancer Microenvironment Cancers, 2022-12-13;14(24):. 2022-12-13 [PMID: 36551640] (Western Blot, Human)	Western Blot	Human

Array MAB7788

• Prostaglandin I2 Synthase Antibodies
• Prostaglandin I2 Synthase ELISA Kits
• Prostaglandin I2 Synthase Lysate
• Prostaglandin I2 Synthase Proteins