p73 Antibody (5B1288) - BSA Free

p73 was identified as a long-lost cousin of tumor suppressor protein, p53. p73 has high homology with p53 as well as with p63, a gene implicated in the maintenance of epithelial stem cells. Significant homology between p53, p63, and p73 (approximately 63% amino acid identity in the DNA-binding domain suggest that they may have overlapping functions in the regulation of gene expression. The targeted disruption of p73 gene leads to defects hippocampal dysgenesis, hydrocephalus, chronic inflammation and infections. Recently, spilicing variant mRNAs of p73 has been identified in MCF-7, a breast carcinoma cell line. These mRNAs code for variant p73 proteins bearing distinct carboxy-terminal structures suggesting that the carboxy-terminal region of p73 may be important for the functions of this protein. Tumor BioMarker: Vella et al (2003) found p73 to be upregulated in a significant fraction of anaplastic thyroid cancers, whereas p73 was not detectable in normal thyroid epithelial cells nor in papillary or follicular thyroid cancer.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 6 applications: Chemotaxis, Co-Immunoprecipitation, ICC/IF, IF/IHC, IP, WB.

Showing Publications 1 - 10 of 29. Show All 29 Publications. Collapse Publications.

Publications using NB100-56674	Applications	Species
Venkatanarayan A, Raulji P, Norton W et al. IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo Nature et al. 2014-11-17 [PMID: 25409149] (WB, Chemotaxis, Mouse)	WB, Chemotaxis	Mouse
de Abreu PA. Role of p53 in muscle wasting Thesis 2016-01-01 (IP, Mouse)	IP	Mouse
Ng KY, Chan LH, Chai S et al. TP53INP1 down-regulation activates a p73-dependent DUSP10/ERK signaling pathway to promote metastasis of hepatocellular carcinoma Cancer Res. 2017-07-03 [PMID: 28674078] (Human)		Human
Lu H, Yan C, Quan XX et al. CK2 Phosphorylates and Inhibits TAp73 Tumor Suppressor Function to Promote Expression of Cancer Stem Cell Genes and Phenotype in Head and Neck Cancer . Neoplasia. 2014-10-01 [PMID: 25379016] (Co-Immunoprecipitation, WB, Human)	Co-Immunoprecipitation, WB	Human
Guerrieri F, Piconese S, Lacoste C et al. The sodium/iodide symporter NIS is a transcriptional target of the p53-family members in liver cancer cells. Cell Death Dis. 2013-01-01 [PMID: 24052075] (Human)		Human
Du W, Jiang P, Mancuso A et al. TAp73 enhances the pentose phosphate pathway and supports cell proliferation. Nat Cell Biol 2013-08-01 [PMID: 23811687]
King KE, Reddi DM, Ponnamperuma RM et al. Dysregulated deltaNp63alpha negatively regulates the maspin promoter in keratinocytes via blocking endogenous p73 binding Mol Carcinog 2013-03-08 [PMID: 23475637] (IP, Mouse)	IP	Mouse
Niemantsverdriet M, Nagle P, Chiu RK et al. deltaNp73 enhances promoter activity of TGF-B induced genes. PLoS One. 2012-01-01 [PMID: 23236396]
Leonard M K, Kommagani R, Payal V et al. DeltaNp63alpha regulates keratinocyte proliferation by controlling PTEN expression and localization. Cell Death Differ. 2011-12-01 [PMID: 21637289]
Rosenbluth JM, Johnson K, Tang L et al. Evaluation of p63 and p73 antibodies for cross-reactivity. Cell Cycle. 2009-11-15 [PMID: 19855172]
Lin Yu-Li, Sengupta Shomit, Gurdziel Katherine et al. p63 and p73 transcriptionally regulate genes involved in DNA repair. PLoS Genet. 2009-10-01 [PMID: 19816568] (IF/IHC, Mouse)	IF/IHC	Mouse
Kommagani R, Whitlatch A, Leonard M K, Kadakia M P. p73 is essential for vitamin D-mediated osteoblastic differentiation. Cell Death Differ. 2010-03-01 [PMID: 19779497] (Human)		Human
Rosenbluth Jennifer M, Mays Deborah J, Pino Maria F et al. A gene signature-based approach identifies mTOR as a regulator of p73. Mol Cell Biol. 2008-10-01 [PMID: 18678646] (Human)		Human
Jones Emma V, Dickman Mark J, Whitmarsh Alan J. Regulation of p73-mediated apoptosis by c-Jun N-terminal kinase. Biochem J. 2007-08-01 [PMID: 17521288]
