Recombinant Equine IFN-gamma Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interferon-gamma (IFN-gamma ), also known as type II or immune interferon, exerts a wide range of immunoregulatory activities and is considered to be the prototype proinflammatory cytokine (1, 2). Mature equine IFN-gamma exists as a noncovalently linked homodimer of 20‑25 kDa variably glycosylated subunits (3, 4). It shares 73%‑82% amino acid sequence identity with bovine, canine, feline, and porcine IFN-gamma and 42%‑64% with cotton rat, human, mouse, rat, and rhesus IFN-gamma . IFN-gamma dimers bind to IFN-gamma RI (alpha subunits) which then interact with IFN-gamma RII (beta subunits) to form the functional receptor complex of two alpha and two beta subunits. Inclusion of IFN-gamma RII increases the binding affinity for ligand and the efficiency of signal transduction (5, 6). IFN-gamma is produced by a variety of immune cells under inflammatory conditions, notably by T cells and NK cells (7). It plays a key role in host defense by promoting the development and activation of Th1 cells, chemoattraction and activation of monocytes and macrophages, upregulation of antigen presentation molecules, and immunoglobulin class switching in B cells. It also exhibits antiviral, antiproliferative, and apoptotic effects (7, 8). In addition, IFN-gamma functions as an anti-inflammatory mediator by promoting the development of regulatory T cells and inhibiting Th17 cell differentiation (9, 10). The pleiotropic effects of IFN-gamma contribute to the development of multiple aspects of atherosclerosis (8).

We have publications tested in 1 confirmed species: Equine.

We have publications tested in 2 applications: Bioassay, Cell Culture.

Showing Publications 1 - 8 of 8.

Publications using 1586-HG	Applications	Species
NA Moyo, D Westcott, R Simmonds, F Steinbach Equine Arteritis Virus in Monocytic Cells Suppresses Differentiation and Function of Dendritic Cells Viruses, 2023-01-16;15(1):. 2023-01-16 [PMID: 36680295] (Bioassay, Equine)	Bioassay	Equine
A Lange-Cons, P Romele, M Magatti, A Silini, A Idda, NA Martino, F Cremonesi, O Parolini Priming with inflammatory cytokines is not a prerequisite to increase immune-suppressive effects and responsiveness of equine amniotic mesenchymal stromal cells Stem Cell Res Ther, 2020-03-04;11(1):99. 2020-03-04 [PMID: 32131892] (Cell Culture, Equine)	Cell Culture	Equine
L Barrachina, A Cequier, A Romero, A Vitoria, P Zaragoza, FJ Vázquez, C Rodellar Allo-antibody production after intraarticular administration of mesenchymal stem cells (MSCs) in an equine osteoarthritis model: effect of repeated administration, MSC inflammatory stimulation, and equine leukocyte antigen (ELA) compatibility Stem Cell Res Ther, 2020-02-07;11(1):52. 2020-02-07 [PMID: 32028995] (Cell Culture, Equine)	Cell Culture	Equine
JM Cassano, LV Schnabel, MB Goodale, LA Fortier Inflammatory licensed equine MSCs are chondroprotective and exhibit enhanced immunomodulation in an inflammatory environment Stem Cell Res Ther, 2018-04-03;9(1):82. 2018-04-03 [PMID: 29615127] (Bioassay, Equine)	Bioassay	Equine
LJ Berghaus, S Giguère, AI Bordin, ND Cohen Effects of priming with cytokines on intracellular survival and replication of Rhodococcus equi in equine macrophages Cytokine, 2017-12-12;102(0):7-11. 2017-12-12 [PMID: 29245049] (Bioassay, Equine)	Bioassay	Equine
Equine dendritic cells generated with horse serum have enhanced functionality in comparison to dendritic cells generated with fetal bovine serum BMC Vet. Res., 2016-11-15;12(1):254. 2016-11-15 [PMID: 27846835] (Bioassay, Equine)	Bioassay	Equine
Danièle Noel Utility of a Mouse Model of Osteoarthritis to Demonstrate Cartilage Protection by IFN?-Primed Equine Mesenchymal Stem Cells Front Immunol, 2016-09-27;7(0):392. 2016-09-27 [PMID: 27729913] (Bioassay, Equine)	Bioassay	Equine
Kwon S, Gewirtz AT, Hurley DJ, Robertson TP, Moore JN, Vandenplas ML Disparities in TLR5 Expression and Responsiveness to Flagellin in Equine Neutrophils and Mononuclear Phagocytes. J. Immunol., 2011-04-25;186(11):6263-70. 2011-04-25 [PMID: 21518971] (Bioassay, Equine)	Bioassay	Equine

Array 1586-HG

• IFN-gamma Antibodies
• IFN-gamma Antibody Pairs
• IFN-gamma ELISA Kits
• IFN-gamma Kits
• IFN-gamma Lysate
• IFN-gamma Proteins
• IFN-gamma ELISAs
• IFN-gamma Proteins and Enzymes