Noxa Antibody (114C307.1) - Non-Recombinant Monoclonal

Noxa, phorbol-12-myristate-13-acetate-induced protein 1, PMA-induced protein 1, PMAIP1 (Human 6 kDa and Mouse 11.6 kDa) is a Bcl2 homology 3 (BH3) domain containing protein which plays a role in the regulation of apoptosis, specifically a pro-apoptotic role. Human Noxa contains only one BH3 domain, while the mouse and rat proteins contain two BH3 domains. The human protein is encoded by Exon 1 and 3, with Exon 2 present only in two splice variants. Human Noxa splice variants lack a BH3 domain, have no known function, and are rapidly targeted for degradation (1).

Noxa mediated apoptosis may follow its transcriptional activation by p53 as part of the DNA damage response. However, Noxa expression may be induced by HIF-1 alpha under hypoxia, promoting apoptosis independently of p53 (1). Inhibition of the anti-apoptotic Bcl2 family member Myeloid cell leukemia-1 (Mcl-1) by Noxa, leads to the activation of pro-apoptotic Bcl2 homologous antagonist killer (Bak) and Bcl2 associated X (Bax) proteins, and apoptosis through the intrinsic mitochondrial pathway (2). Other BH3 only proteins such as Bim, Puma, Bad and Bid act via the same mechanism, targeting Mcl-1 and inducing Bak/Bax mediated mitochondrial outer membrane permeabilization (MOMP), cytochrome c release and caspase 9 activation (3). Overexpression of antiapoptotic Bcl2 family members is common in various types of cancer including prostate cancer. A recent study identified antiapoptotic Bcl2 proteins involved in the development of resistance towards the androgen receptor antagonist enzalutamide, which is used for the treatment of metastatic castration-resistant prostate cancer (mCRPC) (3).

References

1.Ploner, C., Kofler, R., & Villunger, A. (2008). Noxa: At the tip of the balance between life and death. Oncogene. https://doi.org/10.1038/onc.2009.46

2.Xiang, W., Yang, C. Y., & Bai, L. (2018). MCL-1 inhibition in cancer treatment. OncoTargets and Therapy. https://doi.org/10.2147/OTT.S146228

3.Pilling, A. B., & Hwang, C. (2019). Targeting prosurvival BCL2 signaling through Akt blockade sensitizes castration-resistant prostate cancer cells to enzalutamide. Prostate. https://doi.org/10.1002/pros.23843

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 5 applications: ICC/IF, IF/IHC, IHC-P, Immunohistochemistry, WB.

Showing Publications 1 - 10 of 77. Show All 77 Publications. Collapse Publications.

Publications using NB600-1159	Applications	Species
Noxa (IMG-349) [WB, Fig4 (H1299 cells)].
Al Shboul S, El-Sadoni M, Alhesa A et al. NOXA expression is downregulated in human breast cancer undergoing incomplete pathological response and senescence after neoadjuvant chemotherapy Sci Rep 2023-09-23 [PMID: 37741850] (Immunohistochemistry)	Immunohistochemistry
Dewson G, Huang AS, San Chin H, Reljic B E3 ubiquitin ligase MARCHF5 controls BAK apoptotic activity independently of BH3-only proteins bioRxiv 2022-01-01 [PMID: 36171332] (WB, Human)	WB	Human
Gardner EE. STRATEGIES TO MODEL AND CIRCUMVENT ACQUIRED RESISTANCE TO THERAPEUTICS IN SMALL CELL LUNG CANCER Thesis 2016-01-01 (WB, Mouse)	WB	Mouse
Asuzu DT, Alvarez R, Fletcher PA Et al. Pituitary adenomas evade apoptosis via noxa deregulation in Cushing's disease Cell Rep 2022-08-24 [PMID: 36001971] (IHC-P, Human) Details: Citation using the Alexa Fluor 532 version of this antibody.	IHC-P	Human
Hao Liu, Zhenzhan Zhang, Peilin Zhen, Meijuan Zhou High Expression of VSTM2L Induced Resistance to Chemoradiotherapy in Rectal Cancer through Downstream IL-4 Signaling Journal of Immunology Research 2021-01-08 [PMID: 33506057]
Zheng J, Zhuo L, Ran D et al. Cadmium induces apoptosis via generating reactive oxygen species to activate mitochondrial p53 pathway in primary rat osteoblasts Toxicology 2020-10-08 [PMID: 33031904] (WB, Rat) Details: Citation using the Non-Recombinant Monoclonal format of this antibody.	WB	Rat
Tseng HY, Dreyer J, Emran AA et al. Co-targeting bromodomain and extra-terminal proteins and MCL1 induces synergistic cell death in melanoma Int J Cancer 2020-04-07 [PMID: 32249419] Details: Citation using the Non-Recombinant Monoclonal format of this antibody.
