Presenilin-1 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Presenilin-1 (PS-1) and Presenilin-2 (PS-2) are integral membrane proteins that contain multiple transmembrane domains. Both are predominantly located within the endoplasmic reticulum (ER) and early Golgi apparatus. They are primarily expressed in neurons and are ubiquitously expressed in the brain. PS-1 and PS-2 are proteolytically cleaved to generate an N-terminal fragment (NTF) and a C-terminal fragment (CTF). Mutations in the gene for Presenilin may play an important role in the pathology of Alzheimer's disease.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: IHC, Proximity Ligation Assay (PLA).

Showing Publications 1 - 2 of 2.

Publications using AF149	Applications	Species
Teranishi Y, Hur J, Gu G, Kihara T, Ishikawa T, Nishimura T, Winblad B, Behbahani H, Kamali-Moghaddam M, Frykman S, Tjernberg L Erlin-2 is associated with active gamma-secretase in brain and affects amyloid beta-peptide production. Biochem Biophys Res Commun, 2012-07-04;424(3):476-81. 2012-07-04 [PMID: 22771797] (Proximity Ligation Assay (PLA), Human)	Proximity Ligation Assay (PLA)	Human
Cras-Meneur C, Li L, Kopan R, Permutt MA Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window. Genes Dev., 2009-09-01;23(17):2088-101. 2009-09-01 [PMID: 19723764] (IHC, Mouse)	IHC	Mouse

Array AF149

• Presenilin-1 Antibodies
• Presenilin-1 ELISA Kits
• Presenilin-1 Lysate
• Presenilin-1 Proteins