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PSMA/FOLH1/NAALADase I Antibody (GCP-05) [PE]

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Flow Cytometry: PSMA/FOLH1/NAALADase I Antibody (GCP-05) [PE] [NBP1-45056] - Surface staining (flow cytometry) of GCPII / PSMA using anti-GCPII (GCP-05) and goat anti-mouse-PE on LNCaP cell line (positive, green) and HeLa cells (negative, blue).
Flow Cytometry: PSMA/FOLH1/NAALADase I Antibody (GCP-05) [PE] [NBP1-45056] - Surface staining (flow cytometry) of GCPII / PSMA using anti-GCPII (GCP-05) and goat anti-mouse-PE on LNCaP cell line (positive, green) and ...read more
Flow Cytometry: PSMA/FOLH1/NAALADase I Antibody (GCP-05) [PE] [NBP1-45056] - Surface staining (mass cytometry) of LNCaP cell line using anti-GCPII (GCP-05) 173Yb. Gated on singlets.
Flow Cytometry: PSMA/FOLH1/NAALADase I Antibody (GCP-05) [PE] [NBP1-45056] - Surface staining (flow cytometry) of GCPII / PSMA using anti-GCPII (GCP-05) Alexa Fluor 488 on LNCaP cell line.
Flow Cytometry: PSMA/FOLH1/NAALADase I Antibody (GCP-05) [PE] [NBP1-45056] - Surface staining (flow cytometry) of GCPII / PSMA using anti-GCPII (GCP-05) PE on LNCaP cell line.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
GCP-05
Clonality
Monoclonal
Host
Mouse
Conjugate
PE
Concentration
0.1 mg/ml

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP1-45058AF350
Alexa Fluor 405
NBP1-45058AF405
Alexa Fluor 488
NBP1-45058AF488
Alexa Fluor 532
NBP1-45058AF532
Alexa Fluor 594
NBP1-45058AF594
Alexa Fluor 647
NBP1-45058AF647
Alexa Fluor 700
NBP1-45058AF700
Alexa Fluor 750
NBP1-45058AF750
Allophycocyanin
NBP1-45058APC
Allophycocyanin/Cy7
NBP1-45058APCCY7
Biotin
NBP1-45058B
DyLight 350
NBP1-45058UV
DyLight 405
NBP1-45058V
DyLight 488
NBP1-45058G
DyLight 550
NBP1-45058R
DyLight 594
NBP1-45058DL594
DyLight 650
NBP1-45058C
DyLight 680
NBP1-45058FR
DyLight 755
NBP1-45058IR
FITC
NBP1-45058F
Janelia Fluor 549
NBP1-45058JF549
Janelia Fluor 646
NBP1-45058JF646
PE
NBP1-45058PE
PE/Atto594
NBP1-45058PEATT594
PE/Cy5.5
NBP1-45058PECY55
PE/Cy7
NBP1-45058PECY7
PerCP
NBP1-45058PCP
Unconjugated
NBP1-45058
mFluor Violet 450 SE
NBP1-45058MFV450
mFluor Violet 500 SE
NBP1-45058MFV500
mFluor Violet 610 SE
NBP1-45058MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP1-45058
BSA Free
NBP1-45058
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PSMA/FOLH1/NAALADase I Antibody (GCP-05) [PE] Summary

Description
Store in the dark. Avoid prolonged exposure to light.
Immunogen
amino acids 44-750 of human GCPII
Specificity
The antibody GCP-05 recognizes extracellular domain of glutamate carboxypeptidase II (NAALADase, FOLH1, PSMA), an approximately 95-110 kDa transmembrane glycoprotein expressed mainly in tumour neovasculatures, nervous system and jejunum, which is an important prostate tumour marker.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
FOLH1
Purity
Size Exclusion Chromatography
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Flow Cytometry 5 ug/ml
Theoretical MW
110 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
Stabilizing phosphate buffered saline (PBS) solution.
Preservative
0.9% Sodium Azide
Concentration
0.1 mg/ml
Purity
Size Exclusion Chromatography

Alternate Names for PSMA/FOLH1/NAALADase I Antibody (GCP-05) [PE]

  • Cell growth-inhibiting gene 27 protein
  • cell growth-inhibiting protein 27
  • EC 3.4.17.21
  • FGCP
  • folate hydrolase (prostate-specific membrane antigen) 1
  • Folate hydrolase 1
  • FOLH1
  • FOLHNAALADase I
  • Folylpoly-gamma-glutamate carboxypeptidase
  • GCP2
  • GCPII
  • GCPIImGCP
  • glutamate carboxylase II
  • glutamate carboxypeptidase 2
  • Glutamate carboxypeptidase II
  • Membrane glutamate carboxypeptidase
  • mopsm
  • NAALAD1
  • NAALAD1N-acetylated-alpha-linked acidic dipeptidase I
  • NAALADase I
  • NAALAdase
  • N-acetylated alpha-linked acidic dipeptidase 1
  • prostate specific membrane antigen variant F
  • Prostate-specific membrane antigen
  • PSMA
  • PSMAFGCP
  • PSMPteroylpoly-gamma-glutamate carboxypeptidase

Background

This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol FOLH1