Djajawi TM, Liu L, Gong JN et al. MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex Cell Death Differ 2020-02-26 [PMID: 32094511] (WB, Mouse) Details: Citation using the Non-Recombinant Monoclonal format of this antibody.	WB	Mouse
Pilling AB, Hwang C. Targeting prosurvival BCL2 signaling through Akt blockade sensitizes castration-resistant prostate cancer cells to enzalutamide Prostate 2019-06-23 [PMID: 31228231] (WB, Human) Details: Citation using the Non-Recombinant Monoclonal format of this antibody.	WB	Human
Gonzalez PS, O'Prey J, Cardaci S et al. Mannose impairs tumour growth and enhances chemotherapy Nature 2018-11-23 [PMID: 30464341] (Mouse) Details: Citation using the Non-Recombinant Monoclonal format of this antibody.		Mouse
S Gutbier, AS Spreng, J Delp, S Schildknec, C Karreman, I Suciu, T Brunner, M Groettrup, M Leist Prevention of neuronal apoptosis by astrocytes through thiol-mediated stress response modulation and accelerated recovery from proteotoxic stress Cell Death Differ., 2018-11-02;0(0):. 2018-11-02 [PMID: 30390092]
Minieri V, De Dominici M, Porazzi P et al. Targeting STAT5 or STAT5-Regulated Pathways Suppresses Leukemogenesis of Ph+ Acute Lymphoblastic Leukemia Cancer Res 2018-08-30 [PMID: 30154155] (WB, Human) Details: Citation using the Non-Recombinant Monoclonal format of this antibody.	WB	Human
Gallagher SJ, Gunatilake D, Beaumont KA et al. HDAC inhibitors restore BRAF-inhibitor sensitivity by altering PI3K and survival signalling in a subset of melanoma Int J Cancer 2017-12-07 [PMID: 29210065] (WB, Human) Details: Citation using the Non-Recombinant Monoclonal format of this antibody.	WB	Human
Antignani A, Segal D, Simon N et al. Essential role for Bim in mediating the apoptotic and antitumor activities of immunotoxins Oncogene 2017-04-25 [PMID: 28436946] (WB, Mouse) Details: Citation using the Non-Recombinant Monoclonal format of this antibody.	WB	Mouse
Zhang J, Huang K, O'Neill KL et al. Bax/Bak activation in the absence of Bid, Bim, Puma, and p53 Cell Death Dis 2016-06-17 [PMID: 27310874] (WB, Human) Details: Citation using the Non-Recombinant Monoclonal format of this antibody.	WB	Human
Heinemann A, Cullinane C, De Paoli-Iseppi R et al. Combining BET and HDAC inhibitors synergistically induces apoptosis of melanoma and suppresses AKT and YAP signaling Oncotarget 2015-06-19 [PMID: 26087189] (WB, Human) Details: Citation using the Non-Recombinant Monoclonal format of this antibody.	WB	Human
Wang Y, Lv J, Cheng Y et al. Apoptosis induced by Ginkgo biloba (EGb761) in melanoma cells is Mcl-1-dependent PLoS One 2015-04-11 [PMID: 25860257] (WB, Human) Details: Citation using the Non-Recombinant Monoclonal format of this antibody.	WB	Human
SigurDsson HH, Olesen CW, Dybboe R et al. Constitutively active ErbB2 regulates cisplatin-induced cell death in breast cancer cells via pro- and antiapoptotic mechanisms Mol Cancer Res 2014-08-22 [PMID: 25143433] (WB, Human) Details: Citation using the Non-Recombinant Monoclonal format of this antibody.	WB	Human
Wei J, Noto JM, Zaika E et al. Bacterial CagA protein induces degradation of p53 protein in a p14ARF-dependent manner Gut 2014-08-01 [PMID: 25080447] Details: Citation using the Non-Recombinant Monoclonal format of this antibody.
