nNOS Antibody

NOS (nitric oxide synathase) is a mediator of NO (nitric oxide) production, an inorganic gaseous messenger between cells. In cells, NOS catalyzes the oxidization of L-arginine to produce L-citrulline and NO. Three isoforms of NOS has been identified (eNOS, iNOS, and nNOS) with all of them having binding sites for NADPH, FAD, FMN, and tetrahydrobiopterin (1). Specifically, nNOS (Neuronal nitric oxide synthase bNOS, cNOS, Type I) is bound to PSD95 located in the neuronal membrane and at increased level of Ca2+, nNOS is trasnlocated to cytoplasm. In cytoplasm, nNOS is dephosphorylated by calcineurin which initiates NO production (2). A phosphorylation by PKA and PKC on nNOS leads down-regulation of NO production.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Rat.

We have publications tested in 3 applications: IF/IHC, IHC-Fr, WB.

Showing Publications 1 - 10 of 21. Show All 21 Publications. Collapse Publications.

Publications using NBP1-39681	Applications	Species
Roy SC, Sapkota S, Pasula MB et al. Diazepam Binding Inhibitor Control of Eu- and Hypoglycemic Patterns of Ventromedial Hypothalamic Nucleus Glucose-Regulatory Signaling ASN neuro 2023-11-30 [PMID: 38031405] (IHC-Fr, Rat)	IHC-Fr	Rat
Bheemanapally K, Briski KP Differential G-Protein-Coupled Estrogen Receptor-1 Regulation of Counter-Regulatory Transmitter Marker and 5'-AMP-Activated Protein Kinase Expression in Ventrolateral versus Dorsomedial Ventromedial Hypothalamic Nucleus Neuroendocrinology 2023-09-12 [PMID: 37699381]
Briski KP, Napit PR, Alhamyani A et al. Sex-Dimorphic Octadecaneuropeptide (ODN) Regulation of Ventromedial Hypothalamic Nucleus Glucoregulatory Neuron Function and Counterregulatory Hormone Secretion ASN neuro 2023-05-17 [PMID: 37194319] (WB, IHC-Fr, Rat)	WB, IHC-Fr	Rat
SuSnjara P, Mihaljevic Z, Stupin A et al. Consumption of nutritionally enriched hen eggs enhances endothelium-dependent vasodilation via cyclooygenases� metabolites in healthy young persons - A randomized study Research Square 2022-11-02 [PMID: 37049437] (WB, Human)	WB	Human
Briski KP, Mahmood ASMH, Uddin MM et al. Effects of Ventromedial Hypothalamic Nucleus (VMN) Aromatase Gene Knockdown on VMN Glycogen Metabolism and Glucoregulatory Neurotransmission Biology 2023-02-03 [PMID: 36829519] (WB, Rat)	WB	Rat
Roy SC, Napit PR, Pasula MB et al. G-Protein-Coupled Lactate Receptor GPR81 Control of VMNvl Glucoregulatory Neurotransmitter and 5'-AMP-Activated Protein Kinase Expression American journal of physiology. Regulatory, integrative and comparative physiology 2022-11-21 [PMID: 36409024]
Uddin MM, Ibrahim MMH, Briski KP. Glycogen Phosphorylase Isoform Regulation of Ventromedial Hypothalamic Nucleus Gluco-Regulatory Neuron 5'-AMP-Activated Protein Kinase and Transmitter Marker Protein Expression ASN neuro 2021-10-01 [PMID: 34596459] (Rat)		Rat
Bheemanapally K, Napit PR, Ibrahim MMH, Briski KP UHPLC-electrospray ionization-mass spectrometric analysis of brain cell-specific glucogenic and neurotransmitter amino acid content Scientific reports 2021-08-09 [PMID: 34373537] (Rat)		Rat
