p97/VCP Antibody (Hs-14)

This protein is a testis-specific, differentiation antigen, acrosomal vesicle protein 1, that arises within the acrosomal vesicle during spermatogenesis, and is associated with the acrosomal membranes and matrix of mature sperm. The gene encoding this protein consists of 4 exons and its alternative splicing generates 11 distinct transcripts, which encode protein isoforms ranging from 81 to 265 amino acids. The longest transcript is the most abundant, comprising 53-72% of the total acrosomal vesicle protein 1 messages; the second largest transcript comprises 15-32%; the third and the fourth largest transcripts account for 3.4-8.3% and 8.7-12.5%, respectively; and the remaining 7 transcripts combined account for < 1% of the total acrosomal vesicle protein 1 message. It is suggested that phenomena of cryptic splicing and exon skipping occur within this gene. The acrosomal vesicle protein 1 may be involved in sperm-zona binding or penetration, and it is a potential contraceptive vaccine immunogen for humans.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: FLOW.

Showing Publications 1 - 2 of 2.

Publications using NB500-455	Applications	Species
Elemento JK, Cohen PE Dynamic transcriptome profiles within spermatogonial and 2 spermatocyte populations during postnatal testis maturation 3 revealed by single-cell sequencing PLoS Genet 2019-03-21 [PMID: 30893341] (FLOW, Mouse)	FLOW	Mouse
Greenhalgh JR, Griffith TS, Wald M. The Use of Immunofluorescence in Microdissection Testicular Sperm Extraction J rol 2009-01-01 [PMID: 19234316] Details: This citation used the FITC version of this antibody.

Array NB500-455

• p97/VCP Antibodies
• p97/VCP Lysate
• p97/VCP Proteins