Pang X, Zhang J, Lopez H et al. The carboxyl-terminal tail of Noxa protein regulates the stability of Noxa and Mcl-1 J Biol Chem 2014-05-10 [PMID: 24811167] (WB, Human) Details: Citation using the Non-Recombinant Monoclonal format of this antibody.	WB	Human
Thorburn J, Andrysik Z, Staskiewicz L et al. Autophagy controls the kinetics and extent of mitochondrial apoptosis by regulating PUMA levels Cell Rep 2014-04-02 [PMID: 24685133] (WB, Human) Details: Citation using the Non-Recombinant Monoclonal format of this antibody.	WB	Human
Rao F, Cha J, Xu J et al. Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2 Mol Cell 2014-03-25 [PMID: 24657168] (WB, Human) Details: Citation using the Non-Recombinant Monoclonal format of this antibody.	WB	Human
Godbersen JC, Humphries LA, Danilova OV et al. The Nedd8-activating enzyme inhibitor MLN4924 thwarts microenvironment-driven NF-kappa B activation and induces apoptosis in chronic lymphocytic leukemia B cells Clin Cancer Res 2014-03-18 [PMID: 24634471] (WB, Human) Details: Citation using the Non-Recombinant Monoclonal format of this antibody.	WB	Human
Wroblewski D, Jiang CC, Croft A et al. OBATOCLAX and ABT-737 induce ER stress responses in human melanoma cells that limit induction of apoptosis PLoS One 2013-12-25 [PMID: 24367627] (WB, Human) Details: Citation using the Non-Recombinant Monoclonal format of this antibody.	WB	Human
Parrondo R, de Las Pozas A, Reiner T, Perez-Stable C. ABT-737, a small molecule Bcl-2/Bcl-xL antagonist, increases antimitotic-mediated apoptosis in human prostate cancer cells PeerJ 2013-09-24 [PMID: 24058878] (WB, Human) Details: Citation using the Non-Recombinant Monoclonal format of this antibody.	WB	Human
Pascutti MF, Jak M, Tromp JM et al. IL-21 and CD40L signals from autologous T cells can induce antigen-independent proliferation of CLL cells Blood 2013-09-10 [PMID: 24014238] (Human) Details: Citation using the Non-Recombinant Monoclonal format of this antibody.		Human
Dabir S, Kluge A, McColl K et al. PIAS3 activates the intrinsic apoptotic pathway in non-small cell lung cancer cells independent of p53 status Int J Cancer 2013-08-21 [PMID: 23959540] (WB, Human) Details: Citation using the Non-Recombinant Monoclonal format of this antibody.	WB	Human
Thomas RL, Roberts DJ, Kubli DA et al. Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure Genes Dev 2013-06-22 [PMID: 23788623] (WB, Mouse) Details: Citation using the Non-Recombinant Monoclonal format of this antibody.	WB	Mouse
Adamski J, Price A, Dive C, Makin G. Hypoxia-induced cytotoxic drug resistance in osteosarcoma is independent of HIF-1Alpha PLoS One 2013-06-21 [PMID: 23785417] Details: Citation using the Non-Recombinant Monoclonal and Biotin format of this antibody.
