Species: Hu, Mu, Rt
Applications: WB, Simple Western, Flow, ICC/IF, IHC, IP, ChIP, CyTOF-ready
Host: Mouse Monoclonal
Species: Hu, Mu
Applications: WB, ChIP, ICC/IF, IHC, IP, ChIP
Host: Mouse Monoclonal
Species: Hu
Applications: WB, IP
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
p73 is a transcription factor that shares a significant amino acid identity with p53 and p63 (1). p73 and p63 can both activate p53-responsive genes and induce apoptosis upon over expression (2) Unlike p53, p73 is not induced by DNA damage and is not a target for inactivation by viral oncoproteins (3). Similar to p63, p73 has an additional coding region in the C-terminus (not found in p53) that can undergo complex alternative splicing giving rise to 3 splice forms (alpha, beta, and gamma) (4). Activation of p73 requires the presence of functional c-Abl. It has also be found that mutant p53 can bind to and inactivate p73 (5).
Bioinformatics
| Uniprot |
Human
Human
|
| Product By Gene ID |
7161 |
| Alternate Names |
- p53-related protein
- P73p53-like transcription factor
- TA p73
- TAp73
- tumor protein p73
|
