PARD3/Par3 Antibody

Serine proteases are well known as enzymes involved in digestion of dietary proteins, blood coagulation, and homeostasis. A new role of serine proteases as signal molecule acting via protease-activated receptors (PARs) was recently uncovered. Important effects of PAR activation on leukocyte motility, cytokine production, adhesion molecule expression, and a variety of other physiological or pathophysiological functions have been described in vitro and in vivo. PAR activation is also involved in a variety of diseases conditions including neuroinflammatory and neurodegenerative process of skin, joints, and airway inflammation. Additionally Par activation is involved in innate and adaptive immunity (1). PAR receptors belong to the 7TMD family members and are expressed by 4 distinct genes (PAR1-4). PAR receptors and purinergic receptors (P2RY12 ) play important role in homostasis and thrombosis. Par3knockout mice showed nearly complete protection against carotid artery thrombosis caused by low FeCl(3) injury. Par3 and Par4 heterozygous mouse platelets showed partially decreased responses to thrombin, resembling those in PAR1 antagonist-treated human platelets (2). PAR3 is a thrombin receptor that is expressed in mouse megakaryocytes and is responsible for normal thrombin responses in mouse platelets (3).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array NBP2-11253

• PARD3/Par3 Antibodies
• PARD3/Par3 Proteins