Zinn RL, Gardner EE, Dobromilskaya I et al. Combination treatment with ABT-737 and chloroquine in preclinical models of small cell lung cancer Mol Cancer 2013-03-05 [PMID: 23452820] Details: Citation using the Non-Recombinant Monoclonal format of this antibody.
Ryder C, McColl K, Zhong F, Distelhorst CW. Acidosis promotes Bcl-2 family-mediated evasion of apoptosis: involvement of acid-sensing G protein-coupled receptor Gpr65 signaling to Mek/Erk J Biol Chem 2012-06-12 [PMID: 22685289] (WB, Mouse) Details: Citation using the Non-Recombinant Monoclonal format of this antibody.	WB	Mouse
Wong C, Anderson DJ, Lee EF et al. Direct visualization of Bcl-2 family protein interactions using live cell fluorescent protein redistribution assays Cell Death Dis 2012-03-31 [PMID: 22460384] (ICC/IF, Human) Details: Citation using the Non-Recombinant Monoclonal format of this antibody.	ICC/IF	Human
Tromp JM, Geest CR, Breij EC et al. Tipping the Noxa/Mcl-1 balance overcomes ABT-737 resistance in chronic lymphocytic leukemia Clin Cancer Res 2011-12-01 [PMID: 22128299] (WB) Details: Citation using the Non-Recombinant Monoclonal and Biotin format of this antibody.	WB
Chen M, Felix K, Wang J. Immune regulation through mitochondrion-dependent dendritic cell death induced by T regulatory cells J Immunol 2011-10-28 [PMID: 22031758] (WB, Mouse) Details: Citation using the Non-Recombinant Monoclonal format of this antibody.	WB	Mouse
Chu R, Terrano DT, Chambers TC. Cdk1/cyclin B plays a key role in mitotic arrest-induced apoptosis by phosphorylation of Mcl-1, promoting its degradation and freeing Bak from sequestration Biochem Pharmacol 2011-10-26 [PMID: 22024133] Details: Citation using the Non-Recombinant Monoclonal and Biotin format of this antibody.
Kuo KK, Chen YL, Chen LR et al. Involvement of phorbol-12-myristate-13-acetate-induced protein 1 in goniothalamin-induced TP53-dependent and -independent apoptosis in hepatocellular carcinoma-derived cells Toxicol Appl Pharmacol 2011-08-04 [PMID: 21810437] (WB, Human) Details: Citation using the Non-Recombinant Monoclonal format of this antibody.	WB	Human
Ishikita H. Proton-binding sites of acid-sensing ion channel 1 PLoS One 2011-02-23 [PMID: 21340031] Details: Citation using the Non-Recombinant Monoclonal format of this antibody.
Chen CH, Huang PH, Chu PC et al. Energy restriction-mimetic agents induce apoptosis in prostate cancer cells in part through epigenetic activation of KLF6 tumor suppressor gene expression J Biol Chem 2011-02-02 [PMID: 21282102] (WB) Details: Citation using the Non-Recombinant Monoclonal and Biotin format of this antibody.	WB
Poulsen RC, Carr AJ, Hulley PA. Protection against glucocorticoid-induced damage in human tenocytes by modulation of ERK, Akt, and forkhead signaling Endocrinology 2011-01-07 [PMID: 21209015] (WB) Details: Citation using the Non-Recombinant Monoclonal format of this antibody.	WB
Zhang L, Lopez H, George NM et al. Selective involvement of BH3-only proteins and differential targets of Noxa in diverse apoptotic pathways Cell Death Differ 2010-11-30 [PMID: 21113147] (Human) Details: Citation using the Non-Recombinant Monoclonal format of this antibody.		Human
Bodet L, MEnoret E, Descamps G et al. BH3-only protein Bik is involved in both apoptosis induction and sensitivity to oxidative stress in multiple myeloma Br J Cancer 2010-11-11 [PMID: 21063407] (WB, Human) Details: Citation using the Non-Recombinant Monoclonal and Biotin format of this antibody.	WB	Human
Fahham N, Sardari S, Ostad SN et al. C-terminal domain of p16(INK4a) is adequate in inducing cell cycle arrest, growth inhibition and CDK4/6 interaction similar to the full length protein in HT-1080 fibrosarcoma cells J Cell Biochem 2010-11-06 [PMID: 21053367] (Human) Details: Citation using the Non-Recombinant Monoclonal and Biotin format of this antibody.		Human
Tonino SH, van Laar J, van Oers MH et al. ROS-mediated upregulation of Noxa overcomes chemoresistance in chronic lymphocytic leukemia Oncogene 2010-10-12 [PMID: 20935673] Details: Citation using the Non-Recombinant Monoclonal format of this antibody.
