Recombinant Human Angiopoietin-like 4 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Angiopoietin-like 4 (ANGPTL4), also known as FIAF, FARP, and PGAR, is a 55 kDa glycoprotein secreted by the liver and fat tissue. It is structurally related to the angoipoietins and contains an N-terminal coiled coil domain and a C-terminal fibrinogen-like domain which can be proteolytically separated in vivo (1). Mature human ANGPTL4 shares 26%-30% amino acid (aa) sequence identity with ANGPTL1, 2, 3, 5, 6, and 7. It shares approximately 75% aa sequence identity with mouse and rat ANGPT-L4. The coiled coil domain, which is not glycosylated, mediates the formation of variable sized disulfide-linked oligomers (2). This domain directly inhibits lipoprotein lipase, resulting in increased circulating triglyceride levels (3, 4). In humans, the N-terminal fragment and full length ANGPTL4 physically associate with HDL (4). In mouse, however, full length ANGPTL4 associates with HDL, while the N-terminal fragment associates with LDL (4). Circulating ANGPTL4 is decreased in type II diabetics with a subsequent loss of its normal plasma glucose lowering activity (5). Its expression in adipose tissue is induced by fasting and suppressed by feeding (6). In hypoxic areas, ANGPTL4 is induced in both vascular endothelial cells and tumor cells (7, 8). The N-terminal fragment can function as an angiogenesis inhibitor (7, 8). In contrast, the C-terminal fragment modulates cell adhesion through interactions with heparan sulfate proteoglycans, Integrins  beta 1 and beta 5, Vitronectin, and Fibronectin, thereby promoting keratinocyte migration and wound healing (7, 9, 10). ANGPTL4 additionally enhances the survival of hematopoietic and mesenchymal stem cells (11, 12). The expression of an undersialylated form of ANGPTL4 in renal podocytes contributes to proteinuria and nephrotic syndrome (13).

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Binding Assay, Bioassay.

Showing Publications 1 - 10 of 13. Show All 13 Publications. Collapse Publications.

Publications using 4487-AN	Applications	Species
Shen, CJ;Chan, RH;Lin, BW;Li, NC;Huang, YH;Chang, WC;Chen, BK; Oleic acid-induced metastasis of KRAS/p53-mutant colorectal cancer relies on concurrent KRAS activation and IL-8 expression bypassing EGFR activation Theranostics 2023-08-21 [PMID: 37649607] (Bioassay, Human)	Bioassay	Human
Hefni, E;Menon, D;Ma, T;Asiedu, EB;Sultan, A;Meiller, T;Schneider, A;Sodhi, A;Montaner, S; Angiopoietin-like 4 induces head and neck squamous cell carcinoma cell migration through the NRP1/ABL1/PXN pathway Cellular signalling 2023-05-09 [PMID: 37169211] (Bioassay, Human)	Bioassay	Human
DI Cho, MJ Ahn, HH Cho, M Cho, JH Jun, BG Kang, SY Lim, SJ Yoo, MR Kim, HS Kim, SJ Lee, LT Dat, C Lee, YS Kim, Y Ahn ANGPTL4 stabilizes atherosclerotic plaques and modulates the phenotypic transition of vascular smooth muscle cells through KLF4 downregulation Experimental & Molecular Medicine, 2023-02-13;0(0):. 2023-02-13 [PMID: 36782020] (Bioassay, Human)	Bioassay	Human
J Huang, S Zhang Overexpressed Neuropilin-1 in Endothelial Cells Promotes Endothelial Permeability through Interaction with ANGPTL4 and VEGF in Kawasaki Disease Mediators of Inflammation, 2021-08-13;2021(0):9914071. 2021-08-13 [PMID: 34434074] (Bioassay, Human)	Bioassay	Human
M Li, J Hu, L Yao, M Gao Decreased ANGPTL4 impairs endometrial angiogenesis during peri-implantation period in patients with recurrent implantation failure J. Cell. Mol. Med., 2020-08-03;0(0):. 2020-08-03 [PMID: 32745373] (Bioassay, Human)	Bioassay	Human
YT Kang, WC Hsu, CC Ou, HC Tai, HT Hsu, KT Yeh, JL Ko Metformin Mitigates Nickel-Elicited Angiopoietin-Like Protein 4 Expression via HIF-1&alpha for Lung Tumorigenesis Int J Mol Sci, 2020-01-17;21(2):. 2020-01-17 [PMID: 31963541] (Bioassay, Human)	Bioassay	Human
T Zhang, A Kastrenopo, Q Larrouture, NA Athanasou, HJ Knowles Angiopoietin-like 4 promotes osteosarcoma cell proliferation and migration and stimulates osteoclastogenesis BMC Cancer, 2018-05-08;18(1):536. 2018-05-08 [PMID: 29739381] (Bioassay, Human)	Bioassay	Human
K Baba, Y Kitajima, S Miyake, J Nakamura, K Wakiyama, H Sato, K Okuyama, H Kitagawa, T Tanaka, M Hiraki, K Yanagihara, H Noshiro Hypoxia-induced ANGPTL4 sustains tumour growth and anoikis resistance through different mechanisms in scirrhous gastric cancer cell lines Sci Rep, 2017-09-11;7(1):11127. 2017-09-11 [PMID: 28894280] (Bioassay, Human)	Bioassay	Human
Contact of myeloma cells induces a characteristic transcriptome signature in skeletal precursor cells - Implications for myeloma bone disease Bone, 2016-08-09;0(0):. 2016-08-09 [PMID: 27519972] (Bioassay, Human)	Bioassay	Human
Mathieu M, Iampietro M, Chuchana P, Guerit D, Djouad F, Noel D, Jorgensen C Involvement of angiopoietin-like 4 in matrix remodeling during chondrogenic differentiation of mesenchymal stem cells. J Biol Chem, 2014-02-06;289(12):8402-12. 2014-02-06 [PMID: 24505142] (Bioassay, Human)	Bioassay	Human
Robal , Terje, Larsson , Mikael, Martin , Miina, Olivecrona , Gunilla, Lookene , Aivar Fatty acids bind tightly to the N-terminal domain of angiopoietin-like protein 4 and modulate its interaction with lipoprotein lipase. J Biol Chem, 2012-07-07;287(35):29739-52. 2012-07-07 [PMID: 22773878] (Binding Assay, Human)	Binding Assay	Human
Knowles HJ, Cleton-Jansen AM, Korsching E, Athanasou NA Hypoxia-inducible factor regulates osteoclast-mediated bone resorption: role of angiopoietin-like 4. FASEB J., 2010-07-28;24(12):4648-59. 2010-07-28 [PMID: 20667978] (Bioassay, Human)	Bioassay	Human
Ma T, Jham BC, Hu J Viral G protein-coupled receptor up-regulates Angiopoietin-like 4 promoting angiogenesis and vascular permeability in Kaposi's sarcoma. Proc. Natl. Acad. Sci. U.S.A., 2010-07-26;107(32):14363-8. 2010-07-26 [PMID: 20660728] (Bioassay, Human)	Bioassay	Human
Show All 13 Publications. Collapse Publications.

Array 4487-AN

• Angiopoietin-like Protein 4/ANGPTL4 Antibodies
• Angiopoietin-like Protein 4/ANGPTL4 ELISA Kits
• Angiopoietin-like Protein 4/ANGPTL4 Lysate
• Angiopoietin-like Protein 4/ANGPTL4 Proteins and Enzymes
• Angiopoietin-like Protein 4/ANGPTL4 ELISAs