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Proprotein Convertase 1/PCSK1 Antibody

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Western Blot: PC1/3 Antibody [NB120-3532] - Analysis of mouse pituitary extract.
Western Blot: PC1/3 Antibody [NB120-3532] - Analysis of mouse pituitary extract.

Product Details

Summary
Reactivity Mu, RtSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

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Proprotein Convertase 1/PCSK1 Antibody Summary

Immunogen
Synthetic peptide corresponding to residues S(111) V Q K D S A L D L F N D P M W N(127) of mouse PC1.
Specificity
Prohormone Convertase 1
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PCSK1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 0.4 ug/ml
Application Notes
WB: Detects an approx. 80 kDa protein representing PC1 from mouse pituitary extract.
Publications
Read Publications using
NB120-3532 in the following applications:

  • WB
    3 publications

Reactivity Notes

Expected cross-reactivity with Bovine base on sequence identity.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS with 1 mg/ml BSA
Preservative
0.05% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Proprotein Convertase 1/PCSK1 Antibody

  • BMIQ12;NEC1;Neuroendocrine convertase 1;PC1;PC1/3;PC3;SPC3
  • NEC1
  • PCSK1
  • Proprotein Convertase 1

Background

The subtilisin-like Prohormone Convertase (PC) family is a group of cellular enzymes that cleave most prohormones and neuropeptide precursors. Numerous other cellular proteins, some viral proteins, and bacterial toxins that are transported by the constitutive secretory pathway are also targeted for maturation by PCs. PC family members share structural similarities, which include a heterogeneous ~10 kDa amino-terminal proregion, a highly conserved ~55 kDa subtilisin-like catalytic domain, and carboxyl-terminal domain that is heterogeneous in length and sequence. These enzymes become catalytically active following proregion cleavage within the appropriate cellular compartment. The subcellular localization of PC family members varies. Immunolocalization studies show that PC1 is found in the perinuclear region as well as the trans-Golgi network, whereas PC2 can be found in the trans-Golgi network as well as diffusely distributed in the peripheral cytoplasm.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for PC1/3 Antibody (NB120-3532)(3)

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 1 application: WB.


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WB
(3)
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Secondary Antibodies

 

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Bioinformatics

Gene Symbol PCSK1