Hadji A, Clybouw C, Auffredou MT et al. Caspase-3 triggers a TPCK-sensitive protease pathway leading to degradation of the BH3-only protein puma Apoptosis 2010-07-20 [PMID: 20640889] (WB) Details: Citation using the Non-Recombinant Monoclonal format of this antibody.	WB
Zall H, Weber A, Besch R et al. Chemotherapeutic drugs sensitize human renal cell carcinoma cells to ABT-737 by a mechanism involving the Noxa-dependent inactivation of Mcl-1 or A1 Mol Cancer 2010-06-26 [PMID: 20576107] (WB) Details: Citation using the Non-Recombinant Monoclonal and Biotin format of this antibody.	WB
Sosa Seda IM, Mott JL, Akazawa Y et al. Noxa mediates hepatic stellate cell apoptosis by proteasome inhibition Hepatol Res 2010-06-19 [PMID: 20557369] (WB) Details: Citation using the Non-Recombinant Monoclonal and Biotin format of this antibody.	WB
de Bruijn MT, Raats DA, Hoogwater FJ et al. Oncogenic KRAS sensitises colorectal tumour cells to chemotherapy by p53-dependent induction of Noxa Br J Cancer 2010-04-01 [PMID: 20354524] (IF/IHC) Details: Citation using the Non-Recombinant Monoclonal format of this antibody.	IF/IHC
Lopez H, Zhang L, George NM et al. Perturbation of the Bcl-2 network and an induced Noxa/Bcl-xL interaction trigger mitochondrial dysfunction after DNA damage J Biol Chem 2010-03-13 [PMID: 20223826] Details: Citation using the Non-Recombinant Monoclonal and Biotin format of this antibody.
Vilgelm AE, Washington MK, Wei J et al. Interactions of the p53 protein family in cellular stress response in gastrointestinal tumors Mol Cancer Ther 2010-03-04 [PMID: 20197393] (WB, Human) Details: Citation using the Non-Recombinant Monoclonal and Biotin format of this antibody.	WB	Human
Streetly MJ, Maharaj L, Joel S et al. GCS-100, a novel galectin-3 antagonist, modulates MCL-1, NOXA, and cell cycle to induce myeloma cell death Blood 2010-03-02 [PMID: 20190189] (WB) Details: Citation using the Non-Recombinant Monoclonal format of this antibody.	WB
Tahir SK, Wass J, Joseph MK et al. Identification of expression signatures predictive of sensitivity to the Bcl-2 family member inhibitor ABT-263 in small cell lung carcinoma and leukemia/lymphoma cell lines Mol Cancer Ther 2010-02-25 [PMID: 20179162] (WB) Details: Citation using the Non-Recombinant Monoclonal and Biotin format of this antibody.	WB
Ackler S, Mitten MJ, Foster K et al. The Bcl-2 inhibitor ABT-263 enhances the response of multiple chemotherapeutic regimens in hematologic tumors in vivo Cancer Chemother Pharmacol 2010-01-26 [PMID: 20099064] Details: Citation using the Non-Recombinant Monoclonal format of this antibody.
