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Protein Disulfide Isomerase/P4HB Antibody [Janelia Fluor® 646]

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Product Details

Summary
Reactivity Hu, Mu, Rt, Bv, RbSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Janelia Fluor 646

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-41319AF350
Alexa Fluor 405
NBP2-41319AF405
Alexa Fluor 488
NBP2-41319AF488
Alexa Fluor 532
NBP2-41319AF532
Alexa Fluor 594
NBP2-41319AF594
Alexa Fluor 647
NBP2-41319AF647
Alexa Fluor 700
NBP2-41319AF700
Alexa Fluor 750
NBP2-41319AF750
Biotin
NBP2-41319B
CoraFluor 1
NBP2-41319CL1
DyLight 350
NBP2-41319UV
DyLight 405
NBP2-41319V
DyLight 488
NBP2-41319G
DyLight 550
NBP2-41319R
DyLight 594
NBP2-41319DL594
DyLight 650
NBP2-41319C
DyLight 680
NBP2-41319FR
DyLight 755
NBP2-41319IR
FITC
NBP2-41319F
HRP
NBP2-41319H
Janelia Fluor 525
NBP2-41319JF525
Janelia Fluor 549
NBP2-41319JF549
Janelia Fluor 669
NBP2-41319JF669
PerCP
NBP2-41319PCP
Unconjugated
NBP2-41319
mFluor Violet 450 SE
NBP2-41319MFV450
mFluor Violet 500 SE
NBP2-41319MFV500
mFluor Violet 610 SE
NBP2-41319MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP2-41319
BSA Free
NBP2-41319
BSA Free
NBP2-41319-0.025mg
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Protein Disulfide Isomerase/P4HB Antibody [Janelia Fluor® 646] Summary

Immunogen
Antibody was raised against a 17 amino acid peptide near the center of human Protein Disulfide Isomerase/P4HB. The immunogen is located within amino acids 190 - 240 of Protein Disulfide Isomerase/P4HB. Amino Acid Squence: FKKFDEGRNNFEGEVTK
Predicted Species
Rabbit (100%), Bovine (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
P4HB
Purity
Peptide affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Chicken (88%)

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Peptide affinity purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Protein Disulfide Isomerase/P4HB Antibody [Janelia Fluor® 646]

  • Cellular thyroid hormone-binding protein
  • collagen prolyl 4-hydroxylase beta
  • DSI
  • ERBA2L
  • GIT
  • glutathione-insulin transhydrogenase
  • P4HB
  • P4Hbeta
  • p55
  • PDI
  • PDIA1
  • PDIA1procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), betapolypeptide (protein disulfide isomerase-associated 1)
  • PDIEC 5.3.4.1
  • PHDB
  • PO4DB
  • PO4HB
  • procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), betapolypeptide
  • PROHB
  • PROHBprocollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), betapolypeptide (protein disulfide isomerase; thyroid hormone binding protein p55)
  • Prolyl 4-hydroxylase subunit beta
  • prolyl 4-hydroxylase, beta polypeptide
  • protein disulfide isomerase family A, member 1
  • protein disulfide isomerase/oxidoreductase
  • protein disulfide isomerase-associated 1
  • protein disulfide-isomerase
  • protocollagen hydroxylase
  • Thbp
  • thyroid hormone-binding protein p55

Background

P4HB, the beta subunit of prolyl 4-hydroxylase, a highly abundant member of the PDI family. P4HB is a multifunctional enzyme, involved in hydroxylation of prolyl residues in preprocollagen, as well as continual rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol P4HB