Plexin C1 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Plexin C1 (also VESPR and CD232) is a 200‑210 kDa member of the plexin C subfamily, plexin family of proteins. It is a type I transmembrane glycoprotein that is found on monocytes, dendritic cells, neutrophils and embryonic neuroendocrine neurons of the hyypothalamus. Plexin C1 binds Sema7A, and its viral counterpart, vaccinia semaphorin A39R. Ligation induces actin cytoskeletal rearrangement and cell immobilization. Mature mouse Plexin C1 is 1540 amino acids (aa) in length. It contains a 916 aa extracellular domain that shows one Sema-domain (aa 35‑452) and a 603 aa cytoplasmic tail. There are two potential splice variants that show a five and 67 aa substitution for aa 861‑870 and 1206‑1574, respectively. Over aa 35‑950, mouse Plexin C1 is 95% and 85% aa identical to rat and human Plexin C1, respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: IHC.

Showing Publications 1 - 8 of 8.

Publications using AF5375	Applications	Species
N Frezel, M Ranucci, E Foster, H Wende, P Pelczar, R Mendes, RP Ganley, K Werynska, S d'Aquin, C Beccarini, C Birchmeier, HU Zeilhofer, H Wildner c-Maf-positive spinal cord neurons are critical elements of a dorsal horn circuit for mechanical hypersensitivity in neuropathy Cell Reports, 2023-03-21;42(4):112295. 2023-03-21 [PMID: 36947543] (IHC, Mouse)	IHC	Mouse
Gioele W. Albisetti, Robert P. Ganley, Francesca Pietrafesa, Karolina Werynska, Marília Magalhaes de Sousa, Rebecca Sipione et al. Inhibitory Kcnip2 neurons of the spinal dorsal horn control behavioral sensitivity to environmental cold Neuron 2023-01-04 [PMID: 36323322]
N Vilallongu, J Schaeffer, AM Hesse, C Delpech, B Blot, A Paccard, E Plissonnie, B Excoffier, Y Couté, S Belin, H Nawabi Guidance landscapes unveiled by quantitative proteomics to control reinnervation in adult visual system Nature Communications, 2022-10-13;13(1):6040. 2022-10-13 [PMID: 36229455] (IHC, Mouse)	IHC	Mouse
A Chabrat, G Brisson, H Doucet-Bea, C Salesse, M Schaan Pro, A Dovonou, C Akitegetse, J Charest, S Lemstra, D Côté, RJ Pasterkamp, MI Abrudan, E Metzakopia, SL Ang, M Lévesque Transcriptional repression of Plxnc1 by Lmx1a and Lmx1b directs topographic dopaminergic circuit formation Nat Commun, 2017-10-16;8(1):933. 10/16/2017 [PMID: 29038581]
H Lee, LJ Macpherson, CA Parada, CS Zuker, NJP Ryba Rewiring the taste system Nature, 2017-08-09;548(7667):330-333. 2017-08-09 [PMID: 28792937] (IHC, Mouse)	IHC	Mouse
Minlong Zhang, Xue Yan, Wei Liu, Ruilin Sun, Yonghong Xie, Faguang Jin Endothelial semaphorin 7A promotes seawater aspiration-induced acute lung injury through plexin C1 and beta 1 integrin Molecular Medicine Reports 2017-10-01 [PMID: 28765893]
Parkash J, Messina A, Langlet F, Cimino I, Loyens A, Mazur D, Gallet S, Balland E, Malone S, Pralong F, Cagnoni G, Schellino R, De Marchis S, Mazzone M, Pasterkamp R, Tamagnone L, Prevot V, Giacobini P Semaphorin7A regulates neuroglial plasticity in the adult hypothalamic median eminence. Nat Commun, 2015-02-27;6(0):6385. 2/27/2015 [PMID: 25721933]
Usoskin D, Furlan A, Islam S, Abdo H, Lonnerberg P, Lou D, Hjerling-Leffler J, Haeggstrom J, Kharchenko O, Kharchenko P, Linnarsson S, Ernfors P Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing. Nat Neurosci, 2014-11-24;18(1):145-53. 2014-11-24 [PMID: 25420068] (IHC, Mouse)	IHC	Mouse

Array AF5375

• Plexin C1 Antibodies
• Plexin C1 Protein
• Plexin C1 Proteins and Enzymes