Paoluzzi L, Scotto L, Marchi E et al. Romidepsin and belinostat synergize the antineoplastic effect of bortezomib in mantle cell lymphoma Clin Cancer Res 2010-01-14 [PMID: 20068080] (Human) Details: Citation using the Non-Recombinant Monoclonal format of this antibody.		Human
High LM, Szymanska B, Wilczynska-Kalak U et al. The Bcl-2 homology domain 3 mimetic ABT-737 targets the apoptotic machinery in acute lymphoblastic leukemia resulting in synergistic in vitro and in vivo interactions with established drugs Mol Pharmacol 2009-12-30 [PMID: 20038611] (WB) Details: Citation using the Non-Recombinant Monoclonal and Biotin format of this antibody.	WB
Cheung M, Pei J, Pei Y et al. The promyelocytic leukemia zinc-finger gene, PLZF, is frequently downregulated in malignant mesothelioma cells and contributes to cell survival Oncogene 2009-12-17 [PMID: 20010871] (WB, Human) Details: Citation using the Non-Recombinant Monoclonal format of this antibody.	WB	Human
Pilling AB, Hwang C. Expression of BfrH, a putative siderophore receptor of Bordetella bronchiseptica, is regulated by iron, Fur1, and the extracellular function sigma factor EcfI Infect Immun 2009-12-17 [PMID: 20008538] Details: Citation using the Non-Recombinant Monoclonal format of this antibody.
Amschler K, SchOn MP, Pletz N et al. NF-kappaB inhibition through proteasome inhibition or IKKbeta blockade increases the susceptibility of melanoma cells to cytostatic treatment through distinct pathways J Invest Dermatol 2009-11-27 [PMID: 19940859] (WB, Human) Details: Citation using the Non-Recombinant Monoclonal and Biotin format of this antibody.	WB	Human
Stankiewicz AR, Livingstone AM, Mohseni N, Mosser DD. Regulation of heat-induced apoptosis by Mcl-1 degradation and its inhibition by Hsp70 Cell Death Differ 2009-01-17 [PMID: 19148187] (WB, Human) Details: Citation using the Non-Recombinant Monoclonal and Biotin format of this antibody.	WB	Human
Lee W, Belkhiri A, Lockhart AC et al. Overexpression of OATP1B3 confers apoptotic resistance in colon cancer Cancer Res 2008-12-17 [PMID: 19074900] (WB, Human) Details: Citation using the Non-Recombinant Monoclonal and Biotin format of this antibody.	WB	Human
van Gent R, Kater AP, Otto SA et al. In vivo dynamics of stable chronic lymphocytic leukemia inversely correlate with somatic hypermutation levels and suggest no major leukemic turnover in bone marrow Cancer Res 2008-12-17 [PMID: 19074880] (WB, Human) Details: Citation using the Non-Recombinant Monoclonal and Biotin format of this antibody.	WB	Human
Hallaert DY, Jaspers A, van Noesel CJ et al. c-Abl kinase inhibitors overcome CD40-mediated drug resistance in CLL: implications for therapeutic targeting of chemoresistant niches Blood 2008-09-18 [PMID: 18796631] (WB, Human) Details: Citation using the Non-Recombinant Monoclonal and Biotin format of this antibody.	WB	Human
Jiang CC, Lucas K, Avery-Kiejda KA et al. Up-regulation of Mcl-1 is critical for survival of human melanoma cells upon endoplasmic reticulum stress Cancer Res 2008-08-15 [PMID: 18701495] (WB) Details: Citation using the Non-Recombinant Monoclonal and Biotin format of this antibody.	WB
Zhang LJ, Hao YZ, Hu CS et al. Inhibition of apoptosis facilitates necrosis induced by cisplatin in gastric cancer cells Anticancer Drugs 2008-01-08 [PMID: 18176112] (WB, Human) Details: Citation using the Non-Recombinant Monoclonal and Biotin format of this antibody.	WB	Human
Condorelli F, Gnemmi I, Vallario A et al. Inhibitors of histone deacetylase (HDAC) restore the p53 pathway in neuroblastoma cells Br J Pharmacol 2007-12-07 [PMID: 18059320] (WB) Details: Citation using the Non-Recombinant Monoclonal format of this antibody.	WB
Tahir SK, Yang X, Anderson MG et al. Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737 Cancer Res 2007-02-07 [PMID: 17283153] (WB) Details: Citation using the Non-Recombinant Monoclonal and Biotin format of this antibody.	WB
Yu F, Watts RN, Zhang XD et al. Involvement of BH3-only proapoptotic proteins in mitochondrial-dependent Phenoxodiol-induced apoptosis of human melanoma cells Anticancer Drugs 2006-11-01 [PMID: 17075314] (Human) Details: Citation using the Non-Recombinant Monoclonal format of this antibody.		Human
Smit LA, Hallaert DY, Spijker R et al. Differential Noxa/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity Blood 2006-10-14 [PMID: 17038534] Details: Citation using the Non-Recombinant Monoclonal format of this antibody.
