p70 S6 Kinase/S6K [p Thr389] Antibody (1045C) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

p70 S6 Kinase (p70S6K) is responsible for the phosphorylation of 40S ribosomal protein S6 and is ubiquitously expressed in human adult tissues (1). p70S6K is activated by serum stimulation and this activation is inhibited by wortmannin and rapamycin. p70S6K activity undergoes changes in the cell cycle and increases
20-fold in G1 cells released from G0 (2). p70S6K activation requires sequential phosphorylations at proline-directed residues in the putative autoinhibitory pseudosubstrate domain, as well as T389, a site phosphorylated by Phosphoinositide-Dependent Kinase 1 (PDK1).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: Western Blot.

Showing Publications 1 - 6 of 6.

Publications using MAB8963	Applications	Species
Jia-Bing Li, Xiao-Yu Hu, Mu-Wen Chen, Cai-Hong Xiong, Na Zhao, Yan-Hui Ge et al. p85S6K sustains synaptic GluA1 to ameliorate cognitive deficits in Alzheimer’s disease Translational Neurodegeneration 2023-01-09 [PMID: 36624510]
T Walle, JA Kraske, B Liao, B Lenoir, C Timke, E von Bohlen, F Tran, P Griebel, D Albrecht, A Ahmed, M Suarez-Car, A Jiménez-Sá, T Beikert, A Tietz-Dahl, AN Menevse, G Schmidt, M Brom, JHW Pahl, W Antonopoul, M Miller, RL Perez, F Bestvater, NA Giese, P Beckhove, P Rosenstiel, D Jäger, O Strobel, D Pe'er, N Halama, J Debus, A Cerwenka, PE Huber Radiotherapy orchestrates natural killer cell dependent antitumor immune responses through CXCL8 Science Advances, 2022-03-23;8(12):eabh4050. 3/23/2022 [PMID: 35319989]
R Ji, L Ma, X Chen, R Sun, L Zhang, H Saiyin, W Wei Characterizing the distributions of IDO-1 expressing macrophages/microglia in human and murine brains and evaluating the immunological and physiological roles of IDO-1 in RAW264.7/BV-2 cells PLoS ONE, 2021-11-04;16(11):e0258204. 2021-11-04 [PMID: 34735466] (Western Blot, Human)	Western Blot	Human
G Chevalier, E Siopi, L Guenin-Mac, M Pascal, T Laval, A Rifflet, IG Boneca, C Demangel, B Colsch, A Pruvost, E Chu-Van, A Messager, F Leulier, G Lepousez, G Eberl, PM Lledo Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system Nature Communications, 2020-12-11;11(1):6363. 2020-12-11 [PMID: 33311466] (Western Blot, Mouse)	Western Blot	Mouse
Sara M. Ibrahim, Sherin Bakhashab, Asad M. Ilyas, Peter N. Pushparaj, Sajjad Karim, Jalaluddin A. Khan et al. WYE-354 restores Adriamycin sensitivity in multidrug-resistant acute myeloid leukemia cell lines Oncology Reports 2019-04-02 [PMID: 30942458]
Kusch A, Schmidt M, Gurgen D et al. 17-Beta-Estradiol Regulates mTORC2 Sensitivity to Rapamycin in Adaptive Cardiac Remodeling PLoS ONE 4/17/2015 [PMID: 25880554]

Array MAB8963

• p70 S6 Kinase/S6K Antibodies
• p70 S6 Kinase/S6K ELISA Kit
• p70 S6 Kinase/S6K Lysate
• p70 S6 Kinase/S6K Proteins
• p70 S6 Kinase/S6K ELISAs
• p70 S6 Kinase/S6K Proteins and Enzyme