Angiopoietin-like Protein 6/ANGPTL6 Antibody (766544) [Unconjugated] Summary
Immunogen |
E. coli-derived recombinant mouse Angiopoietin-like Protein 6/ANGPTL6 Ala25-Leu457 Accession # Q8ROZ6 |
Specificity |
Detects mouse Angiopoietin-like Protein 6/ANGPTL6 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant
human Angiopoietin-like 6 or recombinant mouse Angiopoietin-like 2 is observed. |
Source |
N/A |
Isotype |
IgG2a |
Clonality |
Monoclonal |
Host |
Rat |
Gene |
ANGPTL6 |
Purity Statement |
Protein A or G purified from hybridoma culture supernatant |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- Immunocytochemistry 8-25 ug/mL
- Western Blot 0.5 ug/mL
|
Publications |
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Packaging, Storage & Formulations
Storage |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. - 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
|
Buffer |
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS. |
Preservative |
No Preservative |
Concentration |
LYOPH |
Reconstitution Instructions |
Sterile PBS to a final concentration of 0.5 mg/mL. |
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Angiopoietin-like Protein 6/ANGPTL6 Antibody (766544) [Unconjugated]
Background
Angiopoietin-like 6 (ANGPTL6), also
known as angiopoietin-related growth factor (AGF), is a secreted 50 kDa protein
that contains a coiled-coil domain (aa 51-77,
126-164) and a fibrinogen-like
domain (aa 238-456). A conserved Integrin-binding RGD motif is located within
the fibrinogen-like domain. This enables ANGPTL6 to promote skin wound healing
by mediating the adhesion and migration of keratinocytes, fibroblasts, and
endothelial cells. ANGPTL6 also promotes the chemotaxis of vascular endothelial
cells resulting in increased vascular permeability and angiogenesis. ANGPTL6 is
also secreted by hepatocytes. It inhibits gluconeogenesis in these cells and
promotes insulin sensitivity and energy expenditure in mice fed high fat diets.
Serum levels of ANGPTL6 are elevated in metabolic syndrome, diabetes, and
preeclampsia but are decreased in chronic renal failure. ANGPTL6 is
additionally produced by several hematopoietic cell types including
megakaryocytes, platelets, mast cells, and uterine NK cells. Mature mouse
ANGPTL6 shares 75% and 95% sequence identity with human and rat ANGPTL6.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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Publications for Angiopoietin-like Protein 6/ANGPTL6 Antibody (MAB7527)(1)
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