Yoshida A, Takemura H, Inoue H et al. Inhibition of glutathione synthesis overcomes Bcl-2-mediated topoisomerase inhibitor resistance and induces nonapoptotic cell death via mitochondrial-independent pathway Cancer Res 2006-06-03 [PMID: 16740716] (WB) Details: Citation using the Non-Recombinant Monoclonal and Biotin format of this antibody.	WB
Xie W, Jiang P, Miao L et al. Novel link between E2F1 and Smac/DIABLO: proapoptotic Smac/DIABLO is transcriptionally upregulated by E2F1 Nucleic Acids Res 2006-04-18 [PMID: 16617145] (WB) Details: Citation using the Non-Recombinant Monoclonal and Biotin format of this antibody.	WB
Simbulan-Rosenthal CM, Daher A, Trabosh V et al. Id3 induces a caspase-3- and -9-dependent apoptosis and mediates UVB sensitization of HPV16 E6/7 immortalized human keratinocytes Oncogene 2006-02-02 [PMID: 16449966] (WB) Details: Citation using the Non-Recombinant Monoclonal and Biotin format of this antibody.	WB
Chen WY, Wang DH, Yen RC et al. Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses Cell 2005-11-05 [PMID: 16269335] Details: Citation using the Non-Recombinant Monoclonal and Biotin format of this antibody.
Kojima K, Konopleva M, Samudio IJ et al. MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy Blood 2005-07-15 [PMID: 16014563] Details: Citation using the Non-Recombinant Monoclonal and Biotin format of this antibody.
Erster S, Mihara M, Kim RH et al. In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation Mol Cell Biol 2004-07-16 [PMID: 15254240] (WB, Human) Details: Citation using the Non-Recombinant Monoclonal and Biotin format of this antibody.	WB	Human
Yakovlev AG, Di Giovanni S, Wang G et al. BOK and NOXA are essential mediators of p53-dependent apoptosis J Biol Chem 2004-04-23 [PMID: 15102863] (ICC/IF, WB, Human) Details: Citation using the Non-Recombinant Monoclonal and Biotin format of this antibody.	ICC/IF, WB	Human
Mihara M, Erster S, Zaika A et al. p53 has a direct apoptogenic role at the mitochondria Mol Cell 2003-04-02 [PMID: 12667443] (WB) Details: Citation using the Non-Recombinant Monoclonal and Biotin format of this antibody.	WB
Deverman BE, Cook BL, Manson SR et al. Bcl-xL deamidation is a critical switch in the regulation of the response to DNA damage Cell 2002-10-10 [PMID: 12372300] (WB, IHC-P) Details: Citation using the Non-Recombinant Monoclonal and Biotin format of this antibody.	WB, IHC-P
Show All 77 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Verified Customer	ICC	Human	09/10/2021	View Summary Application Immunocytochemistry Sample Tested HeLa cells Species Human Lot 114C307.1
Enlarge	4 reviewed by: Verified Customer	WB	Mouse	10/04/2011	View Summary Application Western Blot Sample Tested WEHI 7.2 mouse T cell lymphoma cell lysate, Sample Amount: 100ug Species Mouse

Array NB600-1159

• Noxa Antibodies
• Noxa Lysate