Recombinant Cyno/Rhesus Lysyl Oxidase Homolog 2 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Lysyl Oxidase Homolog 2 (lysyl oxidase-like protein 2, LOXL2) is a member of a five-member lysyl oxidase-like (LOXL) gene family of secreted copper-binding amine oxidases that oxidize primary amine substrates such as collagen and elastin to aldehydes within the extracellular matrix (1, 2). LOXL2 is a secreted protein expressed in many tissues, with elevated levels in reproductive tissues such as placenta, uterus, and prostate (3). The N-terminal region of LOXL2 contains four scavenger receptor cysteine-rich (SRCR) domains responsible for protein-protein interactions while the C-terminal region contains the catalytic domain (1, 2). The catalytic domain contains conserved residues required for copper binding, a lysyl tyrosylquinone (LTQ) element required for co-factor formation essential for activity, and a cytokine receptor-like (CRL) domain (2,4). Modulation of the tissue microenvironment implicates a role for LOXL2 in many pathological conditions including fibrosis, atherosclerosis, and tumor development (5). LOXL2 has been shown to promote cell migration and tumor cell invasiveness (6,7) and to enhance tumor progression in various types of cancer including colon, gastric, hepatic, renal cancers (8,9). Dysregulation of LOXL2 has been linked to fibrosis and inflammation (10). Given its role in modulation of the tissue microenvironment involved in pathological conditions, development of inhibitors to LOXL2 is of interest for therapeutic application (2, 9). 

Array 11431-AO

• Lysyl Oxidase Homolog 2/LOXL2 Antibodies
• Lysyl Oxidase Homolog 2/LOXL2 Antibody Pair
• Lysyl Oxidase Homolog 2/LOXL2 Lysate
• Lysyl Oxidase Homolog 2/LOXL2 Protein
• Lysyl Oxidase Homolog 2/LOXL2 Proteins and Enzymes
• Lysyl Oxidase Homolog 2/LOXL2 ELISA