NHERF-1 Antibody

EBP 50 [ERM (ezrin-radixin-moesin) binding phosphoprotein of 50 kDa] is a PDZ containing protein that is involved in the linkage of integral membrane proteins to the cytoskeleton. EBP50 contains two tandem PDZ domains followed by a carboxy-terminal sequence that binds to members of the ERM family of membrane-cytoskeleton adaptors. The PDZ domains within EBP50 bind to the carboxy termini of such target proteins as beta2 adrenergic receptor, platelet-derived growth factor receptor (PDGFR), and the cystic fibrosis conductance regulator (CFTR). The PDZ domains are also believed to be involved in the oligomerization of EBP 50 to form multiprotein complexes which helps to facilitate the formation of functional signalling complexes.

EBP 50 has been shown to link integral membrane proteins to the cytoskeleton by binding to members of the ERM family of proteins, which bind to F-actin. Through these interactions, EBP 50 is implicated in the localization of interactive groups of proteins into subcellular domains and in the regulation of activity of those interacting proteins. Immunohistochemical studies have shown that EBP 50 is found exclusively at the apical membranes of epithelial cells.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 applications: ICC/IF, IF/IHC.

Showing Publications 1 - 4 of 4.

Publications using NB300-536	Applications	Species
Chen HH, Handel N, Ngeow J et al. Immune dysregulation in patients with PTEN hamartoma tumor syndrome: Analysis of FOXP3 regulatory T cells. J. Allergy Clin. Immunol. 2017-02-01 [PMID: 27477328]
Ji M, Fan D, Yuan L et al. EBP50 inhibits pancreatic cancer cell growth and invasion by targeting the beta-catenin/E-cadherin pathway. Exp Ther Med 2015-10-01 [PMID: 26622484] (IF/IHC)	IF/IHC
Huang T, You Y, Spoor MS, Richer EJ, Kudva VV, Paige RC, Seiler MP, Liebler JM, Zabner J, Plopper CG, Brody SL. Foxj1 is required for apical localization of ezrin in airway epithelial cells. J Cell Sci;116(Pt 24):4935-45. 2003-12-15 [PMID: 14625387] (ICC/IF)	ICC/IF
Hartmann C, Thüring E, Michels B, et al. A novel adhesive complex at the base of intestinal microcilli bioRxiv 2021-01-28

Array NB300-536

• NHERF-1 Antibodies
• NHERF-1 Lysate
• NHERF-1 Proteins