Bheemanapally K, Ibrahim MMH, Alshamrani A, Briski KP Ventromedial Hypothalamic Nucleus Glycogen Regulation of Metabolic-Sensory Neuron AMPK and Neurotransmitter Expression: Role of Lactate American journal of physiology. Regulatory, integrative and comparative physiology 2021-04-07 [PMID: 33825506]
Briski KP, Ali MH, Napit PR et al. Sex differences in ventromedial hypothalamic nucleus glucoregulatory transmitter biomarker protein during recurring insulin-induced hypoglycemia Brain structure & function 2021-02-12 [PMID: 33580322]
Uddin MM, Ibrahim MMH, Briski KP Sex-dimorphic neuroestradiol regulation of ventromedial hypothalamic nucleus glucoregulatory transmitter and glycogen metabolism enzyme protein expression in the rat BMC Neurosci 2020-11-25 [PMID: 33238883]
Mahmood A S M H, Napit P R et al. Estrogen Receptor Involvement in Noradrenergic Regulation of Ventromedial Hypothalamic Nucleus Glucoregulatory Neurotransmitter and Stimulus-Specific Glycogen Phosphorylase Enzyme Isoform Expression. ASN Neuro 2020-03-04 [PMID: 32233668] (WB, Rat)	WB	Rat
Briski KP, Mandal SK, Bheemanapally K, Ibrahim MMH Effects of Acute versus Recurrent Insulin-Induced Hypoglycemia on Ventromedial Hypothalamic Nucleus Metabolic-Sensory Neuron AMPK Activity: Impact of Alpha1-Adrenergic Receptor Signaling Brain Res. Bull. 2020-01-22 [PMID: 31981674] (WB, Rat)	WB	Rat
Ibrahim MMH, Bheemanapally K, Alhamami HN, Briski KP Effects of Intracerebroventricular Glycogen Phosphorylase Inhibitor CP-316,819 Infusion on Hypothalamic Glycogen Content and Metabolic Neuron AMPK Activity and Neurotransmitter Expression in Male Rat J. Mol. Neurosci. 2020-01-11 [PMID: 31925707]
Briski K, Mandal S Hindbrain lactoprivic regulation of hypothalamic neuron transactivation and gluco-regulatory neurotransmitter expression: Impact of antecedent insulin-induced hypoglycemia Neuropeptides 2019-08-01 [PMID: 31488323] (WB, Rat)	WB	Rat
Uddin MM, Mahmood ASMH, Ibrahim MMH, Briski KP Sex-Dimorphic Estrogen Receptor Regulation of Ventromedial Hypothalamic Nucleus Glucoregulatory Neuron Adrenergic Receptor Expression in Hypoglycemic Male and Female Rats Brain Res. 2019-06-29 [PMID: 31265816] (IF/IHC, Rat)	IF/IHC	Rat
Wulamu W, Yisireyili M, Aili A et al. Hindbrain Estrogen Receptor Regulation of Ventromedial Hypothalamic Glycogen Metabolism and Glucoregulatory Transmitter Expression in the Hypoglycemic Female Rat Neuroscience 2019-05-12 [PMID: 31085279] (WB, Rat)	WB	Rat
Hasan Mahmood ASM, Mandal SK, Bheemanapally K et al. Norepinephrine control of ventromedial hypothalamic nucleus glucoregulatory neurotransmitter expression in the female rat: Role of monocarboxylate transporter function. Mol. Cell. Neurosci. 2019-01-17 [PMID: 30660767] (WB, Rat)	WB	Rat
Ibrahim MMH, Alhamami HN, Briski KP. Norepinephrine Regulation of Ventromedial Hypothalamic Nucleus Metabolic Transmitter Biomarker and Astrocyte Enzyme and Receptor Expression: Impact of 5' AMP-Activated Protein Kinase. Brain Res. 2019-01-07 [PMID: 30629946]
Mandal SK, Briski KP. Hindbrain Dorsal Vagal Complex AMPK Controls Hypothalamic Gluco-regulatory Transmitter and Counter-Regulatory Hormone Responses to Hypoglycemia. Brain Res. Bull. 2018-11-24 [PMID: 30481553] (WB, Rat)	WB	Rat
Show All 21 Publications. Collapse Publications.

Array NBP1-39681

• nNOS Antibodies
• nNOS ELISA Kits
• nNOS Lysate
• nNOS Proteins