Limesand KH, Schwertfeger KL, Anderson SM. MDM2 is required for suppression of apoptosis by activated Akt1 in salivary acinar cells. Mol Cell Biol. 2006-12-01 [PMID: 16982679]
Belloni L, Moretti F, Merlo P et al. DNp73alpha protects myogenic cells from apoptosis. Oncogene. 2006-06-15 [PMID: 16652159]
Thottassery JV, Westbrook L, Someya H, Parker WB. c-Abl-independent p73 stabilization during gemcitabine- or 4'-thio-beta-D-arabinofuranosylcytosine-induced apoptosis in wild-type and p53-null colorectal cancer cells. Mol Cancer Ther. 2006-02-01 [PMID: 16505115] (WB, Human) Details: p73 (IMG-246 and IMG-259A) for WB (Figs 5A, 6, 7 and 8B) in HCT 116 human colorectal cell lines (wild-type and p53 knockouts).	WB	Human
Lunghi P, Costanzo A, Salvatore L et al. MEK1 inhibition sensitizes primary acute myelogenous leukemia to arsenic trioxide-induced apoptosis. Blood. 2006-06-01 [PMID: 16467208]
Accardi R, Dong W, Smet A et al. Skin human papillomavirus type 38 alters p53 functions by accumulation of deltaNp73. EMBO Rep. 2006-03-01 [PMID: 16397624] (WB, ICC/IF) Details: Antibodies cited: 1. p73 (IMG-259A) [WB, Fig.3B and Fig.5B (HPV38 keratinocytes)]. [ChIP, Fig.5A (HPV38 keratinocytes)]. [IF/ICC, Fig.6C (keratinocytes of HPV38 E6/E7 transgenic mice)].	WB, ICC/IF
Kulesz-Martin M, Lagowski J, Fei S et al. Melanocyte and keratinocyte carcinogenesis: p53 family protein activities and intersecting mRNA expression profiles. J Investig Dermatol Symp Proc. 2005-11-01 [PMID: 16363065]
Tomasini R, Seux M, Nowak J et al. TP53INP1 is a novel p73 target gene that induces cell cycle arrest and cell death by modulating p73 transcriptional activity. Oncogene. 2005-12-08 [PMID: 16044147]
Merlo P, Fulco M, Costanzo A et al. A role of p73 in mitotic exit. J Biol Chem. 2005-08-26 [PMID: 15985436]
Sayan AE, Paradisi A, Vojtesek B et al. New antibodies recognizing p73: comparison with commercial antibodies. Biochem Biophys Res Commun. 2005-04-29 [PMID: 15781249] (WB, Human) Details: Antibodies cited (p73 transfected cells, SK-N-SH human neuroblastoma cells, HaCaT human keratinocyte cells): 1. p73 (IMG-246): IP, Fig 3B (p73 transfected cells); WB, Figs 1 and 2 (p73 transfected cells). 2. p73 (IMG-259A): WB, Figs 1 and 2 (p73 transfect	WB	Human
Papoutsaki M, Lanza M, Marinari B et al. The p73 gene is an anti-tumoral target of the RARbeta/gamma-selective retinoid tazarotene. J Invest Dermatol. 2004-12-01 [PMID: 15610529] Details: Monoclonal antibodies cited for IHC (Bouin's) in human breast cancer, Fig 1: 1. IL3-Ra/CD123, clone 107D2.08: Cat no DDX0300 2. CD207/Langerin, clone 808E10.01: Cat no DDX0361 3. CD208/DC-LAMP, clone 101E1.01: Cat no DDX0191 4. CD303/BCDA-2, clone 104C12.08: Cat no DDX0041.
Lunghi P, Costanzo A, Levrero M, Bonati A. Treatment with arsenic trioxide (ATO) and MEK1 inhibitor activates the p73-p53AIP1 apoptotic pathway in leukemia cells. Blood. 2004-07-15 [PMID: 15031205] (WB) Details: 1. p73 (IMG-259A) [WB, Fig 1CD, Fig 2B (NB4 acute promyelocytic and k562 erythroleukemia cells)]. 2. deltaNp73 (IMG-313A) [WB, Fig 1CD, Fig 2B (NB4 and k562 cells)].	WB
Tullo A, Mastropasqua G, Bourdon JC et al. Adenosine deaminase, a key enzyme in DNA precursors control, is a new p73 target. Oncogene. 2003-11-27 [PMID: 14647469]
Fulco M, Costanzo A, Merlo P et al. p73 is regulated by phosphorylation at the G2/M transition. J Biol Chem. 2003-12-05 [PMID: 12920125] Details: 1. p73 (IMG-259) [WB, Fig 1ABC, Fig 2A, Fig 3AC, Fig 6A (Hct116 cells)] , [WB, Fig 4B (transfected p21 U2OS cells)], [IF/ICC, Fig 5AB (MCF7 and H1299 cells)].
Vella V, Zhu J, Frasca F et al. Exclusion of c-Abl from the nucleus restrains the p73 tumor suppression function. J Biol Chem. 2003-07-04 [PMID: 12716888]
Costanzo A, Merlo P, Pediconi N et al. DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes. Mol Cell. 2002-01-01 [PMID: 11804596] (WB) Details: 1. p73 (IMG-259A) [WB, Fig.1 (HCT116-3 cells)].	WB
Show All 29 Publications. Collapse Publications.

Array NB100-56674

• p73 Antibodies
• p73 Lysate
• p73 Proteins