APH1A Antibody Summary
Immunogen |
Synthetic peptide, KLH conjugated, corresponding to residues C (245) R R Q E D S R V M V Y S A L R I P P E D (265) of human APH-1aL/CT. |
Specificity |
APH-1 |
Isotype |
IgG |
Clonality |
Polyclonal |
Host |
Rabbit |
Gene |
APH1A |
Purity |
Immunogen affinity purified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- Chromatin Immunoprecipitation (ChIP) 1:10-1:500
- Immunocytochemistry/ Immunofluorescence 1:100
- Immunohistochemistry 1:10 - 1:500
- Immunohistochemistry-Frozen 1:10 - 1:500
- Immunohistochemistry-Paraffin 1:10 - 1:500
- Immunoprecipitation 1:10 - 1:500
- Western Blot 1:1000
|
Application Notes |
WB: Detects an approx. 18 kDa protein representing APH-1 in mouse brain and kidney extracts. ChIP usage was reported in the scientific literature (PMID: 20145246). |
Publications |
|
Packaging, Storage & Formulations
Storage |
Store at -20C. Avoid freeze-thaw cycles. |
Buffer |
PBS with 1 mg/ml BSA |
Preservative |
0.005% Sodium Azide |
Concentration |
0.69 mg/ml |
Purity |
Immunogen affinity purified |
Alternate Names for APH1A Antibody
Background
Anterior Pharynx Defective 1 (APH1a) is an integral transmembrane protein forming a component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein).
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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Publications for APH1A Antibody (NB100-74360)(2)
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