I am highly interested to use couple of Anti-PAPP-A antibodies from your reputed companies for my research work. I have got the information regarding the immunogen used to generate these antibodies, however could not get any information regarding the specific amino acids/epitope to which your Anti-PAPP-A Antibodies binds with the antigen (PAPP-A).

Name: Pappalysin-1/PAPP-A Antibody [Unconjugated]
Brand: Novus Biologicals
SKU: AF2487
Price: 469 USD

Question

Accepted Answer

Unfortunately, none of our PAPP A antibodies have been epitope mapped. Many of them have also been generated against full-length PAPP A, so there are many potential binding sites.

At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	HuSpecies Glossary
Applications	WB, IP
Clonality	Polyclonal
Host	Goat
Conjugate	Unconjugated
Concentration	LYOPH

Catalog# & Conjugate	Size	Price
Biotin BAF2487

Catalog# & Formulation	Size	Price
Carrier Free AF2487-SP

Conjugate	Catalog #	Availability	Size	Price
Biotin	BAF2487

Pappalysin-1/PAPP-A Antibody [Unconjugated]

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Immunogen	Mouse myeloma cell line NS0-derived recombinant human Pappalysin‑1/PAPP‑A Glu82-Asp1214 Accession # Q13219
Specificity	Detects human Pappalysin‑1/PAPP‑A in direct ELISAs and Western blots. In direct ELISAs, less than 5% cross-reactivity with recombinant human PAPP-A2 is observed.
Source	N/A
Isotype	IgG
Clonality	Polyclonal
Host	Goat
Gene	PAPPA
Purity Statement	Antigen Affinity-purified
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Concentration	LYOPH
Reconstitution Instructions	Reconstitute at 0.2 mg/mL in sterile PBS.

Publications using AF2487	Applications	Species
Lluch, A;Latorre, J;Serena-Maione, A;Espadas, I;Caballano-Infantes, E;Moreno-Navarrete, JM;Oliveras-Cañellas, N;Ricart, W;Malagón, MM;Martin-Montalvo, A;Birchmeier, W;Szymanski, W;Graumann, J;Gómez-Serrano, M;Sommariva, E;Fernández-Real, JM;Ortega, FJ; Impaired Plakophilin-2 in obesity breaks cell cycle dynamics to breed adipocyte senescence Nature communications 8/22/2023 [PMID: 37607954]
Roefs MT, Bauzá-Martinez J, van de Wakker SI et al. Cardiac progenitor cell-derived extracellular vesicles promote angiogenesis through both associated- and co-isolated proteins Communications biology 8/1/2023 [PMID: 37528162]
Altered Biomarkers in Trophoblast Cells Obtained Noninvasively Prior to Clinical Manifestation of Perinatal Disease Sci Rep, 2016-09-23;6(0):32382. 2016-09-23 [PMID: 27660926] (IHC, Human)	IHC	Human
Wang J, Qiu Q, Haider M, Bell M, Gruslin A, Christians JK Expression of pregnancy-associated plasma protein A2 during pregnancy in human and mouse. J. Endocrinol., 2009-05-27;202(3):337-45. 2009-05-27 [PMID: 19474058] (Western Blot, Human)	Western Blot	Human
Nishizawa H, Pryor-Koishi K, Suzuki M Increased levels of pregnancy-associated plasma protein-A2 in the serum of pre-eclamptic patients. Mol. Hum. Reprod., 2008-09-18;14(10):595-602. 2008-09-18 [PMID: 18805800] (Western Blot, Human)	Western Blot	Human

Gene Symbol	PAPPA
Uniprot	Q13219()